Index	PubMed-ID	Relationship sentence	Type of interaction	Select	Classify	Check
1	17003041-302	Bestrophin-1 enables Ca2+-activated Cl-conductance in epithelia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2	17003041-304	Calcium-dependent Cl (-) currents were activated by ATP in HEK293 cells expressing BEST1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3	17003041-304	Calcium-dependent Cl (-) currents were activated by ATP in HEK293 cells expressing BEST1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4	17321121-703	The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5	17403602-1067	When Vitreoscilla were grown in medium containing 60mM sodium nitrite under both normal and limited aeration conditions, the levels of Vitreoscilla hemoglobin (VHb) were decreased by greater than 90%, while the levels of the terminal respiratory oxidase, cytochrome bo, were increased 350% under normal aeration and 7-23% under limited aeration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
6	17590240-1233	Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
7	17590240-1233	Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
8	17590240-1233	Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
9	17590240-1234	Here, we used a human neuronal cell line MC65 conditional expression of an amyloid precursor protein fragment (APP-C99) to investigate the protection mechanism of epigallocatechin gallate (EGCG), the main constituent of green tea.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
10	17590240-1234	Here, we used a human neuronal cell line MC65 conditional expression of an amyloid precursor protein fragment (APP-C99) to investigate the protection mechanism of epigallocatechin gallate (EGCG), the main constituent of green tea.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
11	17616381-938	The protease was purified to homogeneity using ammonium sulfate precipitation, and ion exchange chromatography with a fold purification of 1.8 and a recovery of 49%.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
12	17616381-938	The protease was purified to homogeneity using ammonium sulfate precipitation, and ion exchange chromatography with a fold purification of 1.8 and a recovery of 49%.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
13	17629591-228	In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
14	17629591-228	In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
15	17629591-228	In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
16	17692997-193	Furthermore, dithiothreitol was found to be capable of significantly preventing the inhibitory effect of insulin on Abeta oligomer formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
17	17719144-1171	The scavenger receptor, class B, type I (SR-BI) is critical in maintaining the homeostasis of cholesterol and alpha-tocopherol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
18	17719144-1171	The scavenger receptor, class B, type I (SR-BI) is critical in maintaining the homeostasis of cholesterol and alpha-tocopherol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
19	17719144-1172	SR-BI binds high-density lipoproteins (HDL) and mediates the selective transfer of cholesteryl esters and alpha-tocopherol from circulating HDL to cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
20	17719144-1172	SR-BI binds high-density lipoproteins (HDL) and mediates the selective transfer of cholesteryl esters and alpha-tocopherol from circulating HDL to cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
21	17719144-1173	Thus, SR-BI influences neural and cognitive processes, a finding that highlights the contribution of cholesterol and alpha-tocopherol homeostasis in proper cognitive function.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
22	17719144-1173	Thus, SR-BI influences neural and cognitive processes, a finding that highlights the contribution of cholesterol and alpha-tocopherol homeostasis in proper cognitive function.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
23	17768029-984	Alloxan is believed to confer its diabetogenic effect by inhibiting pancreatic glucokinase activity, leading to pancreatic beta-cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
24	17882129-602	Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
25	17888544-779	Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent models, there has not been a direct quantification of sphingomyelin or sterol levels in the brains of patients with different forms of ApoE.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
26	17888546-781	ApoE modified the association between cholesterol and cognitive decline, and the association between the ratio of 27-hydroxycholesterol to cholesterol and cognitive functioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
27	17888546-781	ApoE modified the association between cholesterol and cognitive decline, and the association between the ratio of 27-hydroxycholesterol to cholesterol and cognitive functioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
28	17890844-955	Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
29	17925795-1037	The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
30	17925795-1037	The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
31	17925795-1038	Treatment of cultured rat cortical neurons with therapeutic concentrations of LiCl or VPA selectively increased the levels of exon IV (formerly rat exon III)-containing BDNF mRNA, and the activity of BDNF promoter IV.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
32	17925795-1039	We showed that lithium-induced activation of promoter IV was mimicked by pharmacological inhibition of GSK-3 or short interfering RNA (siRNA)-mediated gene silencing of GSK-3alpha or GSK-3beta isoforms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
33	17925795-1039	We showed that lithium-induced activation of promoter IV was mimicked by pharmacological inhibition of GSK-3 or short interfering RNA (siRNA)-mediated gene silencing of GSK-3alpha or GSK-3beta isoforms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
34	17925795-1039	We showed that lithium-induced activation of promoter IV was mimicked by pharmacological inhibition of GSK-3 or short interfering RNA (siRNA)-mediated gene silencing of GSK-3alpha or GSK-3beta isoforms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
35	17925795-1040	Furthermore, treatment with other HDAC inhibitors, sodium butyrate and trichostatin A, or transfection with an HDAC1-specific siRNA also activated BDNF promoter IV.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
36	17925795-1040	Furthermore, treatment with other HDAC inhibitors, sodium butyrate and trichostatin A, or transfection with an HDAC1-specific siRNA also activated BDNF promoter IV.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
37	17925795-1041	Our study demonstrates for the first time that GSK-3 and HDAC are respective initial targets for lithium and VPA to activate BDNF promoter IV, and that this BDNF induction involves a novel responsive region in promoter IV of the BDNF gene.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
38	17925795-1041	Our study demonstrates for the first time that GSK-3 and HDAC are respective initial targets for lithium and VPA to activate BDNF promoter IV, and that this BDNF induction involves a novel responsive region in promoter IV of the BDNF gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
39	17941873-845	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
40	17941873-845	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
41	17941873-845	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
42	17941873-845	Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
43	17941873-846	Efficacy and safety of biphasic insulin aspart (BIAsp 30, 30% short-acting and 70% intermediate-acting insulin aspart) added to an optimized treatment of metformin and pioglitazone (met/pio) were compared with treatment with optimized met/pio in type 2 diabetes patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
44	17941873-846	Efficacy and safety of biphasic insulin aspart (BIAsp 30, 30% short-acting and 70% intermediate-acting insulin aspart) added to an optimized treatment of metformin and pioglitazone (met/pio) were compared with treatment with optimized met/pio in type 2 diabetes patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
45	17943458-544	N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
46	17943458-544	N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
47	17943458-544	N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
48	17950491-1121	In addition, treatment with rosiglitazone increased interleukin-4 (IL-4) mRNA and reversed the age-related decrease in hippocampal IL-4 concentration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
49	17965987-545	Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
50	17965987-545	Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
51	17965987-546	These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
52	17968352-734	Based on these validities we identified alterations in the Wolframin gene in the CA1 and amygdala regions, specifically in exposed PTSD-like rats, which were normalized after treatment with citalopram.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
53	17968676-958	Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
54	17968676-958	Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
55	17976762-900	Other potential treatments discussed for possible use with long-acting insulin overdoses include incision and drainage of the injection site, glucagon, and octreotide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
56	18037312-321	Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4 weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
57	18042181-811	To assess whether follicle-stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) modulate GSH production in Sertoli cells by regulating the expression of GCLC, GCLM and/or GR, we performed in vitro studies using rat Sertoli cells in primary culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
58	18042181-811	To assess whether follicle-stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) modulate GSH production in Sertoli cells by regulating the expression of GCLC, GCLM and/or GR, we performed in vitro studies using rat Sertoli cells in primary culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
59	18042181-811	To assess whether follicle-stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) modulate GSH production in Sertoli cells by regulating the expression of GCLC, GCLM and/or GR, we performed in vitro studies using rat Sertoli cells in primary culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
60	18042181-812	In conclusion, our results show that FSH and bFGF increase GSH levels in Sertoli cells through stimulation of the de novo synthesis and recycling by upregulating GCLM and GR expression respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
61	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
62	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
63	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
64	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
65	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
66	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
67	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
68	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
69	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
70	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
71	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
72	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
73	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
74	18061671-207	Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
75	18068270-465	Selenium and aluminum levels were not associated to CSF Abeta42.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
76	18068270-466	In vitro, the degradation of synthetic Abeta substrate added to CSF was markedly accelerated by low levels (2microM) of exogenous zinc and copper.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
77	18068871-859	Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
78	18068871-860	Similarly, mutant PS1 impairs the ability of the cholinesterase inhibitor phenserine to enhance LTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
79	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
80	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
81	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
82	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
83	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
84	18077014-827	It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
85	18079026-797	In the present study, we investigated the effects of quetiapine on memory impairment and pathological changes in an amyloid precursor protein (APP)/presenilin-1 (PS-1) double transgenic mouse model of Alzheimer's disease (AD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
86	18079026-797	In the present study, we investigated the effects of quetiapine on memory impairment and pathological changes in an amyloid precursor protein (APP)/presenilin-1 (PS-1) double transgenic mouse model of Alzheimer's disease (AD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
87	18079026-797	In the present study, we investigated the effects of quetiapine on memory impairment and pathological changes in an amyloid precursor protein (APP)/presenilin-1 (PS-1) double transgenic mouse model of Alzheimer's disease (AD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
88	18079026-798	Quetiapine also decreased brain Abeta peptides, beta-secretase activity and expression, and the level of C99 (an APP C-terminal fragment following cleavage by beta-secretase) in the transgenic mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
89	18079026-798	Quetiapine also decreased brain Abeta peptides, beta-secretase activity and expression, and the level of C99 (an APP C-terminal fragment following cleavage by beta-secretase) in the transgenic mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
90	18079026-799	Furthermore, quetiapine attenuated anxiety-like behavior, up-regulated cerebral Bcl-2 protein, and decreased cerebral nitrotyrosine in the transgenic mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
91	18162361-61	Rosuvastatin rapidly phosphorylated Akt and endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
92	18162361-61	Rosuvastatin rapidly phosphorylated Akt and endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
93	18162361-61	Rosuvastatin rapidly phosphorylated Akt and endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
94	18162361-62	Our findings indicate that rosuvastatin protects endothelial cells from death with phosphorylation of Akt and eNOS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
95	18162361-62	Our findings indicate that rosuvastatin protects endothelial cells from death with phosphorylation of Akt and eNOS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
96	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
97	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
98	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
99	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
100	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
101	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
102	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
103	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
104	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
105	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
106	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
107	18164165-377	Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
108	18172601-392	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
109	18172601-392	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
110	18172601-392	Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
111	18177531-936	Carbon monoxide is an endogenous vasodilator gas produced by the enzyme heme oxygenase (HO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
112	18179560-930	The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition receptor, involved in several processes ranging from innate resistance and inflammation to clearance of apoptotic cells and organization of hyaluronic acid-rich extracellular matrices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
113	18180755-369	The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
114	18180755-369	The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
115	18190985-361	Several studies have shown that epsilon 2 carriers have lower low-density lipoprotein and apo B levels and higher high-density lipoprotein cholesterol and apo A-I levels than epsilon 3 carriers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
116	18190985-361	Several studies have shown that epsilon 2 carriers have lower low-density lipoprotein and apo B levels and higher high-density lipoprotein cholesterol and apo A-I levels than epsilon 3 carriers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
117	18191451-670	Toxicity and characterization of cholinesterase-inhibition induced by diisopropyl fluorophosphate in Artemia salina larvae.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
118	18195714-756	Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
119	18195714-757	We report that peripheral administration of lipopolysaccharide (LPS) activates IDO and culminates in a distinct depressive-like behavioral syndrome, measured by increased duration of immobility in both the forced-swim and tail suspension tests.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
120	18195714-758	Administration of L-kynurenine, a metabolite of tryptophan that is generated by IDO, to naive mice dose dependently induces depressive-like behavior.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
121	18195714-758	Administration of L-kynurenine, a metabolite of tryptophan that is generated by IDO, to naive mice dose dependently induces depressive-like behavior.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
122	18198986-243	Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
123	18198986-245	Serum FABP levels were 2.5-fold higher in T2DM group relative to C and were not affected by fenofibrate treatment (C: 20.6+/-2.1 microg/l, T2DM before F: 55.6+/-5.7 microg/l, T2DM after F: 54.2+/-5.4 microg/l, p 0.0001 for C vs. T2DM before F).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
124	18198986-246	FABP levels positively correlated with BMI, triglyceride levels, blood glucose, glycated hemoglobin, atherogenic index and insulin levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
125	18198986-246	FABP levels positively correlated with BMI, triglyceride levels, blood glucose, glycated hemoglobin, atherogenic index and insulin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
126	18198986-246	FABP levels positively correlated with BMI, triglyceride levels, blood glucose, glycated hemoglobin, atherogenic index and insulin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
127	18198997-256	Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
128	18198997-257	We demonstrated that butyrate stimulated the gene expression of both secreted (Muc2) and membrane-linked (Muc1, Muc3, Muc4) mucins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
129	18198997-257	We demonstrated that butyrate stimulated the gene expression of both secreted (Muc2) and membrane-linked (Muc1, Muc3, Muc4) mucins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
130	18198997-258	Butyrate especially induced a 6-fold increase in Muc2 gene expression in proximal colon.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
131	18198997-259	However, butyrate enemas did not modify the number of epithelial cells containing the protein Muc2, and caused a 2-fold decrease in the thickness of adherent mucus layer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
132	18204887-141	We examined the association of MTHFR C677T and A1298C, and changes in plasma homocysteine in 352 Tunisian patients with angiographically-demonstrated CAD, and 390 age and gender-matched healthy subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
133	18205042-213	However, we also observed that clotrimazol (1alpha-hydroxylase inhibitor) enhanced 25(OH)D(3)-induced CYP24 expression in breast cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
134	18207583-646	Expression of senescence-associated beta-galactosidase (SA-beta-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
135	18207583-646	Expression of senescence-associated beta-galactosidase (SA-beta-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
136	18221806-436	Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: a dose-response effect dependent on endothelial nitric oxide synthase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
137	18222028-559	It has been shown that the removal efficiency of COD increased with the increasing applied current density and increasing PAC and Na (2)SO(4) dosage and the most effective removal capacity was achieved at the pH 7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
138	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
139	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
140	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
141	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
142	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
143	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidaseglutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
144	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
145	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
146	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
147	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
148	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
149	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
150	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
151	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
152	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
153	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
154	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
155	18222543-918	The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
156	18226951-1110	Abnormally high CSF 3-OMD occurs frequently for RLS patients indicating either increased l-dopa synthesis, limitations in l-dopa decarboxylation or increased MAT/COMT activity, or some combination of these.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
157	18226951-1110	Abnormally high CSF 3-OMD occurs frequently for RLS patients indicating either increased l-dopa synthesis, limitations in l-dopa decarboxylation or increased MAT/COMT activity, or some combination of these.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
158	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
159	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
160	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
161	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
162	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
163	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
164	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
165	18227836-349	To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
166	18227838-352	The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK pathway-mediated neurite growth, neuronal survival and hippocampal neurogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
167	18227838-352	The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK pathway-mediated neurite growth, neuronal survival and hippocampal neurogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
168	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
169	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
170	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
171	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
172	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
173	18227970-442	In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
174	18228136-547	RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
175	18228136-547	RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
176	18228136-547	RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
177	18228136-547	RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
178	18228136-548	The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
179	18228136-548	The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
180	18228136-548	The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
181	18228136-548	The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
182	18228136-549	In conclusion, 2ME chemosensitizes resistant breast cancer cells to Dox cytotoxicity by down regulating expression of Bcl2 and Cyclin D1, augmenting caspase 3 activity as well as inducing cell cycle block in G(1) and S phases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
183	18228136-549	In conclusion, 2ME chemosensitizes resistant breast cancer cells to Dox cytotoxicity by down regulating expression of Bcl2 and Cyclin D1, augmenting caspase 3 activity as well as inducing cell cycle block in G(1) and S phases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
184	18230627-837	Randomised trials have demonstrated that the efficacy of anti-tumour necrosis factor (TNF) agents is significantly increased by concomitant methotrexate (MTX) in rheumatoid arthritis (RA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
185	18243311-231	Neither apyrase nor ATP altered production of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by bovine monocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
186	18243311-231	Neither apyrase nor ATP altered production of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by bovine monocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
187	18243311-231	Neither apyrase nor ATP altered production of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by bovine monocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
188	18243368-1130	In this systematic review, we have analyzed the results of 52 clinical trials, including 72 intervention groups and 6290 patients, on vitamin D supplementation in order to evaluate the experimental evidence and the effects of age and chronic immobility on responses of parathyroid hormone (PTH).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
189	18243368-1131	The vitamin D supplementation of the chronically immobile patients resulted in a smaller decrease in PTH 0.001).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
190	18243368-1132	Our results also suggest that PTH decreases quite linearly during vitamin D supplementation at any given 25-OHD level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
191	18248398-140	Leptin did not show any effect in long photoperiod but decreased proliferation by stimulating melatonin in short photoperiod.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
192	18249383-1046	To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
193	18249399-1054	Common 677C-->T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
194	18253022-733	Surprisingly, a deletion of the pilR gene affected not only insoluble Fe(III) reduction, which requires pili, but also soluble Fe(III) reduction, which, in contrast, does not require pili.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
195	18253697-765	Furthermore, the suppressive effects of P on cytochrome c release and caspase-9 and caspase-3 activation in serum-deprived MC3T3-E1 cells were also reversed by RU486.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
196	18256928-624	Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
197	18256928-625	However, when ERalpha negative MDA-MB-435 cells were treated with metformin, they demonstrated increased expression of vascular endothelial growth factor (VEGF) in an AMPK dependent manner; while the ERalpha positive MCF-7 cells did not.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
198	18256928-625	However, when ERalpha negative MDA-MB-435 cells were treated with metformin, they demonstrated increased expression of vascular endothelial growth factor (VEGF) in an AMPK dependent manner; while the ERalpha positive MCF-7 cells did not.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
199	18256928-626	The metformin-treated group showed increased VEGF expression, intratumoral microvascular density and reduced necrosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
200	18256928-627	Metformin treatment was sufficient, however, to reduce systemic IGF-1 and the proliferation rate of tumor cells in vascularized regions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
201	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
202	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
203	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
204	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
205	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
206	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
207	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
208	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
209	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
210	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
211	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
212	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
213	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
214	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
215	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
216	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
217	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
218	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
219	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
220	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
221	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
222	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
223	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
224	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
225	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
226	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
227	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
228	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
229	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
230	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
231	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
232	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
233	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
234	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
235	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
236	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
237	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
238	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
239	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
240	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
241	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
242	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
243	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
244	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
245	18260130-109	TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
246	18262559-301	Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
247	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
248	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
249	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
250	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
251	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
252	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
253	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
254	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
255	18262738-416	The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
256	18266054-1214	At the time, glutathione reductase activity was significantly inhibited and gamma-glutamyl cysteine increased by ACA exposure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
257	18268501-1260	The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
258	18268501-1260	The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
259	18270841-348	Increased somatostatin tone and decreased ghrelin concentrations may also contribute to reduced GH levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
260	18272254-1258	Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
261	18274872-320	) O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
262	18274872-320	) O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
263	18274872-320	) O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
264	18274872-320	) O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
265	18279956-684	A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
266	18279956-684	A novel oligodeoxynuleotides containing 11 CpG motifs was synthesized and inserted into the VR1020 plasmid containing pig interleukin-6 (IL-6) gene (VPIL6) to construct recombinant plasmid, VPIL6C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
267	18280595-101	Furthermore, it has also been reported that capsaicin-treated pigs significantly increase mean arterial blood pressure compared with controls and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
268	18283487-569	Since then, the efforts of numerous investigators have led to the following conclusions: (a) This enzyme is indeed the molecular machine for the ATP-dependent and-coupled transport of Na (+) and K(+) across the plasma membrane of a living cell in which such a process (sodium pump) is detected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
269	18283487-569	Since then, the efforts of numerous investigators have led to the following conclusions: (a) This enzyme is indeed the molecular machine for the ATP-dependent and-coupled transport of Na (+) and K(+) across the plasma membrane of a living cell in which such a process (sodium pump) is detected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
270	18286621-29	Affinity electrophoresis analysis provided evidence that carboxymethylated dextran polymers grafted with high amounts of benzylamide groups (named DMCB) interact with BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
271	18286621-29	Affinity electrophoresis analysis provided evidence that carboxymethylated dextran polymers grafted with high amounts of benzylamide groups (named DMCB) interact with BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
272	18286621-30	A screening study provided evidence that the potentiating effects of the dextran derivatives on the BMP-2-induced alkaline phosphatase activity improved with their benzylamide groups content and, therefore, with their affinity for the growth factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
273	18286621-30	A screening study provided evidence that the potentiating effects of the dextran derivatives on the BMP-2-induced alkaline phosphatase activity improved with their benzylamide groups content and, therefore, with their affinity for the growth factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
274	18286621-30	A screening study provided evidence that the potentiating effects of the dextran derivatives on the BMP-2-induced alkaline phosphatase activity improved with their benzylamide groups content and, therefore, with their affinity for the growth factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
275	18286621-30	A screening study provided evidence that the potentiating effects of the dextran derivatives on the BMP-2-induced alkaline phosphatase activity improved with their benzylamide groups content and, therefore, with their affinity for the growth factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
276	18294936-104	Since buprenorphine is metabolized through cytochrome P450 3A4, we genotyped six genetic polymorphisms previously described in poor metabolizers but could not confirm these pharmacogenetic bases in this case.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
277	18295378-334	Mitochondrial dysfunction was associated with higher levels of reactive oxygen species, an altered Bcl-xL/Bax ratio and reduction of COX IV activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
278	18295378-334	Mitochondrial dysfunction was associated with higher levels of reactive oxygen species, an altered Bcl-xL/Bax ratio and reduction of COX IV activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
279	18298568-1058	Peripheral venous levels of testosterone, prolactin, follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), malondialdehyde and glycosylated haemoglobin (HbA(1)c) were obtained in all subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
280	18298568-1058	Peripheral venous levels of testosterone, prolactin, follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), malondialdehyde and glycosylated haemoglobin (HbA(1)c) were obtained in all subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
281	18298570-1059	Our results showed that catalase abolished the effect of the oxidant, protecting spermatozoa against reactive oxygen species, and improving both sperm motility and chromatin status during incubation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
282	18298659-1127	Intranasal and intravenous administration of live Cpn and Aa, respectively induced an accumulation of activated mast cells in the aortic sinus of apolipoprotein E-deficient mice, however, with varying responses in the systemic levels of lipopolysaccharide (LPS) and TNF-alpha.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
283	18304632-1001	MnSOD and two additional catalase isozymes were induced by quinclorac or bensulfuron-methyl in S. maltophilia WZ2, but not in E. coli K12.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
284	18304632-1001	MnSOD and two additional catalase isozymes were induced by quinclorac or bensulfuron-methyl in S. maltophilia WZ2, but not in E. coli K12.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
285	18304632-1001	MnSOD and two additional catalase isozymes were induced by quinclorac or bensulfuron-methyl in S. maltophilia WZ2, but not in E. coli K12.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
286	18304632-1001	MnSOD and two additional catalase isozymes were induced by quinclorac or bensulfuron-methyl in S. maltophilia WZ2, but not in E. coli K12.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
287	18304632-1002	Results indicate that catalase has a much weakly role in the defense against quinclorac or bensulfuron-methyl induced oxidative stress, whereas SOD could be critical.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
288	18304632-1002	Results indicate that catalase has a much weakly role in the defense against quinclorac or bensulfuron-methyl induced oxidative stress, whereas SOD could be critical.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
289	18304632-1002	Results indicate that catalase has a much weakly role in the defense against quinclorac or bensulfuron-methyl induced oxidative stress, whereas SOD could be critical.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
290	18304632-1002	Results indicate that catalase has a much weakly role in the defense against quinclorac or bensulfuron-methyl induced oxidative stress, whereas SOD could be critical.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
291	18304748-1077	Moreover, TARPs (except gamma4) reduce the ion channel block by the synthetic Joro spider toxin analog 1-naphthylacetyl spermine (NASP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
292	18304748-1077	Moreover, TARPs (except gamma4) reduce the ion channel block by the synthetic Joro spider toxin analog 1-naphthylacetyl spermine (NASP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
293	18306310-763	SMC cultured on P(100/0) films modified by covalently attached fibronectin or fibrin layers proliferated at a rate comparable to that observed on control tissue culture polystyrene.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
294	18306310-764	However, prewetting P(70/30) with a phosphate buffer prior to aminolysis significantly improved cell numbers following immobilization of fibronectin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
295	18308488-862	The dose of ACTH (2.5 microg/kg) was chosen to mimic the cortisol concentrations seen during mixing of unfamiliar sows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
296	18311594-236	Our data suggest HumDN1 genotypes are related to total cholesterol levels in Han Chinese MI patients, but deoxyribonuclease I gene polymorphisms are not associated with susceptibility to MI in Han Chinese.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
297	18314895-1018	Specifically, TEG was shown to alter S. mutans gene expression levels of gtfB, a known virulence factor, and yfiV, a putative transcriptional regulator of cell-surface fatty acid genes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
298	18314895-1018	Specifically, TEG was shown to alter S. mutans gene expression levels of gtfB, a known virulence factor, and yfiV, a putative transcriptional regulator of cell-surface fatty acid genes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
299	18314898-1022	Degradation analysis over 8 weeks in the presence of 10 mg/L lysozyme showed a 50% decrease in total weight and an 80% decrease in PLGA molecular weight.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
300	18317936-346	Fluo-3 staining used in flow cytometry and video microscopy revealed an oxysterol-induced Ca(2+) influx, varying according to the oxysterol studied, leading to the activation of the MEK/ERK1/2 pathway as demonstrated by Western blot analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
301	18327670-82	To determine if response to endocrine therapy of breast cancer can be predicted by either a metabolic "flare reaction" detected by positron emission tomography (PET) with 2-((18)F)-fluoro-2-deoxyglucose (FDG), induced by an estradiol challenge, or by estrogen-receptor (ER) status, determined by PET with the estrogen analog 16alpha-((18)F)fluoroestradiol-17beta (FES).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
302	18327670-82	To determine if response to endocrine therapy of breast cancer can be predicted by either a metabolic "flare reaction" detected by positron emission tomography (PET) with 2-((18)F)-fluoro-2-deoxyglucose (FDG), induced by an estradiol challenge, or by estrogen-receptor (ER) status, determined by PET with the estrogen analog 16alpha-((18)F)fluoroestradiol-17beta (FES).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
303	18328561-582	Depletion of GSH levels was accompanied by the induction of glutathione reductase (GR) after 24h exposure with each of the four carbamates to CHO-K1 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
304	18330498-512	Chloroquine and wortmannin inhibited the upregulation induced by insulin stimulation and amino acid deprivation but not that induced by osmotic shock.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
305	18330498-512	Chloroquine and wortmannin inhibited the upregulation induced by insulin stimulation and amino acid deprivation but not that induced by osmotic shock.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
306	18330498-513	Moreover, PD98059 and SP600125 inhibited only amino acid deprivation-induced upregulation and SB202190 inhibited only insulin-induced upregulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
307	18330498-513	Moreover, PD98059 and SP600125 inhibited only amino acid deprivation-induced upregulation and SB202190 inhibited only insulin-induced upregulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
308	18330498-513	Moreover, PD98059 and SP600125 inhibited only amino acid deprivation-induced upregulation and SB202190 inhibited only insulin-induced upregulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
309	18331557-1201	The role of phosphorylated Akt (p-Akt) in oral carcinogenesis induced by nicotine and alkaline environments was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
310	18336537-456	Sera from a population sample of infants with cryptorchidism (n = 43), hypospadias (n = 41) and controls (n = 113) were analyzed for inhibin B, anti-Müllerian hormone (AMH), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin (SHBG).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
311	18336537-456	Sera from a population sample of infants with cryptorchidism (n = 43), hypospadias (n = 41) and controls (n = 113) were analyzed for inhibin B, anti-Müllerian hormone (AMH), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin (SHBG).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
312	18340529-389	Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
313	18343629-1064	In present study, we investigated the combined effect of emodin and baicalin on pancreatic damage and pancreatitis associated lung injury, as well as tissue TLR4 expression in the setting of AP.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
314	18343629-1064	In present study, we investigated the combined effect of emodin and baicalin on pancreatic damage and pancreatitis associated lung injury, as well as tissue TLR4 expression in the setting of AP.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
315	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
316	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
317	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
318	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
319	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
320	18343629-1065	The results showed that combination of emodin and baicalin significantly reduced serum amylase, tumor necrosis factor-alpha and interleukin-6, attenuated pancreatic and pulmonary damage, also suppressed TLR4 expression in pancreas and lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
321	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
322	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
323	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
324	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
325	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
326	18346857-498	Results showed that a moderate dose of leptin (250 microg/kg body weight/day) injected during the re-feeding period: (i) promoted the recovery of the regressed ovary as evidenced by an increase in ovary weight and recovery of yellow hierarchical follicles; (ii) elevated the plasma 17beta-estradiol (E(2)) level; (iii) increased the mRNA levels of ovary follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and estrogen receptor-beta (ER-beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
327	18357521-771	The anti-neoplastic drug taxol binds to beta-tubulin to prevent tumor cell division, promoting cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
328	18357521-772	In the current study, we knocked down Bcl-2 expression using cognate siRNA during low-dose taxol treatment to induce apoptosis in two human glioblastoma U138MG and U251MG cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
329	18357521-773	The cells were treated with either 100 nM taxol or 100 nM Bcl-2 siRNA or both for 72 h. Immunofluorescent stainings for calpain and active caspase-3 showed increases in expression and co-localization of these proteases in apoptotic cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
330	18357521-774	Our current study demonstrated that Bcl-2 siRNA significantly augmented taxol mediated apoptosis in different human glioblastoma cells through induction of calpain and caspase proteolytic activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
331	18357522-775	Based on these findings, altered expression of PLP1 in most areas of the striatum suggests that widespread changes to the myelin structure could be associated with the adaptive changes following chronic cocaine abuse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
332	18359113-478	No correlation was detected between serum leptin level and vitamin D-25(OH)D3, which was under normal range in 60% of the patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
333	18359113-479	The higher leptin levels in women was accompanied by higher serum levels of glucose, albumin, Ca, cholesterol, Na and FT4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
334	18359113-479	The higher leptin levels in women was accompanied by higher serum levels of glucose, albumin, Ca, cholesterol, Na and FT4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
335	18359113-479	The higher leptin levels in women was accompanied by higher serum levels of glucose, albumin, Ca, cholesterol, Na and FT4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
336	18359113-480	Comparison of 50 patients with the lowest leptin levels (mean of 3.4ng/ml) to 50 patients with highest leptin levels (mean of 34ng/ml), did not indicate differences in both 25(OH)D3 and ICTP between these two populations in spite of the highly significant difference in leptin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
337	18363836-902	The effects on the early secretory pathway in HEK293 cells were: reduction of the rate of ER-to-Golgi transport of the vesicular stomatitis virus glycoprotein (VSVG), slowed accumulation of a Golgi marker plasmid in pre-Golgi structures after Brefeldin A treatment and inhibition of cargo concentration of the neuronal glutamate transporter excitatory amino-acid carrier 1 (EAAC1) into transpor complexes in HEK293 cells, an effect that could be completely reversed in the presence of an excess of Rab1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
338	18363836-902	The effects on the early secretory pathway in HEK293 cells were: reduction of the rate of ER-to-Golgi transport of the vesicular stomatitis virus glycoprotein (VSVG), slowed accumulation of a Golgi marker plasmid in pre-Golgi structures after Brefeldin A treatment and inhibition of cargo concentration of the neuronal glutamate transporter excitatory amino-acid carrier 1 (EAAC1) into transpor complexes in HEK293 cells, an effect that could be completely reversed in the presence of an excess of Rab1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
339	18363836-902	The effects on the early secretory pathway in HEK293 cells were: reduction of the rate of ER-to-Golgi transport of the vesicular stomatitis virus glycoprotein (VSVG), slowed accumulation of a Golgi marker plasmid in pre-Golgi structures after Brefeldin A treatment and inhibition of cargo concentration of the neuronal glutamate transporter excitatory amino-acid carrier 1 (EAAC1) into transpor complexes in HEK293 cells, an effect that could be completely reversed in the presence of an excess of Rab1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
340	18363836-902	The effects on the early secretory pathway in HEK293 cells were: reduction of the rate of ER-to-Golgi transport of the vesicular stomatitis virus glycoprotein (VSVG), slowed accumulation of a Golgi marker plasmid in pre-Golgi structures after Brefeldin A treatment and inhibition of cargo concentration of the neuronal glutamate transporter excitatory amino-acid carrier 1 (EAAC1) into transpor complexes in HEK293 cells, an effect that could be completely reversed in the presence of an excess of Rab1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
341	18367388-537	Resveratrol did not attenuate GA-induced generation of hydrogen peroxide, but it did block GA-induced phosphorylation of connexin 43 (Cx43), a key modulator of GJIC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
342	18367388-537	Resveratrol did not attenuate GA-induced generation of hydrogen peroxide, but it did block GA-induced phosphorylation of connexin 43 (Cx43), a key modulator of GJIC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
343	18367388-537	Resveratrol did not attenuate GA-induced generation of hydrogen peroxide, but it did block GA-induced phosphorylation of connexin 43 (Cx43), a key modulator of GJIC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
344	18367388-537	Resveratrol did not attenuate GA-induced generation of hydrogen peroxide, but it did block GA-induced phosphorylation of connexin 43 (Cx43), a key modulator of GJIC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
345	18367388-538	Furthermore, resveratrol down-regulated GA-induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2, one of the critical regulators of Cx43.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
346	18367388-538	Furthermore, resveratrol down-regulated GA-induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2, one of the critical regulators of Cx43.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
347	18368465-1220	DFMO accumulated cells in S phase of the cell cycle and reduced cyclin A expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
348	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
349	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
350	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
351	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
352	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
353	18368485-1240	Indeed, treatment of cells with 1 muM all-trans retinoic acid (ATRA) or 1 muM 13-cis retinoic acid (13-CRA) for 7 days induced astrocytic differentiation with upregulation of glial fibrillary acidic protein (GFAP) and down regulation of telomerase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
354	18368485-1241	Wright staining and ApopTag assay showed, respectively, morphological and biochemical features of apoptosis in glioblastoma cells following exposure to 200 units/ml IFN-gamma for 48 h. Induction of differentiation was associated with decreases in levels of nuclear factor kappa B (NFkappaB), inducible nitric oxide synthase (iNOS), and production of nitric oxide (NO) so as to increase sensitivity to IFN-gamma for apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
355	18368485-1241	Wright staining and ApopTag assay showed, respectively, morphological and biochemical features of apoptosis in glioblastoma cells following exposure to 200 units/ml IFN-gamma for 48 h. Induction of differentiation was associated with decreases in levels of nuclear factor kappa B (NFkappaB), inducible nitric oxide synthasenitric oxide synthase (iNOS), and production of nitric oxide (NO) so as to increase sensitivity to IFN-gamma for apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
356	18368485-1241	Wright staining and ApopTag assay showed, respectively, morphological and biochemical features of apoptosis in glioblastoma cells following exposure to 200 units/ml IFN-gamma for 48 h. Induction of differentiation was associated with decreases in levels of nuclear factor kappa B (NFkappaB), inducible nitric oxide synthase (iNOS), and production of nitric oxide (NO) so as to increase sensitivity to IFN-gamma for apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
357	18371961-849	Because annexin V binds phosphatidylserine, this study is using this feature to select functional spermatozoa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
358	18373731-672	Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
359	18373731-674	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
360	18373731-674	Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
361	18374997-195	In women, Plg levels were higher in individuals with diagnosed ischemic heart disease (IHD) and increased with triglycerides (TG) and glucose level.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
362	18375536-500	To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
363	18375536-500	To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
364	18375536-500	To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
365	18378405-1044	Using a cell culture model of synaptic NMDA receptor-dependent synaptic potentiation, we find that this is mediated exclusively by NR2B-containing N-methyl-D-aspartate receptors, as implicated by NR2B-specific antagonists and the use of selective vs. non-selective doses of the NR2A-preferring antagonist NVP-AAM077.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
366	18379782-593	Dexrazoxane protects against doxorubicin-induced cardiomyopathy: upregulation of Akt and Erk phosphorylation in a rat model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
367	18380536-252	Intracellular oxidative status was assessed by analysis of GSH/GSSG levels and time course of ROS production and glutathione reductase (GR) activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
368	18380536-252	Intracellular oxidative status was assessed by analysis of GSH/GSSG levels and time course of ROS production and glutathione reductase (GR) activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
369	18380539-1099	A recently discussed cardiovascular risk factor, asymmetric dimethylarginine (ADMA), is known to act as an endogenous inhibitor of endothelial nitric oxide synthase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
370	18380539-1099	A recently discussed cardiovascular risk factor, asymmetric dimethylarginine (ADMA), is known to act as an endogenous inhibitor of endothelial nitric oxide synthase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
371	18380542-1100	The net exercise-induced increase in 6-keto-PGF (1alpha) concentration, expressed as the difference between the end-exercise minus pre-exercise concentration positively correlated with VO(2max) (r=0.78, p=0.004) as well as with the net VO(2) increase at exhaustion (r=0.81, p=0.003), but not with other respiratory, cardiac, metabolic or inflammatory parameters of the exercise (minute ventilation, heart rate, plasma lactate, IL-6 or TNF-alpha concentrations).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
372	18380542-1100	The net exercise-induced increase in 6-keto-PGF (1alpha) concentration, expressed as the difference between the end-exercise minus pre-exercise concentration positively correlated with VO(2max) (r=0.78, p=0.004) as well as with the net VO(2) increase at exhaustion (r=0.81, p=0.003), but not with other respiratory, cardiac, metabolic or inflammatory parameters of the exercise (minute ventilation, heart rate, plasma lactate, IL-6 or TNF-alpha concentrations).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
373	18380542-1100	The net exercise-induced increase in 6-keto-PGF (1alpha) concentration, expressed as the difference between the end-exercise minus pre-exercise concentration positively correlated with VO(2max) (r=0.78, p=0.004) as well as with the net VO(2) increase at exhaustion (r=0.81, p=0.003), but not with other respiratory, cardiac, metabolic or inflammatory parameters of the exercise (minute ventilation, heart rate, plasma lactate, IL-6 or TNF-alpha concentrations).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
374	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
375	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
376	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
377	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
378	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
379	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
380	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
381	18380545-1104	Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
382	18380545-1105	Significant elevation of numbers of GM-CFC evoked by the combinations of IB-MECA with IL-3, SCF, or GM-CSF as compared with these growth factors alone has been noted.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
383	18380545-1105	Significant elevation of numbers of GM-CFC evoked by the combinations of IB-MECA with IL-3, SCF, or GM-CSF as compared with these growth factors alone has been noted.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
384	18380545-1106	Combination of IB-MECA with G-CSF did not induce significantly higher numbers of GM-CFC in comparison with G-CSF alone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
385	18380545-1107	Joint action of three drugs, namely of IB-MECA+ IL-3+ GM-CSF, produced significantly higher numbers of GM-CFC in comparison with the combinations of IB-MECA+ IL-3, IB-MECA+ GM-CSF, or IL-3+ GM-CSF.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
386	18380545-1107	Joint action of three drugs, namely of IB-MECA+ IL-3+ GM-CSF, produced significantly higher numbers of GM-CFC in comparison with the combinations of IB-MECA+ IL-3, IB-MECA+ GM-CSF, or IL-3+ GM-CSF.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
387	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
388	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
389	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
390	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
391	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
392	18381637-476	Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
393	18381638-477	Fibronectin modulates osteoblast behavior on Nitinol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
394	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
395	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
396	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
397	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
398	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
399	18384163-783	Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
400	18386138-732	Treatment of H9c2 cell with low concentrations of Dox causes alterations in fibrous structural proteins including the nuclear lamina and sarcomeric cardiac myosin, as well as mitochondrial depolarization and fragmentation, membrane blebbing with cell shape changes, and phosphatidylserine externalization.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
401	18387753-460	We monitored bcr-abl transcript levels by quantitative real time PCR in 50 tunisian patients treated with imatinib for chronic myeloid leukemia in chronic phase for a median of 29 months (3-60) after they started imatinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
402	18387753-460	We monitored bcr-abl transcript levels by quantitative real time PCR in 50 tunisian patients treated with imatinib for chronic myeloid leukemia in chronic phase for a median of 29 months (3-60) after they started imatinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
403	18389169-121	The non-covalent interaction of brilliant red (BR) with lysozyme was investigated by the UV spectrometry, circular dichroism (CD) and isothermal titration calorimetry (ITC).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
404	18390571-968	Recent studies suggest that crystals of monosodium urate (MSU), deposited in joints of patients with acute gouty arthritis, activate the NACHT domain, leucine-rich repeat and pyrin domain-containing protein (NALP)3 inflammasome.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
405	18390571-968	Recent studies suggest that crystals of monosodium urate (MSU), deposited in joints of patients with acute gouty arthritis, activate the NACHT domain, leucine-rich repeat and pyrin domain-containing protein (NALP)3 inflammasome.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
406	18393628-298	Nicotine, muscarine, and chlorpyrifos induced the phosphorylation of extracellular signal-regulated kinases 1 and 2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
407	18393628-298	Nicotine, muscarine, and chlorpyrifos induced the phosphorylation of extracellular signal-regulated kinases 1 and 2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
408	18393628-298	Nicotine, muscarine, and chlorpyrifos induced the phosphorylation of extracellular signal-regulated kinases 1 and 2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
409	18393672-326	Adult bone marrow (BM)-derived insulin-producing cells (IPCs) are capable of regulating blood glucose levels in chemically induced hyperglycemic mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
410	18393672-328	Treatment with benfotiamine activated glucose metabolism in INS-1 cells in high-glucose culture conditions, and appeared to maximize the BM-derived IPCs ability to synthesize insulin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
411	18393672-328	Treatment with benfotiamine activated glucose metabolism in INS-1 cells in high-glucose culture conditions, and appeared to maximize the BM-derived IPCs ability to synthesize insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
412	18393672-329	Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
413	18393672-329	Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
414	18393672-329	Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
415	18393672-329	Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
416	18393672-330	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
417	18393672-330	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
418	18393672-330	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
419	18393672-330	However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
420	18394828-1061	) and two oxygen tensions (5 and 20%) were compared for their ability to sustain blastocyst survival and IFNT production from days 8 to 11 post-insemination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
421	18394828-1062	In conclusion, culturing blastocysts of cattle in a 5% oxygen environment with M199 containing serum sustains embryo viability and permits constitutive and inducible IFNT production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
422	18394828-1063	Incubation in 20% oxygen increases IFNT production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
423	18395421-172	Histologic examination investigated deposition of extracellular matrix (ECM) including collagen, elastin, hyaluronic acid (HA), fibronectin, and decorin in the lamina propria of the scarred vocal folds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
424	18395421-172	Histologic examination investigated deposition of extracellular matrix (ECM) including collagen, elastin, hyaluronic acid (HA), fibronectin, and decorin in the lamina propria of the scarred vocal folds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
425	18395421-172	Histologic examination investigated deposition of extracellular matrix (ECM) including collagen, elastin, hyaluronic acid (HA), fibronectin, and decorin in the lamina propria of the scarred vocal folds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
426	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
427	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
428	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
429	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
430	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
431	18396353-715	A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
432	18396355-716	In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
433	18396355-716	In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
434	18396355-717	A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
435	18396355-717	A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
436	18396355-717	A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
437	18396355-717	A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
438	18396355-718	Among the synthesized compounds, alpha,alpha'xylene-bis-(3,3'-(hydroxyiminomethyl) pyridinium) dibromide (3b) was found to be most potent reactivator for AChE inhibited by sarin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
439	18396356-720	Of the compounds synthesized, compound 2a, which has a primary amide at warhead region of the inhibitor most potently inhibited mu-calpain with an IC(50) value of 2.81+/-1.26 microM, which is ca.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
440	18397836-365	Recent studies have focused on possible functional disorders of the enteric nervous system within the abomasal wall, since cattle with abomasal displacement have an increased activity of neuronal nitric oxide synthase, as well as decreased acetylcholine sensitivity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
441	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
442	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
443	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
444	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
445	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
446	18397960-447	Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
447	18398609-866	Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
448	18398609-866	Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
449	18398611-867	An individual's response to fludarabine may be influenced by the amount of CD4 (+) and CD8(+) T-lymphocyte suppression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
450	18398624-876	We hypothesise that arginine aspartate acts as a chemical or pharmacological chaperone, and suggest amino acid supplementation as a possible therapy in PDHA1 mutations with mild phenotypes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
451	18400050-469	mRNA expressions of matrix metallopeptidase-9, inducible nitric oxide synthase and pro-inflammatory cytokines interleukin-1 beta and tumour necrosis factor-alpha in EAN sciatic nerves were greatly decreased by administration of minocycline as well.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
452	18400404-699	Then the review evaluates the involvement of KARs activated by the endogenous agonist glutamate in the generation and propagation of epileptiform activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
453	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
454	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
455	18403016-272	Glutamate cysteine ligasecysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
456	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
457	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
458	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
459	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
460	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
461	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
462	18403016-272	Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
463	18403053-226	We observed that lactacystin inhibited the proteasome activities and increased the level and insolubility of different tau species, including phosphorylated tau.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
464	18404246-532	Serine and cysteine proteases proved to be suitable tools for the production of amino acids and peptides conjugated to 4-aminoantipyrine, whereas metalloproteases do not seem to be very qualified for accepting this nucleophile.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
465	18405417-151	Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
466	18405417-152	The present study was undertaken to evaluate the potential role of 5-HT1A receptors in the antidepressant-like effect and antinociceptive effect of venlafaxine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
467	18405417-154	These findings show that 5-HT1A receptors play differing roles in modulating the antidepressant-like and antinociceptive effects of venlafaxine in the models investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
468	18405417-155	In contrast, the antinociceptive effect of venlafaxine is probably potentiated due to the blockade of somatodendritic 5-HT1A receptors in the same raphe nuclei, facilitating the descending monoaminergic pain control system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
469	18407279-655	Moreover, beta-glucuronidase hydrolysis of baicalin sequentially yielded glucuronic acid and baicalein as confirmed by co-TLC with authentic samples.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
470	18407279-655	Moreover, beta-glucuronidase hydrolysis of baicalin sequentially yielded glucuronic acid and baicalein as confirmed by co-TLC with authentic samples.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
471	18407527-68	The effect of this diet alone or after 2 weeks of treatment with rosiglitazone or glimepiride on glucose homeostasis, lipid profile, and levels of resistin and leptin was studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
472	18407527-68	The effect of this diet alone or after 2 weeks of treatment with rosiglitazone or glimepiride on glucose homeostasis, lipid profile, and levels of resistin and leptin was studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
473	18407527-71	Rosiglitazone corrected the altered parameters measured, except for liver TGs ; similarly, glimepiride reinstated the inverted parameters but raised insulin level and, consequently, the HOMA index.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
474	18407527-71	Rosiglitazone corrected the altered parameters measured, except for liver TGs ; similarly, glimepiride reinstated the inverted parameters but raised insulin level and, consequently, the HOMA index.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
475	18407527-71	Rosiglitazone corrected the altered parameters measured, except for liver TGs ; similarly, glimepiride reinstated the inverted parameters but raised insulin level and, consequently, the HOMA index.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
476	18409068-1012	AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of FAK and paxillin in a dose-dependent manner in a Calu-6 xenograft model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
477	18409068-1012	AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of FAK and paxillin in a dose-dependent manner in a Calu-6 xenograft model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
478	18409071-995	Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
479	18409071-997	Treatment with the EGFR inhibitor gefitinib preferentially inhibited growth and reduced the S phase fraction in the resistant cell lines concomitant with inhibition of Erk and unaltered Akt activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
480	18410309-540	Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
481	18410309-541	Melatonin significantly improved animal survival and decreased transaminase levels, the indices for necrosis, liver damage, leukocyte infiltration, and iNOS expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
482	18410309-542	At the same time, melatonin reduced the expression of both PCNA 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
483	18410309-543	Melatonin is hepatoprotective most likely via mechanisms including inhibition of IKK and JNK pathways and regulation of cell proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
484	18410522-611	Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide generation in both human 'Swedish' mutant APP transgene-bearing neuron-like cells and primary neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
485	18410522-611	Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide generation in both human 'Swedish' mutant APP transgene-bearing neuron-like cells and primary neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
486	18410522-612	We also find that luteolin induces changes consistent with GSK-3 inhibition that (i) decrease amyloidogenic gamma-secretase APP processing, and (ii) promote presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
487	18410522-612	We also find that luteolin induces changes consistent with GSK-3 inhibition that (i) decrease amyloidogenic gamma-secretase APP processing, and (ii) promote presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
488	18410522-612	We also find that luteolin induces changes consistent with GSK-3 inhibition that (i) decrease amyloidogenic gamma-secretase APP processing, and (ii) promote presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
489	18410522-612	We also find that luteolin induces changes consistent with GSK-3 inhibition that (i) decrease amyloidogenic gamma-secretase APP processing, and (ii) promote presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
490	18410522-613	As validation of these findings in vivo, we find that luteolin, when applied to the Tg2576 mouse model of AD, decreases soluble Abeta levels, reduces GSK-3 activity, and disrupts PS1-APP association.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
491	18410522-613	As validation of these findings in vivo, we find that luteolin, when applied to the Tg2576 mouse model of AD, decreases soluble Abeta levels, reduces GSK-3 activity, and disrupts PS1-APP association.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
492	18410522-613	As validation of these findings in vivo, we find that luteolin, when applied to the Tg2576 mouse model of AD, decreases soluble Abeta levels, reduces GSK-3 activity, and disrupts PS1-APP association.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
493	18410527-619	Since biliverdin and bilirubin are downstream products of heme degradation by heme oxygenase (HO), it has been suggested that HO-activity protects against curcumin-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
494	18410527-619	Since biliverdin and bilirubin are downstream products of heme degradation by heme oxygenase (HO), it has been suggested that HO-activity protects against curcumin-induced apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
495	18410527-619	Since biliverdin and bilirubin are downstream products of heme degradation by heme oxygenase (HO), it has been suggested that HO-activity protects against curcumin-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
496	18410529-629	Here, we examine the effect of resistin on glucose uptake in human trophoblast cells and we demonstrate that transplacental glucose transport is mediated by glucose transporter (GLUT)-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
497	18410529-630	ERK1 and 2 activation stimulated GLUT-1 synthesis and resulted in increase of placental glucose uptake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
498	18410529-630	ERK1 and 2 activation stimulated GLUT-1 synthesis and resulted in increase of placental glucose uptake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
499	18410529-631	High resistin levels (50-100 ng/ml) seem able to affect glucose-uptake, presumably by decreasing the cell surface glucose transporter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
500	18410530-134	CpG methylation as well as histone H3 methylation of lysines 9 and 27 contribute independently to ARF gene silencing in adenocarcinoma cell lines and can be reversed by 5-aza-2'-deoxycytidine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
501	18410530-134	CpG methylation as well as histone H3 methylation of lysines 9 and 27 contribute independently to ARF gene silencing in adenocarcinoma cell lines and can be reversed by 5-aza-2'-deoxycytidine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
502	18410982-929	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
503	18410982-929	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
504	18410982-929	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
505	18410982-929	Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
506	18413191-1010	However, increased blood glucose (200 mg/dl) significantly impaired the inhibitory effect of ASA (84% for GPIIb.005; 48% for P-selectin, P=NS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
507	18413206-1026	The expressions of MCP-1 mRNA in renal tissues were markedly up-regulated in untreated diabetic rats, and these could be notably reduced by rosiglitazone treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
508	18413206-1027	In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
509	18414844-751	The homomeric P2X (7) receptor is extraordinary in that in addition to distinctive localization and biological functions it exhibits several hallmark properties, for example, the receptor is potently inhibited by divalent cations such as calcium, magnesium, zinc and copper.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
510	18414844-751	The homomeric P2X (7) receptor is extraordinary in that in addition to distinctive localization and biological functions it exhibits several hallmark properties, for example, the receptor is potently inhibited by divalent cations such as calcium, magnesium, zinc and copper.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
511	18414894-793	Replacement doses of hydrocortisone (HC) (10 mg/m2/day) failed to produce a feedback inhibition of adrenocorticotropic hormone (ACTH), and testosterone levels remained high.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
512	18414894-793	Replacement doses of hydrocortisone (HC) (10 mg/m2/day) failed to produce a feedback inhibition of adrenocorticotropic hormone (ACTH), and testosterone levels remained high.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
513	18414894-793	Replacement doses of hydrocortisone (HC) (10 mg/m2/day) failed to produce a feedback inhibition of adrenocorticotropic hormone (ACTH), and testosterone levels remained high.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
514	18414894-793	Replacement doses of hydrocortisone (HC) (10 mg/m2/day) failed to produce a feedback inhibition of adrenocorticotropic hormone (ACTH), and testosterone levels remained high.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
515	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
516	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
517	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
518	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
519	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
520	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
521	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
522	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
523	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
524	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
525	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
526	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
527	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
528	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
529	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
530	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
531	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
532	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
533	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
534	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
535	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
536	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
537	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
538	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
539	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
540	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
541	18414974-853	Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
542	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
543	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
544	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
545	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
546	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
547	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
548	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
549	18414974-854	On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
550	18415015-878	This paper describes (1) the preparation of the intact oligosaccharides from GM1 (II(3)NeuAcGgOse(4) Cer) and GbOse(4) Cer as examples to show the use of CGase to prepare intact glycan chains from GSLs, and (2) the specificity and detergent requirements of Rhodococcal EGCases for the release of glycan chains from different GSLs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
551	18415121-949	The discovery of the PLN/HAX-1 interaction therefore unveils an important new link between Ca(2+) homeostasis and cell survival, with significant therapeutic potential.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
552	18415121-949	The discovery of the PLN/HAX-1 interaction therefore unveils an important new link between Ca(2+) homeostasis and cell survival, with significant therapeutic potential.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
553	18418358-391	UFP-101 alone evoked effects similar to low N/OFQ doses, suggesting tonic inhibitory control over forelimb movement by endogenous N/OFQ.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
554	18418709-605	Treating MCF-7 cells with AVE-1642 Qdots, but not unconjugated Qdots alone, downregulated IGF1R levels and rendered cells refractory to IGF-I stimulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
555	18418709-605	Treating MCF-7 cells with AVE-1642 Qdots, but not unconjugated Qdots alone, downregulated IGF1R levels and rendered cells refractory to IGF-I stimulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
556	18418709-606	Our data suggest that AVE-1642 Qdots can be used to detect IGF1R expression and measure changes in cell surface receptor levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
557	18420260-309	Although previous studies indicated reduced levels of sialic acid residues during apoptosis, elevated Sambucus nigra agglutinin (SNA) reactivity might be due to the degradation of high molecular weight glycoproteins (probably including cadherin) that masked the SNA-binding residues of the plasma membrane prior to apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
558	18420260-309	Although previous studies indicated reduced levels of sialic acid residues during apoptosis, elevated Sambucus nigra agglutinin (SNA) reactivity might be due to the degradation of high molecular weight glycoproteins (probably including cadherin) that masked the SNA-binding residues of the plasma membrane prior to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
559	18423787-1115	We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
560	18423787-1115	We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
561	18423943-93	Polyhydroxy phenolic compounds, such as flavonoids, vitamin E, rosmarinic acid and aristolochic acid, are able to inhibit PLA (2) from different sources.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
562	18423943-93	Polyhydroxy phenolic compounds, such as flavonoids, vitamin E, rosmarinic acid and aristolochic acid, are able to inhibit PLA (2) from different sources.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
563	18423943-93	Polyhydroxy phenolic compounds, such as flavonoids, vitamin E, rosmarinic acid and aristolochic acid, are able to inhibit PLA (2) from different sources.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
564	18425600-1102	Analysis of the protein domain features indicated typical conserved cysteine residues containing a single whey acidic protein (WAP) domain at the C-terminus.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
565	18425600-1102	Analysis of the protein domain features indicated typical conserved cysteine residues containing a single whey acidic protein (WAP) domain at the C-terminus.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
566	18427801-1197	Cross-linked P2X (1/2) heteromers showed strongly reduced or absent function that was selectively recovered upon treatment with DTT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
567	18431601-998	Permeabilization of K. marxianus cells in relation to beta-galactosidase activity was carried out using cetyltrimethyl ammonium bromide (CTAB) to avoid the problem of enzyme extraction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
568	18431601-998	Permeabilization of K. marxianus cells in relation to beta-galactosidase activity was carried out using cetyltrimethyl ammonium bromide (CTAB) to avoid the problem of enzyme extraction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
569	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
570	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
571	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
572	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
573	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
574	18431759-1114	Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
575	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
576	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
577	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
578	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
579	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
580	18431773-1123	Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
581	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
582	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
583	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
584	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
585	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
586	18431776-1124	To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
587	18433938-1194	Prediction of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas based on the heuristic method, support vector machine and projection pursuit regression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
588	18433938-1195	Quantitative structure-activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas using linear free energy relationship (LFER).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
589	18434046-291	It is suggested that GABA acting through the GABA(A) receptor mechanism on the expression of GnRH gene and GnRH-R gene in the hypothalamus may be involved in two processes: the biosynthesis of GnRH and the release of this neurohormone in the hypothalamus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
590	18434046-291	It is suggested that GABA acting through the GABA(A) receptor mechanism on the expression of GnRH gene and GnRH-R gene in the hypothalamus may be involved in two processes: the biosynthesis of GnRH and the release of this neurohormone in the hypothalamus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
591	18434046-291	It is suggested that GABA acting through the GABA(A) receptor mechanism on the expression of GnRH gene and GnRH-R gene in the hypothalamus may be involved in two processes: the biosynthesis of GnRH and the release of this neurohormone in the hypothalamus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
592	18435693-994	TT-induced increases in cortisol, adrenocorticotropic hormone and prolactin were reduced only after 3-h REC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
593	18435693-994	TT-induced increases in cortisol, adrenocorticotropic hormone and prolactin were reduced only after 3-h REC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
594	18435693-994	TT-induced increases in cortisol, adrenocorticotropic hormone and prolactin were reduced only after 3-h REC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
595	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
596	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
597	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
598	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
599	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
600	18436224-84	Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
601	18436224-87	Furthermore, ET-1 increased intracellular O(2*)(-) production in all layers of the vessel, protein expression of NADPH oxidase subunit p47 (phox) without affecting p22 (phox) expression and lucigenin-enhanced chemiluminescence signal stimulated by calcium ionophore A23187.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
602	18436224-87	Furthermore, ET-1 increased intracellular O(2*)(-) production in all layers of the vessel, protein expression of NADPH oxidase subunit p47 (phox) without affecting p22 (phox) expression and lucigenin-enhanced chemiluminescence signal stimulated by calcium ionophore A23187.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
603	18436224-89	Moreover, quercetin but not isorhamnetin, inhibited the increased PKC activity induced by ET-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
604	18436224-89	Moreover, quercetin but not isorhamnetin, inhibited the increased PKC activity induced by ET-1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
605	18436224-90	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
606	18436224-90	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
607	18436224-90	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
608	18436224-90	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
609	18436227-91	We hypothesized that variants in PCSK9 that lower LDL cholesterol levels are associated with reduced prevalence and incidence of peripheral artery disease (PAD).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
610	18436346-156	A series of 2-aryl-naphtho(1,2-d) oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
611	18436348-931	A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
612	18436399-180	Polyunsaturated fatty acids differentially alter PGF (2alpha) and PGE (2) release from bovine trophoblast and endometrial tissues during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
613	18436399-180	Polyunsaturated fatty acids differentially alter PGF (2alpha) and PGE (2) release from bovine trophoblast and endometrial tissues during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
614	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
615	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
616	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
617	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
618	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
619	18436399-181	Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
620	18437529-872	1-Deoxy-D-xylulose-5-phosphate synthase (DXS) catalyses the first committed step of the 2C-methyl-D-erythritol-4-phosphate (MEP) pathway, which is an alternative isoprenoids biosynthetic route that has been recently discovered.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
621	18437529-872	1-Deoxy-D-xylulose-5-phosphate synthase (DXS) catalyses the first committed step of the 2C-methyl-D-erythritol-4-phosphate (MEP) pathway, which is an alternative isoprenoids biosynthetic route that has been recently discovered.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
622	18437557-896	To get insight into the underlying mechanisms, we compared the ability of recombinant wild type and variant (D327N) SHBG to influence estradiol effects in MCF-7 breast cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
623	18437557-897	D327N SHBG was more effective than wild type protein in inhibiting estradiol-induced cell proliferation and anti-apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
624	18437699-978	Our results suggest that Ni(II)-induced changes in cytokine secretion by monocytes are diverse and may be influenced by Nrf2 but are not likely influenced by changes in whole-cell Trx1 levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
625	18437699-978	Our results suggest that Ni(II)-induced changes in cytokine secretion by monocytes are diverse and may be influenced by Nrf2 but are not likely influenced by changes in whole-cell Trx1 levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
626	18439591-271	To test the hypothesis that increasing DHEAS levels is associated with improved insulin resistance in patients with polycystic ovary syndrome (PCOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
627	18440842-362	Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
628	18440842-362	Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
629	18440842-362	Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
630	18440842-362	Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
631	18442069-1161	The gene expressions of CYP1A1 and CYP2E1 in the placenta increased significantly in nicotine-treated groups on GD 15 and GD 18, but returned to the level similar to the corresponding control on GD 21.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
632	18442069-1161	The gene expressions of CYP1A1 and CYP2E1 in the placenta increased significantly in nicotine-treated groups on GD 15 and GD 18, but returned to the level similar to the corresponding control on GD 21.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
633	18442069-1162	In nicotine group, there was a decrease of mdr1a expression on GD 15, GD 18, and GD 21, with the most significant decrease on GD 15.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
634	18442070-1163	The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent (red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrite levels) and serum damage marker enzymes (aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase, and lactate dehydrogenase) in rats at subacute period under laboratory conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
635	18442070-1163	The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent (red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrite levels) and serum damage marker enzymes (aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase, and lactate dehydrogenase) in rats at subacute period under laboratory conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
636	18442070-1163	The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent (red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrite levels) and serum damage marker enzymes (aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase, and lactate dehydrogenase) in rats at subacute period under laboratory conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
637	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
638	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
639	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
640	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
641	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
642	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
643	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
644	18442075-634	Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
645	18443829-973	The hydrolysis reaction of p-nitrophenyl butyrate catalyzed by lipases was followed with in situ UV/vis diode array spectrophotometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
646	18443829-974	Five enzymes-Candida antarctica lipase B and Fusarium solani pisi cutinase wild-type and three single-mutation variants-were tested as catalysts in homogeneous conditions and immobilized on zeolite NaY, on a polyacrylate support and as cross-linked aggregates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
647	18443829-974	Five enzymes-Candida antarctica lipase B and Fusarium solani pisi cutinase wild-type and three single-mutation variants-were tested as catalysts in homogeneous conditions and immobilized on zeolite NaY, on a polyacrylate support and as cross-linked aggregates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
648	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
649	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
650	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
651	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
652	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
653	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidaseglutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
654	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
655	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
656	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
657	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
658	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
659	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
660	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
661	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
662	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
663	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
664	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
665	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
666	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
667	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
668	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
669	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
670	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
671	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
672	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
673	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
674	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
675	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
676	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
677	18443843-1157	At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
678	18443843-1158	Catalase was decreased with endosulfan and the coexposure, but not with arsenic, whereas GSH was decreased with arsenic and endosulfan, but not with the coexposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
679	18443843-1158	Catalase was decreased with endosulfan and the coexposure, but not with arsenic, whereas GSH was decreased with arsenic and endosulfan, but not with the coexposure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
680	18443843-1159	Na+-K+-ATPase activity was decreased in the endosulfan-treated and the coexposed birds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
681	18443897-1003	mRNA and protein levels of TNF-alpha, Fas, and caspase-8, which are closely related to cell apoptosis by a death ligand/receptor-dependent apoptosis pathway, were increased by L-carnitine treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
682	18443897-1003	mRNA and protein levels of TNF-alpha, Fas, and caspase-8, which are closely related to cell apoptosis by a death ligand/receptor-dependent apoptosis pathway, were increased by L-carnitine treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
683	18443897-1004	In addition, L-carnitine treatment regulated mitochondria-dependent apoptosis pathways by inducing the up-regulation of caspase-9 and caspase-3 and the down-regulation of Bcl-2 in hepa1c1c 7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
684	18443897-1005	Taken together, the findings of this study have demonstrated that L-carnitine could induce apoptosis in hepa1c1c7 cells by regulating Fas ligands and inhibiting the expression of Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
685	18443897-1005	Taken together, the findings of this study have demonstrated that L-carnitine could induce apoptosis in hepa1c1c7 cells by regulating Fas ligands and inhibiting the expression of Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
686	18445079-363	Merlin is known to bind paxillin, beta1 integrin and focal adhesion kinase, members of focal contacts, multi-protein complexes that mediate cell adhesion to the extracellular matrix.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
687	18445307-585	Furthermore, free radical overproduction and oxidative stress were associated with a significant decrease in hepatic glutathione levels in septic mice, and with an excessive NO production attributed to the induction of the inducible isoform of NO synthase (iNOS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
688	18445307-586	In fact, hepatic glutathione levels were significantly increased in the group of mice receiving the probiotic, and the increased iNOS expression both in the colon and lungs was down-regulated in those mice treated with L. fermentum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
689	18448193-1146	Furthermore, supplementation of specific inhibitors of PAL, C4H and 4CL in elicited cell cultures led to suppressed accumulation of p-hydroxybenzoic acid, which opens up interesting questions regarding the probable route of the biosynthesis of this phenolic acid in C. nucifera.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
690	18448193-1146	Furthermore, supplementation of specific inhibitors of PAL, C4H and 4CL in elicited cell cultures led to suppressed accumulation of p-hydroxybenzoic acid, which opens up interesting questions regarding the probable route of the biosynthesis of this phenolic acid in C. nucifera.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
691	18448193-1146	Furthermore, supplementation of specific inhibitors of PAL, C4H and 4CL in elicited cell cultures led to suppressed accumulation of p-hydroxybenzoic acid, which opens up interesting questions regarding the probable route of the biosynthesis of this phenolic acid in C. nucifera.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
692	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
693	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
694	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
695	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
696	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
697	18449471-648	Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
698	18449471-650	In conclusion, P-gp and BCRP have only a modest effect on the ADME of imatinib in comparison to metabolic elimination.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
699	18449471-651	The considerable drug-drug interaction observed with elacridar or pantoprazole is only partly mediated by inhibition of P-gp and BCRP and far more by the inhibition of other elimination pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
700	18449471-651	The considerable drug-drug interaction observed with elacridar or pantoprazole is only partly mediated by inhibition of P-gp and BCRP and far more by the inhibition of other elimination pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
701	18449536-687	There is clear evidence for TREK-1 and TASK-1 in the heart and these channels are likely to regulate cardiac action potential duration through their regulation by stretch, polyunsaturated fatty acids, pH, and neurotransmitters.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
702	18449536-687	There is clear evidence for TREK-1 and TASK-1 in the heart and these channels are likely to regulate cardiac action potential duration through their regulation by stretch, polyunsaturated fatty acids, pH, and neurotransmitters.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
703	18449536-688	TREK-1 may also have a critical role in mediating the vasodilator response of resistance arteries to polyunsaturated fatty acids, thus contributing to their protective effect on the cardiovascular system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
704	18449944-953	Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-alpha-, and OPG-mRNA in the THP-1 human monocytic cell line.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
705	18449944-953	Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-alpha-, and OPG-mRNA in the THP-1 human monocytic cell line.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
706	18449944-953	Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-alpha-, and OPG-mRNA in the THP-1 human monocytic cell line.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
707	18450412-1248	Indirubin-3-oxime-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
708	18452177-145	Three proteins, porcine somatotropin, bovine serum albumin, and immunoglobulin, as well as materials with a strong calorimetric glass transition (T(g)), that is, indomethacin and poly(vinypyrrolidone) (PVP), were studied by both TSC and differential scanning calorimetry (DSC).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
709	18452177-145	Three proteins, porcine somatotropin, bovine serum albumin, and immunoglobulin, as well as materials with a strong calorimetric glass transition (T(g)), that is, indomethacin and poly(vinypyrrolidone) (PVP), were studied by both TSC and differential scanning calorimetry (DSC).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
710	18454352-1155	The recombinant protein exhibited high PAL activity and could catalyze the conversion of L:-Phe to trans-cinnamic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
711	18456422-1170	Only the beta-lactamases of pI 5.4 and superior to 7.6 hydrolyze the cefotaxime.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
712	18457934-815	To investigate this relationship, we used actively growing young Sprague-Dawley rats and CKD-732, one of the angiogenesis inhibitor (AI) to reveal the relationship of angiogenesis in the effect of PTH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
713	18458677-190	Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
714	18458952-1204	An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
715	18458952-1205	Towards this end, we propose a fixed-length alpha-numeric code for representing N-linked glycan structures commonly found in secreted glycoproteins from mammalian cell cultures.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
716	18458994-119	There was a significant increase in cytochrome-c oxidase activity at 2.5 mg/L, which might indicate irgarol's disruption of the mitochondrial membrane and subsequently ATP synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
717	18458994-119	There was a significant increase in cytochrome-c oxidase activity at 2.5 mg/L, which might indicate irgarol's disruption of the mitochondrial membrane and subsequently ATP synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
718	18459128-282	Treatment of A549, which express wild-type p53, and H1299, which are p53-deficient, human lung cancer cells with berberine resulted in inhibition of cell proliferation and an increase in apoptotic cell death ; however, A549 cells were more sensitive to the berberine-induced cytotoxic effects than H1299 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
719	18459941-785	Furthermore atorvastatin treatment markedly decreased the levels of TNF-alpha, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
720	18459941-785	Furthermore atorvastatin treatment markedly decreased the levels of TNF-alpha, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
721	18459941-785	Furthermore atorvastatin treatment markedly decreased the levels of TNF-alpha, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
722	18459941-785	Furthermore atorvastatin treatment markedly decreased the levels of TNF-alpha, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
723	18459941-787	Our study suggests that the modulation of the balance between pro- and anti-inflammatory cytokines towards the anti-inflammatory cytokine IL-10 is one salutary mechanism underlying how atorvastatin influences post-MI remodelling and thus improves LV function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
724	18459944-788	In addition, AUDA treatment attenuated macrophage infiltration and inhibited urinary excretion of MCP-1 (monocyte chemoattractant protein-1) and kidney cortex MCP-1 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
725	18459944-788	In addition, AUDA treatment attenuated macrophage infiltration and inhibited urinary excretion of MCP-1 (monocyte chemoattractant protein-1) and kidney cortex MCP-1 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
726	18462831-74	Exogenous spermidine, arsenic and beta-aminobutyric acid modulate tobacco resistance to tobacco mosaic virus, and affect local and systemic glucosylsalicylic acid levels and arginine decarboxylase gene expression in tobacco leaves.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
727	18462831-74	Exogenous spermidine, arsenic and beta-aminobutyric acid modulate tobacco resistance to tobacco mosaic virus, and affect local and systemic glucosylsalicylic acid levels and arginine decarboxylase gene expression in tobacco leaves.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
728	18462831-75	Moreover, this phenotypic response was correlated with changes in the endogenous concentration of the SAR-related molecule salicylic acid and in transcript levels of some pathogenesis/stress-related genes (pathogenesis-related proteins PR-1a and PR-2 and arginine decarboxylase (ADC)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
729	18462831-75	Moreover, this phenotypic response was correlated with changes in the endogenous concentration of the SAR-related molecule salicylic acid and in transcript levels of some pathogenesis/stress-related genes (pathogenesis-related proteins PR-1a and PR-2 and arginine decarboxylase (ADC)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
730	18462831-75	Moreover, this phenotypic response was correlated with changes in the endogenous concentration of the SAR-related molecule salicylic acid and in transcript levels of some pathogenesis/stress-related genes (pathogenesis-related proteins PR-1a and PR-2 and arginine decarboxylase (ADC)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
731	18462831-75	Moreover, this phenotypic response was correlated with changes in the endogenous concentration of the SAR-related molecule salicylic acid and in transcript levels of some pathogenesis/stress-related genes (pathogenesis-related proteins PR-1a and PR-2 and arginine decarboxylase (ADC)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
732	18462962-149	She had a mutation in PANK2 gene consisting of an aminoacid change of Alanine to Valine in exon 5 (A382V).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
733	18462962-149	She had a mutation in PANK2 gene consisting of an aminoacid change of Alanine to Valine in exon 5 (A382V).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
734	18466349-969	Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
735	18466349-969	Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
736	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
737	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
738	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
739	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
740	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
741	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
742	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
743	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
744	18466352-971	RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
745	18467006-128	A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
746	18468607-1101	Genetic variation in CETP (cholesteryl ester transfer protein) has been clearly associated with HDL cholesterol levels but its association with cardiovascular disease and related phenotypes has been more controversial, possibly due to variability of polymorphisms and their frequencies across different ethnic populations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
747	18468607-1101	Genetic variation in CETP (cholesteryl ester transfer protein) has been clearly associated with HDL cholesterol levels but its association with cardiovascular disease and related phenotypes has been more controversial, possibly due to variability of polymorphisms and their frequencies across different ethnic populations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
748	18470629-1072	However, methomyl exhibited more potency in reducing AChE activity than methiocarb.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
749	18470629-1072	However, methomyl exhibited more potency in reducing AChE activity than methiocarb.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
750	18470874-1230	Early and late 2-cell and late 4-cell stage embryos, prepared by in vitro fertilization (IVF), parthenogenetic activation (PG), and nuclear transfer of mouse embryonic fibroblast (MEF) and mouse HM1 embryonic stem cells (HM1), were processed for autoradiography following (3)H-uridine incubation (transcriptional activity), transmission electron microscopy (ultrastructure) and immunofluorescence (nucleolar proteins; upstream binding factor, UBF and nucleophosmin, B23).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
751	18470874-1230	Early and late 2-cell and late 4-cell stage embryos, prepared by in vitro fertilization (IVF), parthenogenetic activation (PG), and nuclear transfer of mouse embryonic fibroblast (MEF) and mouse HM1 embryonic stem cells (HM1), were processed for autoradiography following (3)H-uridine incubation (transcriptional activity), transmission electron microscopy (ultrastructure) and immunofluorescence (nucleolar proteins; upstream binding factor, UBF and nucleophosmin, B23).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
752	18470874-1230	Early and late 2-cell and late 4-cell stage embryos, prepared by in vitro fertilization (IVF), parthenogenetic activation (PG), and nuclear transfer of mouse embryonic fibroblast (MEF) and mouse HM1 embryonic stem cells (HM1), were processed for autoradiography following (3)H-uridine incubation (transcriptional activity), transmission electron microscopy (ultrastructure) and immunofluorescence (nucleolar proteins; upstream binding factor, UBF and nucleophosmin, B23).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
753	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
754	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
755	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
756	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
757	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
758	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
759	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
760	18471929-584	Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
761	18472163-737	Significant ALP activity changes, sensitivity of isozyme patterns (Mr of 60, 64, and 85kDa) and increased variation in ALP plasticity during acute exposure to cadmium point to its possible aplication as an exposure biomarker.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
762	18472187-928	To decrease the level of androgen testosterone in the prostate, we are interested in developing inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD5).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
763	18472187-928	To decrease the level of androgen testosterone in the prostate, we are interested in developing inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD5).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
764	18472342-221	A role for guanosine 3',5'-cyclic monophosphate (cGMP) and the protein kinase G (PKG) pathway in synaptic long-term depression (LTD) in the hippocampal CA1 region has been proposed, based on observations in vitro, where, for example, increases of (cGMP) result in short-term depression (STD) coupled with a reduction in presynaptic glutamate release.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
765	18472342-221	A role for guanosine 3',5'-cyclic monophosphate (cGMP) and the protein kinase G (PKG) pathway in synaptic long-term depression (LTD) in the hippocampal CA1 region has been proposed, based on observations in vitro, where, for example, increases of (cGMP) result in short-term depression (STD) coupled with a reduction in presynaptic glutamate release.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
766	18472342-221	A role for guanosine 3',5'-cyclic monophosphate (cGMP) and the protein kinase G (PKG) pathway in synaptic long-term depression (LTD) in the hippocampal CA1 region has been proposed, based on observations in vitro, where, for example, increases of (cGMP) result in short-term depression (STD) coupled with a reduction in presynaptic glutamate release.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
767	18472342-222	Application of an inhibitor of soluble guanylate cyclase prevented LTD induced by low-frequency stimulation (LFS), and impaired LFS-STD elicited in the presence of Zaprinast.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
768	18472342-222	Application of an inhibitor of soluble guanylate cyclase prevented LTD induced by low-frequency stimulation (LFS), and impaired LFS-STD elicited in the presence of Zaprinast.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
769	18473163-133	beta-Hexosaminidases (EC 3.2.1.52) are lysosomal enzymes that remove terminal beta-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from a number of glycoconjugates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
770	18473163-133	beta-Hexosaminidases (EC 3.2.1.52) are lysosomal enzymes that remove terminal beta-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from a number of glycoconjugates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
771	18473182-143	Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
772	18474445-915	Distribution of the androgen receptor in the diencephalon and the pituitary gland in goats: Co-localisation with corticotrophin releasing hormone, arginine vasopressin and corticotrophs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
773	18475288-1020	Bicalutamide induced apoptosis in androgen-dependent PWR-1E cells via a caspase-dependent and calpain-independent mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
774	18475288-1021	In androgen-independent PC-3 cells, bicalutamide also induced apoptosis by mechanisms that were partially inhibited by pan-caspase inhibition but were partially calpain dependent.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
775	18477686-347	A differential regulation of the two GABA synthesizing enzymes (GAD65 and GAD67) parallels GABAergic neuron differentiation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
776	18477686-347	A differential regulation of the two GABA synthesizing enzymes (GAD65 and GAD67) parallels GABAergic neuron differentiation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
777	18479249-96	The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-alpha1 and TGF-beta1, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
778	18479249-96	The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-alpha1 and TGF-beta1, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
779	18479249-96	The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-alpha1 and TGF-beta1, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
780	18479249-96	The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-alpha1 and TGF-beta1, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
781	18479249-97	The increased levels of hepatic GSH and SOD activity and decreased levels of TBARS and nitrite were also observed in UDCA-treated BDL rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
782	18479251-501	The production of rhG-CSF was induced by switching from growth on glycerol to growth on methanol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
783	18479251-501	The production of rhG-CSF was induced by switching from growth on glycerol to growth on methanol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
784	18479251-502	In the induction phase, the methanol feed rate had a significant effect on the specific expression rate of rhG-CSF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
785	18479251-503	Under this condition, a maximum concentration of 300 mg/l of rhG-CSF and the expression yield of 0.6 mg of rhG-CSF/g of methanol were attained.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
786	18479251-504	Among seven additives tested, Tween 20, Tween 80 and betaine exhibited the best results in respect of preventing the formation of rhG-CSF protein aggregates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
787	18479251-504	Among seven additives tested, Tween 20, Tween 80 and betaine exhibited the best results in respect of preventing the formation of rhG-CSF protein aggregates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
788	18479686-323	Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
789	18479686-324	Hypercholesterolemia is associated with decreased vascular nitric oxide bioavailability and deletion of endothelial nitric oxide synthase (eNOS) markedly accelerates atherosclerosis development in apolipoprotein E knockout (apoE ko) mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
790	18479686-324	Hypercholesterolemia is associated with decreased vascular nitric oxide bioavailability and deletion of endothelial nitric oxide synthase (eNOS) markedly accelerates atherosclerosis development in apolipoprotein E knockout (apoE ko) mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
791	18479896-454	Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
792	18479896-454	Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
793	18479896-455	The protein inhibitors wortmannin (phosphoinositide 3 kinase inhibitor), PD 98059 (MEK inhibitor) and SB 203580 (p38 inhibitor) as well as silencing RNA (small interfering RNA (siRNA)) of the p38 MAPK protein, were used to investigate cross-talk between signalling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
794	18479896-455	The protein inhibitors wortmannin (phosphoinositide 3 kinase inhibitor), PD 98059 (MEK inhibitor) and SB 203580 (p38 inhibitor) as well as silencing RNA (small interfering RNA (siRNA)) of the p38 MAPK protein, were used to investigate cross-talk between signalling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
795	18479896-455	The protein inhibitors wortmannin (phosphoinositide 3 kinase inhibitor), PD 98059 (MEK inhibitor) and SB 203580 (p38 inhibitor) as well as silencing RNA (small interfering RNA (siRNA)) of the p38 MAPK protein, were used to investigate cross-talk between signalling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
796	18479896-455	The protein inhibitors wortmannin (phosphoinositide 3 kinase inhibitor), PD 98059 (MEK inhibitor) and SB 203580 (p38 inhibitor) as well as silencing RNA (small interfering RNA (siRNA)) of the p38 MAPK protein, were used to investigate cross-talk between signalling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
797	18479897-371	Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
798	18479897-371	Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
799	18479897-373	Furthermore, adding docosahexaenoic acid (DHA) or an AMP-activated protein kinase (AMPK.05) in intestinal preparations obtained from the offspring fed the control diet, devoid of the PFO product and containing minimal concentrations of n-3 PUFA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
800	18479897-373	Furthermore, adding docosahexaenoic acid (DHA) or an AMP-activated protein kinase (AMPK.05) in intestinal preparations obtained from the offspring fed the control diet, devoid of the PFO product and containing minimal concentrations of n-3 PUFA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
801	18479897-373	Furthermore, adding docosahexaenoic acid (DHA) or an AMP-activated protein kinase (AMPK.05) in intestinal preparations obtained from the offspring fed the control diet, devoid of the PFO product and containing minimal concentrations of n-3 PUFA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
802	18479950-485	Prior to vitamin E supplementation, exercise induced a significant decrease in PON1 activity, EMF, vitamin E concentration and a significant increase in MDA concentration at t+1d.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
803	18479950-485	Prior to vitamin E supplementation, exercise induced a significant decrease in PON1 activity, EMF, vitamin E concentration and a significant increase in MDA concentration at t+1d.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
804	18479950-486	After a 10 week vitamin E supplementation period, these exercise-induced changes in PON1 activity, EMF and MDA concentration were still significant in the control group, but not in the supplemented group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
805	18479950-486	After a 10 week vitamin E supplementation period, these exercise-induced changes in PON1 activity, EMF and MDA concentration were still significant in the control group, but not in the supplemented group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
806	18481266-77	In adulthood, testosterone secreted by the testes is converted into estrogens by the preoptic aromatase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
807	18481276-83	The model was used to investigate how on-treatment CRP related to baseline CRP and estimated treatment effects with rosuvastatin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
808	18481313-107	Hepatocyte growth factor, keratinocyte growth factor or insulin prevented the effect of ethanol on cell permeability, but not on PGE (2) release.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
809	18481313-107	Hepatocyte growth factor, keratinocyte growth factor or insulin prevented the effect of ethanol on cell permeability, but not on PGE (2) release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
810	18481313-108	Cyclooxygenase-2 stimulated PGE (2) release mediated the reversible effect of ethanol on tight junctions and, meanwhile, contributed to cell survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
811	18481313-108	Cyclooxygenase-2 stimulated PGE (2) release mediated the reversible effect of ethanol on tight junctions and, meanwhile, contributed to cell survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
812	18482727-966	Interestingly, atorvastatin inhibited the expression of ICAM and MCP-1, followed by the suppression of macrophage recruitment into the aortic wall at 1 week after operation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
813	18482727-967	In addition, synthesis of collagen and elastin in the vascular wall were significantly increased by atorvastatin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
814	18484100-516	Organic cations (OCs) are primarily excreted via vectorial transport by various renal organic cation transporters (OCTs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
815	18484100-517	In a rat ARF model, induction of ARF by uranyl nitrate (UN) treatment significantly decreased the levels of Oct2 (slc22a2) mRNA and protein in the kidney medulla.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
816	18484622-1118	In all final products, dimethylsulfoxide used to prepare the insulin/lipid mixture was below 20 ppm.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
817	18485500-951	Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
818	18485500-951	Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
819	18486150-336	Cyclosporin A up-regulates and activates protein kinase C-zeta in EBV-infected and EBV-transformed human B-cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
820	18486150-337	We have proposed that cyclosporin A (CsA), despite being a calcineurin inhibitor, will activate PKC in B cells, thus promoting Epstein-Barr virus (EBV)-induced transformation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
821	18486150-337	We have proposed that cyclosporin A (CsA), despite being a calcineurin inhibitor, will activate PKC in B cells, thus promoting Epstein-Barr virus (EBV)-induced transformation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
822	18486994-189	Our results showed 2a, 2d and 2g as the most active compounds that inhibited the HIV-1 reverse transcriptase catalytic activity with cytotoxicity lower than AZT and SI higher than DDC and DDI.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
823	18487053-332	Resveratrol (4,3',5'-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
824	18487053-332	Resveratrol (4,3',5'-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
825	18487053-332	Resveratrol (4,3',5'-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
826	18487053-332	Resveratrol (4,3',5'-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
827	18489490-99	After NMDA stimulation of SV-FHAS and neoplastic astrocytes, real-time polymerase chain reaction showed an increase of the CPE, containing EGR-1 splice variant only in astrocytoma cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
828	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
829	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
830	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
831	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
832	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
833	18489909-317	Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
834	18489909-318	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
835	18489909-318	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
836	18489909-318	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
837	18489909-318	Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
838	18489909-319	However the quercetin metabolites, quercetin 3'-sulfate, quercetin 3-glucuronide and 3'-methylquercetin 3-glucuronide, had no effect on TNFalpha-induced up regulation of adhesion molecule or chemokine expression, at either concentration tested.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
839	18490188-482	In its active form, thiamin pyrophosphate (TPP), it is a co-enzyme for several enzymes, including transketolase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
840	18492032-354	Coexpression pattern with VDR provides an indication that calcitriol could be the modulator of these adaptive responses to involution and dietary P restriction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
841	18492301-527	Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
842	18492301-528	The present study investigates the benefits of the dietary intake of chia seed (Salvia hispanica L.) rich in alpha-linolenic acid and fibre upon dyslipidaemia and insulin resistance (IR), induced by intake of a sucrose-rich (62.5 %) diet (SRD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
843	18492301-528	The present study investigates the benefits of the dietary intake of chia seed (Salvia hispanica L.) rich in alpha-linolenic acid and fibre upon dyslipidaemia and insulin resistance (IR), induced by intake of a sucrose-rich (62.5 %) diet (SRD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
844	18492302-529	Pigs fed the high-lysine diet moreover had an increased concentration of trimethyllysine (TML), a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine (BB) in muscle, indicating that the conversion of TML into BB in muscle was impaired.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
845	18492302-529	Pigs fed the high-lysine diet moreover had an increased concentration of trimethyllysine (TML), a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine (BB) in muscle, indicating that the conversion of TML into BB in muscle was impaired.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
846	18492302-529	Pigs fed the high-lysine diet moreover had an increased concentration of trimethyllysine (TML), a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine (BB) in muscle, indicating that the conversion of TML into BB in muscle was impaired.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
847	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
848	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
849	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
850	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
851	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
852	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
853	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
854	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
855	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
856	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
857	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
858	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
859	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
860	18494609-496	The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
861	18495128-1028	3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE (-/-)/LDL(-/-) double knockout mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
862	18495129-1029	Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
863	18495129-1029	Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
864	18495129-1030	Treatment of ECs with anthocyanins cyanidin-3-O-beta-glucoside (Cy-3-g) and peonidin-3-O-beta-glucoside (Pn-3-g) prevents CD40-induced endothelial activation by inhibiting production of proinflammatory cytokines and matrix metalloproteinases (MMPs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
865	18495129-1031	Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
866	18495129-1031	Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
867	18495129-1031	Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
868	18495357-1187	Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
869	18495456-706	However, the MTHFR C677T genotype, alone or together with a diet, influenced betaine (P=.03) and phosphatidylcholine (P=.03).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
870	18495456-707	In addition, the MTHFR C677T genotype appears to influence the direction and use of choline moieties in this group of women.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
871	18495458-1236	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
872	18495458-1236	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
873	18495458-1236	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
874	18495458-1236	Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
875	18495460-1238	Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
876	18495460-1238	Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
877	18495460-1238	Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
878	18495461-1165	Lack of vitamin A significantly changed mucin (MUC) dynamics, as reflected by the enlarged goblet-cell "cup" area relative to controls; decreased MUC2 mRNA expression in the jejunum, ileum and colon of VAD rats and increased MUC3 mRNA expression in the ileum and colon of these rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
879	18495461-1165	Lack of vitamin A significantly changed mucin (MUC) dynamics, as reflected by the enlarged goblet-cell "cup" area relative to controls; decreased MUC2 mRNA expression in the jejunum, ileum and colon of VAD rats and increased MUC3 mRNA expression in the ileum and colon of these rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
880	18495461-1166	In addition, vitamin A deficiency down-regulated defensin 6 mRNA expression while up-regulating toll-like receptors 2 and 5 mRNA expressions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
881	18495463-1243	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
882	18495463-1243	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
883	18495463-1243	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
884	18496518-35	Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
885	18496518-37	In contrast, chronic fluoxetine markedly decreased 5-HTT levels in all regions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
886	18496518-38	This downregulation of 5-HTHTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
887	18496518-38	This downregulation of 5-HTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
888	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
889	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
890	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
891	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
892	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
893	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
894	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
895	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
896	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
897	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
898	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
899	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
900	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
901	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
902	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
903	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
904	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
905	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
906	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
907	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
908	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
909	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
910	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
911	18496650-691	Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
912	18496767-753	Using in vitro binding assays we have demonstrated that transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region spanning the sequence-200 to-162 relative to ATG and that formation of complexes could be efficiently reduced by mithramycin A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
913	18496767-753	Using in vitro binding assays we have demonstrated that transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region spanning the sequence-200 to-162 relative to ATG and that formation of complexes could be efficiently reduced by mithramycin A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
914	18496861-830	Treatment with hyaluronidase indicates that the dimensions of the small fibrils may be dependent upon the presence of hyaluronan within the matrix.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
915	18496865-833	Tetraglyme coatings reduce fibrinogen and von Willebrand factor adsorption and platelet adhesion under both static and flow conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
916	18496865-833	Tetraglyme coatings reduce fibrinogen and von Willebrand factor adsorption and platelet adhesion under both static and flow conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
917	18496865-834	Previous studies have showed that radio-frequency plasma deposited tetraglyme coatings greatly reduced fibrinogen adsorption (Gamma(Fg)) from highly diluted plasmas (0.1 and 1%) and subsequent platelet adhesion under static conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
918	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
919	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
920	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
921	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
922	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
923	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
924	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
925	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
926	18497703-873	Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
927	18497707-589	Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
928	18497707-590	The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
929	18497707-590	The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
930	18497707-590	The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
931	18497707-591	The aim of this study was to evaluate the effect of age on the modulation of TLRs and IRAK-1 and IRAK-M in peripheral blood mononuclear cells (PBMCs) exposed in vitro to endotoxin under conditions that could induce endotoxin tolerance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
932	18497707-591	The aim of this study was to evaluate the effect of age on the modulation of TLRs and IRAK-1 and IRAK-M in peripheral blood mononuclear cells (PBMCs) exposed in vitro to endotoxin under conditions that could induce endotoxin tolerance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
933	18497707-591	The aim of this study was to evaluate the effect of age on the modulation of TLRs and IRAK-1 and IRAK-M in peripheral blood mononuclear cells (PBMCs) exposed in vitro to endotoxin under conditions that could induce endotoxin tolerance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
934	18497709-959	We also previously demonstrated that glutamine (GLN) significantly induced HO-1 in the lower intestinal tract.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
935	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
936	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
937	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
938	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
939	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
940	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
941	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
942	18497709-961	Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
943	18497709-964	Glutamine treatment may thus protect mucosal cells from HS-induced oxidative damage via the anti-inflammatory and antiapoptotic properties of HO-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
944	18498083-305	In this work, we identified a high affinity and potency metallocene-containing triazole peptide conjugate that suppresses the interactions of HIV-1 envelope gp120 at both its CD4 and co-receptor binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
945	18498083-305	In this work, we identified a high affinity and potency metallocene-containing triazole peptide conjugate that suppresses the interactions of HIV-1 envelope gp120 at both its CD4 and co-receptor binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
946	18498083-306	Surface plasmon resonance interaction analysis revealed that, compared to a previously reported phenyl-containing triazole conjugate HNG-105 (105), peptide 156 had a higher direct binding affinity for several subtypes of HIV-1 gp120 due mainly to the decreased dissociation rate of the conjugate-gp120 complex.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
947	18498083-306	Surface plasmon resonance interaction analysis revealed that, compared to a previously reported phenyl-containing triazole conjugate HNG-105 (105), peptide 156 had a higher direct binding affinity for several subtypes of HIV-1 gp120 due mainly to the decreased dissociation rate of the conjugate-gp120 complex.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
948	18498083-307	The ferrocene triazole conjugate bound to gp120 of both clade A (92UG037-08) and clade B (YU-2 and SF162) virus subtypes with nanomolar KD in direct binding and inhibited the binding of gp120 to soluble CD4 and to antibodies that bind to HIV-1YU-2 gp120 at both the CD4 binding site and CD4-induced binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
949	18498083-307	The ferrocene triazole conjugate bound to gp120 of both clade A (92UG037-08) and clade B (YU-2 and SF162) virus subtypes with nanomolar KD in direct binding and inhibited the binding of gp120 to soluble CD4 and to antibodies that bind to HIV-1YU-2 gp120 at both the CD4 binding site and CD4-induced binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
950	18498357-470	Screening of risk factors for thromboembolism revealed that all patients carried a methylenetetrahydrofolate reductase 677C-->T (MTHFR) mutation in a gene involved in folate metabolism, and either borderline or elevated homocysteine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
951	18498357-470	Screening of risk factors for thromboembolism revealed that all patients carried a methylenetetrahydrofolate reductase 677C-->T (MTHFR) mutation in a gene involved in folate metabolism, and either borderline or elevated homocysteine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
952	18498673-382	Circulating leptin was negatively correlated with mRNA expression of adiponectin, LEPR and LPL, whereas thyroxine was positively correlated with levels of PPARGC1A.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
953	18498673-382	Circulating leptin was negatively correlated with mRNA expression of adiponectin, LEPR and LPL, whereas thyroxine was positively correlated with levels of PPARGC1A.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
954	18498673-382	Circulating leptin was negatively correlated with mRNA expression of adiponectin, LEPR and LPL, whereas thyroxine was positively correlated with levels of PPARGC1A.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
955	18498673-382	Circulating leptin was negatively correlated with mRNA expression of adiponectin, LEPR and LPL, whereas thyroxine was positively correlated with levels of PPARGC1A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
956	18500430-564	In the absence of exogenous Ca(2+) and Mg(2+) and in the presence of EGTA, which favours the release of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
957	18500430-564	In the absence of exogenous Ca(2+) and Mg(2+) and in the presence of EGTA, which favours the release of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
958	18500430-564	In the absence of exogenous Ca(2+) and Mg(2+) and in the presence of EGTA, which favours the release of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
959	18500430-565	At concentrations higher than 0.5 mM, spermine still stimulates PDC, when compared with the control, but shows a slight dose-dependent decrease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
960	18500430-566	Changes in PDC stimulation are very close to the phosphorylation level of the E(1alpha) subunit of PDC, which regulates the activity of the complex, but it is also the target of spermine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
961	18500430-567	These results provide the first evidence that, when transported in RLM, spermine can interact in various ways with PDC, showing dose-dependent behaviour.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
962	18500522-58	This study assessed relationships between hNT levels and fludarabine uptake and cytotoxicity in cultures of human renal proximal tubule cells (hRPTCs) that produce multiple transporter types.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
963	18502597-1034	Multiple metabolic and neuroendocrine mechanisms are responsible for the CR-mediated anti-inflammatory effects, including reduced adiposity and secretion of pro-inflammatory adipokines, enhanced glucocorticoid production, reduced plasma glucose and advanced glycation end-product concentrations, increased parasympathetic tone, and increased ghrelin production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
964	18503570-926	From the known regulatory mechanisms of Arc expression, HFD reduced N-methyl-D-aspartate receptor (NMDAR) activity, as seen by decreases in tyrosine phosphorylation of NMDAR2A and levels of NMDAR1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
965	18503570-926	From the known regulatory mechanisms of Arc expression, HFD reduced N-methyl-D-aspartate receptor (NMDAR) activity, as seen by decreases in tyrosine phosphorylation of NMDAR2A and levels of NMDAR1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
966	18503570-926	From the known regulatory mechanisms of Arc expression, HFD reduced N-methyl-D-aspartate receptor (NMDAR) activity, as seen by decreases in tyrosine phosphorylation of NMDAR2A and levels of NMDAR1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
967	18503570-927	Additionally, we demonstrated that 27-hydroxycholesterol, a cholesterol metabolite that enters the brain from the blood, decreases Arc levels as well as NMDAR and Src kinase activities in rat primary hippocampal neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
968	18503570-927	Additionally, we demonstrated that 27-hydroxycholesterol, a cholesterol metabolite that enters the brain from the blood, decreases Arc levels as well as NMDAR and Src kinase activities in rat primary hippocampal neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
969	18505747-21	Cyclooxygenase-2, an inducible enzyme important in inflammation, catalyzes the production of prostanoids from arachidonic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
970	18506596-495	cDNA probes have been developed for subsequent use in monitoring the cadmium exposure of the clam Ruditapes decussatus and the cockle Cerastoderma glaucum using metallothionein (MT) gene expression in different tissues of these species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
971	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
972	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
973	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
974	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
975	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
976	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
977	18506630-727	Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
978	18506630-728	Tryptophan stabilizes the lignin peroxidase activity during decolorization of dyes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
979	18506631-523	To achieve enzymatic production of calcium-stearate at unfavorable conditions, i.e., pH 10 and 60 degrees C, suitable lipase was selected and reaction conditions were optimized using calcium hydroxide and hydrogenated beef tallow as substrates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
980	18506631-523	To achieve enzymatic production of calcium-stearate at unfavorable conditions, i.e., pH 10 and 60 degrees C, suitable lipase was selected and reaction conditions were optimized using calcium hydroxide and hydrogenated beef tallow as substrates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
981	18506631-524	Under optimum conditions, 95% of beef tallow, in 2.5 h, was converted into calcium-stearate by using commercial lipase SDL 451.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
982	18506760-597	Celecoxib could selectively inhibited COX-2 expression and PGE2 production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
983	18506760-597	Celecoxib could selectively inhibited COX-2 expression and PGE2 production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
984	18506760-598	Celecoxib also inhibited p(473Ser) Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
985	18506760-598	Celecoxib also inhibited p(473Ser) Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
986	18506760-598	Celecoxib also inhibited p(473Ser) Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
987	18506760-598	Celecoxib also inhibited p(473Ser) Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
988	18509327-948	However, the simultaneous presence of the CYP3A4 *1B and CYP3A5 *1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
989	18509327-948	However, the simultaneous presence of the CYP3A4 *1B and CYP3A5 *1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
990	18509591-45	It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
991	18509591-46	In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than those in the untreated control or the taurine depleted groups, while hepatic malondialdehyde content exhibited the negative effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
992	18509591-46	In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than those in the untreated control or the taurine depleted groups, while hepatic malondialdehyde content exhibited the negative effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
993	18509591-46	In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than those in the untreated control or the taurine depleted groups, while hepatic malondialdehyde content exhibited the negative effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
994	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
995	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
996	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
997	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
998	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
999	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1000	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1001	18509591-47	Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1002	18509644-1152	Pharmacological (flavopiridol) and molecular (shRNA) transcription inhibitor were used to impede formation of MET transcripts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1003	18509748-1206	Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L:-ascorbate on pancreatic tumors in athymic mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1004	18511076-738	Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1005	18511076-738	Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1006	18511076-738	Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1007	18511076-739	We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1008	18511076-739	We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1009	18511076-739	We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1010	18511076-740	Sertraline increased BDNF levels after 5 weeks and 6 months of treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1011	18511076-741	Venlafaxine increased BDNF levels only after 6 months.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1012	18511076-742	Escitalopram did not affect BDNF levels at either time point.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1013	18513727-1142	The increase of cholesterol was accompanied by a marked posttranslational down-regulation of liver SR-BI expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1014	18513727-1143	Taken together, a diet-induced increase of plasma and hepatic cholesterol levels leads to a posttranscriptional down-regulation of SR-BI in mouse liver via a mechanism likely involving PDZK1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1015	18513727-1143	Taken together, a diet-induced increase of plasma and hepatic cholesterol levels leads to a posttranscriptional down-regulation of SR-BI in mouse liver via a mechanism likely involving PDZK1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1016	18513857-1213	A 5.5 kilobase-pair (kbp) Pst1-Kpn1 fragment containing gene(s) encoding for zearalenone degradation was cloned.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1017	18514659-430	However, TXA(2) formation remains elevated in patients with cardiovascular disease on doses of aspirin that fully suppress platelet COX-1, suggesting other tissue sources for TXA(2) formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1018	18514659-430	However, TXA(2) formation remains elevated in patients with cardiovascular disease on doses of aspirin that fully suppress platelet COX-1, suggesting other tissue sources for TXA(2) formation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1019	18514900-1098	) production increased; metallothionein (MT) and glutathione levels increased in most cases, and acetylcholinesterase (AChE) activity decreased in summer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1020	18514900-1098	) production increased; metallothionein (MT) and glutathione levels increased in most cases, and acetylcholinesterase (AChE) activity decreased in summer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1021	18515453-577	From these findings, it is suggested that distigmine bromide may produce centrally mediated behavioural signs by increasing the ACh levels in the brain, resulting from its AChE and BuChE inhibitions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1022	18515457-594	Using DBA/2OlaHsd mice, we investigated the effects of chronic social defeat and concomitant treatment with R121919/NBI 30775 on 1) the behavioural profile in the modified hole board test and 2) in-situ hybridization analysis-based expression of arginine vasopressin (AVP) and CRH mRNA in both the hypothalamic paraventricular nucleus and supraoptic nucleus.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1023	18515457-594	Using DBA/2OlaHsd mice, we investigated the effects of chronic social defeat and concomitant treatment with R121919/NBI 30775 on 1) the behavioural profile in the modified hole board test and 2) in-situ hybridization analysis-based expression of arginine vasopressin (AVP) and CRH mRNA in both the hypothalamic paraventricular nucleus and supraoptic nucleus.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1024	18515973-10	7-Ketocholesterol also enhanced IL-6 release from VSMC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1025	18515973-11	IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1026	18515973-11	IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1027	18515973-12	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1028	18515973-12	These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1029	18515973-3	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1030	18515973-3	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1031	18515973-4	Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1032	18515973-5	IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1033	18515973-6	7alpha-Hydroxycholesterol, 27-hydroxycholesterol or cholesterol, however, did not induce IL-6 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1034	18515973-6	7alpha-Hydroxycholesterol, 27-hydroxycholesterol or cholesterol, however, did not induce IL-6 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1035	18515973-6	7alpha-Hydroxycholesterol, 27-hydroxycholesterol or cholesterol, however, did not induce IL-6 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1036	18515973-7	Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1037	18515973-7	Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1038	18515973-7	Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1039	18515973-8	Whereas TNF-alpha activated IL-6 promoter, which was impaired by p38 MAPK inhibitors or by mutation in the NF-kappaB-binding site within the promoter region, 7-ketocholesterol did not affect IL-6 promoter activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1040	18515973-8	Whereas TNF-alpha activated IL-6 promoter, which was impaired by p38 MAPK inhibitors or by mutation in the NF-kappaB-binding site within the promoter region, 7-ketocholesterol did not affect IL-6 promoter activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1041	18515973-9	7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1042	18515973-9	7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1043	18521540-51	AGI-1067 is a novel, phenolic antioxidant, and vascular protectant which dose-dependently inhibits PEA biomarkers in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1044	18521605-224	Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1045	18521605-225	Clinically, it has been approved that DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-dC), can reverse APC promoter methylation, but widespread clinical use of these inhibitors is limited by their toxicity and instability in aqueous solution.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1046	18521605-225	Clinically, it has been approved that DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-dC), can reverse APC promoter methylation, but widespread clinical use of these inhibitors is limited by their toxicity and instability in aqueous solution.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1047	18521740-1015	Lastly, we found that the downstream metabolite of 5alpha-dihydrotestosterone, 5alpha- androstane-3beta,17beta-diol (3betaAdiol), is estrogenic in breast cancer cells, and induces growth and ER-signaling via activation of ERalpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1048	18521741-219	Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1049	18521741-219	Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1050	18521748-1184	Here, we constructed variants to test whether any of these motifs may explain why TRPM2-DeltaN does not respond to stimulation with either ADP ribose or hydrogen peroxide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1051	18521846-1089	We found that 2-methoxyestradiol induced the activation of JNK, ERK, and p38 MAPKs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1052	18521846-1089	We found that 2-methoxyestradiol induced the activation of JNK, ERK, and p38 MAPKs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1053	18521846-1089	We found that 2-methoxyestradiol induced the activation of JNK, ERK, and p38 MAPKs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1054	18521846-1090	2-methoxyestradiol-induced JNK activation was associated with the induction of apoptosis through the mitochondrial pathways as a result of increased phosphorylation (inactivation) of the anti-apoptotic Bcl-2 and Bcl-xL proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1055	18521846-1090	2-methoxyestradiol-induced JNK activation was associated with the induction of apoptosis through the mitochondrial pathways as a result of increased phosphorylation (inactivation) of the anti-apoptotic Bcl-2 and Bcl-xL proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1056	18521846-1091	In comparison, 2-methoxyestradiol-induced activation of ERK and p38 in these cells was found to have a protective effect against 2-MeO-E(2)-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1057	18521846-1091	In comparison, 2-methoxyestradiol-induced activation of ERK and p38 in these cells was found to have a protective effect against 2-MeO-E(2)-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1058	18521846-1093	Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1059	18521846-1093	Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1060	18521846-1093	Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1061	18521846-1093	Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1062	18521846-1093	Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1063	18521859-1108	Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1064	18521859-1108	Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1065	18521859-1108	Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1066	18522674-789	Celecoxib caused a 60% reduction in testicular interstitial fluid (IF) prostaglandin E(2) (PGE (2)) concentrations, accompanied by a compensatory increase in COX-2 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1067	18522674-789	Celecoxib caused a 60% reduction in testicular interstitial fluid (IF) prostaglandin E(2) (PGE (2)) concentrations, accompanied by a compensatory increase in COX-2 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1068	18522674-790	However, celecoxib had no effect on COX-2 protein levels or LPS-induced expression of the inflammatory mediators interleukin-1beta, tumour necrosis factor-alpha or inducible nitric-oxide synthase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1069	18522674-790	However, celecoxib had no effect on COX-2 protein levels or LPS-induced expression of the inflammatory mediators interleukin-1beta, tumour necrosis factor-alpha or inducible nitric-oxide synthase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1070	18522674-791	These data indicate that celecoxib reduces intratesticular activity of COX-2 (as indicated by PGE (2) levels) and inhibits IF formation in the testis, but has no appreciable effect on steroidogenesis or spermatogenesis, at least in the short term.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1071	18522674-791	These data indicate that celecoxib reduces intratesticular activity of COX-2 (as indicated by PGE (2) levels) and inhibits IF formation in the testis, but has no appreciable effect on steroidogenesis or spermatogenesis, at least in the short term.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1072	18522674-792	These results indicate significant roles for products of the COX-2 pathway in testicular vascular control and steroidogenesis, which may have implications for men with marginal fertility taking celecoxib for extended periods, but also highlight the potential of this drug to ameliorate testicular damage caused by systemic or local inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1073	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1074	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1075	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1076	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1077	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1078	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1079	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1080	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1081	18528683-286	At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1082	18528683-287	The obtained data revealed that BCNU induced pathological changes and markedly increased lung collagen and level of Hpr but decreased GSH content and GR activity and increased serum TNF-alpha compared to both control and MT-administered rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1083	18528683-287	The obtained data revealed that BCNU induced pathological changes and markedly increased lung collagen and level of Hpr but decreased GSH content and GR activity and increased serum TNF-alpha compared to both control and MT-administered rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1084	18528683-287	The obtained data revealed that BCNU induced pathological changes and markedly increased lung collagen and level of Hpr but decreased GSH content and GR activity and increased serum TNF-alpha compared to both control and MT-administered rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1085	18528683-287	The obtained data revealed that BCNU induced pathological changes and markedly increased lung collagen and level of Hpr but decreased GSH content and GR activity and increased serum TNF-alpha compared to both control and MT-administered rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1086	18528747-574	Collectively, HMB supplementation increased concentrations of short-chain fatty acids in intestinal lumen, expression of proglucagon, GLP-2R, and eNOS genes, and net portal absorption of AA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1087	18528747-574	Collectively, HMB supplementation increased concentrations of short-chain fatty acids in intestinal lumen, expression of proglucagon, GLP-2R, and eNOS genes, and net portal absorption of AA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1088	18528747-574	Collectively, HMB supplementation increased concentrations of short-chain fatty acids in intestinal lumen, expression of proglucagon, GLP-2R, and eNOS genes, and net portal absorption of AA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1089	18528783-293	In search for the pharmacophore and to analyze structure-activity relationships we synthesized a series of truncated derivatives and analogs of RB-2, including 1-amino-2-sulfo-4-ar(alk)ylaminoanthraquinones, 1-amino-2-methyl-4-arylaminoanthraquinones, 1-amino-4-bromoanthraquinone 2-sulfonic acid esters and sulfonamides, and bis-(1-amino-4-bromoanthraquinone) sulfonamides, and investigated them in preparations of rat NTPDase1, 2, and 3 using a capillary electrophoresis assay.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1090	18528783-293	In search for the pharmacophore and to analyze structure-activity relationships we synthesized a series of truncated derivatives and analogs of RB-2, including 1-amino-2-sulfo-4-ar(alk)ylaminoanthraquinones, 1-amino-2-methyl-4-arylaminoanthraquinones, 1-amino-4-bromoanthraquinone 2-sulfonic acid esters and sulfonamides, and bis-(1-amino-4-bromoanthraquinone) sulfonamides, and investigated them in preparations of rat NTPDase1, 2, and 3 using a capillary electrophoresis assay.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1091	18533896-944	Plasma insulin 0.05) following ingestion of GluF than after Glu alone, without any differences between the effects of either intervention on plasma glucose concentrations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1092	18534791-223	No significant differences were observed in plasma concentrations of glucose, NEFA, and insulin-like growth factor or hepatic triglyceride content, but all supplements tended to decrease beta hydroxybutyrate postpartum compared to CTL cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1093	18534791-223	No significant differences were observed in plasma concentrations of glucose, NEFA, and insulin-like growth factor or hepatic triglyceride content, but all supplements tended to decrease beta hydroxybutyrate postpartum compared to CTL cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1094	18534811-234	The results showed that colchicine augmented splenic-specific IgG1 and IL-4 as well as cell proliferation but suppressed specific IgG2a and IFN-gamma levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1095	18534811-234	The results showed that colchicine augmented splenic-specific IgG1 and IL-4 as well as cell proliferation but suppressed specific IgG2a and IFN-gamma levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1096	18534874-957	Sunitinib malate (Pfizer, Inc.) is a multitargeted kinase inhibitor that inhibits vascular endothelial growth factor (VEGF) receptor (R)-1, 2 and 3, platelet-derived growth factor receptors (PDGFR)-alpha and beta, Flt3, RET, and Kit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1097	18534874-957	Sunitinib malate (Pfizer, Inc.) is a multitargeted kinase inhibitor that inhibits vascular endothelial growth factor (VEGF) receptor (R)-1, 2 and 3, platelet-derived growth factor receptors (PDGFR)-alpha and beta, Flt3, RET, and Kit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1098	18534874-957	Sunitinib malate (Pfizer, Inc.) is a multitargeted kinase inhibitor that inhibits vascular endothelial growth factor (VEGF) receptor (R)-1, 2 and 3, platelet-derived growth factor receptors (PDGFR)-alpha and beta, Flt3, RET, and Kit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1099	18536700-664	Narp deletion blocks extinction of morphine place preference conditioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1100	18536700-665	Accordingly, to assess its potential role in the long-lasting behavioral effects of drugs of abuse, we have investigated the impact of Narp deletion on sustained behavioral responses elicited by repeated morphine administration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1101	18536704-162	Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1102	18536705-163	injection of PACAP provoked a significant increase in plasma glucose level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1103	18536954-285	In 17 adults on a fixed metabolic diet, an 11-day course of cinacalcet increased serum gastrin and basal gastric acid output, but not maximal gastric acid output, compared with a placebo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1104	18537150-81	Since PSC-833 was found to be a weak inhibitor of CYP 3A4 and to have no inhibitory effects on esterases, phenol sulfotransferases, and glucuronyltransferases, it is suggested PSC-833 enhances intestinal mucosal permeation of these cyclic prodrugs by inhibiting their polarized efflux and not by inhibiting their metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1105	18537150-81	Since PSC-833 was found to be a weak inhibitor of CYP 3A4 and to have no inhibitory effects on esterases, phenol sulfotransferases, and glucuronyltransferases, it is suggested PSC-833 enhances intestinal mucosal permeation of these cyclic prodrugs by inhibiting their polarized efflux and not by inhibiting their metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1106	18538372-777	We showed that after treatment of HCT116 cells with a low dose of doxorubicin most of them stopped proliferation as documented by SA-beta-galactosidase activity and the lack of Ki67 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1107	18539357-492	Tumor MUC1 differs from normal MUC1 by modified glycan side chains.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1108	18539387-509	Mineralization and dehalogenation of 2,4,6-TCP was evidenced by high COD removal efficiencies (approximately 95%), and by the stoichiometric release of chloride ions from the halogenated compound (approximately 80%).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1109	18539387-509	Mineralization and dehalogenation of 2,4,6-TCP was evidenced by high COD removal efficiencies (approximately 95%), and by the stoichiometric release of chloride ions from the halogenated compound (approximately 80%).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1110	18541345-459	Gliclazide can change the conformation of the active sites and decrease obviously the affinities between gliclazide in the active site and enzymes when it is docked in the second active sites in CYP2C9 and CYP2C19.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1111	18541345-459	Gliclazide can change the conformation of the active sites and decrease obviously the affinities between gliclazide in the active site and enzymes when it is docked in the second active sites in CYP2C9 and CYP2C19.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1112	18541345-459	Gliclazide can change the conformation of the active sites and decrease obviously the affinities between gliclazide in the active site and enzymes when it is docked in the second active sites in CYP2C9 and CYP2C19.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1113	18541345-459	Gliclazide can change the conformation of the active sites and decrease obviously the affinities between gliclazide in the active site and enzymes when it is docked in the second active sites in CYP2C9 and CYP2C19.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1114	18543297-399	Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1115	18543297-399	Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1116	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1117	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1118	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1119	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1120	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1121	18543297-400	Cytochrome P450 2D6 (CYP2D6) mediated formation of dextrorphan (DOR) from dextromethorphan (DEX) is widely used as a marker to assess the activity of this enzyme both in vitro and in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1122	18543297-401	The sequential metabolism of DOR during in vitro studies, particularly using recombinant systems (rCYPs) expressing human CYP2D6, is assumed to be negligible.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1123	18543297-402	The extent of metabolism was investigated for a range of DEX and DOR concentrations in microsomal preparations from three different rCYPs expressing human CYP2D6 (yeast, Supersomes and Bactosomes) containing 10 pmol of the enzyme.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1124	18543297-403	Two novel CYP2D6 related metabolites were identified in Bactosomes, and assigned as single hydroxylations in the phenyl rings of DOR and HYM using ion-trap mass spectrometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1125	18543297-403	Two novel CYP2D6 related metabolites were identified in Bactosomes, and assigned as single hydroxylations in the phenyl rings of DOR and HYM using ion-trap mass spectrometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1126	18543330-427	The metal-coordinating residues in the active site of ILL2 include a conserved cysteine that clearly distinguishes this protein from previously structurally characterized members of the M20 peptidase family.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1127	18543330-428	Finally, the active site of ILL2 harbors an absolutely conserved glutamate (Glu172), which is well positioned to act as a general acid-base residue.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1128	18544044-880	In this study, we tested the hypothesis that the Angiopoietin 1 (Ang1)/Tie2 pathway mediates simvastatin-induced vascular integrity and migration of neuroblasts after stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1129	18544044-880	In this study, we tested the hypothesis that the Angiopoietin 1 (Ang1)/Tie2 pathway mediates simvastatin-induced vascular integrity and migration of neuroblasts after stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1130	18544044-881	Simvastatin treatment significantly decreased blood-brain barrier (BBB) leakage and concomitantly, increased Ang1, Tie2 and Occludin expression in the ischaemic border (IBZ) compared to the MCAo control group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1131	18544044-881	Simvastatin treatment significantly decreased blood-brain barrier (BBB) leakage and concomitantly, increased Ang1, Tie2 and Occludin expression in the ischaemic border (IBZ) compared to the MCAo control group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1132	18544044-881	Simvastatin treatment significantly decreased blood-brain barrier (BBB) leakage and concomitantly, increased Ang1, Tie2 and Occludin expression in the ischaemic border (IBZ) compared to the MCAo control group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1133	18544044-882	Simvastatin also significantly increased doublecortin (DCX, a marker of migrating neuroblasts) expression in the IBZ compared to control MCAo rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1134	18544044-883	The data show that simvastatin treatment of RBMEC increased Ang1 and Tie2 gene and protein expression and promoted phosphorylated-Tie2 activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1135	18544044-883	The data show that simvastatin treatment of RBMEC increased Ang1 and Tie2 gene and protein expression and promoted phosphorylated-Tie2 activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1136	18544044-884	Simvastatin treatment of stroke increases Ang1/Tie2 expression and thereby reduces BBB leakage and promotes vascular stabilization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1137	18544044-884	Simvastatin treatment of stroke increases Ang1/Tie2 expression and thereby reduces BBB leakage and promotes vascular stabilization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1138	18544044-885	Ang1/Tie2 expression induced by simvastatin treatment promotes neuroblast micro-vascular coupling after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1139	18544044-885	Ang1/Tie2 expression induced by simvastatin treatment promotes neuroblast micro-vascular coupling after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1140	18544047-888	Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1141	18544047-891	Therefore, ERRalpha stands at the crossroad of glucose and fatty acid utilization and acts as a homeostatic switch to regulate the flux of TCA cycle, mitochondrial membrane potential and glycolysis to maintain a steady level of ATP production, particularly, when mitochondrial biogenesis is reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1142	18544047-891	Therefore, ERRalpha stands at the crossroad of glucose and fatty acid utilization and acts as a homeostatic switch to regulate the flux of TCA cycle, mitochondrial membrane potential and glycolysis to maintain a steady level of ATP production, particularly, when mitochondrial biogenesis is reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1143	18544592-1218	A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1144	18544592-1218	A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1145	18544592-1218	A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1146	18544592-1219	Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1147	18544592-1219	Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1148	18544592-1219	Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1149	18544592-1219	Even if partially compensated with u-PA and protein C, increased FVIII and vWF activity, and decreased nitric oxide levels may still partially contribute to progress of thrombosis risk in rhG-CSF plus dexamethasone administered healthy granulocyte donors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1150	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1151	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1152	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1153	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1154	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1155	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1156	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1157	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1158	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1159	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1160	18547170-484	Amyloglucosidase from Rhizopus mould and beta-glucosidase from sweet almond were employed for the preparation of phenolic and vitamin glycosides of vanillin, N-vanillylnonanamide, DL-dopa, dopamine, curcumin, alpha-tocopherol (vitamin E), pyridoxine (vitamin B(6)), ergocalciferol (vitamin D (2)), thiamin (vitamin B(1)) and riboflavin (vitamin B(2)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1161	18547363-1222	Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1162	18547363-1223	Therefore, in the present study, the effects of OTA on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes including glutathione-S-transferase and gamma-glutamylcysteinyl synthetase have been studied in cultured porcine kidney tubulus cells (LLC-PK1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1163	18547363-1223	Therefore, in the present study, the effects of OTA on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes including glutathione-S-transferase and gamma-glutamylcysteinyl synthetase have been studied in cultured porcine kidney tubulus cells (LLC-PK1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1164	18547363-1224	Nrf2 was induced by sulforaphane, a well-known activator of this transcription factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1165	18547363-1225	Ochratoxin A significantly decreased gamma-glutamylcysteinyl synthetase and glutathione-S-transferase mRNA levels in LLC-PK1 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1166	18547363-1226	Furthermore, OTA also lowered Nrf2 mRNA levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1167	18547363-1227	Current data indicate that OTA nephrotoxicity may be, at least partly, mediated by an Nrf2-dependent signal transduction pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1168	18547754-637	Parthenogenetic porcine blastocysts were generated by the following methods: (1) electroporation followed by blocking the activity of specific protein kinases with butyrolactone I ; (2) electroporation followed by inhibition of protein synthesis using cycloheximide ; and (3) electroporation only (control).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1169	18547754-637	Parthenogenetic porcine blastocysts were generated by the following methods: (1) electroporation followed by blocking the activity of specific protein kinases with butyrolactone I ; (2) electroporation followed by inhibition of protein synthesis using cycloheximide ; and (3) electroporation only (control).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1170	18547755-125	The aim of the present study was to investigate differences in the expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus at different stages of the estrous cycle as well as in inseminated sows at estrus and during early pregnancy by use of solution hybridization and in relation to plasma levels of estradiol and progesterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1171	18547755-125	The aim of the present study was to investigate differences in the expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus at different stages of the estrous cycle as well as in inseminated sows at estrus and during early pregnancy by use of solution hybridization and in relation to plasma levels of estradiol and progesterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1172	18547755-125	The aim of the present study was to investigate differences in the expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus at different stages of the estrous cycle as well as in inseminated sows at estrus and during early pregnancy by use of solution hybridization and in relation to plasma levels of estradiol and progesterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1173	18547755-125	The aim of the present study was to investigate differences in the expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus at different stages of the estrous cycle as well as in inseminated sows at estrus and during early pregnancy by use of solution hybridization and in relation to plasma levels of estradiol and progesterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1174	18547796-661	Increased incorporation of dietary plant sterols and cholesterol correlates with decreased expression of hepatic and intestinal Abcg5 and Abcg8 in diabetic BB rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1175	18547796-661	Increased incorporation of dietary plant sterols and cholesterol correlates with decreased expression of hepatic and intestinal Abcg5 and Abcg8 in diabetic BB rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1176	18547796-662	This increase in cholesterol and plant sterols and stanols was associated with a marked decrease in hepatic and intestinal Abcg5 (ATP-binding cassette transporter G5) and Abcg8 (ATP-binding cassette transporter G8) expressions in diabetic rats, as well as decreased mRNA levels of several other genes involved in sterol regulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1177	18547796-662	This increase in cholesterol and plant sterols and stanols was associated with a marked decrease in hepatic and intestinal Abcg5 (ATP-binding cassette transporter G5) and Abcg8 (ATP-binding cassette transporter G8) expressions in diabetic rats, as well as decreased mRNA levels of several other genes involved in sterol regulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1178	18547796-663	Therefore, lower expression levels of Abcg5/Abcg8 in diabetic rats may account for the increased accumulation of plant sterols and cholesterol in these rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1179	18547796-663	Therefore, lower expression levels of Abcg5/Abcg8 in diabetic rats may account for the increased accumulation of plant sterols and cholesterol in these rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1180	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1181	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1182	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1183	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1184	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1185	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1186	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1187	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1188	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1189	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1190	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1191	18547798-666	Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg(-1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1192	18547799-292	These effects of genistein during the differentiation period were associated with down-regulation of ERalpha and ERbeta expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1193	18547799-292	These effects of genistein during the differentiation period were associated with down-regulation of ERalpha and ERbeta expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1194	18548182-922	Activities of microbial extracellular enzymes involved in carbon, nitrogen, and phosphorus cycling declined appreciably with depth, the only exception being peroxidase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1195	18548182-922	Activities of microbial extracellular enzymes involved in carbon, nitrogen, and phosphorus cycling declined appreciably with depth, the only exception being peroxidase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1196	18548275-801	Sulfonylurea (SU) treatment restores insulin secretion in patients with KCNJ11 mutations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1197	18548275-801	Sulfonylurea (SU) treatment restores insulin secretion in patients with KCNJ11 mutations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1198	18548615-1193	The purpose of this study was to investigate the effect of three zinc salts (i.e., zinc oxide, zinc carbonate, and zinc acetate) on insulin encapsulation efficiency (EE), stability, and in vitro release kinetics from poly(lactic-co-glycolic acid) (PLGA) microspheres.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1199	18548615-1193	The purpose of this study was to investigate the effect of three zinc salts (i.e., zinc oxide, zinc carbonate, and zinc acetate) on insulin encapsulation efficiency (EE), stability, and in vitro release kinetics from poly(lactic-co-glycolic acid) (PLGA) microspheres.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1200	18548615-1193	The purpose of this study was to investigate the effect of three zinc salts (i.e., zinc oxide, zinc carbonate, and zinc acetate) on insulin encapsulation efficiency (EE), stability, and in vitro release kinetics from poly(lactic-co-glycolic acid) (PLGA) microspheres.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1201	18548615-1193	The purpose of this study was to investigate the effect of three zinc salts (i.e., zinc oxide, zinc carbonate, and zinc acetate) on insulin encapsulation efficiency (EE), stability, and in vitro release kinetics from poly(lactic-co-glycolic acid) (PLGA) microspheres.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1202	18550063-794	Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1203	18550063-795	In the present study, we investigated whether endotoxin-induced inflammatory reactions lead to a decrease of endothelial glycocalyx thickness in humans and whether tumor necrosis factor-alpha (TNFalpha) plays a role in this process.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1204	18550063-795	In the present study, we investigated whether endotoxin-induced inflammatory reactions lead to a decrease of endothelial glycocalyx thickness in humans and whether tumor necrosis factor-alpha (TNFalpha) plays a role in this process.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1205	18550164-868	The amino acid sequence deduced from the coding sequence encodes for a protein of 73 amino acids containing 21 cysteine residues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1206	18550594-1147	Ultrastructural analysis in the macaque mediodorsal nucleus revealed that thalamic interneurons are a main postsynaptic target of DAT-ir axons ; this suggests that the marked expansion of the dopamine innervation in the primate in comparison to the rodent thalamus may be related to the presence of a sizable interneuron population in primates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1207	18550596-1150	Synapsin-dependent facilitation in MF synapses of WT mice was attenuated by blocking F-actin polymerization with cytochalasin B in hippocampal slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1208	18550596-1150	Synapsin-dependent facilitation in MF synapses of WT mice was attenuated by blocking F-actin polymerization with cytochalasin B in hippocampal slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1209	18551377-641	Transformation was achieved using a vector that targets genes to the rrn16/rps12 intergenic region of the sugar beet plastome, employing the aadA gene as a selectable marker against spectinomycin and the gfp gene for visual screening of plastid transformants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1210	18551377-641	Transformation was achieved using a vector that targets genes to the rrn16/rps12 intergenic region of the sugar beet plastome, employing the aadA gene as a selectable marker against spectinomycin and the gfp gene for visual screening of plastid transformants.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1211	18552508-1057	Celecoxib inhibits serum amyloid a-induced matrix metalloproteinase-10 expression in human endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1212	18553142-185	This article investigated the effect of sulfite on total antioxidant capacity (TAC), total oxidant status, lipid hydroperoxide (LOOH), and total free sulfydryl groups (-SH) levels in normal and SOX-deficient male albino rat plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1213	18553142-186	SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1214	18553142-186	SOX deficiency was established by feeding rats a low molybdenum diet and adding to their drinking water 200 ppm tungsten.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1215	18554595-1071	To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells and that this production is augmented by the presence of sex steroids or insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1216	18554595-1071	To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells and that this production is augmented by the presence of sex steroids or insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1217	18554598-1073	Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1218	18554598-1073	Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1219	18554598-1073	Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1220	18554598-1073	Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1221	18554690-393	The differences in tissue distribution and protein levels of EcR-B1 during the programmed cell death indicate that the receptor plays a major role in the modulation and function of ecdysone activity in Bombyx anterior silk glands.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1222	18555241-208	Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1223	18555557-379	Methylthioadenosine phosphorylase (MTAP) is involved in the metabolism of purines and converts methylthioadenosine (MTA) to adenine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1224	18555557-380	Methylation-specific primers were used to analyze methylation of the MTAP promoter, using DNA treated with sodium bisulfite.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1225	18555679-458	Long-chain fatty alcohols also reduced tumor necrosis factor-alpha and prostaglandin E(2) production, although the potency of inhibition for the latter was lower.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1226	18556000-671	Neopterin is released from human monocyte-derived macrophages upon stimulation with interferon-gamma and is a sensitive indicator for cellular immune activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1227	18556087-712	Both activity and expression of sulfate transporters and APS reductase in plants are modulated by the sulfur status of the plant.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1228	18560889-729	Complex I deficiency is a novel cause of secretory diarrhea and may act via disrupting the supply of adenosine triphosphate (ATP) needed for the maintenance of ion gradients across membranes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1229	18560889-729	Complex I deficiency is a novel cause of secretory diarrhea and may act via disrupting the supply of adenosine triphosphate (ATP) needed for the maintenance of ion gradients across membranes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1230	18561093-53	This prospective cross-sectional study was performed to investigate the influence of GH excess on leptin and ghrelin levels at baseline and after glucose load in a large group of acromegalic patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1231	18561093-53	This prospective cross-sectional study was performed to investigate the influence of GH excess on leptin and ghrelin levels at baseline and after glucose load in a large group of acromegalic patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1232	18561170-499	Trypsin digestion, fluorescence anisotropy, and NMR experiments presented here were designed to resolve the issue and show that in arm-dimerization domain, the arms are structured, although differently, in the presence and absence of arabinose.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1233	18561187-110	DNA array studies have revealed that YhaK is strongly up-regulated by nitroso-glutathione (GSNO) and also displays a 12-fold increase in expression during biofilm growth of E. coli 83972 and VR50 in human urine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1234	18561187-111	We found that the third cysteine in YhaK, Cys122, is oxidized to a sulfenic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1235	18561187-111	We found that the third cysteine in YhaK, Cys122, is oxidized to a sulfenic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1236	18561187-112	E. coli thioredoxin reductase and NADPH produced ROS and caused oxidation and oligomerization of reduced YhaK.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1237	18561187-112	E. coli thioredoxin reductase and NADPH produced ROS and caused oxidation and oligomerization of reduced YhaK.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1238	18562331-1081	In this report, we investigated the possible role of LA and vmPFC NR2Bs in the consolidation of fear extinction using the NR2B-selective antagonist ifenprodil.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1239	18562331-1081	In this report, we investigated the possible role of LA and vmPFC NR2Bs in the consolidation of fear extinction using the NR2B-selective antagonist ifenprodil.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1240	18562423-1156	Patients under clozapine-risperidone therapy developed a rise of serum prolactin levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1241	18562423-1156	Patients under clozapine-risperidone therapy developed a rise of serum prolactin levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1242	18562442-1178	In experiment 3, administration of E(2) or DPN to ovariectomised wildtype, but not betaERKO, mice decreased immobility compared with vehicle administration, these data suggest that ERbeta may be required for some of the anti-depressant-like effects of E(2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1243	18563306-164	Simvastatin treatment significantly increased the number of peripheral blood CD34+ CD133+ cells, and serum concentration of vascular endothelial growth factor (VEGF) and AKT was markedly increased in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1244	18563306-165	In cultured EPC, simvastatin increased the concentrations of VEGF, AKT and eNOS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1245	18563306-165	In cultured EPC, simvastatin increased the concentrations of VEGF, AKT and eNOS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1246	18563306-166	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1247	18563306-166	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1248	18563306-166	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1249	18563306-166	Western blots analysis showed that simvastatin increased the phosphorylation of eNOS and FKHRL1, which can be blocked by the PI3K/AKT pathway blocker LY294002.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1250	18563306-167	In in vitro study, simvastatin increases the phosphorylation of eNOS and of FKHRL1 through the PI3K/AKT signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1251	18563306-167	In in vitro study, simvastatin increases the phosphorylation of eNOS and of FKHRL1 through the PI3K/AKT signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1252	18563306-167	In in vitro study, simvastatin increases the phosphorylation of eNOS and of FKHRL1 through the PI3K/AKT signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1253	18563517-342	Only the intracellular IL-2 response in the lower tertile of IL-2 production was improved with glutamine indicating a small influence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1254	18563517-343	The elevation of glutamine plasma levels by a perioperative intravenous infusion of L-alanyl-L-glutamine influenced the intracellular expression of IL-2 in the lower tertile only slightly.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1255	18563542-358	Determination of bioactive matter by affinity adsorption solid substrate-room temperature phosphorimetry based on lectin labeled with self-ordered ring of eosin Y.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1256	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1257	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1258	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1259	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1260	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1261	18563542-359	Specific affinity adsorption (AA) reactions could be carried out between the products of concanavalin agglutinin (Con A), triticum vulgaris lectin (WGA) labeled with ESOR and alpha-fetoprotein variant (AFP-V), alkaline phosphatase (ALP), glucose (G), respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1262	18563554-369	In this paper we demonstrate that hedgehog signaling antagonists, including cyclopamine, and a second compound, CUR0199691, can inhibit growth of estrogen receptor (ER)-positive and ER-negative tumorigenic breast cancer cells at elevated doses.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1263	18563559-375	The equality of K (D) of paroxetine binding to blood platelet membranes and to membranes from nerve endings appears to encourage the use of such membranes as a model for brain SERT.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1264	18563560-376	With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1265	18563560-376	With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1266	18563560-376	With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1267	18563560-376	With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1268	18563560-377	GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1269	18563560-377	GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1270	18563560-377	GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1271	18563560-377	GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1272	18563561-378	Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels and myeloperoxidase activity (MPO) were examined in plasma, liver and brain tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1273	18563561-378	Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels and myeloperoxidase activity (MPO) were examined in plasma, liver and brain tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1274	18563561-378	Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels and myeloperoxidase activity (MPO) were examined in plasma, liver and brain tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1275	18563561-378	Malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels and myeloperoxidase activity (MPO) were examined in plasma, liver and brain tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1276	18563616-418	Glutathione peroxidase 1 (GPX1) is a ubiquitously expressed selenium-dependent enzyme that protects cells against oxidative damage by reducing hydrogen peroxide and a wide range of organic peroxides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1277	18563616-418	Glutathione peroxidase 1 (GPX1) is a ubiquitously expressed selenium-dependent enzyme that protects cells against oxidative damage by reducing hydrogen peroxide and a wide range of organic peroxides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1278	18563708-512	Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1279	18563708-512	Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1280	18563803-210	In conclusion, TAD-A has sufficient bonding strength and comparatively low toxicity in clinical use of 0.3 mmol or less of TAD and 0.8 mL of 44 w/w % HSA solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1281	18563826-616	Long intercalated defects in canine ribs can be repaired successfully using porous beta-tricalcium phosphate (beta-TCP) cylinders, infused with a biodegradable polymer (poly D,L-lactic acid-polyethylene block copolymer) containing recombinant human bone morphogenetic protein-2 (rhBMP-2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1282	18564056-810	In the present study we explored the possibility of using genetic engineering to increase the artemisinin content of A. annua by suppressing the expression of SQS (squalene synthase), a key enzyme of sterol pathway (a pathway competitive with that of artemisinin biosynthesis) by means of a hairpin-RNA-mediated RNAi (RNA interference) technique.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1283	18564176-915	Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1284	18564211-943	It has been reported that tamoxifen may affect hepatoma cell growth in vitro by suppressing transforming growth factor beta-1 (TGF-beta1) expression, suggesting that tamoxifen might also retard fibrogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1285	18564211-944	Thus, we examined whether tamoxifen might suppress TGF-beta1 expression and consequently inhibit the process of hepatic fibrosis in vivo.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1286	18564281-1010	We also explored the effect of substance P released by capsaicin because this neuropeptide is known to affect the microvasculature environment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1287	18564281-1010	We also explored the effect of substance P released by capsaicin because this neuropeptide is known to affect the microvasculature environment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1288	18565553-422	Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1289	18565553-422	Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1290	18565553-424	These findings suggest that AEC IIs play an important role in initial inflammatory reactions of the lung by releasing LTC4, and that they also modulate later inflammatory reactions, evidenced by consistent elevation of MCP-1 gene expression after and during exogenous challenge in pigs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1291	18565581-347	Whereas their toxicity is due to acetylcholinesterase inhibition, their secondary toxic effects have been related to free oxygen radicals.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1292	18565581-348	Diazinon diminished the plasma acetylcholinesterase activity on day 1 post-treatment, although testosterone levels remained unaffected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1293	18565581-348	Diazinon diminished the plasma acetylcholinesterase activity on day 1 post-treatment, although testosterone levels remained unaffected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1294	18565581-349	Melatonin pretreatment prevented every alteration induced by diazinon, except the diminution of acetylcholinesterase plasmatic activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1295	18565581-349	Melatonin pretreatment prevented every alteration induced by diazinon, except the diminution of acetylcholinesterase plasmatic activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1296	18566887-1426	Sialic acid-specific O-acetyltransferases and O-acetylesterases are responsible for the metabolism of esterified sialic acids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1297	18566887-1426	Sialic acid-specific O-acetyltransferases and O-acetylesterases are responsible for the metabolism of esterified sialic acids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1298	18567517-267	Endomorphin-2 vector injection also reduced spontaneous pain-related behaviors in the delayed phase of the formalin test and in both CFA and formalin models suppressed spinal c-fos expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1299	18567517-267	Endomorphin-2 vector injection also reduced spontaneous pain-related behaviors in the delayed phase of the formalin test and in both CFA and formalin models suppressed spinal c-fos expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1300	18568363-1000	Furthermore, 8-bromo-cGMP and peroxynitrite failed to reproduce the inhibitory effect of NO, indicating that NO acts directly on TonEBP rather than through classical NO signaling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1301	18568363-1000	Furthermore, 8-bromo-cGMP and peroxynitrite failed to reproduce the inhibitory effect of NO, indicating that NO acts directly on TonEBP rather than through classical NO signaling pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1302	18568363-998	Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1303	18568363-999	Because nitric oxide (NO) is abundantly produced in the renal medulla, the present studies addressed the effect of NO on expression of osmoprotective genes and TonEBP activation in MDCK cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1304	18568422-1042	Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1305	18568422-1042	Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1306	18568422-1043	An RCC1 mutant in which all N-terminal serine and threonine residues were substituted with glutamate residues to mimic phosphorylation at these residues showed decreased binding to the karyopherin, KPNA4, compared with wild type RCC1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1307	18568422-1043	An RCC1 mutant in which all N-terminal serine and threonine residues were substituted with glutamate residues to mimic phosphorylation at these residues showed decreased binding to the karyopherin, KPNA4, compared with wild type RCC1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1308	18568422-1043	An RCC1 mutant in which all N-terminal serine and threonine residues were substituted with glutamate residues to mimic phosphorylation at these residues showed decreased binding to the karyopherin, KPNA4, compared with wild type RCC1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1309	18568426-1046	ATP, acting on P2X (7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1310	18568426-1046	ATP, acting on P2X (7) receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1311	18570315-909	While the total insulin released during a 1 h glucose stimulation period was the same from islets in each sample, increasing hydrogel crosslinking density contributed to delays in insulin release from hydrogel samples within the 1 h stimulation period.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1312	18570630-1172	Ischaemia and insulin, but not ischaemia and contraction, act synergistically in stimulating muscle glucose uptake in vivo in humans.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1313	18570630-1173	In summary, ischaemia and insulin independently stimulate skeletal muscle glucose uptake in vivo in humans, whereas ischaemia and contraction do not.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1314	18570631-224	A comparison of the inhibitory effect of paraoxon on soluble and immobilized AChE showed that immobilization increased the linearity of the inhibition plot particularly in the range 0.1 nM-0.1 microM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1315	18570695-1236	7,12-Dimethyl-benz(a) anthracene (DMBA) can induce expressions of CYP1A1 and CYP1B1 which are known to be responsive to PAH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1316	18570695-1236	7,12-Dimethyl-benz(a) anthracene (DMBA) can induce expressions of CYP1A1 and CYP1B1 which are known to be responsive to PAH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1317	18571801-413	Extracellular lipase LIP prepared in our lab from the yeast Yarrowia lipolytica was used for the resolution of racemic ibuprofen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1318	18571801-413	Extracellular lipase LIP prepared in our lab from the yeast Yarrowia lipolytica was used for the resolution of racemic ibuprofen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1319	18571801-414	The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1320	18571801-414	The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1321	18571801-414	The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1322	18571801-414	The high purity (S)-ibuprofen (ee = 0.98) was obtained using lipase LIP to catalyze hydrolysis of (S)-ester in 0.1 M phosphate buffer (pH = 8).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1323	18571950-552	The potential action of galactose as a "chemical chaperone": increase of beta galactosidase activity in fibroblasts from an adult GM1-gangliosidosis patient.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1324	18571954-554	Citric acid perfusion marginally increased NGF levels to 7.3 fg/microg/ml on average in the upper arm and control axilla.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1325	18571954-555	In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1326	18571954-555	In contrast, perfusion of the inflamed axilla with citric acid significantly enhanced the release of both NGF and BDNF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1327	18572174-747	Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1328	18572174-747	Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1329	18572174-747	Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1330	18572174-748	Both PON1 gene promoter activity and PON1 protein expression were elevated by pitavastatin stimulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1331	18572174-749	Pitavastatin phosphorylated p44/42 MAP kinase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1332	18572174-751	Pitavastatin increased the Sp1-PON1 DNA complex and this effect was attenuated by PD98059.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1333	18572174-751	Pitavastatin increased the Sp1-PON1 DNA complex and this effect was attenuated by PD98059.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1334	18572174-751	Pitavastatin increased the Sp1-PON1 DNA complex and this effect was attenuated by PD98059.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1335	18572174-751	Pitavastatin increased the Sp1-PON1 DNA complex and this effect was attenuated by PD98059.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1336	18572174-752	These observations suggest that pitavastatin phosphorylates p44/42 MAP kinase and then activates the transcription of PON1 gene and increases the PON1 protein expression in Huh7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1337	18572174-752	These observations suggest that pitavastatin phosphorylates p44/42 MAP kinase and then activates the transcription of PON1 gene and increases the PON1 protein expression in Huh7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1338	18572174-753	Furthermore, we speculate that pitavastatin affects both the phosphorylation of SREBP-2 and the Sp1 binding to PON1 DNA through the activation of p44/42 MAP kinase signaling cascade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1339	18572174-753	Furthermore, we speculate that pitavastatin affects both the phosphorylation of SREBP-2 and the Sp1 binding to PON1 DNA through the activation of p44/42 MAP kinase signaling cascade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1340	18572174-753	Furthermore, we speculate that pitavastatin affects both the phosphorylation of SREBP-2 and the Sp1 binding to PON1 DNA through the activation of p44/42 MAP kinase signaling cascade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1341	18572174-753	Furthermore, we speculate that pitavastatin affects both the phosphorylation of SREBP-2 and the Sp1 binding to PON1 DNA through the activation of p44/42 MAP kinase signaling cascade.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1342	18573668-277	Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1343	18573668-277	Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1344	18573668-278	Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1345	18573668-278	Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1346	18574025-577	Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1347	18574025-577	Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1348	18574025-577	Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1349	18574025-578	In conclusion, CYP2C9 and VKORC1 significantly influenced warfarin dose and predicted individuals predisposed to unstable anticoagulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1350	18574025-578	In conclusion, CYP2C9 and VKORC1 significantly influenced warfarin dose and predicted individuals predisposed to unstable anticoagulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1351	18574490-986	BMI and testosterone levels were evaluated for their ability to predict overall survival (OS) and prostate-specific antigen (PSA) declines in the TAX327 clinical trial, an international phase III randomized trial of one of the two schedules of docetaxel and prednisone compared with mitoxantrone and prednisone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1352	18574490-986	BMI and testosterone levels were evaluated for their ability to predict overall survival (OS) and prostate-specific antigen (PSA) declines in the TAX327 clinical trial, an international phase III randomized trial of one of the two schedules of docetaxel and prednisone compared with mitoxantrone and prednisone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1353	18574490-986	BMI and testosterone levels were evaluated for their ability to predict overall survival (OS) and prostate-specific antigen (PSA) declines in the TAX327 clinical trial, an international phase III randomized trial of one of the two schedules of docetaxel and prednisone compared with mitoxantrone and prednisone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1354	18574490-986	BMI and testosterone levels were evaluated for their ability to predict overall survival (OS) and prostate-specific antigen (PSA) declines in the TAX327 clinical trial, an international phase III randomized trial of one of the two schedules of docetaxel and prednisone compared with mitoxantrone and prednisone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1355	18574490-987	In multivariate analysis, neither BMI, presence of obesity, nor baseline testosterone was significantly associated with OS or PSA declines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1356	18574670-1109	The interaction between PAF and the platelet agonists ADP, thrombin and convulxin was analyzed in vitro in whole blood with the use of flow cytometry and was further characterized with the use of receptor antagonists to PAF (ABT-491), P2Y1 (MRS-2179), and P2Y12 (cangrelor) as well as a monoclonal anti-PSGL-1 antibody (anti-CD162).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1357	18574670-1109	The interaction between PAF and the platelet agonists ADP, thrombin and convulxin was analyzed in vitro in whole blood with the use of flow cytometry and was further characterized with the use of receptor antagonists to PAF (ABT-491), P2Y1 (MRS-2179), and P2Y12 (cangrelor) as well as a monoclonal anti-PSGL-1 antibody (anti-CD162).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1358	18575957-472	Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1359	18575957-472	Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1360	18575957-472	Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1361	18575957-472	Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1362	18575957-472	Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1363	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1364	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1365	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1366	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1367	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1368	18575957-473	Effects of remifentanyl and fentanyl on spontaneous and endotoxin (lipopolysaccharide ; 100 ng ml(-1))-stimulated cytokine release were studied in whole blood from volunteers (n = 10) cultured for 6 h. Results IL-6, TNF-alpha and IL-10 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1369	18575957-475	Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1370	18575957-475	Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1371	18575957-475	Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1372	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1373	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1374	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1375	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1376	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1377	18577298-1601	This reduction was associated with the storage of decreased TAG and increased glycogen, which was a result of enhanced tyrosine phosphorylation of anti-insulin receptor substrate-2 and serine473 phosphporylation of protein kinase B (PKB, Akt).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1378	18577298-1602	Improved hepatic insulin signalling led to decreased phosphoenolpyruvate carboxykinase expression and reduced hepatic glucose output accordingly.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1379	18577871-351	These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1380	18579232-1493	Inhibition of these enzymes shows that chagasic autoantibodies up-regulation of COX-2/iNOS mRNA level is under the control of endogenous iNO/cGMP signaling system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1381	18579232-1493	Inhibition of these enzymes shows that chagasic autoantibodies up-regulation of COX-2/iNOS mRNA level is under the control of endogenous iNO/cGMP signaling system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1382	18580872-1175	Pre-synaptic CB1Rs inhibit neurotransmitter release, suggesting that CB1R activation during extinction may decrease CCK peptide release as well as GABA release.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1383	18580872-1175	Pre-synaptic CB1Rs inhibit neurotransmitter release, suggesting that CB1R activation during extinction may decrease CCK peptide release as well as GABA release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1384	18580872-1175	Pre-synaptic CB1Rs inhibit neurotransmitter release, suggesting that CB1R activation during extinction may decrease CCK peptide release as well as GABA release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1385	18580876-1179	Acute cocaine, through D(2) dopamine receptors, induced a dose-response increase in FADD protein in the cortex, with opposite effects over pFADD (Ser191/194), and no induction of apoptotic cell death (poly-(ADP-ribose) polymerase cleavage).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1386	18580876-1179	Acute cocaine, through D(2) dopamine receptors, induced a dose-response increase in FADD protein in the cortex, with opposite effects over pFADD (Ser191/194), and no induction of apoptotic cell death (poly-(ADP-ribose) polymerase cleavage).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1387	18580876-1180	FADD was increased by cocaine in cytosol (approximately 142%), membranes (approximately 23%) and nucleus (approximately 54%).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1388	18580876-1181	In a second experiment, possible FADD differences were investigated in rats selectively bred for differential responsiveness to novelty, propensity for drug-seeking and cocaine sensitization.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1389	18581264-1465	Lignin peroxidases have the unique ability to catalyze oxidative cleavage of C-C bonds and ether (C-O-C) bonds in non-phenolic aromatic substrates of high redox potential.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1390	18581264-1466	Manganese peroxidases oxidize Mn(II) to Mn(III), which facilitates the degradation of phenolic compounds or, in turn, oxidizes a second mediator for the breakdown of non-phenolic compounds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1391	18581264-1466	Manganese peroxidases oxidize Mn(II) to Mn(III), which facilitates the degradation of phenolic compounds or, in turn, oxidizes a second mediator for the breakdown of non-phenolic compounds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1392	18581264-1467	Laccases are multi-copper-containing proteins that catalyze the oxidation of phenolic substrates with concomitant reduction of molecular oxygen to water.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1393	18581264-1467	Laccases are multi-copper-containing proteins that catalyze the oxidation of phenolic substrates with concomitant reduction of molecular oxygen to water.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1394	18581270-1477	The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1395	18581270-1477	The co-expression of SERT with M6B results in a significant decrease in SERT-mediated serotonin uptake caused by a down-regulation of SERT surface expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1396	18582556-870	Hence, resistance to cancer in old Snell dwarf mice may be mediated by neuroendocrine factors that reduce glucose utilization besides elevated adiponectin, reduced IGF-I and a lack of GH, PRL and TSH, seen in both Snell and Ames dwarf mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1397	18582556-870	Hence, resistance to cancer in old Snell dwarf mice may be mediated by neuroendocrine factors that reduce glucose utilization besides elevated adiponectin, reduced IGF-I and a lack of GH, PRL and TSH, seen in both Snell and Ames dwarf mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1398	18582992-1242	Therefore, cinacalcet, which inhibit the production of parathormone by negative feedback, was considered a treatment option to control the evolution of calciphylaxis in a dialysed patient suffering from cholangiocarcinoma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1399	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1400	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1401	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1402	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1403	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1404	18583434-1596	Glucose levels and hormones (Peptide YY(3-36), glucagon-like peptide-1 (GLP-1), leptin, ghrelin, insulin) that regulate EI were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1405	18584285-592	Transglutaminases catalyze a calcium-dependent transamidation reaction that produces covalent cross-linking of available substrate glutamine residues and modifies the extracellular matrix.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1406	18584286-593	We fed rats lysine or valine deficient diet for 4 weeks and examined the mRNA expressions of serine synthesising (3-phosphoglycerate dehydrogenase, PHGDH) and serine/threonine degrading enzymes (serine dehydratase, SDS) in the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1407	18584286-593	We fed rats lysine or valine deficient diet for 4 weeks and examined the mRNA expressions of serine synthesising (3-phosphoglycerate dehydrogenase, PHGDH) and serine/threonine degrading enzymes (serine dehydratase, SDS) in the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1408	18584286-593	We fed rats lysine or valine deficient diet for 4 weeks and examined the mRNA expressions of serine synthesising (3-phosphoglycerate dehydrogenase, PHGDH) and serine/threonine degrading enzymes (serine dehydratase, SDS) in the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1409	18584286-593	We fed rats lysine or valine deficient diet for 4 weeks and examined the mRNA expressions of serine synthesising (3-phosphoglycerate dehydrogenase, PHGDH) and serine/threonine degrading enzymes (serine dehydratase, SDS) in the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1410	18584286-594	Dietary deficiency induced marked elevation of hepatic serine and threonine levels associated with enhancement of PHGDH mRNA expression and repression of SDS mRNA expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1411	18584286-594	Dietary deficiency induced marked elevation of hepatic serine and threonine levels associated with enhancement of PHGDH mRNA expression and repression of SDS mRNA expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1412	18584286-594	Dietary deficiency induced marked elevation of hepatic serine and threonine levels associated with enhancement of PHGDH mRNA expression and repression of SDS mRNA expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1413	18584286-594	Dietary deficiency induced marked elevation of hepatic serine and threonine levels associated with enhancement of PHGDH mRNA expression and repression of SDS mRNA expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1414	18584306-333	Site-directed mutation test and mithramycin A treatment demonstrated that the ZNF230 promoter contained a functional Sp1 site.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1415	18584306-333	Site-directed mutation test and mithramycin A treatment demonstrated that the ZNF230 promoter contained a functional Sp1 site.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1416	18584320-630	Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1417	18584320-630	Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1418	18584320-631	(4) Our data indicated that progesterone maintained in part neuronal ultrastructure, attenuated chromatolysis, and preclude the loss of MAP2, suggesting a protective effect during the early phases of spinal cord injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1419	18584336-637	In conclusion, our results indicate that chronic THC modulates the expression and subcellular localization of proteins implicated in Ras signaling, calcium-buffering potential, and trafficking.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1420	18584896-1102	For this purpose, on day 0, male Wistar rats received NTG (120 microg/kg, iv) with or without pre-administration of PKC inhibitor chelerythrine (CHE), capsaicin (CAP) to deplete CGRP from sensory nerves or mK(ATP) channel blocker 5-hydroxydecaonic acid (5HD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1421	18584896-1102	For this purpose, on day 0, male Wistar rats received NTG (120 microg/kg, iv) with or without pre-administration of PKC inhibitor chelerythrine (CHE), capsaicin (CAP) to deplete CGRP from sensory nerves or mK(ATP) channel blocker 5-hydroxydecaonic acid (5HD).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1422	18584896-1102	For this purpose, on day 0, male Wistar rats received NTG (120 microg/kg, iv) with or without pre-administration of PKC inhibitor chelerythrine (CHE), capsaicin (CAP) to deplete CGRP from sensory nerves or mK(ATP) channel blocker 5-hydroxydecaonic acid (5HD).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1423	18585399-1508	The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1424	18585720-96	Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1425	18585721-97	With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance, the metabolic syndrome and renal failure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1426	18585721-97	With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance, the metabolic syndrome and renal failure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1427	18585744-108	The distribution of sugar moieties within the epididymal region of the Sudani duck was investigated using ten different fluorescein isothiocyanate (FITC) conjugated lectins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1428	18585744-108	The distribution of sugar moieties within the epididymal region of the Sudani duck was investigated using ten different fluorescein isothiocyanate (FITC) conjugated lectins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1429	18586252-521	High glucose and interferon gamma synergistically stimulate MMP-1 expression in U937 macrophages by increasing transcription factor STAT1 activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1430	18586252-521	High glucose and interferon gamma synergistically stimulate MMP-1 expression in U937 macrophages by increasing transcription factor STAT1 activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1431	18586252-521	High glucose and interferon gamma synergistically stimulate MMP-1 expression in U937 macrophages by increasing transcription factor STAT1 activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1432	18586252-522	To test our hypothesis that hyperglycemia interplays with interferon gamma (IFN gamma), a key factor involved in atherosclerosis, to up-regulate the expression of genes such as matrix metalloproteinases (MMPs) and cytokines that are involved in plaque destabilization, U937 macrophages cultured in medium containing either normal or high glucose were challenged with IFN gamma and the expression of MMPs and cytokines were then quantified by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1433	18586252-522	To test our hypothesis that hyperglycemia interplays with interferon gamma (IFN gamma), a key factor involved in atherosclerosis, to up-regulate the expression of genes such as matrix metalloproteinases (MMPs) and cytokines that are involved in plaque destabilization, U937 macrophages cultured in medium containing either normal or high glucose were challenged with IFN gamma and the expression of MMPs and cytokines were then quantified by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1434	18586252-523	Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1435	18586252-523	Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1436	18586252-523	Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1437	18586252-523	Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1438	18586252-525	Furthermore, high glucose and IFN gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1439	18586252-525	Furthermore, high glucose and IFN gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1440	18586252-525	Furthermore, high glucose and IFN gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1441	18586420-663	In Experiment 2, lactoferrin (10 mg/mL) combined with cidofovir (62.5 microg/mL) inhibited up to 100,200 PFU/mL of virus in cell culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1442	18586549-790	We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1443	18586549-790	We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1444	18586549-790	We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1445	18586549-790	We systematically investigated whether PD-related stresses including MG132 and epoxomicin (proteasomal impairment), tunicamycin (unfolded protein stress), and rotenone (mitochondrial dysfunction) resulted in expressional changes of parkin and other E3 ubiquitin ligases (dorfin, SIAH-1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1446	18587580-1638	CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1447	18587580-1638	CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1448	18587580-1639	To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1449	18587580-1639	To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1450	18587580-1639	To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1451	18587580-1639	To explore potential therapeutic strategies for interrupting signaling through this pathway, we assessed the ability of CDDO-Me, a synthetic triterpenoid, to inhibit IL-6 secretion, Stat3 phosphorylation, Stat3 nuclear translocation and paclitaxel sensitivity in several cell line model systems.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1452	18587580-1640	These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6-or oncostatin M-induced Stat3 nuclear translocation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1453	18587580-1640	These studies demonstrated that CDDO-Me significantly inhibits IL-6 secretion in paclitaxel-resistant ovarian cancer cells and specifically suppresses IL-6-or oncostatin M-induced Stat3 nuclear translocation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1454	18587580-1641	Treatment with CDDO-Me significantly decreases the levels of Stat3, Jak2, and Src phosphorylation in ovarian and breast cancer cell lines with constitutively activated Stat3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1455	18587580-1641	Treatment with CDDO-Me significantly decreases the levels of Stat3, Jak2, and Src phosphorylation in ovarian and breast cancer cell lines with constitutively activated Stat3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1456	18587580-1642	Our data confirm that CDDO-Me interrupts the signaling of multiple kinases involved in the IL-6-Stat3 and Src signaling pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1457	18587580-1642	Our data confirm that CDDO-Me interrupts the signaling of multiple kinases involved in the IL-6-Stat3 and Src signaling pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1458	18587580-1642	Our data confirm that CDDO-Me interrupts the signaling of multiple kinases involved in the IL-6-Stat3 and Src signaling pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1459	18587601-1586	The anti-hyperlipemia effect of EPS and intracellular polysaccharide (IPS) extracted from mycelia were observed that both EPS and IPS can obviously reduce the serum triglyceride (TG), the blood cholesterol (TC) and serum low density lipoprotein (LDL) level, and increase the high density lipoprotein (HDL) level of the hyperlipemia mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1460	18587610-1674	On a molar basis, streptomycin yields a signal that is approximately 0.67 times that of MurA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1461	18587665-16	Puerarin regulates expressions of VEGF and HIF-1alpha stimulated by STZ.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1462	18587665-16	Puerarin regulates expressions of VEGF and HIF-1alpha stimulated by STZ.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1463	18588512-710	In patients with hypertension and diabetes, ARB, ACEi and diuretic treatment increased Ras activation only during the first week.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1464	18590515-661	Although the co-expression of alpha2,3-ST and CMP-SAS did not further increase sialylation, an increase in the intracellular pool of CMP-sialic acid was noted.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1465	18590587-733	NOPE-EGCG treatment improved insulin 0.0001).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1466	18590597-739	A 23.5-fold increase in 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity suggested that metabolic resistance through elevated levels of cytochrome P450 dependent monooxygenase-activity is a possible resistance mechanism.However, synergism studies with different metabolic inhibitors revealed some contrasting resistance mechanisms between the METI-acaricides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1467	18592271-409	The activities of Rho GTPases are predominantly controlled by guanine nucleotide exchange factors (GEFs), which activate GTPases by catalyzing the exchange of bound GDP for GTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1468	18592327-379	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1469	18592327-379	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1470	18592344-477	Rebinding experiments with Lys-Gly-Asp, an analogue of Arg-Gly-Asp, and other different peptides, such as cholecystokinin C-terminal tri- and pentapeptide and gramicidin, further indicated the selectivity of methacrylic acid-trimethylpropane trimethacrylate copolymer for Arg-Gly-Asp giving specific selectivity factor values 1.27, 1.98, 1.31 and 1.67, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1471	18592367-499	Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using ((18)F) setoperone to image cortical serotonin type-2 (5-HT2) receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1472	18592408-535	Natural anacardic acid was enzymatically polymerized using soybean peroxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1473	18592416-542	Vesicle mobilization requires Ca(2+)-induced Ca2+ release by presynaptic endoplasmic reticulum (ER) ryanodine receptors (RyRs) that in turn stimulates Ca2+/calmodulin-dependent kinase II (CamKII).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1474	18593507-1421	These results highlight both the interactions between mGluR5 and NMDA receptors in the determination of schizophreniform behaviours and the potential for the effects of clozapine to be mediated by NMDA receptor regulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1475	18594129-259	Expression of rhtC reduced the intracellular L-threonine concentration from 140 to 11 mM and resulted in maximal excretion rates of 11.2 nmol min(-1) mg(-1) as compared to 2.3 nmol min(-1) mg(-1) obtained without rhtC expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1476	18594129-260	In combination with an ilvA mutation generated and introduced into the chromosome, an accumulation of up to 54 mM L-threonine was achieved as compared to 21 mM obtained with the ancestor strain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1477	18594817-847	This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1478	18594817-848	Furthermore, the CD3(+) T cells co-cultured with topotecan treated U-87 and autologous GBM tumor cells showed a significant increase in expression in IFN-gamma, a key cytokine produced by activated T cells, and accordingly enhanced tumor cytotoxicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1479	18594856-883	Hypergravity also induced a transient reorganization of actin fibers in 3 min, which was inhibited by Rho-kinase inhibitor (Y27632) and tyrosine kinase inhibitors (herbimycin A and tyrphostin 46).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1480	18594856-883	Hypergravity also induced a transient reorganization of actin fibers in 3 min, which was inhibited by Rho-kinase inhibitor (Y27632) and tyrosine kinase inhibitors (herbimycin A and tyrphostin 46).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1481	18594856-883	Hypergravity also induced a transient reorganization of actin fibers in 3 min, which was inhibited by Rho-kinase inhibitor (Y27632) and tyrosine kinase inhibitors (herbimycin A and tyrphostin 46).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1482	18594856-886	Collectively, these results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK phosphorylation, thereby activating cell proliferation and migration in BAECs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1483	18594856-886	Collectively, these results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK phosphorylation, thereby activating cell proliferation and migration in BAECs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1484	18594856-886	Collectively, these results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK phosphorylation, thereby activating cell proliferation and migration in BAECs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1485	18594946-953	Cell exposure to 250 microM homocysteine was able to induce transglutaminase 2 up-regulation and increased in situ transglutaminase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1486	18594946-953	Cell exposure to 250 microM homocysteine was able to induce transglutaminase 2 up-regulation and increased in situ transglutaminase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1487	18594946-954	Homocysteine also induced NF-kappaB activation that seemed associated with transglutaminase 2 up-regulation since the specific NF-kappaB inhibition by SN50 was able to reduce transglutaminase expression and activity levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1488	18594946-954	Homocysteine also induced NF-kappaB activation that seemed associated with transglutaminase 2 up-regulation since the specific NF-kappaB inhibition by SN50 was able to reduce transglutaminase expression and activity levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1489	18594965-980	Lysophosphatidic acid can support the formation of membranous structures and an increase in MBP mRNA levels in differentiating oligodendrocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1490	18594989-1002	There was no correlation between the presence of significant heart-valve regurgitation and cabergoline cumulative dose, duration of cabergoline treatment, prior use of bromocriptine, age, adenoma size, or prolactin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1491	18594989-1002	There was no correlation between the presence of significant heart-valve regurgitation and cabergoline cumulative dose, duration of cabergoline treatment, prior use of bromocriptine, age, adenoma size, or prolactin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1492	18595002-930	CHH elevates glucose levels in the hemolymph by stimulating glycogenolysis in target tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1493	18596195-276	Here, we assessed the regulation of pancreatic cytochrome c release by Ca(2+), mitochondrial membrane potential (Delta Psi m), and reactive oxygen species (ROS), the signals involved in acute pancreatitis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1494	18596687-690	Here, we report the efficacy of betaxolol in reducing increases in gene expression of amygdalar corticotropin-releasing factor (CRF), a peptide known to be involved in mediating 'anxiety-like' behaviors during initial phases of cocaine abstinence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1495	18596687-690	Here, we report the efficacy of betaxolol in reducing increases in gene expression of amygdalar corticotropin-releasing factor (CRF), a peptide known to be involved in mediating 'anxiety-like' behaviors during initial phases of cocaine abstinence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1496	18596687-690	Here, we report the efficacy of betaxolol in reducing increases in gene expression of amygdalar corticotropin-releasing factor (CRF), a peptide known to be involved in mediating 'anxiety-like' behaviors during initial phases of cocaine abstinence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1497	18596687-690	Here, we report the efficacy of betaxolol in reducing increases in gene expression of amygdalar corticotropin-releasing factor (CRF), a peptide known to be involved in mediating 'anxiety-like' behaviors during initial phases of cocaine abstinence.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1498	18596687-691	Results showed that betaxolol treatment during early cocaine withdrawal attenuated increases in amygdalar CRF gene expression and cyclic adenosine monophosphate-dependent protein kinase regulatory and catalytic subunit (nuclear fraction) protein expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1499	18596687-691	Results showed that betaxolol treatment during early cocaine withdrawal attenuated increases in amygdalar CRF gene expression and cyclic adenosine monophosphate-dependent protein kinase regulatory and catalytic subunit (nuclear fraction) protein expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1500	18596687-691	Results showed that betaxolol treatment during early cocaine withdrawal attenuated increases in amygdalar CRF gene expression and cyclic adenosine monophosphate-dependent protein kinase regulatory and catalytic subunit (nuclear fraction) protein expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1501	18596687-691	Results showed that betaxolol treatment during early cocaine withdrawal attenuated increases in amygdalar CRF gene expression and cyclic adenosine monophosphate-dependent protein kinase regulatory and catalytic subunit (nuclear fraction) protein expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1502	18596687-692	The present findings suggest that the efficacy of betaxolol treatment on cocaine withdrawal-induced anxiety may be related, in part, to its effect on amygdalar beta(1)-adrenergic receptor, modulation of its downstream cell-signaling elements and CRF gene expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1503	18596687-692	The present findings suggest that the efficacy of betaxolol treatment on cocaine withdrawal-induced anxiety may be related, in part, to its effect on amygdalar beta(1)-adrenergic receptor, modulation of its downstream cell-signaling elements and CRF gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1504	18597051-1012	Furthermore, it is demonstrated that this strain has xylanase activity, and the activity can be optimized under suitable growing conditions where wheat bran and urea are the primary sources of carbon and nitrogen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1505	18597051-1012	Furthermore, it is demonstrated that this strain has xylanase activity, and the activity can be optimized under suitable growing conditions where wheat bran and urea are the primary sources of carbon and nitrogen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1506	18597073-1033	Glutathione S-transferase (GST) isozymes catalyze nucleophilic attack by reduced Glutathione (GSH) on a variety of electrophilic compounds and play a central role in biotransformation of xenobiotics (Hayes et al., Annu Rev Pharmacol Toxicol 45:51-88, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1507	18597073-1033	Glutathione S-transferase (GST) isozymes catalyze nucleophilic attack by reduced Glutathione (GSH) on a variety of electrophilic compounds and play a central role in biotransformation of xenobiotics (Hayes et al., Annu Rev Pharmacol Toxicol 45:51-88, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1508	18597073-1033	Glutathione S-transferase (GST) isozymes catalyze nucleophilic attack by reduced Glutathione (GSH) on a variety of electrophilic compounds and play a central role in biotransformation of xenobiotics (Hayes et al., Annu Rev Pharmacol Toxicol 45:51-88, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1509	18597073-1033	Glutathione S-transferase (GST) isozymes catalyze nucleophilic attack by reduced Glutathione (GSH) on a variety of electrophilic compounds and play a central role in biotransformation of xenobiotics (Hayes et al., Annu Rev Pharmacol Toxicol 45:51-88, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1510	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1511	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1512	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1513	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1514	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1515	18597869-1683	Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1516	18599066-769	Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1517	18599066-769	Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1518	18599066-769	Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1519	18599066-769	Palmitate phosphorylated p38 and JNK kinases, and blocking of these kinases with specific inhibitors diminished the palmitate-induced cytokine secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1520	18599066-770	Palmitate also activated the AP-1 (c-Jun) transcription factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1521	18599093-1004	Characterisation of ATP analogues to cross-link and label P2X receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1522	18599093-1005	In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2', 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1523	18599093-1005	In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2', 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1524	18599093-1005	In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2', 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1525	18599093-1005	In this study we determined whether the UV light-reactive ATP analogues 2-azido ATP, ATP azidoanilide (ATP-AA) and 2', 3'-O-(4-benzoylbenzoyl)-ATP (BzATP) can be used to label the ATP binding site of P2X1 receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1526	18599093-1006	cross-linked to P2X1 receptors and this binding was reduced by co-incubation with ATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1527	18599093-1007	These studies demonstrate that photo-reactive ATP analogues can be used to label P2X receptor and may prove useful in elucidating the ATP binding site at this novel class of ATP binding proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1528	18599154-1053	TGF-beta1 treatment for 72 h also induced EMT in the A549 cells and this transition led to resistance to gefitinib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1529	18599191-1078	Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1530	18599210-1087	Optimization of decolorization of methylene blue (MB) dye by lignin peroxidase (LiP) enzyme produced by white-rot fungus Phanerochaete chrysosporium using sewage treatment plant (STP) sludge as a major substrate was carried out in the laboratory.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1531	18600448-401	Glycine release was potentiated by the activation of protein kinase C and diminished by increasing cyclic guanosine monophosphate levels with a phosphodiesterase inhibitor, zaprinast.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1532	18600448-401	Glycine release was potentiated by the activation of protein kinase C and diminished by increasing cyclic guanosine monophosphate levels with a phosphodiesterase inhibitor, zaprinast.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1533	18600448-401	Glycine release was potentiated by the activation of protein kinase C and diminished by increasing cyclic guanosine monophosphate levels with a phosphodiesterase inhibitor, zaprinast.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1534	18600455-406	Our study demonstrates that taurocholate causes evident damage to acinar cells, impairing both calcium homeostasis and secretory response to CCK.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1535	18600456-407	Enteric neuronal dopamine (DA) inhibits acetylcholine release and gastric motility; this has been thought to be mediated via neuronal dopamine-2 receptor (D2R).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1536	18600473-984	As compared with parental B16 cells, the inhibitory effects of TGF-beta1 and activin A on melanin content were relative smaller in B16 F10 cells, a subline of B16 cells that contain more pigment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1537	18601937-1660	ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1538	18601937-1662	However asynchronous EPSCs were increased following synaptic depression and a component of these appeared to be initiated by endogenously released ATP acting on presynaptic P2X receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1539	18601937-1663	Unexpectedly, the data suggest P2X receptor activation initiates a form of asynchronous glutamate release, rather than detectably affecting the vesicles underlying action potential evoked release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1540	18601945-1673	The second enzyme of GSH synthesis, GSH synthase (GS) is also regulated in a coordinated manner as GCL subunits and its up-regulation can further enhance the capacity of the cell to synthesize GSH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1541	18602447-1075	The rise in (Ca(2+))(i) elicited by hGH is associated with an enhanced insulin secretion, effects that are mediated mainly through the prolactin receptor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1542	18602447-1075	The rise in (Ca(2+))(i) elicited by hGH is associated with an enhanced insulin secretion, effects that are mediated mainly through the prolactin receptor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1543	18602447-1076	These mechanisms indicate that a rise in (Ca(2+))(i) elicited by activation of PRLR is JAK2-dependent and is associated with enhanced insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1544	18602447-1076	These mechanisms indicate that a rise in (Ca(2+))(i) elicited by activation of PRLR is JAK2-dependent and is associated with enhanced insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1545	18602447-1076	These mechanisms indicate that a rise in (Ca(2+))(i) elicited by activation of PRLR is JAK2-dependent and is associated with enhanced insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1546	18602447-1077	In contrast, GH receptor-mediated increase in (Ca(2+))(i) is JAK2-independent and is dissociated from insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1547	18602447-1077	In contrast, GH receptor-mediated increase in (Ca(2+))(i) is JAK2-independent and is dissociated from insulin secretion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1548	18602447-1077	In contrast, GH receptor-mediated increase in (Ca(2+))(i) is JAK2-independent and is dissociated from insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1549	18602691-569	SEMG I expression is upregulated by IL-4, IL-6 and 5-azacytidine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1550	18602691-569	SEMG I expression is upregulated by IL-4, IL-6 and 5-azacytidine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1551	18602691-569	SEMG I expression is upregulated by IL-4, IL-6 and 5-azacytidine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1552	18602794-652	Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1553	18602807-667	Consumption of the trichothecene mycotoxin deoxynivalenol (DON) induces interleukin-6 (IL-6)-dependent IgA nephropathy (IgAN) in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1554	18602807-667	Consumption of the trichothecene mycotoxin deoxynivalenol (DON) induces interleukin-6 (IL-6)-dependent IgA nephropathy (IgAN) in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1555	18602807-668	The purpose of this study was to identify the signal transduction pathways by which DON up-regulates IL-6 in the peritoneal macrophage and how consumption of fish oil enriched with the n-3 PUFA docosahexaenoic acid (DHA) suppresses these processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1556	18602814-672	The aim of the present study was to determine the effects of niacin and chromium on HDL formation by investigating the changes in ABCA1 and ApoA-1 transcription in the human hepatoblastoma cell line (HepG2 cells).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1557	18602814-672	The aim of the present study was to determine the effects of niacin and chromium on HDL formation by investigating the changes in ABCA1 and ApoA-1 transcription in the human hepatoblastoma cell line (HepG2 cells).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1558	18602814-674	Niacin and chromium cotreatment significantly induced the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) mRNA by approximately 1.3-1.8-fold.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1559	18602814-674	Niacin and chromium cotreatment significantly induced the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) mRNA by approximately 1.3-1.8-fold.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1560	18602814-674	Niacin and chromium cotreatment significantly induced the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) mRNA by approximately 1.3-1.8-fold.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1561	18602814-674	Niacin and chromium cotreatment significantly induced the expression of peroxisome proliferator-activated receptor-alpha (PPARalpha) mRNA by approximately 1.3-1.8-fold.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1562	18602814-675	A combination of niacin and chromium chloride did not significantly increase (3+1 mM) but instead reduced (1+3 mM) ABCA1 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1563	18602814-675	A combination of niacin and chromium chloride did not significantly increase (3+1 mM) but instead reduced (1+3 mM) ABCA1 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1564	18602814-676	We hypothesize that the stimulation of ABCA1 gene expression causes an enhanced cholesterol efflux, perhaps mediated by PPARalpha pathway(s).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1565	18602814-676	We hypothesize that the stimulation of ABCA1 gene expression causes an enhanced cholesterol efflux, perhaps mediated by PPARalpha pathway(s).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1566	18602823-684	Sulforaphane inhibited cell proliferation with IC(50) values at 24 and 48 h of 12.5 and 7.5 muM doses, respectively, and decreased ERalpha protein expression at concentrations between 2.5 and 30 muM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1567	18602823-685	30 muM, the SUL-induced suppression of ERalpha protein was reversed by preincubation with the proteasome inhibitor MG132 and was accompanied by an increase in protein levels of the 20S catalytic core subunit PSMB5.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1568	18602823-685	30 muM, the SUL-induced suppression of ERalpha protein was reversed by preincubation with the proteasome inhibitor MG132 and was accompanied by an increase in protein levels of the 20S catalytic core subunit PSMB5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1569	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1570	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1571	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1572	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1573	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1574	18603252-1055	Of importance, treatment with ezetimibe significantly improved endothelial dysfunction as assessed by the vasodilator response to acetylcholine, accompanied by inhibition of interleukin-6 mRNA and an increase in endothelial nitric oxide synthase (eNOS) mRNA in the aorta.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1575	18603333-1106	A series of adamantane derivatives of thiazolyl-N-substituted amides were synthesized in a three-step reaction and tested for anti-inflammatory activity as well as lipoxygenase and cycloxygenase inhibitory actions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1576	18604600-443	Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1577	18604600-443	Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1578	18604600-443	Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1579	18606045-1675	Plasma levels of magnesium, zinc and carotenoids did not vary across quintiles, but weak negative correlations were observed with serum ferritin and transferrin saturation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1580	18606045-1675	Plasma levels of magnesium, zinc and carotenoids did not vary across quintiles, but weak negative correlations were observed with serum ferritin and transferrin saturation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1581	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1582	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1583	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1584	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1585	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1586	18606396-239	Two major groups of ligand-activated nuclear receptors/xenosensors evolved: the Ah receptor (activated by aryl hydrocarbons and drugs such as omeprazole) and type 2 steroid receptors such as PXR and CAR, activated by drugs such as rifampicin, carbamazepin and phenytoin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1587	18607531-1203	The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1588	18607531-1204	We have investigated the structure-activity relationship between 63 natural oxycoumarin derivatives and their effects on the expression of inducible-nitric oxide synthase (iNOS) induced by lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1589	18607531-1204	We have investigated the structure-activity relationship between 63 natural oxycoumarin derivatives and their effects on the expression of inducible-nitric oxide synthase (iNOS) induced by lipopolysaccharide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1590	18607531-1204	We have investigated the structure-activity relationship between 63 natural oxycoumarin derivatives and their effects on the expression of inducible-nitric oxide synthase (iNOS) induced by lipopolysaccharide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1591	18607531-1204	We have investigated the structure-activity relationship between 63 natural oxycoumarin derivatives and their effects on the expression of inducible-nitric oxide synthase (iNOS) induced by lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1592	18607542-1212	Inhibition of protein synthesis by imexon reduces HIF-1alpha expression in normoxic and hypoxic pancreatic cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1593	18607542-1213	Western blot analyses of imexon-treated cells demonstrated that imexon reduces HIF-1alpha protein levels in both normoxic and hypoxic conditions in a time- and concentration-dependant fashion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1594	18607542-1214	Gemcitabine did not similarly affect HIF-1alpha levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1595	18607542-1216	Concurrently, the half-life of existing HIF-1alpha protein was increased by imexon, in association with a marked inhibition of chymotryptic activity in the 20S proteasome.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1596	18607542-1217	The inhibition of HIF-1alpha translation was not specific, rather it was part of a general decrease in protein translation caused by imexon.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1597	18607689-1312	To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1598	18607689-1312	To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1599	18607689-1312	To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1600	18607689-1312	To determine whether a regimen of aspirin pretreatment, bivalirudin during the procedure and clopidogrel (600 mg) immediately after percutaneous coronary intervention (PCI) was associated with platelet activation during and shortly after (1 and 2 h) PCI, we characterized platelet function in 10 patients with the use of flow cytometry in the absence of agonist and in response to thrombin (10 nM), ADP (1 microM), the collagen-mimetic convulxin (5 ng/ml), and platelet activating factor (10 nM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1601	18607722-1326	Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1602	18607722-1327	The low-density lipoprotein receptor (LDLr) mediates the uptake of LDL particles enriched with cholesterol, into several tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1603	18607918-1505	Under the condition of delayed intervention (30 days after deafening) following gentamicin+ furosemide deafening in rats, we conclude that chronic intracochlear electrical stimulation (ES) and continuous intracochlear administration of brain-derived neurotrophic factor (BDNF) enhance spiral ganglion cell (SGC) body and peripheral process survival and improve auditory sensitivity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1604	18607918-1505	Under the condition of delayed intervention (30 days after deafening) following gentamicin+ furosemide deafening in rats, we conclude that chronic intracochlear electrical stimulation (ES) and continuous intracochlear administration of brain-derived neurotrophic factor (BDNF) enhance spiral ganglion cell (SGC) body and peripheral process survival and improve auditory sensitivity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1605	18607918-1505	Under the condition of delayed intervention (30 days after deafening) following gentamicin+ furosemide deafening in rats, we conclude that chronic intracochlear electrical stimulation (ES) and continuous intracochlear administration of brain-derived neurotrophic factor (BDNF) enhance spiral ganglion cell (SGC) body and peripheral process survival and improve auditory sensitivity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1606	18607918-1505	Under the condition of delayed intervention (30 days after deafening) following gentamicin+ furosemide deafening in rats, we conclude that chronic intracochlear electrical stimulation (ES) and continuous intracochlear administration of brain-derived neurotrophic factor (BDNF) enhance spiral ganglion cell (SGC) body and peripheral process survival and improve auditory sensitivity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1607	18608753-1365	For this purpose, human erythrocyte glutathione reductase was initially purified 2139-fold in a yield of 29% by using 2', 5'-ADP Sepharose 4B affinity gel and Sephadex G-200 gel filtration chromatography.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1608	18608754-503	The enzyme deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and PPi thus controlling the incorporation of uracil into DNA genomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1609	18608754-503	The enzyme deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and PPi thus controlling the incorporation of uracil into DNA genomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1610	18608754-504	In the present study we perform a kinetic analysis of Campylobacter dUTPase using the continuous spectrophotometric method and show that the enzyme is highly specific for deoxyuridine nucleotides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1611	18608755-505	Tryptophanase (tryptophan indole-lyase, Tnase, EC 4.1.99.1), a bacterial enzyme with no counterpart in eukaryotic cells, produces from L-tryptophan pyruvate, ammonia and indole.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1612	18608755-505	Tryptophanase (tryptophan indole-lyase, Tnase, EC 4.1.99.1), a bacterial enzyme with no counterpart in eukaryotic cells, produces from L-tryptophan pyruvate, ammonia and indole.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1613	18608755-505	Tryptophanase (tryptophan indole-lyase, Tnase, EC 4.1.99.1), a bacterial enzyme with no counterpart in eukaryotic cells, produces from L-tryptophan pyruvate, ammonia and indole.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1614	18608766-514	Urease allows soil microorganisms to use urea as a source of nitrogen and aid in the rapid break down of urea-based fertilizers resulting in phytopathicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1615	18608766-514	Urease allows soil microorganisms to use urea as a source of nitrogen and aid in the rapid break down of urea-based fertilizers resulting in phytopathicity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1616	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1617	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1618	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1619	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1620	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1621	18608782-527	Adenosine deaminase (ADA), an enzyme involved in purine metabolism, catalyzes the hydrolytic breakdown of adenosine into inosine and free ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1622	18609042-761	Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1623	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1624	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1625	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1626	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1627	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1628	18609294-966	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1629	18609433-1079	Fluvoxamine, a SSRI, is mainly metabolized by cytochrome P450 (CYP) 2D6 and 1A2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1630	18609433-1079	Fluvoxamine, a SSRI, is mainly metabolized by cytochrome P450 (CYP) 2D6 and 1A2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1631	18612599-292	GCK is expressed in the rat DVC, where mRNA is localized to neurons that exhibit electrophysiological sensitivity to glucose imbalance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1632	18612775-1047	Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of Kynurenine pathway along the major route of Tryptophan catabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1633	18612775-1047	Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of Kynurenine pathway along the major route of Tryptophan catabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1634	18612777-425	Type I transglutaminase (TG1), an enzyme that catalyzes the formation of epsilon-(gamma-glutamyl) lysine bonds, is the key protein responsible for generation of the crosslinks.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1635	18612811-461	Myc-oncogene inactivating effect by proline rich polypeptide (PRP-1) in chondrosarcoma JJ012 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1636	18612819-471	Like PSC, DSL6A cells secrete less ET-1 when cultured with bosentan.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1637	18612824-1284	Caspase inhibition with z-VAD was unable to prevent AIF localization to the nucleus and subsequently unable to prevent cell death.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1638	18614168-1607	Purinergic receptor agonists ATP and UTP selectively activate certain Src family tyrosine kinases and stimulate Na,K-ATPase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1639	18614168-1607	Purinergic receptor agonists ATP and UTP selectively activate certain Src family tyrosine kinases and stimulate Na,K-ATPase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1640	18615010-596	Early deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT(1A)R) mRNA and binding ((3H)WAY100635), and to increased vesicular GABA transporter mRNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1641	18615010-596	Early deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT(1A)R) mRNA and binding ((3H)WAY100635), and to increased vesicular GABA transporter mRNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1642	18615010-596	Early deprivation led to decreases in hippocampal growth-associated protein-43 (GAP-43) mRNA, serotonin 1A receptor (5-HT(1A)R) mRNA and binding ((3H)WAY100635), and to increased vesicular GABA transportervesicular GABA transporter mRNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1643	18615011-597	We measured the ability to increase GABA in eight healthy subjects by comparing the binding of ((11)C) flumazenil, a positron emission tomography (PET) radiotracer specific for the benzodiazepine (BDZ) site, at baseline and in the presence of an acute elevation in GABA levels through the blockade of the GABA membrane transporter (GAT1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1644	18615011-598	GAT1 blockade resulted in significant increases in mean (+/-SD) ((11)C) flumazenil-binding potential (BP(ND)) over baseline in brain regions representing the major functional domains of the cerebral cortex: association cortex+15.2+/-20.2% (p=0.05), sensory cortex+13.5+/-15.5% (p=0.03) and limbic (medial temporal lobe, MTL)+16.4+/-20.2% (p=0.03).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1645	18615280-830	alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1646	18615280-830	alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1647	18615280-831	Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1648	18615280-831	Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1649	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1650	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1651	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1652	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1653	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1654	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1655	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1656	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1657	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1658	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1659	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1660	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1661	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1662	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1663	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1664	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1665	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1666	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1667	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1668	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1669	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1670	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1671	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1672	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1673	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1674	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1675	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1676	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1677	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1678	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1679	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1680	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1681	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1682	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1683	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1684	18615705-81	The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists (triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)), activities of major detoxification enzymes (general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)), and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1685	18615705-83	All these results clearly indicated that the observed malathion resistance in the FR was conferred by multiple mechanisms, including increased detoxification by ESTs and GSTs, and increased activity and reduced sensitivity of AChE to OP inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1686	18615705-83	All these results clearly indicated that the observed malathion resistance in the FR was conferred by multiple mechanisms, including increased detoxification by ESTs and GSTs, and increased activity and reduced sensitivity of AChE to OP inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1687	18615707-1194	Lysozymes act as crucial bacteriolytic enzymes in insect immune system by hydrolyzing the beta (1-->4) bonds between N-acetylglucosamine and N-acetylmuramic acid in the peptidoglycan of prokaryotic cell walls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1688	18615707-1194	Lysozymes act as crucial bacteriolytic enzymes in insect immune system by hydrolyzing the beta (1-->4) bonds between N-acetylglucosamine and N-acetylmuramic acid in the peptidoglycan of prokaryotic cell walls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1689	18615707-1194	Lysozymes act as crucial bacteriolytic enzymes in insect immune system by hydrolyzing the beta (1-->4) bonds between N-acetylglucosamine and N-acetylmuramic acid in the peptidoglycan of prokaryotic cell walls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1690	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1691	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1692	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1693	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1694	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1695	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1696	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1697	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1698	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1699	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1700	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1701	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1702	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1703	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1704	18615734-449	These mRNAs no longer encode the pleckstrin homology (PH) domain of collybistin, which we now show binds phosphatidylinositol-3-phosphate (PI3P/PtdIns-3-P), a phosphoinositide with an emerging role in membrane trafficking and signal transduction, rather than phosphatidylinositol 3,4,5-trisphosphate (PIP3/PtdIns-3,4,5-P) as previously suggested in the " membrane activation model" of gephyrin clustering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1705	18616717-310	We investigated whether several different inflammatory markers including C-reactive protein (CRP) and fibrinogen and white blood cells (WBCs) count, are associated with maximal oxygen consumption (VO(2 max)) in women with polycystic ovary syndrome (PCOS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1706	18616717-310	We investigated whether several different inflammatory markers including C-reactive protein (CRP) and fibrinogen and white blood cells (WBCs) count, are associated with maximal oxygen consumption (VO(2 max)) in women with polycystic ovary syndrome (PCOS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1707	18617682-1119	CSE activated the MMP-1 promoter, and this induction was prevented by PD98059 blockade of ERK1/2 phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1708	18617682-1119	CSE activated the MMP-1 promoter, and this induction was prevented by PD98059 blockade of ERK1/2 phosphorylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1709	18617682-1120	Cotransfection, mithramycin, and electrophoretic mobility shift assay studies identified activating and repressive roles for Sp1 and PEA3 transcription factors, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1710	18617751-1188	We have previously demonstrated that iloprost, a stable prostacyclin (PGI (2)) analogue, induces angiogenesis in vivo, through a vascular endothelial growth factor (VEGF)-dependent mechanism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1711	18617751-1188	We have previously demonstrated that iloprost, a stable prostacyclin (PGI (2)) analogue, induces angiogenesis in vivo, through a vascular endothelial growth factor (VEGF)-dependent mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1712	18617751-1189	In this study, we demonstrate that iloprost-induced angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays multiple biological activities in the vascular system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1713	18617751-1189	In this study, we demonstrate that iloprost-induced angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays multiple biological activities in the vascular system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1714	18617751-1189	In this study, we demonstrate that iloprost-induced angiogenesis and VEGF upregulation are modulated by peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-inducible transcription factor that belongs to the nuclear hormone receptor superfamily and plays multiple biological activities in the vascular system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1715	18617751-1191	In contrast, iloprost induces a robust angiogenic response in wild-type mice, along with local upregulation of VEGF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1716	18617751-1192	Importantly, mice lacking the PPARalpha gene exhibit a normal angiogenic response to VEGF, indicating that the absence of PPARalpha does not result in a general impairment of angiogenesis, but specifically affects the ability of iloprost to induce angiogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1717	18618086-1425	The proportion of APP molecules that are directed to the novel cleavage pathway is regulated by the ratio of free cholesterol and cholesteryl esters in cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1718	18618240-1582	In the hormone receptor-positive breast cancer cell line T47-D expression of hCAR and its soluble isoforms was increased by treatment with estradiol and tamoxifen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1719	18618240-1582	In the hormone receptor-positive breast cancer cell line T47-D expression of hCAR and its soluble isoforms was increased by treatment with estradiol and tamoxifen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1720	18618241-1584	In contrast to the behavior in aqueous solution, lactose binding in DMSO resulted in an increase of the lectin's radius of gyration from 49+/-1 to 55.5+/-1 A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1721	18618243-1587	Tumor necrosis factor-alpha (TNF-alpha) levels were also investigated in rat serum, but there was no statistically significant difference between the TNF-alpha levels of the caffeine-treated rats groups and the control rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1722	18618243-1587	Tumor necrosis factor-alpha (TNF-alpha) levels were also investigated in rat serum, but there was no statistically significant difference between the TNF-alpha levels of the caffeine-treated rats groups and the control rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1723	18618243-1588	Our study indicates that brain arginase activity decreases after caffeine administration at doses of 30 mg/kg and 100 mg/kg.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1724	18618245-1590	Comparison of the PTM's of MBP's isolated from several vertebrate species reveals marked differences in their phosphate content.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1725	18618245-1591	Chicken MBP does not share any phosphorylated sites with dogfish MBP ; However, it does contain phosphorylated serine and threonine residues in common with mammalian MBP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1726	18618245-1591	Chicken MBP does not share any phosphorylated sites with dogfish MBP ; However, it does contain phosphorylated serine and threonine residues in common with mammalian MBP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1727	18618304-1646	Riluzole/NaPB administration increased acetylation at H4 and increased NF-kappaB p50 translocation to the nucleus in G93A mice, consistent with a therapeutic effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1728	18618304-1646	Riluzole/NaPB administration increased acetylation at H4 and increased NF-kappaB p50 translocation to the nucleus in G93A mice, consistent with a therapeutic effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1729	18618472-1060	Due to the absence of hydrophobic solute-material interactions, which limit the scope of microstructures fabricated from poly(dimethylsiloxane) for biocatalytic applications, the new microreactor was fully compatible with the alternate enzyme substrate 2-nitro-phenyl-beta-D-galactoside and the 2-nitro-phenol product resulting from its hydrolysis catalyzed by CelB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1730	18618621-1255	These findings suggest that multiple variations in the SLC6A4 gene are associated with remission in white non-Hispanic depressed adults treated with citalopram.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1731	18618694-248	The planar angle between the carbamoyl phosphate and aspartate domains of the catalytic chain is more open at pH 8.5 than in ATCase structures determined at lower pH values.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1732	18618694-248	The planar angle between the carbamoyl phosphate and aspartate domains of the catalytic chain is more open at pH 8.5 than in ATCase structures determined at lower pH values.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1733	18618700-254	At 0.15 microM Ca(2+), ((35)S) CaM bound to RyR2 with decreased affinity and binding enthalpy compared with RyR1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1734	18618700-254	At 0.15 microM Ca(2+), ((35)S) CaM bound to RyR2 with decreased affinity and binding enthalpy compared with RyR1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1735	18618700-254	At 0.15 microM Ca(2+), ((35)S) CaM bound to RyR2 with decreased affinity and binding enthalpy compared with RyR1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1736	18618700-255	The rates of ((35)S) CaM dissociation from RyR1 increased as the temperature was raised, whereas at 0.15 microM Ca(2+) the rate from RyR2 was little affected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1737	18618700-255	The rates of ((35)S) CaM dissociation from RyR1 increased as the temperature was raised, whereas at 0.15 microM Ca(2+) the rate from RyR2 was little affected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1738	18618700-255	The rates of ((35)S) CaM dissociation from RyR1 increased as the temperature was raised, whereas at 0.15 microM Ca(2+) the rate from RyR2 was little affected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1739	18619522-636	In rats, infusion of angiotensin II increases ferritin levels and arterial thickness which are reversed by treatment with the iron chelator deferoxamine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1740	18619705-1094	Furthermore, ellipticine regulated endogenous survival signaling by up-regulating phosphorylated Akt that returned to its basal level later.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1741	18619705-1095	Furthermore, ellipticine induced nucleus translocalization of p53 and Akt and recruitment of autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1742	18619705-1095	Furthermore, ellipticine induced nucleus translocalization of p53 and Akt and recruitment of autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1743	18619713-1104	The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1744	18621093-545	Recent findings indicate that the polypyrimidine tract-binding protein (PTB), also named hnRNP I, by binding to the 3'-UTR (untranslated region) of the preproinsulin mRNA molecule, stabilizes the messenger, thereby participating in the glucose-induced increase in preproinsulin mRNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1745	18621093-545	Recent findings indicate that the polypyrimidine tract-binding protein (PTB), also named hnRNP I, by binding to the 3'-UTR (untranslated region) of the preproinsulin mRNA molecule, stabilizes the messenger, thereby participating in the glucose-induced increase in preproinsulin mRNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1746	18621373-794	Pretreatment with extracellular signal-regulated kinase (ERK) and Jun N-terminal kinase (JNK) inhibitors, but not p38 mitogen-activated protein kinase (p38MAPK) significantly decreased CRP-induced superoxide anion release from macrophages in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1747	18621373-794	Pretreatment with extracellular signal-regulated kinase (ERK) and Jun N-terminal kinase (JNK) inhibitors, but not p38 mitogen-activated protein kinase (p38MAPK) significantly decreased CRP-induced superoxide anion release from macrophages in vivo.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1748	18621413-823	The free radicals produced are thought to be generated during the production of uric acid, a reaction catalyzed by xanthine oxidase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1749	18621448-855	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1750	18621448-855	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1751	18621448-855	In the diabetic group, a decrease in the pancreatic glutathione levels, glutathione peroxidase and superoxide dismutase activities and an increase in the pancreatic lipid peroxidation level and catalase activities were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1752	18621563-947	The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1753	18621563-947	The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1754	18621563-948	In the central nervous system, TNF-alpha is involved in induction of a fever response and triggers the release of other cytokines, and may also influence transport of compounds into the brain, leading to cerebrospinal fluid leukocytosis, increased protein influx, and lactate accumulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1755	18621563-949	Thalidomide has been shown to down-regulate the production of TNF-alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1756	18622696-162	Both cell types expressed estrogen and progesterone receptors, although only the epithelial LM05-E cells were stimulated by estradiol and inhibited by tamoxifen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1757	18622696-162	Both cell types expressed estrogen and progesterone receptors, although only the epithelial LM05-E cells were stimulated by estradiol and inhibited by tamoxifen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1758	18622720-185	This study was performed to investigate the effect of combined treatment with niacin and chromium on vascular endothelial dysfunction, with the aim of gaining insight to the mechanisms by detecting the expression levels of ox-LDL and LOX-1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1759	18622720-185	This study was performed to investigate the effect of combined treatment with niacin and chromium on vascular endothelial dysfunction, with the aim of gaining insight to the mechanisms by detecting the expression levels of ox-LDL and LOX-1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1760	18622720-186	In HF group, the serum levels of total cholesterol (TC), low-density lipoprotein (LDL), oxidized low-density lipoprotein (ox-LDL) and endothelin (ET) were higher, whereas the levels of high-density lipoprotein (HDL), serum NO were lower than those in CG group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1761	18622720-187	These findings indicated that combined treatment with niacin and chromium has potential therapeutic protection of endothelial function by down-regulating ox-LDL/LOX-1 signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1762	18622720-187	These findings indicated that combined treatment with niacin and chromium has potential therapeutic protection of endothelial function by down-regulating ox-LDL/LOX-1 signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1763	18622759-218	The deduced amino acid sequence of Ai Lec was highly similar to those of the C-type lectins from other animals and contained a typical carbohydrate-recognition domain (CRD) of 131 residues, which has four conserved disulfide-bonded cysteine residues that define the CRD and two additional cysteine residues at the amino terminus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1764	18623061-1275	Src kinases can be activated by trans-phosphorylation of a tyrosine located in the central activation loop of the catalytic domain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1765	18623061-1276	However, because the required exposure of this tyrosine is not observed in the down-regulated X-ray structures of Src kinases, transient partial opening of the activation loop appears to be necessary for such processes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1766	18623078-486	The growth of L. minor (as fresh weight) and chlorophyll a content were significantly reduced and superoxide dismutase (SOD) activity was significantly decreased at microcystins concentration up to 0.5 mg/L.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1767	18623078-486	The growth of L. minor (as fresh weight) and chlorophyll a content were significantly reduced and superoxide dismutase (SOD) activity was significantly decreased at microcystins concentration up to 0.5 mg/L.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1768	18623078-487	The experiment also indicated that catalase (CAT) activity was not significantly influenced by microcystin for both the two tested aquatic plants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1769	18623078-487	The experiment also indicated that catalase (CAT) activity was not significantly influenced by microcystin for both the two tested aquatic plants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1770	18623211-610	The purpose of this study was to investigate the solid-state properties of lyophilized formulations of protein (ribonuclease A) containing sucrose or trehalose across a wide range of compositions, both in the presence or absence of hydroxyethylstarch (HES).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1771	18623211-610	The purpose of this study was to investigate the solid-state properties of lyophilized formulations of protein (ribonuclease A) containing sucrose or trehalose across a wide range of compositions, both in the presence or absence of hydroxyethylstarch (HES).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1772	18624726-1067	The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1773	18624726-1067	The stimulatory effects of stearic, palmitic and palmitoleic acids on resistin secretion and the stimulatory effect of stearic acid on MCP-1 secretion are mediated via TLR-4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1774	18624760-178	Acitretin increased the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1775	18624766-181	Since lithium and SB-415286-induced G(2)/M arrest we studied changes in the expression of proteins involved in this phase, specifically cyclin B, cdc2 and the phosphorylated form of this protein (tyr15-cdc2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1776	18624766-181	Since lithium and SB-415286-induced G(2)/M arrest we studied changes in the expression of proteins involved in this phase, specifically cyclin B, cdc2 and the phosphorylated form of this protein (tyr15-cdc2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1777	18624766-181	Since lithium and SB-415286-induced G(2)/M arrest we studied changes in the expression of proteins involved in this phase, specifically cyclin B, cdc2 and the phosphorylated form of this protein (tyr15-cdc2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1778	18624766-181	Since lithium and SB-415286-induced G(2)/M arrest we studied changes in the expression of proteins involved in this phase, specifically cyclin B, cdc2 and the phosphorylated form of this protein (tyr15-cdc2).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1779	18624766-182	On the other hand, SB-415286 increased the expression of SIRT2, involved in the regulation of proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1780	18624766-184	We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1781	18624766-184	We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1782	18624772-192	Reduction of intracellular Ca(2+) levels abolished eNOS reduction by HOG-LDL, as did pharmacological or genetic through calcium channel blockers or calcium chelator BAPTA or inhibition of NAD(P)H oxidase (with apocynin) or inhibition of calpain (calpain 1-specific siRNA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1783	18624772-192	Reduction of intracellular Ca(2+) levels abolished eNOS reduction by HOG-LDL, as did pharmacological or genetic through calcium channel blockers or calcium chelator BAPTA or inhibition of NAD(P)H oxidase (with apocynin) or inhibition of calpain (calpain 1-specific siRNA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1784	18624772-192	Reduction of intracellular Ca(2+) levels abolished eNOS reduction by HOG-LDL, as did pharmacological or genetic through calcium channel blockers or calcium chelator BAPTA or inhibition of NAD(P)H oxidase (with apocynin) or inhibition of calpain (calpain 1-specific siRNA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1785	18624794-206	In addition to transporting glutamate, EAAC1 plays other roles in regulating GABA synthesis, reducing oxidative stress in neurons, and is important in supporting neuron viability.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1786	18624794-206	In addition to transporting glutamate, EAAC1 plays other roles in regulating GABA synthesis, reducing oxidative stress in neurons, and is important in supporting neuron viability.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1787	18625283-633	Whereas both peptides lactoferricin (17-30) and lactoferrampin (265-284) did not have bactericidal activity, 40 microM of lactoferrin chimera (a fusion of the two peptides) inhibited the growth of all Vibrio tested to the same extent as the antibiotic gentamicin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1788	18625283-633	Whereas both peptides lactoferricin (17-30) and lactoferrampin (265-284) did not have bactericidal activity, 40 microM of lactoferrin chimera (a fusion of the two peptides) inhibited the growth of all Vibrio tested to the same extent as the antibiotic gentamicin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1789	18625298-638	We have recently shown that the antidepressant fluoxetine enhances T cell proliferation and T(H)1 cytokine production in vivo, without changes on CD4/CD8 subsets.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1790	18625298-639	We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-gamma and tumor necrosis factor-alpha production by compensatory mechanisms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1791	18625298-639	We found that fluoxetine restored T cell proliferation and interleukin-2, interferon-gamma and tumor necrosis factor-alpha production by compensatory mechanisms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1792	18625569-874	Here we report a case of intragenic EGFR microdeletion in renal cell carcinoma (RCC) associated with the effect of treatment by gefitinib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1793	18626508-1659	Taking advantage of this prostate cancer-specific property of PSMA (E/P), we successfully introduced bacterial UPRT into LNCaP cells where the tumoricidal effect of 5-fluorouracil (5-FU) was significantly increased when compared with the cells without the exogenous UPRT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1794	18626508-1659	Taking advantage of this prostate cancer-specific property of PSMA (E/P), we successfully introduced bacterial UPRT into LNCaP cells where the tumoricidal effect of 5-fluorouracil (5-FU) was significantly increased when compared with the cells without the exogenous UPRT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1795	18626658-281	UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1796	18626658-281	UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1797	18626658-281	UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1798	18626658-281	UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1799	18626658-283	Neither UCP1 expression nor UCP2 overexpression modified basal or glucose-stimulated metabolic changes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1800	18626658-283	Neither UCP1 expression nor UCP2 overexpression modified basal or glucose-stimulated metabolic changes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1801	18626709-112	The chitinase activity was increased by Mn(2+), Cu(2+), and Mg(2+), while strongly inhibited by Fe(2+) and Ba(2+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1802	18626709-112	The chitinase activity was increased by Mn(2+), Cu(2+), and Mg(2+), while strongly inhibited by Fe(2+) and Ba(2+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1803	18626709-112	The chitinase activity was increased by Mn(2+), Cu(2+), and Mg(2+), while strongly inhibited by Fe(2+) and Ba(2+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1804	18626709-112	The chitinase activity was increased by Mn(2+), Cu(2+), and Mg(2+), while strongly inhibited by Fe(2+) and Ba(2+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1805	18626709-113	Meanwhile, SDS, ethyleneglycoltetraacetic acid, urea, and ethylenediaminetetraacetic acid were found to have significantly inhibitory effect on chitinase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1806	18626709-113	Meanwhile, SDS, ethyleneglycoltetraacetic acid, urea, and ethylenediaminetetraacetic acid were found to have significantly inhibitory effect on chitinase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1807	18626726-122	In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1808	18626726-122	In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1809	18626791-1140	Following thermal denaturation, rabbit reticulocyte lysate and ATP were added and luciferase activity measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1810	18626794-227	These results are in contrast to postmortem findings in schizophrenia and suggest that reduced synaptophysin protein levels in schizophrenia patients' postmortem brain do not result from perinatal oxygen deprivation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1811	18627006-344	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1812	18627006-344	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1813	18627006-344	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1814	18627006-344	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1815	18627006-344	We found that the acetylated histone H3 at lysine 9 and lysine 14 (H3K9/K14ac) is reduced in both the myelin basic protein (MBP) and proteolipid protein (PLP) genes of maturing oligodendroglial OL-1 cells, and furthermore, this temporally correlates with increases in MBP, PLP, and histone deacetylase (HDAC) 11 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1816	18627414-696	Although the current studies associating particular genes and their variants with seizure control or adverse events have inherent weaknesses and have not provided unifying conclusions, several results, for example that Asian patients with a particular HLA allele, HLA-B *1502, are at a higher risk for Stevens-Johnson syndrome when using carbamazepine, are helpful to increase our knowledge how genetic variation affects the treatment of epilepsy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1817	18627421-707	However, OPN-(/-) mice showed increased serum levels of tumour necrosis factor (TNF)-alpha, which could be due to systemically present lipopolysaccharide translocated to the gut.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1818	18627421-707	However, OPN-(/-) mice showed increased serum levels of tumour necrosis factor (TNF)-alpha, which could be due to systemically present lipopolysaccharide translocated to the gut.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1819	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1820	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1821	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1822	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1823	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1824	18627475-762	The expression of the ERG1, ERG3, ERG7, ERG9, ERG11 and ERG25 genes in response to incubation with fluconazole and biofilm formation was investigated using reverse-transcription PCR and real-time PCR in Candida albicans and Candida dubliniensis clinical isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1825	18627475-763	Expression of the ERG11 gene was found to be low or moderate and it was regulated by fluconazole addition more so than by biofilm formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1826	18627475-764	The expression of the ERG9 increased in the presence of fluconazole in some isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1827	18629545-780	Concentrations of polyethylene glycol 1000 and Na2SO4 were selected as independent variables to evaluate their impact on parameters of partitioning in aqueous two-phase system--the partition coefficient of pectinase, purification factor and pectinase yield.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1828	18629545-780	Concentrations of polyethylene glycol 1000 and Na2SO4 were selected as independent variables to evaluate their impact on parameters of partitioning in aqueous two-phase system--the partition coefficient of pectinase, purification factor and pectinase yield.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1829	18629605-1551	In aged animals, administration of L-carnitine for 21 days significantly decreased the levels of lipid peroxides and improved the activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1830	18629605-1551	In aged animals, administration of L-carnitine for 21 days significantly decreased the levels of lipid peroxides and improved the activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1831	18629605-1551	In aged animals, administration of L-carnitine for 21 days significantly decreased the levels of lipid peroxides and improved the activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1832	18629605-1551	In aged animals, administration of L-carnitine for 21 days significantly decreased the levels of lipid peroxides and improved the activities of antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1833	18629605-1552	L-Carnitine enhanced T-cell proliferative responses as evaluated by T-cell proliferation assay using (3H) thymidine incorporation and also significantly reduced DNA damage, apoptosis and TNF-alpha level in lymphocytes of aged animals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1834	18629605-1552	L-Carnitine enhanced T-cell proliferative responses as evaluated by T-cell proliferation assay using (3H) thymidine incorporation and also significantly reduced DNA damage, apoptosis and TNF-alpha level in lymphocytes of aged animals.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1835	18629630-845	In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1836	18629630-845	In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1837	18629630-845	In our microarray analysis we observed that Seven-in-Absentia Homolog 2 (SIAH2) levels were low in estrogen receptor (ER) positive breast tumors of patients resistant to first-line tamoxifen therapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1838	18629637-851	Fluorocitrate, an inhibitor of glial metabolism, inhibits the up-regulation of NOS expression, activity and NO production in the spinal cord induced by formalin test in rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1839	18629637-852	In order to explore the involvement of glia in the NO-mediated nociceptive transmission, the present study was undertaken to investigate the effect of fluorocitrate (FC), an inhibitor of glial metabolism, on NOS expression and activity and NO production in the spinal cord during the process of peripheral inflammatory pain and hyperalgesia induced by formalin test in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1840	18629640-41	Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1841	18629640-41	Oral administration of morin remarkably prevented weight loss in the body and liver from DMN and inhibited the elevation of serum alanine transaminase (ALT), aspartate transaminase (AST), and total bilirubin levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1842	18631247-468	Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1843	18631247-469	We found that while OM24 treatment did not significantly affect UV-induced erythema and thymidine dimer formation, OM24 treatment significantly reduced UV-induced p53 expression in keratinocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1844	18632742-27	Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1845	18632742-27	Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1846	18632742-28	These effects of NRG-1beta are blocked by PD158780, a pan-specific antagonist of ErbB receptors, and are mediated specifically via ErbB4 receptors, because mice harboring a targeted mutation of ErbB4 do not respond to NRG-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1847	18633436-86	Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1848	18633436-86	Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1849	18633436-86	Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1850	18633446-279	We have generated two novel chimeric VEGF-binding molecules, sFLT01 and sFLT02, which consist of the second immunoglobulin (IgG)-like domain of Flt-1 fused either to a human IgG1 Fc or solely to the CH3 domain of IgG1 Fc through a polyglycine linker 9Gly.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1851	18633446-279	We have generated two novel chimeric VEGF-binding molecules, sFLT01 and sFLT02, which consist of the second immunoglobulin (IgG)-like domain of Flt-1 fused either to a human IgG1 Fc or solely to the CH3 domain of IgG1 Fc through a polyglycine linker 9Gly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1852	18633600-1063	By contrast, treatment of N2a cells with 1-10 microM DZO resulted in marked reductions in the expression of the axon growth-associated protein GAP-43.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1853	18633600-1064	DZO-treated cells also showed an increased expression of the heat shock protein HSP-70 compared to controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1854	18633701-1577	We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1855	18633701-1577	We showed that in comparison to stage VI, stages I-V oocytes expressed higher levels of O-GlcNAc correlating changes in OGT expression, but not in UDP-GlcNAc pools.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1856	18633701-1578	Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1857	18633701-1578	Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1858	18633701-1578	Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1859	18633701-1578	Upon progesterone stimulation, an O-GlcNAc level burst occurred during meiotic resumption long before MPF and Mos-Erk2 pathways activations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1860	18633707-828	Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1861	18633707-828	Mean plasma levels of folic acid, homocysteine, and vitamin B12 did not change, but there was a significant decrease of CRP at T1, 0.36 mg dl(-1) on average (P = 0.01), which was maintained at T2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1862	18634065-1113	Chondrocytes grown in monolayer were treated with interleukin-1alpha (IL-1alpha), insulin-like growth factor-I (IGF-I), C3 Transferase, Y27632, or transfected with Rho wild type or two constitutively active mutants of Rho (Q63L and G14V).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1863	18634065-1113	Chondrocytes grown in monolayer were treated with interleukin-1alpha (IL-1alpha), insulin-like growth factor-I (IGF-I), C3 Transferase, Y27632, or transfected with Rho wild type or two constitutively active mutants of Rho (Q63L and G14V).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1864	18634065-1113	Chondrocytes grown in monolayer were treated with interleukin-1alpha (IL-1alpha), insulin-like growth factor-I (IGF-I), C3 Transferase, Y27632, or transfected with Rho wild type or two constitutively active mutants of Rho (Q63L and G14V).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1865	18634065-1115	Affinity assays were performed to measure endogenous GTP-bound Rho, and confocal microscopy was used to assess changes in organization of the actin cytoskeleton.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1866	18634065-1115	Affinity assays were performed to measure endogenous GTP-bound Rho, and confocal microscopy was used to assess changes in organization of the actin cytoskeleton.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1867	18634065-1116	IL-1alpha and RhoG14V increased cytoplasmic actin stress fiber formation, which was blocked by C3 Transferase, and Y27632.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1868	18634065-1116	IL-1alpha and RhoG14V increased cytoplasmic actin stress fiber formation, which was blocked by C3 Transferase, and Y27632.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1869	18634065-1118	Expression of RhoQ63L or RhoG14V resulted in increased MMP-13 expression; however, inhibition of Rho with Y27632 was unable to inhibit IL-1alpha-induced MMP-13 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1870	18634065-1118	Expression of RhoQ63L or RhoG14V resulted in increased MMP-13 expression; however, inhibition of Rho with Y27632 was unable to inhibit IL-1alpha-induced MMP-13 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1871	18634065-1118	Expression of RhoQ63L or RhoG14V resulted in increased MMP-13 expression; however, inhibition of Rho with Y27632 was unable to inhibit IL-1alpha-induced MMP-13 expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1872	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1873	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1874	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1875	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1876	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1877	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1878	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1879	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1880	18634706-392	Plasma total cholesterol, TAG, HDL, HDL2, HDL3, LDL, C-reactive protein, IL-6, IL-18, intercellular adhesion molecule-1, oxidised LDL, oxygen radical absorbance capacity using perchloric acid (ORACPCA), whole-blood fatty acids, bleeding time and blood pressure were measured at the beginning and end of each dietary period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1881	18634843-1147	The increase of mature IL-18 by macrophages was inhibited by caspase-1 inhibitor : caspase-1 is known to cleave the proform of IL-18 to produce active mature IL-18.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1882	18635261-398	In absence of stretch, we could activate Gns and deactivate GK1 by 1-oleoyl-2-acetyl-sn-glycerol (OAG) and other amphipaths.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1883	18635261-398	In absence of stretch, we could activate Gns and deactivate GK1 by 1-oleoyl-2-acetyl-sn-glycerol (OAG) and other amphipaths.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1884	18635261-398	In absence of stretch, we could activate Gns and deactivate GK1 by 1-oleoyl-2-acetyl-sn-glycerol (OAG) and other amphipaths.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1885	18635261-398	In absence of stretch, we could activate Gns and deactivate GK1 by 1-oleoyl-2-acetyl-sn-glycerol (OAG) and other amphipaths.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1886	18635336-453	Using enzyme-linked immunosorbent assays, we showed DHMEQ to inhibit LPS-induced secretion of IL-6 and TNF-alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1887	18635336-453	Using enzyme-linked immunosorbent assays, we showed DHMEQ to inhibit LPS-induced secretion of IL-6 and TNF-alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1888	18635390-1443	The inhibition of DMBA-carcinogenesis by GLN application was associated with increased arterial GLN and GSH, elevated buccal mucosa GSH as well as induction of bax and PARP, and inhibition of bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1889	18635390-1443	The inhibition of DMBA-carcinogenesis by GLN application was associated with increased arterial GLN and GSH, elevated buccal mucosa GSH as well as induction of bax and PARP, and inhibition of bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1890	18635390-1443	The inhibition of DMBA-carcinogenesis by GLN application was associated with increased arterial GLN and GSH, elevated buccal mucosa GSH as well as induction of bax and PARP, and inhibition of bcl-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1891	18635693-781	Dopamine release and direct stimulation of dopamine D2 and serotonin 5-HT2A receptors also contributes to the overall action of MDMA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1892	18635693-783	Our findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1893	18635704-791	These results suggest that AKT1 does not play a significant role in clinical and functional manifestations in patients with schizophrenia who receive risperidone treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1894	18635814-879	Urethane is a chemical carcinogen found in tobacco smoke that causes activating mutations in Kras and induces lung tumors in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1895	18636040-1068	In the present study, we measured plasma GSTA1-1 levels by enzyme-linked immunosorbent assay in seven healthy volunteers after repeated experimental endotoxemia induced by 2 ng kg Escherichia coli endotoxin per day (to investigate inflammation-induced hepatic injury) and in 21 patients within 12 h after the occurrence of severe sepsis/septic shock (to investigate its ability to predict an increase of transaminases on day 7).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1896	18636040-1069	Furthermore, GSTA1-1 levels did not correlate with IL-6 levels but did with dobutamine infusion rate (Spearman r = 0.94; P = 0.02), suggesting that the extent of hemodynamic instability and not the degree of inflammation could be of importance for the occurrence of liver damage.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1897	18636040-1069	Furthermore, GSTA1-1 levels did not correlate with IL-6 levels but did with dobutamine infusion rate (Spearman r = 0.94; P = 0.02), suggesting that the extent of hemodynamic instability and not the degree of inflammation could be of importance for the occurrence of liver damage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1898	18636042-1310	Heparin (H), argatroban (A), antithrombin III (ATIII), and recombinant human activated protein C (rhAPC) with and without thrombin were added to cells suspended in septic plasma and normal plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1899	18636042-1310	Heparin (H), argatroban (A), antithrombin III (ATIII), and recombinant human activated protein C (rhAPC) with and without thrombin were added to cells suspended in septic plasma and normal plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1900	18636042-1310	Heparin (H), argatroban (A), antithrombin III (ATIII), and recombinant human activated protein C (rhAPC) with and without thrombin were added to cells suspended in septic plasma and normal plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1901	18636042-1310	Heparin (H), argatroban (A), antithrombin III (ATIII), and recombinant human activated protein C (rhAPC) with and without thrombin were added to cells suspended in septic plasma and normal plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1902	18636044-1070	Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system, including the heart.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1903	18636044-1070	Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system, including the heart.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1904	18636044-1070	Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system, including the heart.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1905	18636044-1070	Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system, including the heart.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1906	18636221-1488	Chemotaxis, lysozyme release and superoxide anion production have been measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1907	18636241-1243	According to annexin V-binding, arsenic trioxide (7 microM) within 48 h significantly increased phosphatidylserine exposure of human erythrocytes without inducing hemolysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1908	18636241-1244	Removal of extracellular Ca2+ or inhibition of the Ca2+-permeable cation channels with amiloride blunted the effects of arsenic on annexin V-binding and cell shrinkage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1909	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1910	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1911	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1912	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1913	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1914	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1915	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1916	18636311-1287	In the present study, we investigated the inhibitory effect of the known oxycoumarins poncitrin (3), osthol (4), and xanthoxyletin (5), newly isolated from Clausena guillauminii (Rutaceae), together with the known carbazoles heptaphylline (1) and 7-methoxyheptaphylline (2) on inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) and the NO generation in RAW 264.7 mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1917	18636399-1328	Cell viability and reactive oxygen species concentration were determined, and the effects of pre-treatment with LA on these parameters were investigated together with the GST and GPx activity as well as the concentration of reduced glutathione.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1918	18636399-1328	Cell viability and reactive oxygen species concentration were determined, and the effects of pre-treatment with LA on these parameters were investigated together with the GST and GPx activity as well as the concentration of reduced glutathione.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1919	18636508-1410	Fibril growth was a second-order process with an enthalpy of activation (27+/-5 kcal mol(-1)), which is indistinguishable from that of tetramer formation by cystatins, which involves limited conformational changes including proline trans to cis isomerization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1920	18636565-515	Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and low 3,3',5'-triiodothyronine (rT3) levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1921	18636565-515	Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and low 3,3',5'-triiodothyronine (rT3) levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1922	18637152-268	Results showed that MENT treatments increased PSA secretion and proliferation rate with a potency ranged between T and DHT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1923	18637152-268	Results showed that MENT treatments increased PSA secretion and proliferation rate with a potency ranged between T and DHT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1924	18637152-269	The studies with finasteride showed that in BPH and CaP cells, the conversion of T into DHT significantly contributes to its effect on the proliferation and PSA secretion, and corroborated the resistance of MENT to the 5-AR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1925	18637152-269	The studies with finasteride showed that in BPH and CaP cells, the conversion of T into DHT significantly contributes to its effect on the proliferation and PSA secretion, and corroborated the resistance of MENT to the 5-AR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1926	18637152-269	The studies with finasteride showed that in BPH and CaP cells, the conversion of T into DHT significantly contributes to its effect on the proliferation and PSA secretion, and corroborated the resistance of MENT to the 5-AR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1927	18637154-273	Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1928	18637154-273	Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1929	18637154-273	Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1930	18637154-273	Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1931	18637154-273	Pregnant Sprague-Dawley female rats were treated once with TCDD (0, 0.3 or 1 microg/kg) by gavage on embryonic day (ED) 11 and the expression levels of androgen (AR) and estrogen receptors (ER), steroidogenic enzymes (P450scc and 3beta-HSD) and four regulatory factors (StAR, SF-1, GATA-4 and Insl-3) involved in foetal Leydig cell and adrenal function were analysed on ED 19.5.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1932	18637154-274	In utero exposure to TCDD reduced intratesticular T of foetal males (significant at 0.3 microg/kg TCDD) and tended to reduce the protein expression of ERalpha and AR of foetal male rat testis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1933	18637154-275	mRNA expression of developmental regulatory factors was not influenced by foetal TCDD exposure, except for significantly reduced adrenal SF-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1934	18637708-746	Nitrogen-containing bisphosphonates were found to inhibit farnesyl diphosphate synthase-an essential enzyme in the cholesterol biosynthesis pathway, but their effect on cholesterol synthesis per se in the central nervous system (CNS) remains unknown.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1935	18637708-746	Nitrogen-containing bisphosphonates were found to inhibit farnesyl diphosphate synthase-an essential enzyme in the cholesterol biosynthesis pathway, but their effect on cholesterol synthesis per se in the central nervous system (CNS) remains unknown.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1936	18637712-756	hsBAFF-upregulated intracellular free Ca(2+) homeostasis regulates ERK1/2 activity and cell proliferation in B cells in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1937	18637712-757	Using immunocytochemistry and Western blot analysis, we found that the activation of ERK1/2 due to hsBAFF was triggered by a (Ca(2+))(i)-dependent pathway, leading to elevation of B cell proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1938	18637712-758	This is supported by the findings that intracellular Ca(2+) chelator BAPTA/AM attenuated phosphorylated ERK1/2 expression and cell proliferation in hsBAFF-stimulated B cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1939	18637712-759	Taken together, the main finding of this study is that hsBAFF elicits higher but homeostatic (Ca(2+))(i) levels, which regulates ERK1/2 activity and cell proliferation in in vitro B cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1940	18637714-1311	Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1941	18637715-1322	In this study we have investigated a long-term pattern of expression and production of spinal COX-1 and COX-2 in the model of osteoarthritis induced in rats by injection of monoiodoacetate (MIA) into the knee joint.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1942	18637715-1322	In this study we have investigated a long-term pattern of expression and production of spinal COX-1 and COX-2 in the model of osteoarthritis induced in rats by injection of monoiodoacetate (MIA) into the knee joint.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1943	18639339-380	The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1944	18639339-380	The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1945	18639339-380	The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1946	18639339-380	The enzyme indoleamine 2,3-dioxygenase (IDO) converts tryptophan to kynurenine, blocking T-cell activation and inducing immunosuppression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1947	18639341-381	Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1948	18639341-381	Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1949	18639341-381	Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1950	18639341-381	Serum l-kynurenine (l-KYN) concentrations, l-KYN/l-TRP ratio, and the level of IDO mRNA expression in ATLL cells were significantly increased in ATLL patients compared to those in healthy and HTLV-positive carrier subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1951	18639629-311	Peripheral administration of the acetylcholinesterase inhibitor galantamine significantly reduced serum TNF levels through vagus nerve signaling, and protected against lethality during murine endotoxemia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1952	18639629-312	Administration of a centrally-acting muscarinic receptor antagonist abolished the suppression of TNF by galantamine, indicating that suppressing acetylcholinesterase activity, coupled with central muscarinic receptors, controls peripheral cytokine responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1953	18639629-312	Administration of a centrally-acting muscarinic receptor antagonist abolished the suppression of TNF by galantamine, indicating that suppressing acetylcholinesterase activity, coupled with central muscarinic receptors, controls peripheral cytokine responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1954	18639629-313	Administration of galantamine to alpha7nAChR knockout mice failed to suppress TNF levels, indicating that the alpha7nAChR-mediated cholinergic anti-inflammatory pathway is required for the anti-inflammatory effect of galantamine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1955	18639930-897	The involvement of superoxide and nitric oxide was verified by the block of MSC using specific scavengers (tiron and PTIO, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1956	18639930-897	The involvement of superoxide and nitric oxide was verified by the block of MSC using specific scavengers (tiron and PTIO, respectively).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1957	18639930-897	The involvement of superoxide and nitric oxide was verified by the block of MSC using specific scavengers (tiron and PTIO, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1958	18639930-898	Accordingly, MSC were blocked by the peroxynitrite scavenger uric acid and could be mimicked by application of exogenous peroxynitrite.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1959	18639930-899	This conclusion is supported by our findings that MSC were suppressed by inhibitors of phospholipases but could be mimicked by exogenous phospholipases or by amphipaths (oleic acid, Triton X-100).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1960	18639930-899	This conclusion is supported by our findings that MSC were suppressed by inhibitors of phospholipases but could be mimicked by exogenous phospholipases or by amphipaths (oleic acid, Triton X-100).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1961	18640003-956	In the present study, therefore, the effect of FA/AD in presence or absence of p38MAPK inhibitor SB203580 on the proliferation, apoptosis, p38MAPK, caspase-3, location of p38MAPK and caspase-3, and interaction between p38MAPK and caspase-3 in Bel-7402 cell was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), annexin V-FITC/propidium iodide (PI) double staining, electron microscopy, immunoblot, immunofluorescence and immunoprecipitation/immunoblot assay, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1962	18640003-956	In the present study, therefore, the effect of FA/AD in presence or absence of p38MAPK inhibitor SB203580 on the proliferation, apoptosis, p38MAPK, caspase-3, location of p38MAPK and caspase-3, and interaction between p38MAPK and caspase-3 in Bel-7402 cell was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), annexin V-FITC/propidium iodide (PI) double staining, electron microscopy, immunoblot, immunofluorescence and immunoprecipitation/immunoblot assay, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1963	18640003-956	In the present study, therefore, the effect of FA/AD in presence or absence of p38MAPK inhibitor SB203580 on the proliferation, apoptosis, p38MAPK, caspase-3, location of p38MAPK and caspase-3, and interaction between p38MAPK and caspase-3 in Bel-7402 cell was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), annexin V-FITC/propidium iodide (PI) double staining, electron microscopy, immunoblot, immunofluorescence and immunoprecipitation/immunoblot assay, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1964	18640059-934	To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE (2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1965	18640059-934	To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE (2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1966	18640059-934	To investigate the role of adenosine analogs and electromagnetic field (EMF) stimulation on prostaglandin E(2) (PGE (2)) release and cyclooxygenase-2 (COX-2) expression in bovine synovial fibroblasts (SFs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1967	18640663-1479	In this study, we compared the effects of insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), transforming growth factor beta1 (TGF-beta1), and glucosamine sulphate on porcine TMJ condylar cartilage and ankle cartilage cells in monolayer culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1968	18640663-1479	In this study, we compared the effects of insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), transforming growth factor beta1 (TGF-beta1), and glucosamine sulphate on porcine TMJ condylar cartilage and ankle cartilage cells in monolayer culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1969	18640663-1479	In this study, we compared the effects of insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), transforming growth factor beta1 (TGF-beta1), and glucosamine sulphate on porcine TMJ condylar cartilage and ankle cartilage cells in monolayer culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1970	18640663-1479	In this study, we compared the effects of insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), transforming growth factor beta1 (TGF-beta1), and glucosamine sulphate on porcine TMJ condylar cartilage and ankle cartilage cells in monolayer culture.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1971	18640679-288	Meanwhile, both the enhanced expression of VCAM-1 and increased activation of NF-kappaB induced by CRH in aortas of LDLr-/-mice were also largely suppressed by NBI27914, whereas these inhibitory effects were not observed in anti-Svg-30 group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1972	18640679-288	Meanwhile, both the enhanced expression of VCAM-1 and increased activation of NF-kappaB induced by CRH in aortas of LDLr-/-mice were also largely suppressed by NBI27914, whereas these inhibitory effects were not observed in anti-Svg-30 group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1973	18640717-1523	PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1974	18640717-1523	PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1975	18640717-1523	PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1976	18640717-1524	Vincristine but not doxorubicin increased p-Akt expression whereas co-treatment with PI3K inhibitors and vincristine increased apoptosis in the three cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1977	18640717-1524	Vincristine but not doxorubicin increased p-Akt expression whereas co-treatment with PI3K inhibitors and vincristine increased apoptosis in the three cell lines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1978	18640717-1524	Vincristine but not doxorubicin increased p-Akt expression whereas co-treatment with PI3K inhibitors and vincristine increased apoptosis in the three cell lines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1979	18640717-1525	Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1980	18640717-1525	Wortmannin and LY294002 inhibited P-glycoprotein (Pgp) function and also increased NF-kappaB activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1981	18640746-1557	Namely, the results obtained for the most active compounds, 5-(chloroacetylamino) uracil (2) and its acyclic sugar analogue 18, suggest that formation of a covalent bond between reactive substituent and several possible targets within the thymidylate synthase mechanism (sulphur of the cysteine residue, basic part of the enzyme, N,N-methylene tetrahydrofolate or its reactive iminium forms) is the most probable mode of action.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1982	18641920-846	PTK787/ZK222584, a potent orally active angiogenesis inhibitor capable of inhibiting all known isoforms of Vascular Endothelial Growth Factor (VEGF) receptor, belongs to the class of aminophthalazines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1983	18642040-946	Recent evidence for toxic superoxide (O(2)(-)) production by marine microalgae is afforded particular attention given that release of O(2)(-) anions can be exacerbated by the binding of mannose-specific lectins to the microalgal cell wall ; a novel model for grazing-activated chemical defence is proposed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1984	18642088-995	Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst (5) (pasireotide, or SOM230) or D(2) (cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1985	18642088-995	Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst (5) (pasireotide, or SOM230) or D(2) (cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1986	18642088-995	Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst (5) (pasireotide, or SOM230) or D(2) (cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1987	18642106-1330	The glutamate induced chemotaxis was accompanied by polarization of the actin cytoskeleton, and by polymerization of F-actin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1988	18642386-611	SD4 in anionic DSPG liposomes stimulated murine IL-6 production in RAW 264 cells at concentrations 25-to 30-fold lower than free drug.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1989	18643838-993	To elucidate the mechanism by which rosiglitazone regulates adipose triglyceride lipase (ATGL).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1990	18643908-800	Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1991	18643908-800	Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1992	18643908-800	Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1993	18643908-800	Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1994	18644606-1339	Olanzapine was associated with a lower frequency of extrapyramidal symptoms than other antipsychotics, fewer prolactin-related adverse events than risperidone and other atypical antipsychotics, but greater weight gain than typicals and risperidone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1995	18646192-1003	In our earlier method, glutathione disulfide (GSSG) was measured by first reducing it to GSH with glutathione reductase (GR) in the presence of NADPH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1996	18646192-1003	In our earlier method, glutathione disulfide (GSSG) was measured by first reducing it to GSH with glutathione reductase (GR) in the presence of NADPH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1997	18646192-1003	In our earlier method, glutathione disulfide (GSSG) was measured by first reducing it to GSH with glutathione reductase (GR) in the presence of NADPH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1998	18646192-1003	In our earlier method, glutathione disulfide (GSSG) was measured by first reducing it to GSH with glutathione reductase (GR) in the presence of NADPH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
1999	18647135-78	The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2000	18648748-1370	Administration of hesperetin to DMH treated rats significantly decreased the tumor incidence, the number of aberrant crypt foci with simultaneous enhancement of tissue lipid peroxidation, GST, GPx, SOD, and CAT activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2001	18648748-1370	Administration of hesperetin to DMH treated rats significantly decreased the tumor incidence, the number of aberrant crypt foci with simultaneous enhancement of tissue lipid peroxidation, GST, GPx, SOD, and CAT activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2002	18648748-1370	Administration of hesperetin to DMH treated rats significantly decreased the tumor incidence, the number of aberrant crypt foci with simultaneous enhancement of tissue lipid peroxidation, GST, GPx, SOD, and CAT activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2003	18648826-1446	Culture of mid-segments of hair follicles in low calcium culture medium kept on agarose increased expression of filaggrin and Kdap, but downregulated expression of involucrin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2004	18648826-1446	Culture of mid-segments of hair follicles in low calcium culture medium kept on agarose increased expression of filaggrin and Kdap, but downregulated expression of involucrin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2005	18648826-1446	Culture of mid-segments of hair follicles in low calcium culture medium kept on agarose increased expression of filaggrin and Kdap, but downregulated expression of involucrin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2006	18648877-1504	The p-hydroxyphenylpyruvate produced by the Escherichia coli host was converted to HGA through the oxidation reaction of introduced HPPD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2007	18648877-1504	The p-hydroxyphenylpyruvate produced by the Escherichia coli host was converted to HGA through the oxidation reaction of introduced HPPD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2008	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2009	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2010	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2011	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2012	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2013	18649000-1622	The results showed that the intakes of dry matter (DM), organic matter (OM), nitrogen (N), the N-balance, urinary purine derivatives (PD) excretion, the ratios of allantoin to creatinine (CR), PD to CR, the plasma urea-N (PUN) and insulin increased in the animals, but the intake of neutral detergent fiber (NDF), the coefficient of whole tract, apparent digestibility of NDF, the transit time (TT) and the mean retention time (TMRT) decreased, when the proportion of concentrate in the diet increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2014	18649135-39	Activation of interleukin-6/STAT3 in rat cholangiocyte proliferation induced by lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2015	18649135-39	Activation of interleukin-6/STAT3 in rat cholangiocyte proliferation induced by lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2016	18650080-816	To investigate the activation pathways triggered by laccase, ESR spin-trapping techniques using N-tert-butyl-alpha-phenylnitrone (PBN) as spin trap followed by ethyl acetate extraction were employed to identify and quantify the free radical intermediates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2017	18650805-1377	Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2018	18651093-1447	Two infants with elevated serum gamma-GT had a decreased serum glutamine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2019	18651113-1681	Human bone marrow-derived mesenchymal stem cells and osteoblast differentiation on titanium with surface-grafted chitosan and immobilized bone morphogenetic protein-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2020	18651133-1703	None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2021	18651133-1703	None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2022	18651191-669	Functional analysis demonstrated that elkj encoded a C20-elongase that mediated the elongation of EPA into docosapentaenoic acid (22:5n-3), confirming the two-step conversion from EPA to DHA in marine microalga.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2023	18651838-564	ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2024	18651838-564	ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2025	18651838-564	ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2026	18651838-564	ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2027	18651838-564	ANP (atrial natriuretic peptide) exerts its biological effects by binding to GC (guanylate cyclase)-A/NPR (natriuretic peptide receptor)-A, which generates the second messenger cGMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2028	18651838-565	Overexpression of Ets-1 enhanced significantly Npr1 mRNA levels, protein expression, GC activity and ANP-stimulated intracellular accumulation of cGMP in transfected cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2029	18651838-565	Overexpression of Ets-1 enhanced significantly Npr1 mRNA levels, protein expression, GC activity and ANP-stimulated intracellular accumulation of cGMP in transfected cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2030	18651838-565	Overexpression of Ets-1 enhanced significantly Npr1 mRNA levels, protein expression, GC activity and ANP-stimulated intracellular accumulation of cGMP in transfected cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2031	18652538-1158	In the current study, these cells were cultured with three different media: " BMP-plus" medium containing dexamethasone and 100 ng/mL of rhBMP-2, "odontogenic" medium containing dexamethasone, and "control" medium without supplements.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2032	18652864-1389	The allatostatins (ASTs), with a Tyr/Phe-Xaa-Phe-Gly-Leu/Ile-amide C-terminus, are neuropeptides that occur in many orders of insects, but are known to inhibit juvenile hormone (JH) synthesis by corpora allata (CA) only in cockroaches, crickets, and termites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2033	18652864-1389	The allatostatins (ASTs), with a Tyr/Phe-Xaa-Phe-Gly-Leu/Ile-amide C-terminus, are neuropeptides that occur in many orders of insects, but are known to inhibit juvenile hormone (JH) synthesis by corpora allata (CA) only in cockroaches, crickets, and termites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2034	18652864-1389	The allatostatins (ASTs), with a Tyr/Phe-Xaa-Phe-Gly-Leu/Ile-amide C-terminus, are neuropeptides that occur in many orders of insects, but are known to inhibit juvenile hormone (JH) synthesis by corpora allata (CA) only in cockroaches, crickets, and termites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2035	18652909-1018	Lecithin:retinol acyltransferase (LRAT) catalyzes the esterification of retinol (vitamin A).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2036	18652909-1019	Retinoic acid (RA) treatment increased this LRAT promoter-luciferase activity in PrEC cells, but not in PC-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2037	18652909-1019	Retinoic acid (RA) treatment increased this LRAT promoter-luciferase activity in PrEC cells, but not in PC-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2038	18654608-1184	As multidrug resistance (MDR) is a major problem in the chemotherapy of progressive breast cancer, the in vitro effects of Ad-REIC treatment were investigated in terms of the sensitivity of multidrug-resistant MCF7/ADR cells to doxorubicin and of the P-glycoprotein expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2039	18654608-1184	As multidrug resistance (MDR) is a major problem in the chemotherapy of progressive breast cancer, the in vitro effects of Ad-REIC treatment were investigated in terms of the sensitivity of multidrug-resistant MCF7/ADR cells to doxorubicin and of the P-glycoprotein expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2040	18654608-1185	Ad-REIC treatment in MCF7/ADR cells also downregulated P-glycoprotein expresssion through JNK activation, and sensitized its drug resistance against doxorubicin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2041	18654608-1185	Ad-REIC treatment in MCF7/ADR cells also downregulated P-glycoprotein expresssion through JNK activation, and sensitized its drug resistance against doxorubicin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2042	18654608-1185	Ad-REIC treatment in MCF7/ADR cells also downregulated P-glycoprotein expresssion through JNK activation, and sensitized its drug resistance against doxorubicin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2043	18654747-1289	Diflomotecan, a homocamptothecin, targets DNA topoisomerase I.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2044	18654835-1331	Both MudPIT and cDNA microarray analyses indicate that H2O2 treatment caused elevated levels of thioredoxin reductase 1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2045	18655070-1550	Altogether these changes offer a straightforward explanation for how following the addition of Ca(2+), the coelenterazine could escape and become available for bioluminescence on Renilla luciferase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2046	18655070-1550	Altogether these changes offer a straightforward explanation for how following the addition of Ca(2+), the coelenterazine could escape and become available for bioluminescence on Renilla luciferase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2047	18655138-1615	The APTS functionalization was then used to immobilize bone morphogenetic protein on the bioactive glasses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2048	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2049	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2050	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2051	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2052	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2053	18655158-1630	L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2054	18655176-1654	Exposure to benzo(a)pyrene (BaP) by intraperitoneal injection increased biliary BaP metabolites and liver CYP1A gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2055	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2056	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2057	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2058	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2059	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2060	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2061	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2062	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2063	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2064	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2065	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2066	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2067	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2068	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2069	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2070	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2071	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2072	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2073	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2074	18655177-1378	We examined the effect of several different doses of malathion (25, 75, 200 microM), or malathion in combination with vitamin C (VC; 10 microM) or vitamin E (VE; 30 microM), on the levels of malondialdehyde (MDA), and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in human erythrocytes in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2075	18655177-1379	Erythrocytes were incubated under various treatment conditions (malathion alone, vitamins alone, or malathion plus vitamin) at 37 degrees C for 60 min, and the levels of MDA, and SOD, CAT and GPx activities, were determined.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2076	18655177-1379	Erythrocytes were incubated under various treatment conditions (malathion alone, vitamins alone, or malathion plus vitamin) at 37 degrees C for 60 min, and the levels of MDA, and SOD, CAT and GPx activities, were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2077	18655177-1380	Treatment with malathion alone increased the levels of MDA and decreased SOD, CAT 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2078	18655177-1380	Treatment with malathion alone increased the levels of MDA and decreased SOD, CAT 0.05).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2079	18655190-1668	Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2080	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2081	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2082	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2083	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2084	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2085	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2086	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2087	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2088	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2089	18655190-1669	In the present study, we investigated the effect of AdM, Pb+ AdM, and Cd+ AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2090	18655797-440	We found that Fos expression in LH orexin neurons varied in proportion to preference for morphine, cocaine or food.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2091	18655797-440	We found that Fos expression in LH orexin neurons varied in proportion to preference for morphine, cocaine or food.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2092	18655797-441	Recent studies showed that LH orexin neurons that project to ventral tegmental area (VTA) have greater Fos induction in association with elevated morphine preference during protracted withdrawal than non-VTA-projecting orexin neurons, indicating that the VTA is an important site of action for orexin's role in reward processing.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2093	18655808-447	Cytochromes c are metalloproteins that function in electron transfer reactions and contain a heme moiety covalently attached via thioether linkages between the co-factor and a CXXCH motif in the protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2094	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2095	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2096	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2097	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2098	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2099	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2100	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2101	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2102	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2103	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2104	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2105	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2106	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2107	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2108	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2109	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2110	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2111	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2112	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2113	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2114	18655848-489	The antioxidant roles of selenium (Se) were evaluated in Brycon cephalus exposed to 2 mg L(-1) of Folisuper 600 BR (MP commercial formulation-MPc, 600 g L(-1)) for 96 h. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) levels in the gills, white muscle and liver were evaluated in fish fed on diets containing 0 or 1.5 mg Se kg(-1) for 8 weeks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2115	18655848-490	MPc also increased GST activity in all tissues with a concurrent decrease in GSH levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2116	18656273-863	Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2117	18656273-863	Resveratrol reverses ET-1-evoked mitogenic effects in human coronary arterial cells by activating the kinase-G to inhibit ERK-enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2118	18656273-864	Pretreatment with the MEK-ERK inhibitor (PD98059) appreciably reversed the mitogenic effects of ET-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2119	18656273-865	On the other hand, pretreatment with the polyphenolic stilbene resveratrol (RSVL, 1-100 microM) triggered more prominent inhibition of ET-1-evoked cell proliferation and ERK1/2 activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2120	18656273-865	On the other hand, pretreatment with the polyphenolic stilbene resveratrol (RSVL, 1-100 microM) triggered more prominent inhibition of ET-1-evoked cell proliferation and ERK1/2 activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2121	18656273-866	Further, pretreatment with the specific cGMP-phosphodiesterase inhibitor, zaprinast (10 microM) appreciably augmented RSVL-evoked cGMP formation, ERK inhibition, and cytostatic response.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2122	18656273-867	Moreover, the RSVL-induced ERK-inhibitory effects were significantly reversed by the kinase-G inhibitor, KT-5823 (10 microM; 69%), but not by the kinase-A inhibitor (KT-5720).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2123	18656273-867	Moreover, the RSVL-induced ERK-inhibitory effects were significantly reversed by the kinase-G inhibitor, KT-5823 (10 microM; 69%), but not by the kinase-A inhibitor (KT-5720).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2124	18656335-913	Adding beta-carotene to the diet of the mice during the period of irradiation suppressed the activity and expression of MMP-9 as well as the wrinkling and sagging formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2125	18656335-914	Dietary beta-carotene prevents the expression of MMP-9, at least partly, by inhibiting photodynamic action involved in the formation of Chol-OOHs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2126	18656337-916	Exposure to linoleic acid for 6 h induced expression of both caveolin-1 and cyclooxygenase (COX)-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2127	18656337-916	Exposure to linoleic acid for 6 h induced expression of both caveolin-1 and cyclooxygenase (COX)-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2128	18656337-917	Pretreatment with EGCG blocked fatty-acid-induced caveolin-1 and COX-2 expression in a time- and concentration-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2129	18656337-917	Pretreatment with EGCG blocked fatty-acid-induced caveolin-1 and COX-2 expression in a time- and concentration-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2130	18656337-918	Exposure to linoleic acid rapidly increased phosphorylation of several kinases, including p38 MAPK, extracellular signal regulated kinase 1/2 (ERK1/2) and amino kinase terminal (Akt), with maximal induction at about 10 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2131	18656337-918	Exposure to linoleic acid rapidly increased phosphorylation of several kinases, including p38 MAPK, extracellular signal regulated kinase 1/2 (ERK1/2) and amino kinase terminal (Akt), with maximal induction at about 10 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2132	18656337-918	Exposure to linoleic acid rapidly increased phosphorylation of several kinases, including p38 MAPK, extracellular signal regulated kinase 1/2 (ERK1/2) and amino kinase terminal (Akt), with maximal induction at about 10 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2133	18656337-918	Exposure to linoleic acid rapidly increased phosphorylation of several kinases, including p38 MAPK, extracellular signal regulated kinase 1/2 (ERK1/2) and amino kinase terminal (Akt), with maximal induction at about 10 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2134	18656337-919	Inhibitors of ERK1/2 and Akt down-regulated the linoleic-acid-induced increase in COX-2 protein, which also occurred after pretreatment with EGCG.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2135	18656337-919	Inhibitors of ERK1/2 and Akt down-regulated the linoleic-acid-induced increase in COX-2 protein, which also occurred after pretreatment with EGCG.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2136	18656337-920	Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2137	18656337-920	Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2138	18656337-920	Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2139	18656337-920	Caveolin-1 silencing blocked linoleic-acid-induced phosphorylation of ERK1/2 and protein expression of COX-2, suggesting that specific MAPK signaling is caveolae dependent.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2140	18656338-921	Apigenin causes G(2)/M arrest associated with the modulation of p21 (Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2141	18656338-921	Apigenin causes G(2)/M arrest associated with the modulation of p21 (Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2142	18656338-921	Apigenin causes G(2)/M arrest associated with the modulation of p21 (Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2143	18656338-921	Apigenin causes G(2)/M arrest associated with the modulation of p21 (Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2144	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2145	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2146	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2147	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2148	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2149	18656338-922	To investigate the regulatory proteins of cell cycle arrest affected by apigenin, we treated cells with 50 and 100 microM apigenin for 72 h. Apigenin caused a slight decrease in cyclin D and cyclin E expression, with no change in CDK2 and CDK4.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2150	18656338-923	In addition, the apigenin-induced accumulation of the cell population in the G(2)/M phase resulted in a decrease in CDK1 together with cyclin A and cyclin B.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2151	18656338-923	In addition, the apigenin-induced accumulation of the cell population in the G(2)/M phase resulted in a decrease in CDK1 together with cyclin A and cyclin B.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2152	18656338-924	In an additional study, apigenin also increased the accumulation of p53 and further enhanced the level of p21 (Cip1), with no change in p27 (Kip1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2153	18656338-924	In an additional study, apigenin also increased the accumulation of p53 and further enhanced the level of p21 (Cip1), with no change in p27 (Kip1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2154	18656338-924	In an additional study, apigenin also increased the accumulation of p53 and further enhanced the level of p21 (Cip1), with no change in p27 (Kip1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2155	18656338-924	In an additional study, apigenin also increased the accumulation of p53 and further enhanced the level of p21 (Cip1), with no change in p27 (Kip1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2156	18656338-925	The expression of Bax and cytochrome c of p53 downstream target was increased markedly at high concentration treatment over 50 microM apigenin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2157	18656338-925	The expression of Bax and cytochrome c of p53 downstream target was increased markedly at high concentration treatment over 50 microM apigenin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2158	18656338-925	The expression of Bax and cytochrome c of p53 downstream target was increased markedly at high concentration treatment over 50 microM apigenin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2159	18656400-711	Therefore, we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2160	18656400-711	Therefore, we next examined whether 5-HT2A5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2161	18656400-711	Therefore, we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2162	18656400-711	Therefore, we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2163	18656400-713	These results indicate that 5-HT released into peripheral tissue and its receptors, 5-HT2A as well as 5-HT2C, at the periphery have an important role in pain-related behaviors during acute peripheral inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2164	18656400-713	These results indicate that 5-HT released into peripheral tissue and its receptors, 5-HT2A as well as 5-HT2C, at the periphery have an important role in pain-related behaviors during acute peripheral inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2165	18656896-1449	Haloperidol strongly decreased the expression of BDNF 0.01).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2166	18656896-1450	In contrast, the administration of ziprasidone significantly attenuated the immobilization stress-induced decrease in BDNF 0.01).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2167	18656896-1451	Ziprasidone exhibited differential effects on BDNF mRNA expression in the rat hippocampus and neocortex.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2168	18656896-1452	These results suggest that ziprasidone might have a neuroprotective effect by recovering stress-induced decreases in BDNF mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2169	18657000-1427	In conclusion, fructose overload in rats induced hypertriglyceridemia and insulin resistance associated with an enhanced oxidative stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2170	18657005-297	Clinical and biochemical parameters including fructosamine (FAM), glycated hemoglobin (HbA1c) and serum AGEs were investigated in children and adolescents with 1 type diabetes with (+DC) and without (-DC) complications.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2171	18657005-297	Clinical and biochemical parameters including fructosamine (FAM), glycated hemoglobin (HbA1c) and serum AGEs were investigated in children and adolescents with 1 type diabetes with (+DC) and without (-DC) complications.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2172	18657007-1437	Leptin and soluble leptin receptor changes after pulmonary endarterectomy: relations to cortisol and cytokine network.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2173	18657007-1437	Leptin and soluble leptin receptor changes after pulmonary endarterectomy: relations to cortisol and cytokine network.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2174	18657007-1438	Leptin and soluble leptin receptor (SLR) were compared with evolution of cortisol and inflammatory cytokines in twenty-two patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy using cardiopulmonary bypass (CBP) and deep hypothermic circulatory arrest (DHCA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2175	18657007-1438	Leptin and soluble leptin receptor (SLR) were compared with evolution of cortisol and inflammatory cytokines in twenty-two patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy using cardiopulmonary bypass (CBP) and deep hypothermic circulatory arrest (DHCA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2176	18657009-1440	Using this method, we also determined whether streptozotocin-induced DM in rats (4-week duration) leads to changes in renal subcellular targeting of CAV-1, and evaluated the effects of tight metabolic control (insulin, 12 IU/day) and angiotensin receptor blocker, losartan (4 weeks, 20 mg/kg/day).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2177	18657009-1440	Using this method, we also determined whether streptozotocin-induced DM in rats (4-week duration) leads to changes in renal subcellular targeting of CAV-1, and evaluated the effects of tight metabolic control (insulin, 12 IU/day) and angiotensin receptor blocker, losartan (4 weeks, 20 mg/kg/day).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2178	18657194-724	Androgenic action correlates inversely with a polymorphic CAG repeat region in the AR gene encoding for glutamine residues the length of which appears to influence high density lipoprotein (HDL) cholesterol levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2179	18657194-724	Androgenic action correlates inversely with a polymorphic CAG repeat region in the AR gene encoding for glutamine residues the length of which appears to influence high density lipoprotein (HDL) cholesterol levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2180	18657228-1396	These vessels are formed by proliferating cells that incorporate bromodeoxyuridine and express the endothelial cell markers vegfr2/kdr and fli1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2181	18657228-1396	These vessels are formed by proliferating cells that incorporate bromodeoxyuridine and express the endothelial cell markers vegfr2/kdr and fli1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2182	18657228-1398	Moreover, similar to rFGF2, injection of the zebrafish form of vascular endothelial growth factor-A (VEGF-A) induces a significant angiogenic response in the ZFYM assay that is suppressed by the VEGF receptor-2/KDR TK inhibitor SU5416.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2183	18657228-1398	Moreover, similar to rFGF2, injection of the zebrafish form of vascular endothelial growth factor-A (VEGF-A) induces a significant angiogenic response in the ZFYM assay that is suppressed by the VEGF receptor-2/KDR TK inhibitor SU5416.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2184	18657961-1695	In this study, we examined ferulate for its ability to suppress redox-sensitive, proinflammatory NF-kappaB activation via NF-kappaB-inducing kinase (NIK)/IkappaB kinase (IKK) and mitogen-activated protein kinases (MAPKs) by reducing oxidative stress in aged rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2185	18657961-1695	In this study, we examined ferulate for its ability to suppress redox-sensitive, proinflammatory NF-kappaB activation via NF-kappaB-inducing kinase (NIK)/IkappaB kinase (IKK) and mitogen-activated protein kinases (MAPKs) by reducing oxidative stress in aged rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2186	18657961-1695	In this study, we examined ferulate for its ability to suppress redox-sensitive, proinflammatory NF-kappaB activation via NF-kappaB-inducing kinase (NIK)/IkappaB kinase (IKK) and mitogen-activated protein kinases (MAPKs) by reducing oxidative stress in aged rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2187	18657961-1695	In this study, we examined ferulate for its ability to suppress redox-sensitive, proinflammatory NF-kappaB activation via NF-kappaB-inducing kinase (NIK)/IkappaB kinase (IKK) and mitogen-activated protein kinases (MAPKs) by reducing oxidative stress in aged rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2188	18657961-1696	Data show that in aged kidney tissue, ferulate exhibited its antioxidative action by maintaining redox regulation, suppressing NF-kappaB activation and modulating the expression of NF-kappaB-induced, proinflammatory COX-2, iNOS, VCAM-1 and ICAM-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2189	18657961-1696	Data show that in aged kidney tissue, ferulate exhibited its antioxidative action by maintaining redox regulation, suppressing NF-kappaB activation and modulating the expression of NF-kappaB-induced, proinflammatory COX-2, iNOS, VCAM-1 and ICAM-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2190	18657961-1696	Data show that in aged kidney tissue, ferulate exhibited its antioxidative action by maintaining redox regulation, suppressing NF-kappaB activation and modulating the expression of NF-kappaB-induced, proinflammatory COX-2, iNOS, VCAM-1 and ICAM-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2191	18657961-1696	Data show that in aged kidney tissue, ferulate exhibited its antioxidative action by maintaining redox regulation, suppressing NF-kappaB activation and modulating the expression of NF-kappaB-induced, proinflammatory COX-2, iNOS, VCAM-1 and ICAM-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2192	18657961-1698	The molecular modulation of NF-kappaB by ferulate was further revealed in endothelial YPEN-1 cells through ferulate's ability to suppress the activation of NIK/IKK and MAPKs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2193	18657961-1698	The molecular modulation of NF-kappaB by ferulate was further revealed in endothelial YPEN-1 cells through ferulate's ability to suppress the activation of NIK/IKK and MAPKs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2194	18657961-1699	Based on these results, we conclude that ferulate's antioxidative capacity suppressed the age-related increase in NF-kappaB activity through inhibition of NIK/IKK and MAPKs in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2195	18657961-1699	Based on these results, we conclude that ferulate's antioxidative capacity suppressed the age-related increase in NF-kappaB activity through inhibition of NIK/IKK and MAPKs in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2196	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2197	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2198	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2199	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2200	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2201	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2202	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2203	18658095-656	Previous studies have shown that wounding of human corneal epithelial cells (HCECs) results in the release of G-protein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EGFR) through ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2204	18660796-396	Nitric oxide is a free radical molecule synthesized from L-arginine by nitric oxide synthases that plays a critical role in various physiological and pathological processes, including tumor growth and angiogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2205	18660796-396	Nitric oxide is a free radical molecule synthesized from L-arginine by nitric oxide synthases that plays a critical role in various physiological and pathological processes, including tumor growth and angiogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2206	18661133-1463	Furthermore, restoration of KSR1 expression in KSR (-/-) MEFs following stable transduction of cells with a KSR1 expression vector, enhanced sensitivity of cells to tunicamycin and cytochalasin H and decreased ERK1/2 activation following exposure to these drugs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2207	18661133-1463	Furthermore, restoration of KSR1 expression in KSR (-/-) MEFs following stable transduction of cells with a KSR1 expression vector, enhanced sensitivity of cells to tunicamycin and cytochalasin H and decreased ERK1/2 activation following exposure to these drugs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2208	18661233-1568	We demonstrated the increase in the levels of p53, Bax, and cytochrome c and decrease in the level of Bcl-2, which are associated with the induction of apoptotic cell death after 24 h treatment with baicalein in N18 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2209	18661233-1568	We demonstrated the increase in the levels of p53, Bax, and cytochrome c and decrease in the level of Bcl-2, which are associated with the induction of apoptotic cell death after 24 h treatment with baicalein in N18 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2210	18661233-1568	We demonstrated the increase in the levels of p53, Bax, and cytochrome c and decrease in the level of Bcl-2, which are associated with the induction of apoptotic cell death after 24 h treatment with baicalein in N18 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2211	18661233-1568	We demonstrated the increase in the levels of p53, Bax, and cytochrome c and decrease in the level of Bcl-2, which are associated with the induction of apoptotic cell death after 24 h treatment with baicalein in N18 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2212	18661547-124	GFP-fluorescent cells were slowly cycling, as shown by their long-term retention of BrdU, and less than 10% expressed the proliferative markers Ki67 and Mcm2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2213	18662278-741	MTHFR gene polymorphisms and high levels of homocysteine are associated with a high degree of steatosis and fibrosis, conditions associated with a low sustained virological response (SVR) rate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2214	18662930-1285	Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2215	18662930-1285	Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2216	18663366-1650	The discovery that a common polymorphism (5-HTTLPR, short variant) in the human serotonin transporter gene (SLC6A4) can influence personality traits and increase the risk for depression in adulthood has led to the hypothesis that a relative increase in the extracellular levels of serotonin (5-HT) during development could be critical for the establishment of brain circuits.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2217	18663367-1653	Besides the biogenesis of lysosome-related organelles complex 1 and dystrophin-associated protein complex, several molecules in the DTNBP1 network likely provide insight into the role of DTNBP1 in biological systems: retinoic acid, beta-estradiol, calmodulin and tumour necrosis factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2218	18663367-1653	Besides the biogenesis of lysosome-related organelles complex 1 and dystrophin-associated protein complex, several molecules in the DTNBP1 network likely provide insight into the role of DTNBP1 in biological systems: retinoic acid, beta-estradiol, calmodulin and tumour necrosis factor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2219	18663367-1653	Besides the biogenesis of lysosome-related organelles complex 1 and dystrophin-associated protein complex, several molecules in the DTNBP1 network likely provide insight into the role of DTNBP1 in biological systems: retinoic acid, beta-estradiol, calmodulin and tumour necrosis factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2220	18663367-1653	Besides the biogenesis of lysosome-related organelles complex 1 and dystrophin-associated protein complex, several molecules in the DTNBP1 network likely provide insight into the role of DTNBP1 in biological systems: retinoic acid, beta-estradiol, calmodulin and tumour necrosis factor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2221	18663553-101	Prior to the first dose of leflunomide, serum concentrations of studied chemokines correlated with marker of RA activity such as the erythrocyte sedimentation rate and IL-8 level with DAS.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2222	18663559-103	Hypothetically, cytochrome P450 2D6 influences the transport of taurine across the blood-brain barrier.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2223	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2224	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2225	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2226	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2227	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2228	18663659-168	Most genes involved in lipid metabolism and especially in ergosterol biosynthesis were up-regulated in response to itraconazole, including ERG6, ERG7, ERG11, ERG24, ERG25 and ERG26.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2229	18665046-1318	In prolonged OJ with LPS administration, hepatocyte apoptosis depending on Fas ligand expression significantly increased in association with a decrease in ATP contents, thus resulting in liver necrapoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2230	18665051-1321	Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2231	18665051-1321	Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2232	18665051-1321	Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2233	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2234	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2235	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2236	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2237	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2238	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2239	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2240	18665052-290	In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate (ADP) ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2241	18665326-1562	Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2242	18665326-1563	NDEA administered rats showed increased MCD as revealed by toluidine blue staining along with upregulated expressions of MMP-2 and MMP-9.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2243	18665326-1563	NDEA administered rats showed increased MCD as revealed by toluidine blue staining along with upregulated expressions of MMP-2 and MMP-9.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2244	18665326-1564	Silymarin treatment inhibited this increase in MCD and downregulated the expressions of MMP-2 and MMP-9 as revealed by Western blotting and immunohistochemistry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2245	18665326-1564	Silymarin treatment inhibited this increase in MCD and downregulated the expressions of MMP-2 and MMP-9 as revealed by Western blotting and immunohistochemistry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2246	18665326-1565	In conclusion, silymarin exerted beneficial effects on liver carcinogenesis by attenuating the recruitment of mast cells and thereby decreased the expressions of MMP-2 and MMP-9.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2247	18665326-1565	In conclusion, silymarin exerted beneficial effects on liver carcinogenesis by attenuating the recruitment of mast cells and thereby decreased the expressions of MMP-2 and MMP-9.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2248	18665390-1624	As a result, combined glucose and insulin infusion significantly decreased plasma K+ concentration despite a significant decrease of urinary K+ excretion in sgk1+/+ but not in sgk1-/-mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2249	18665391-1625	While it is clearly demonstrated that members of the TRPC3/6/7 subfamily are activated by diacylglycerol, the mechanism by which phospholipase C activates members of the TRPC1/4/5 subfamily remains a mystery.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2250	18665391-1625	While it is clearly demonstrated that members of the TRPC3/6/7 subfamily are activated by diacylglycerol, the mechanism by which phospholipase C activates members of the TRPC1/4/5 subfamily remains a mystery.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2251	18665391-1626	Depletion of polyphosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate (PIP2) through inhibition of phosphatidylinositol 4-kinase activates calcium entry and membrane currents in TRPC5-expressing but not in TRPC3-or TRPC7-expressing cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2252	18665391-1626	Depletion of polyphosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate (PIP2) through inhibition of phosphatidylinositol 4-kinase activates calcium entry and membrane currents in TRPC5-expressing but not in TRPC3-or TRPC7-expressing cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2253	18665391-1626	Depletion of polyphosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate (PIP2) through inhibition of phosphatidylinositol 4-kinase activates calcium entry and membrane currents in TRPC5-expressing but not in TRPC3-or TRPC7-expressing cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2254	18665391-1626	Depletion of polyphosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate (PIP2) through inhibition of phosphatidylinositol 4-kinase activates calcium entry and membrane currents in TRPC5-expressing but not in TRPC3-or TRPC7-expressing cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2255	18665391-1627	Inclusion of polyphosphatidylinositol 4-phosphate or PIP2, but not phosphatidylinositol 3,4,5-trisphosphate, in the patch pipette inhibited TRPC5 currents.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2256	18665432-1672	Osteogenic differentiation was enhanced after treatment with alendronate as confirmed by Alizarin Red S staining, elevated alkaline phosphatase activity and osteocalcin mRNA expression, a greater calcium peak by energy-dispersive xray spectrophotometry, and by immunofluorescence staining against CD44 by flow cytometric analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2257	18665432-1672	Osteogenic differentiation was enhanced after treatment with alendronate as confirmed by Alizarin Red S staining, elevated alkaline phosphatase activity and osteocalcin mRNA expression, a greater calcium peak by energy-dispersive xray spectrophotometry, and by immunofluorescence staining against CD44 by flow cytometric analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2258	18665432-1672	Osteogenic differentiation was enhanced after treatment with alendronate as confirmed by Alizarin Red S staining, elevated alkaline phosphatase activity and osteocalcin mRNA expression, a greater calcium peak by energy-dispersive xray spectrophotometry, and by immunofluorescence staining against CD44 by flow cytometric analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2259	18667202-1391	Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2260	18667202-1393	Ghrelin was able to inhibit angiotensin II-induced proliferation and contraction in a dose-response fashion via the cAMP/PKA pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2261	18667302-1496	The results indicated that the backbone of POP was composed of (1-->6)-linked-alpha-D-galactopyranosyl and (1-->2,6)-linked-alpha-D-galactopyranosyl residues, which were terminated with a single terminal (1-->)-beta-D-glucose residue at the O-2 position of galactosyl along the main chain in the ratio of 1:1:1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2262	18667302-1496	The results indicated that the backbone of POP was composed of (1-->6)-linked-alpha-D-galactopyranosyl and (1-->2,6)-linked-alpha-D-galactopyranosyl residues, which were terminated with a single terminal (1-->)-beta-D-glucose residue at the O-2 position of galactosyl along the main chain in the ratio of 1:1:1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2263	18667302-1497	Preliminary tests in vitro showed POP is capable of enhancing concanavalin A (ConA)-or lipopolysaccharide (LPS)-induced lymphocyte proliferation, which suggested that POP could be a potential immunostimulating agent for use in functional foods or medicine against both pathogens and cancer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2264	18667302-1497	Preliminary tests in vitro showed POP is capable of enhancing concanavalin A (ConA)-or lipopolysaccharide (LPS)-induced lymphocyte proliferation, which suggested that POP could be a potential immunostimulating agent for use in functional foods or medicine against both pathogens and cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2265	18667302-1497	Preliminary tests in vitro showed POP is capable of enhancing concanavalin A (ConA)-or lipopolysaccharide (LPS)-induced lymphocyte proliferation, which suggested that POP could be a potential immunostimulating agent for use in functional foods or medicine against both pathogens and cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2266	18668138-492	Inhibition of the phosphatidyl-inositol-3 kinase/Akt pathway by wortmannin and specific abrogation of Akt1 protein using small-interfering RNA revealed a regulatory function of Akt1 in insulin-mediated VEGF biosynthesis in keratinocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2267	18668138-492	Inhibition of the phosphatidyl-inositol-3 kinase/Akt pathway by wortmannin and specific abrogation of Akt1 protein using small-interfering RNA revealed a regulatory function of Akt1 in insulin-mediated VEGF biosynthesis in keratinocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2268	18668138-492	Inhibition of the phosphatidyl-inositol-3 kinase/Akt pathway by wortmannin and specific abrogation of Akt1 protein using small-interfering RNA revealed a regulatory function of Akt1 in insulin-mediated VEGF biosynthesis in keratinocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2269	18668211-556	Cross-linked hydrogels showed increased resistance to digestion by testicular hyaluronidase and hyaluronidase SD with increasing hyaluronan concentration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2270	18668222-95	Chlorpyrifos (CPF), a commonly used organophosphorus insecticide, induces acetylcholinesterase inhibition and cholinergic toxicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2271	18668243-580	Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2272	18668351-55	It was observed that administration of the PKC inhibitor chelerythrine chloride (5 mg/kg) suppressed the activation of three exercise-induced PKC isoforms (PKCalpha, PKCdelta, and PKCepsilon) and attenuated the exercise-mediated reduction of myocardial infarct size during ischemia-reperfusion injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2273	18668351-55	It was observed that administration of the PKC inhibitor chelerythrine chloride (5 mg/kg) suppressed the activation of three exercise-induced PKC isoforms (PKCalpha, PKCdelta, and PKCepsilon) and attenuated the exercise-mediated reduction of myocardial infarct size during ischemia-reperfusion injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2274	18668366-689	Capsaicin is known to have regulatory effects on gastrointestinal functions via the vanilloid receptor (VR1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2275	18670196-1382	Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the plasma concentration of high density lipoprotein cholesterol (HDL-C).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2276	18670196-1382	Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the plasma concentration of high density lipoprotein cholesterol (HDL-C).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2277	18670196-1382	Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the plasma concentration of high density lipoprotein cholesterol (HDL-C).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2278	18670196-1382	Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of neutral lipids and phospholipids between lipoproteins and contributes to the regulation of the plasma concentration of high density lipoprotein cholesterol (HDL-C).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2279	18670732-960	These studies frequently showed that erythropoietic stimulating agents (ESA) with oral or IV iron often resulted in improvement in left ventricular systolic and diastolic function, dilation, and hypertrophy, stabilization or improvement in renal function, reduced hospitalizations, diuretic dose, mitral regurgitation, pulmonary artery pressure, plasma volume, heart rate, serum brain natriuretic peptide levels, and the inflammatory markers C reactive protein and Interleukin 6, and an improvement in New York Heart Association class, exercise capacity, oxygen utilization during exercise, sleep apnea, caloric intake, depression, and quality of life.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2280	18670732-960	These studies frequently showed that erythropoietic stimulating agents (ESA) with oral or IV iron often resulted in improvement in left ventricular systolic and diastolic function, dilation, and hypertrophy, stabilization or improvement in renal function, reduced hospitalizations, diuretic dose, mitral regurgitation, pulmonary artery pressure, plasma volume, heart rate, serum brain natriuretic peptide levels, and the inflammatory markers C reactive protein and Interleukin 6, and an improvement in New York Heart Association class, exercise capacity, oxygen utilization during exercise, sleep apnea, caloric intake, depression, and quality of life.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2281	18670809-1037	DNA sequences of a calmodulin (CaM)-encoding gene region containing three exons, two introns and a 411-bp mt intergenic spacer (IGS) spanning the cytochrome b (cytb) and NADH 2 genes, were obtained from 49 Acropora species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2282	18670809-1037	DNA sequences of a calmodulin (CaM)-encoding gene region containing three exons, two introns and a 411-bp mt intergenic spacer (IGS) spanning the cytochrome b (cytb) and NADH 2 genes, were obtained from 49 Acropora species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2283	18670809-1037	DNA sequences of a calmodulin (CaM)-encoding gene region containing three exons, two introns and a 411-bp mt intergenic spacer (IGS) spanning the cytochrome b (cytb) and NADH 2 genes, were obtained from 49 Acropora species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2284	18670809-1037	DNA sequences of a calmodulin (CaM)-encoding gene region containing three exons, two introns and a 411-bp mt intergenic spacer (IGS) spanning the cytochrome b (cytb) and NADH 2 genes, were obtained from 49 Acropora species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2285	18670810-1039	Both expression of tac and tac2 were induced by 2% sucrose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2286	18670880-1082	Contaminants of current high use in the LRGV, such as atrazine, and some of the highly persistent organochlorines, such as toxaphene and DDE, could be potentially associated with modulation of aromatase activity in avian tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2287	18670880-1082	Contaminants of current high use in the LRGV, such as atrazine, and some of the highly persistent organochlorines, such as toxaphene and DDE, could be potentially associated with modulation of aromatase activity in avian tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2288	18670880-1082	Contaminants of current high use in the LRGV, such as atrazine, and some of the highly persistent organochlorines, such as toxaphene and DDE, could be potentially associated with modulation of aromatase activity in avian tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2289	18670892-1460	In this view, this study aimed at the investigating the use of a crude peroxidase preparation from onion solid by-products for oxidising caffeic acid, a widespread o-diphenol, whose various derivatives may occur in food industry wastes, such as olive mill waste waters.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2290	18670896-1090	Ziram exposures that caused a loss of binding function were examined for effects on expression of key NK cell-surface proteins needed for binding to targets.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2291	18670905-814	Here, we have investigated how the post-synthetic acetylation of HMGB1 affects its interaction with negatively supercoiled DNA by employing monoacetylated at Lys2 protein, isolated from butyrate-treated cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2292	18670906-1096	KAP8.1 protein contains high glycine and tyrosine, which concerns regulation and function of the matrix structure fiber.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2293	18670906-1096	KAP8.1 protein contains high glycine and tyrosine, which concerns regulation and function of the matrix structure fiber.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2294	18671273-1368	Cycloheximide inhibited MIH induced Mos expression and its phosphorylation, which in turn reduced Myt1 phosphorylation and GVBD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2295	18671273-1368	Cycloheximide inhibited MIH induced Mos expression and its phosphorylation, which in turn reduced Myt1 phosphorylation and GVBD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2296	18671273-1368	Cycloheximide inhibited MIH induced Mos expression and its phosphorylation, which in turn reduced Myt1 phosphorylation and GVBD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2297	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2298	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2299	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2300	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2301	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2302	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2303	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2304	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2305	18671672-48	CLNO2 levels were found to increase approximately 20-fold 24 h after macrophage activation with Escherichia coli lipopolysaccharide plus interferon-gamma ; this response was concurrent with an increase in the expression of NOS2 (inducible nitric oxide synthase) and was inhibited by the (*)NO (nitric oxide) inhibitor L-NAME (N(G)-nitro-L-arginine methyl ester).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2306	18671761-109	Parkin-mediated ubiquitination regulates phospholipase C-gamma1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2307	18671795-129	Short-acting insulin analogues, in comparison with regular human insulin (HRI), provide a greater control of postprandial glucose, while their superiority on haemoglobin A1c (HbA1c) is controversial.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2308	18671795-129	Short-acting insulin analogues, in comparison with regular human insulin (HRI), provide a greater control of postprandial glucose, while their superiority on haemoglobin A1c (HbA1c) is controversial.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2309	18671897-205	Western blotting showed that carbenoxolone down-regulated Cx43 protein expression in the BA, which in the SAH-only group was significantly higher than that of the normal group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2310	18672341-581	Hepatocytes exposed to resistin, but only in the presence of insulin, show a decrease in insulin-stimulated glycogen content.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2311	18673089-1229	Differentiated EBD cells in both monolayer and three-dimensional in vitro culture demonstrated fat granules by light microscopy, stained positive for lipids with oil red-O, and expressed adipocyte-specific genes (lipoprotein lipase (LPL), peroxisome proliferator activated receptor gamma2, and adipocyte-specific fatty acid binding protein (alphaP2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2312	18673089-1229	Differentiated EBD cells in both monolayer and three-dimensional in vitro culture demonstrated fat granules by light microscopy, stained positive for lipids with oil red-O, and expressed adipocyte-specific genes (lipoprotein lipase (LPL), peroxisome proliferator activated receptor gamma2, and adipocyte-specific fatty acid binding protein (alphaP2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2313	18673089-1229	Differentiated EBD cells in both monolayer and three-dimensional in vitro culture demonstrated fat granules by light microscopy, stained positive for lipids with oil red-O, and expressed adipocyte-specific genes (lipoprotein lipase (LPL), peroxisome proliferator activated receptor gamma2, and adipocyte-specific fatty acid binding protein (alphaP2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2314	18673089-1229	Differentiated EBD cells in both monolayer and three-dimensional in vitro culture demonstrated fat granules by light microscopy, stained positive for lipids with oil red-O, and expressed adipocyte-specific genes (lipoprotein lipase (LPL), peroxisome proliferator activated receptor gamma2, and adipocyte-specific fatty acid binding protein (alphaP2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2315	18673303-1358	In addition, AIT induced a more favourable regulation of blood glucose and insulin compared with MTG.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2316	18673333-52	Beta1,4-galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2317	18673333-52	Beta1,4-galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2318	18673333-52	Beta1,4-galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2319	18673333-53	When compared to the other mammalian B4GALT1 genes, the porcine coding sequence contained a single threonine codon inserted into the region encoding the cytoplasmic domain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2320	18674953-1307	Gyp inhibited the levels of the anti-apoptotic proteins Bcl-2 and Bcl-xl, but promoted the levels of the pro-apoptotic protein Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2321	18674953-1307	Gyp inhibited the levels of the anti-apoptotic proteins Bcl-2 and Bcl-xl, but promoted the levels of the pro-apoptotic protein Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2322	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2323	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2324	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2325	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2326	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2327	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2328	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2329	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2330	18674953-1308	In conclusion, Gyp induced ER stress and production of reactive oxygen species and Ca(2+), change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2331	18675966-641	To compare expression of endometrial estrogen (ER) and progesterone (PR) receptors, beta(3)-integrin subunit, leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and pinopodes in Indian women using ormeloxifene as a contraceptive with fertile and infertile subjects during the window of implantation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2332	18675966-641	To compare expression of endometrial estrogen (ER) and progesterone (PR) receptors, beta(3)-integrin subunit, leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and pinopodes in Indian women using ormeloxifene as a contraceptive with fertile and infertile subjects during the window of implantation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2333	18675966-641	To compare expression of endometrial estrogen (ER) and progesterone (PR) receptors, beta(3)-integrin subunit, leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and pinopodes in Indian women using ormeloxifene as a contraceptive with fertile and infertile subjects during the window of implantation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2334	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2335	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2336	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2337	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2338	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2339	18676014-229	We have also observed that the reduction of transition at 95+/-3 degrees C in thermal scans of nuclear preparations isolated from blood of B-CLL randomized patients who showed response to cladribine or fludarabine combined with cyclophosphamide, i.e., CC and FC, respectively, corresponded with the decrease or disappearance of anti-apoptotic proteins Bcl-2 and/or Mcl 1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2340	18676199-799	Exposure of erythrocytes to PGNs increased cytosolic Ca(2+) concentration, increased ceramide formation, enhanced the percentage of annexin V-binding erythrocytes, decreased erythrocyte forward scatter, and lowered the intracellular ATP concentration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2341	18676199-799	Exposure of erythrocytes to PGNs increased cytosolic Ca(2+) concentration, increased ceramide formation, enhanced the percentage of annexin V-binding erythrocytes, decreased erythrocyte forward scatter, and lowered the intracellular ATP concentration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2342	18676199-799	Exposure of erythrocytes to PGNs increased cytosolic Ca(2+) concentration, increased ceramide formation, enhanced the percentage of annexin V-binding erythrocytes, decreased erythrocyte forward scatter, and lowered the intracellular ATP concentration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2343	18676199-799	Exposure of erythrocytes to PGNs increased cytosolic Ca(2+) concentration, increased ceramide formation, enhanced the percentage of annexin V-binding erythrocytes, decreased erythrocyte forward scatter, and lowered the intracellular ATP concentration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2344	18676776-233	Inhibition of mitogen-activated protein kinase (MAPK) and Akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2345	18676776-233	Inhibition of mitogen-activated protein kinase (MAPK) and Akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2346	18676776-233	Inhibition of mitogen-activated protein kinase (MAPK) and Akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2347	18676776-235	Nicotine up-regulated Akt-mediated antiapoptotic X-linked inhibitor of apoptosis protein and phosphorylated proapoptotic Bcl2-antagonist of cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2348	18677478-391	Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2'-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2349	18677478-391	Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2'-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2350	18677521-1468	In the absence of OmcB, cells lost the ability to reduce soluble or insoluble Fe(III).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2351	18677521-1470	DNA sequences of upstream regions of coregulated operons in the adapted mutant are divergent, suggesting the presence of recognition sites for different transcriptional regulators and indicating that adaptation of the omcB mutant to growth on soluble Fe(III) has shifted the relevant expression networks involved to a more diverse molecular basis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2352	18677561-697	Elevated beta1,4-galactosyltransferase-I induced by the intraspinal injection of lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2353	18677561-698	E-selectin, which ligand was modified by beta1,4-GalT-I, was correlated with galactose-containing glycans following injecting LPS into spinal cord.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2354	18677571-1520	Effects of P85 on amino acid transporters were examined using their substrates: (3)H-phenylalanine, (3)H-lysine, and (3)H-methylaminoisobutyric acid, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2355	18677571-1520	Effects of P85 on amino acid transporters were examined using their substrates: (3)H-phenylalanine, (3)H-lysine, and (3)H-methylaminoisobutyric acid, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2356	18677583-1526	Valproate, an anticonvulsant and mood stabilizer, up-regulates Bcl-2, a neurotrophic/neuroprotective protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2357	18677583-1527	In this study, we investigated the molecular mechanism through which Bcl-2 is up-regulated by valproate using cultured human neuron-like cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2358	18677583-1528	Valproate, within therapeutically relevant ranges, induced time- and concentration-dependent up-regulations of both Bcl-2 messenger RNA and protein implicating an underlying gene transcriptional-mediated mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2359	18677583-1529	Valproate increased transcriptional activity of a human bcl-2 promoter-reporter gene construct.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2360	18677583-1530	ERK and/or PI3K pathway inhibitors and RSK1 small hairpin RNA knockdown reduced, but did not abolish, baseline and valproate-induced promoter activities and lowered Bcl-2 protein levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2361	18677583-1531	These data collectively suggest that valproate induces Bcl-2 regulation partially through activations of the ERK and PI3K cascades and their convergent kinase, RSK, although other unknown mechanism(s) are likely involved.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2362	18677583-1531	These data collectively suggest that valproate induces Bcl-2 regulation partially through activations of the ERK and PI3K cascades and their convergent kinase, RSK, although other unknown mechanism(s) are likely involved.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2363	18677583-1531	These data collectively suggest that valproate induces Bcl-2 regulation partially through activations of the ERK and PI3K cascades and their convergent kinase, RSK, although other unknown mechanism(s) are likely involved.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2364	18677583-1531	These data collectively suggest that valproate induces Bcl-2 regulation partially through activations of the ERK and PI3K cascades and their convergent kinase, RSK, although other unknown mechanism(s) are likely involved.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2365	18677583-1532	Given the known roles of Bcl-2 in the central nervous system, the current findings offer a partial yet complex molecular mechanistic explanation for the known neurobiological effects of valproate including neurite growth, neuronal survival, and neurogenesis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2366	18679593-620	With covalent method, glutaraldehyde was introduced to immobilize cellobiase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2367	18679731-726	As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2368	18679731-726	As metabolic flux for the operation of the flavonoid pathway is maintained through the activities of PAL and C4H, thus, catechins biosynthesis in tea is critically dependent on the products of these enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2369	18679812-4	Activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutatione-S-transferase, and reduced glutathione) in liver also decreased in carcinogen-administered rats, which were significantly elevated in bacoside A-pretreated rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2370	18679812-4	Activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutatione-S-transferase, and reduced glutathione) in liver also decreased in carcinogen-administered rats, which were significantly elevated in bacoside A-pretreated rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2371	18679812-4	Activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutatione-S-transferase, and reduced glutathione) in liver also decreased in carcinogen-administered rats, which were significantly elevated in bacoside A-pretreated rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2372	18679812-4	Activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutatione-S-transferase, and reduced glutathione) in liver also decreased in carcinogen-administered rats, which were significantly elevated in bacoside A-pretreated rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2373	18679831-20	In this study, we report that AR-M1896, a non-GalR1 agonist, inhibited plasma extravasation induced by substance P and calcitonin gene-related peptide in a manner similar to galanin, confirming a non-GalR1-mediated effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2374	18679831-20	In this study, we report that AR-M1896, a non-GalR1 agonist, inhibited plasma extravasation induced by substance P and calcitonin gene-related peptide in a manner similar to galanin, confirming a non-GalR1-mediated effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2375	18679831-20	In this study, we report that AR-M1896, a non-GalR1 agonist, inhibited plasma extravasation induced by substance P and calcitonin gene-related peptide in a manner similar to galanin, confirming a non-GalR1-mediated effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2376	18680102-211	Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2377	18680102-211	Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2378	18680102-215	Additionally, UO126 and ODQ inhibited the migration restoring effects of L-arginine in L-NAME-treated cells, suggesting the involvement of cGMP and MAPK pathways in NO-mediated migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2379	18680102-215	Additionally, UO126 and ODQ inhibited the migration restoring effects of L-arginine in L-NAME-treated cells, suggesting the involvement of cGMP and MAPK pathways in NO-mediated migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2380	18680102-215	Additionally, UO126 and ODQ inhibited the migration restoring effects of L-arginine in L-NAME-treated cells, suggesting the involvement of cGMP and MAPK pathways in NO-mediated migration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2381	18680102-216	GSPs inhibited L-arginine and 8-Br-cGMP-induced activation of ERK1/2 in A549 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2382	18680102-216	GSPs inhibited L-arginine and 8-Br-cGMP-induced activation of ERK1/2 in A549 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2383	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2384	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2385	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2386	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2387	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2388	18680106-970	Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2389	18680106-971	We have reported previously that apigenin, a naturally occurring nonmutagenic flavonoid, increased wild-type p53 protein expression in the mouse keratinocyte 308 cell line by a mechanism involving p53 protein stabilization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2390	18680106-971	We have reported previously that apigenin, a naturally occurring nonmutagenic flavonoid, increased wild-type p53 protein expression in the mouse keratinocyte 308 cell line by a mechanism involving p53 protein stabilization.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2391	18680106-973	Instead, biosynthetic labeling showed that apigenin increased nascent p53 protein synthesis by enhancing p53 translation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2392	18680106-975	Furthermore, apigenin treatment increased the level of association of the RNA binding protein HuR with endogenous p53 mRNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2393	18680106-975	Furthermore, apigenin treatment increased the level of association of the RNA binding protein HuR with endogenous p53 mRNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2394	18680106-975	Furthermore, apigenin treatment increased the level of association of the RNA binding protein HuR with endogenous p53 mRNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2395	18680106-976	Apigenin treatment also augmented HuR translocation into the cytoplasm.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2396	18680106-979	Overall, these findings indicate that, in addition to modulating p53 protein stability, one of the mechanisms by which apigenin induces p53 protein expression is enhancement of translation through the RNA binding protein HuR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2397	18680106-979	Overall, these findings indicate that, in addition to modulating p53 protein stability, one of the mechanisms by which apigenin induces p53 protein expression is enhancement of translation through the RNA binding protein HuR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2398	18680106-979	Overall, these findings indicate that, in addition to modulating p53 protein stability, one of the mechanisms by which apigenin induces p53 protein expression is enhancement of translation through the RNA binding protein HuR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2399	18680156-264	Immunoblot analysis of signaling molecules, including cyclic-AMP response element binding protein (CREB), mitogen-activated protein kinases (MAPKp44/42; ERK1/2), in area CA1 revealed that thyroxin treatment reversed hypothyroidism-induced reduction of signaling molecules essential for learning and memory, and L-LTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2400	18680156-264	Immunoblot analysis of signaling molecules, including cyclic-AMP response element binding protein (CREB), mitogen-activated protein kinases (MAPKp44/42; ERK1/2), in area CA1 revealed that thyroxin treatment reversed hypothyroidism-induced reduction of signaling molecules essential for learning and memory, and L-LTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2401	18680156-264	Immunoblot analysis of signaling molecules, including cyclic-AMP response element binding protein (CREB), mitogen-activated protein kinases (MAPKp44/42; ERK1/2), in area CA1 revealed that thyroxin treatment reversed hypothyroidism-induced reduction of signaling molecules essential for learning and memory, and L-LTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2402	18680156-264	Immunoblot analysis of signaling molecules, including cyclic-AMP response element binding protein (CREB), mitogen-activated protein kinases (MAPKp44/42; ERK1/2), in area CA1 revealed that thyroxin treatment reversed hypothyroidism-induced reduction of signaling molecules essential for learning and memory, and L-LTP.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2403	18680550-1533	Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis C patients receiving peginterferon alpha-2b plus ribavirin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2404	18680550-1535	Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese genotype 1 CHC patients receiving a 24-week course therapy with peginterferon alpha-2b/ribavirin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2405	18680626-658	We hypothesised that OAT could be a limiting step in glutamine-arginine interconversion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2406	18680626-658	We hypothesised that OAT could be a limiting step in glutamine-arginine interconversion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2407	18680626-659	OAT overexpression decreased plasma and liver ornithine concentrations but did not affect glutamine or arginine homeostasis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2408	18680626-659	OAT overexpression decreased plasma and liver ornithine concentrations but did not affect glutamine or arginine homeostasis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2409	18680626-659	OAT overexpression decreased plasma and liver ornithine concentrations but did not affect glutamine or arginine homeostasis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2410	18680626-660	There was an inverse relationship between ornithine levels and OAT activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2411	18681858-1	In men there is a large interindividual variation of SHBG levels and consequently of testosterone (T) and E(2) levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2412	18682334-364	Bone marrow cells were obtained from 5-day-old Muscovy ducks and cultured with (Group A) No added factors, (B) 30ng/mL soluble RANKL (sRANKL), (C) 30ng/mL sRANKL and 10ng/mL OPG, (D) 10ng/mL OPG, (E) 50ng/mL OPG, (F) 100ng/mL OPG and (G) 30ng/mL sRANKL, 6mmol/L Ca and 3mmol/L P. sRANKL promoted the survival of OCs on day 2, whereas the number of OCs decreased with addition of OPG in a dose-dependent manner.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2413	18682334-364	Bone marrow cells were obtained from 5-day-old Muscovy ducks and cultured with (Group A) No added factors, (B) 30ng/mL soluble RANKL (sRANKL), (C) 30ng/mL sRANKL and 10ng/mL OPG, (D) 10ng/mL OPG, (E) 50ng/mL OPG, (F) 100ng/mL OPG and (G) 30ng/mL sRANKL, 6mmol/L Ca and 3mmol/L P. sRANKL promoted the survival of OCs on day 2, whereas the number of OCs decreased with addition of OPG in a dose-dependent manner.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2414	18682988-518	Over-expression of GDH decreased the yield of ethanol and 2,3-butanediol, meanwhile it increased the concentration of acetic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2415	18682988-518	Over-expression of GDH decreased the yield of ethanol and 2,3-butanediol, meanwhile it increased the concentration of acetic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2416	18682988-518	Over-expression of GDH decreased the yield of ethanol and 2,3-butanediol, meanwhile it increased the concentration of acetic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2417	18683011-1547	Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2418	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2419	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2420	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2421	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2422	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2423	18683188-1093	Furthermore, HA induced dose-dependent elevation of reactive oxygen species (ROS) level in SMCs, and antioxidant vitamin C and Trolox effectively suppressed HA-induced DNA damage and dysregulation of Bcl-2/Bax.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2424	18683221-1122	The adsorption of ovine fibrinogen onto PMA-modified surfaces was reduced relative to unmodified surfaces, and in vitro ovine blood contact through a rocking test revealed marked reductions in platelet deposition and bulk phase platelet activation relative to unmodified TiAl6V4 and polystyrene controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2425	18683225-1127	When the thrombin concentration was higher than 15 U/mL, the gelation could be finished within 1 min and yielded a composite with evenly suspended and distributed PLGA microspheres.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2426	18683233-58	The culture tests using MSCs show that the level of alkaline phosphatase (ALP) activity in the cells cultured on SPV-H increased during the 21-day culture in a medium without Dex and beta-GP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2427	18683233-58	The culture tests using MSCs show that the level of alkaline phosphatase (ALP) activity in the cells cultured on SPV-H increased during the 21-day culture in a medium without Dex and beta-GP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2428	18683233-59	The level was unchanged in MSCs cultured on PV-H. In the case of supplementing Dex and beta-GP to the medium, the level of ALP activity in MSCs cultured on SPV-H was higher than that on PV-H at all time points during the 21-day culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2429	18683244-106	The combined treatment strategy not only decreased ubiquitin-positive aggregation in striatum, alleviated polyglutamine aggregation formation, and reduced striatal volume, but also extended life span in the R6/2 animal model.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2430	18683246-1143	Vasoactive intestinal peptide inhibits toll-like receptor 3-induced nitric oxide production in Schwann cells and subsequent sensory neuronal cell death in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2431	18683252-1154	The GUS and LUC genes were chosen because they can be used as markers for the easy detection of transgenic plants, while histidine tail better enables the isolation of protein expressed in plant tissue.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2432	18683262-1162	Expression was performed in fusion to maltose binding protein using chemically defined minimal medium, followed by a single-step affinity capture and enzymatic cleavage using tobacco etch virus protease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2433	18683263-1164	The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of acetyl-CoA, generated during vanillin production from ferulic acid, to CoA, which is essential for vanillin production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2434	18683263-1164	The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of acetyl-CoA, generated during vanillin production from ferulic acid, to CoA, which is essential for vanillin production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2435	18683263-1164	The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of acetyl-CoA, generated during vanillin production from ferulic acid, to CoA, which is essential for vanillin production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2436	18683263-1164	The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of acetyl-CoA, generated during vanillin production from ferulic acid, to CoA, which is essential for vanillin production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2437	18683263-1167	The gltA amplification of the glyoxylate bypass in the icdA null mutant remarkably increased the production rate of vanillin with a little increase in the amount of vanillin production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2438	18683263-1168	The real synergistic effect of gltA amplification and icdA deletion was observed with use of XAD-2 resin reducing the toxicity of vanillin produced during culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2439	18683263-1168	The real synergistic effect of gltA amplification and icdA deletion was observed with use of XAD-2 resin reducing the toxicity of vanillin produced during culture.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2440	18683889-1688	Treatment of dermal fibroblasts with vitamin D(3) induced expression of BMP-4 (1.2+/-0.2, 1.7+/-0.2, and 1.8+/-0.2 relative fold increase) and BMP-6 (9.1+/-0.3, 23.3+/-2.1, and 30.4+/-3.0 relative fold increase) at 3, 14, and 21 days, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2441	18683889-1688	Treatment of dermal fibroblasts with vitamin D(3) induced expression of BMP-4 (1.2+/-0.2, 1.7+/-0.2, and 1.8+/-0.2 relative fold increase) and BMP-6 (9.1+/-0.3, 23.3+/-2.1, and 30.4+/-3.0 relative fold increase) at 3, 14, and 21 days, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2442	18683889-1689	Vitamin D(3) was also shown to induce the expression of the osteoblast-specific markers, alkaline phosphatase and osteocalcin, in a dose-dependent manner in human dermal fibroblasts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2443	18683889-1689	Vitamin D(3) was also shown to induce the expression of the osteoblast-specific markers, alkaline phosphatase and osteocalcin, in a dose-dependent manner in human dermal fibroblasts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2444	18684212-1656	The aims of this study were: (i) to characterize the basal circadian rhythm of adrenocorticotropin hormone (ACTH) and cortisol in IBS vs healthy controls; (ii) to compare stimulated ACTH, cortisol and noradrenaline responses to a pelvic visceral stressor (sigmoidoscopy) in IBS and controls; and (iii) to correlate neuroendocrine responses with colonic mucosal cytokine expression and symptoms in IBS.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2445	18684212-1656	The aims of this study were: (i) to characterize the basal circadian rhythm of adrenocorticotropin hormone (ACTH) and cortisol in IBS vs healthy controls; (ii) to compare stimulated ACTH, cortisol and noradrenaline responses to a pelvic visceral stressor (sigmoidoscopy) in IBS and controls; and (iii) to correlate neuroendocrine responses with colonic mucosal cytokine expression and symptoms in IBS.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2446	18684212-1657	In Study 1, basal cortisol levels were analysed in 41 IBS and 25 controls using 24-h collections of plasma ACTH and cortisol (q10 min sampling).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2447	18684212-1658	Basal ACTH 0.05), while basal and stimulated plasma cortisol levels were higher in patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2448	18684339-438	A 3-fold increase in the expression of the MnSOD gene was associated with decreased CpG methylation of the analysed promoter region in the vegetarian group compared with the age-matched omnivores group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2449	18684712-650	ALK2 (R206H) with Smad1 or Smad5 induced osteoblastic differentiation that could be inhibited by Smad7 or dorsomorphin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2450	18684712-650	ALK2 (R206H) with Smad1 or Smad5 induced osteoblastic differentiation that could be inhibited by Smad7 or dorsomorphin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2451	18684712-650	ALK2 (R206H) with Smad1 or Smad5 induced osteoblastic differentiation that could be inhibited by Smad7 or dorsomorphin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2452	18684712-650	ALK2 (R206H) with Smad1 or Smad5 induced osteoblastic differentiation that could be inhibited by Smad7 or dorsomorphin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2453	18685817-1575	Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2454	18686014-49	The aim of the present study was to examine whether increased serum Hsp70 levels are related to clinical characteristics and standard laboratory parameters of preeclamptic patients, as well as to markers of inflammation (C-reactive protein), endothelial activation (von Willebrand factor antigen) or endothelial injury (fibronectin), trophoblast debris (cell-free fetal DNA) and oxidative stress (malondialdehyde).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2455	18686014-49	The aim of the present study was to examine whether increased serum Hsp70 levels are related to clinical characteristics and standard laboratory parameters of preeclamptic patients, as well as to markers of inflammation (C-reactive protein), endothelial activation (von Willebrand factor antigen) or endothelial injury (fibronectin), trophoblast debris (cell-free fetal DNA) and oxidative stress (malondialdehyde).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2456	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2457	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2458	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2459	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2460	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2461	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2462	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2463	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2464	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2465	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2466	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2467	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2468	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2469	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2470	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2471	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2472	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2473	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2474	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2475	18686014-50	Furthermore, serum levels of blood urea nitrogen, creatinine, bilirubin and CRP, serum alanine aminotransferase and lactate dehydrogenase (LDH) activities, as well as plasma levels of VWF :Ag, fibronectin, cell-free fetal DNA and malondialdehyde were also significantly higher in preeclamptic patients than in normotensive, healthy pregnant women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2476	18686014-51	In preeclamptic patients, serum Hsp70 levels showed significant correlations with serum CRP levels (Spearman R = 0.32, p = 0.010), serum aspartate aminotransferase (R = 0.32, p = 0.008) and LDH (0.001), as well as with plasma malondialdehyde levels (R = 0.25, p = 0.043).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2477	18686014-51	In preeclamptic patients, serum Hsp70 levels showed significant correlations with serum CRP levels (Spearman R = 0.32, p = 0.010), serum aspartate aminotransferase (R = 0.32, p = 0.008) and LDH (0.001), as well as with plasma malondialdehyde levels (R = 0.25, p = 0.043).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2478	18686014-51	In preeclamptic patients, serum Hsp70 levels showed significant correlations with serum CRP levels (Spearman R = 0.32, p = 0.010), serum aspartate aminotransferase (R = 0.32, p = 0.008) and LDH (0.001), as well as with plasma malondialdehyde levels (R = 0.25, p = 0.043).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2479	18686014-51	In preeclamptic patients, serum Hsp70 levels showed significant correlations with serum CRP levels (Spearman R = 0.32, p = 0.010), serum aspartate aminotransferase (R = 0.32, p = 0.008) and LDH (0.001), as well as with plasma malondialdehyde levels (R = 0.25, p = 0.043).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2480	18686047-887	In an effort to identify agents which enhance the activity of oligos and which possess less toxicity than traditionally employed chemotherapeutics, Rapamycin, an immunosuppressive agent known to regulate tumor growth and signal transduction mediated by the mTOR receptor, is compared to paclitaxel in combination therapy employing monospecific or bispecific oligos.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2481	18686047-887	In an effort to identify agents which enhance the activity of oligos and which possess less toxicity than traditionally employed chemotherapeutics, Rapamycin, an immunosuppressive agent known to regulate tumor growth and signal transduction mediated by the mTOR receptor, is compared to paclitaxel in combination therapy employing monospecific or bispecific oligos.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2482	18686136-131	In this study we investigated the superoxide radicals scavenging effect and xanthine oxidase inhibitory activity by magnesium lithospermate B, which was originally isolated from the roots of Salvia miltiorrhiza (also named Danshen or Dansham), an important herb in Oriental medicine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2483	18686136-131	In this study we investigated the superoxide radicals scavenging effect and xanthine oxidase inhibitory activity by magnesium lithospermate B, which was originally isolated from the roots of Salvia miltiorrhiza (also named Danshen or Dansham), an important herb in Oriental medicine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2484	18686136-132	Superoxide radicals were generated both in beta-NADH/PMS system and xanthine/xanthine oxidase system.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2485	18686136-132	Superoxide radicals were generated both in beta-NADH/PMS system and xanthine/xanthine oxidase system.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2486	18686136-132	Superoxide radicals were generated both in beta-NADH/PMS system and xanthine/xanthine oxidase system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2487	18686136-132	Superoxide radicals were generated both in beta-NADH/PMS system and xanthine/xanthine oxidase system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2488	18686136-133	Further study suggested that magnesium lithospermate B can directly inhibit xanthine oxidase and exhibits competitive inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2489	18686136-134	In addition, magnesium lithospermate B significantly protected HL-60 cells from superoxide radicals-induced apoptosis in the xanthine/xanthine oxidase reactions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2490	18686136-134	In addition, magnesium lithospermate B significantly protected HL-60 cells from superoxide radicals-induced apoptosis in the xanthine/xanthine oxidase reactions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2491	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2492	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2493	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2494	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2495	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2496	18686165-403	Four different molecules contain galactofuranose in A. fumigatus: (i) the galactomannan present in the alkali soluble and insoluble fraction of the cell wall (ii) N- and O glycan moieties of secreted glycoproteins (iii) a GPI-anchored lipophosphogalactomannan and (iv) several sphingolipids also anchored to the membrane by an inositol phosphoceramide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2497	18687549-1315	The estimated CRP level and the IMCL content in these patients were correlated with body mass index, percentage of body fat, other measures of abdominal obesity, serum lipoproteins, fasting and post-oral glucose load serum insulin levels and other surrogate markers of insulin resistance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2498	18687549-1315	The estimated CRP level and the IMCL content in these patients were correlated with body mass index, percentage of body fat, other measures of abdominal obesity, serum lipoproteins, fasting and post-oral glucose load serum insulin levels and other surrogate markers of insulin resistance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2499	18687985-1621	Studies suggest that DKK1 activation in osteoblasts is the underlying cause of glucocorticoid- and estrogen deficiency-mediated osteoporosis, and at least partially underlies the teratogenic effects of thalidomide on limb development.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2500	18688040-30	The IL-13-induced up-regulation of RhoA was inhibited by leflunomide, an inhibitor of signal transducer and activator of transcription 6 (STAT6).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2501	18688040-30	The IL-13-induced up-regulation of RhoA was inhibited by leflunomide, an inhibitor of signal transducer and activator of transcription 6 (STAT6).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2502	18688040-30	The IL-13-induced up-regulation of RhoA was inhibited by leflunomide, an inhibitor of signal transducer and activator of transcription 6 (STAT6).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2503	18688042-1313	The goal of this study was to determine the mechanisms by which 17beta-estradiol induces MUC5B gene expression in airway epithelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2504	18688042-1314	Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2505	18688042-1314	Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2506	18688042-1314	Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2507	18688696-558	We here show that calumenin in the presence of Ca(2+) binds to TSP1 with a dissociation constant K (d) around 0.4 muM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2508	18688816-657	It represents transition in sulfur-deprived conditions, known to lead to H2 production in Chlamydomonas reinhardtii, and the two main processes then induced which are an over-accumulation of intracellular starch and a progressive reduction of PSII activity for anoxia achievement.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2509	18689429-1187	We examined whether aldosterone produced locally in the brain may contribute to the activation of mineralocorticoid receptors in the CNS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2510	18690415-286	Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2511	18690549-796	Rat dicarboxylate transporter (SDCT1), expressed in renal tubular epithelial cells, plays a key role in regulating blood and urinary citrate level by reabsorbing citrate from the lumen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2512	18690792-145	However, as opposed to exogenous HS, the continuous use of FGF-2 during in vitro differentiation completely blocked rMSC mineralization.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2513	18690792-146	We show that the effects of both FGF-2 and HS are mediated through FGF receptor 1 (FGFR1) and that inhibition of signaling through this receptor arrests cell growth, resulting in the cells being unable to reach the critical density necessary to induce differentiation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2514	18690792-146	We show that the effects of both FGF-2 and HS are mediated through FGF receptor 1 (FGFR1) and that inhibition of signaling through this receptor arrests cell growth, resulting in the cells being unable to reach the critical density necessary to induce differentiation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2515	18690792-146	We show that the effects of both FGF-2 and HS are mediated through FGF receptor 1 (FGFR1) and that inhibition of signaling through this receptor arrests cell growth, resulting in the cells being unable to reach the critical density necessary to induce differentiation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2516	18691156-926	Two related polytopic membrane proteins of the major facilitator family, NarK and NarU, catalyse nitrate uptake, nitrite export and nitrite uptake across the Escherichia coli cytoplasmic membrane by an unknown mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2517	18691156-926	Two related polytopic membrane proteins of the major facilitator family, NarK and NarU, catalyse nitrate uptake, nitrite export and nitrite uptake across the Escherichia coli cytoplasmic membrane by an unknown mechanism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2518	18691156-926	Two related polytopic membrane proteins of the major facilitator family, NarK and NarU, catalyse nitrate uptake, nitrite export and nitrite uptake across the Escherichia coli cytoplasmic membrane by an unknown mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2519	18691343-1073	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2520	18691343-1073	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2521	18691343-1073	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2522	18691343-1073	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2523	18691603-1685	This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB2) cannabinoid receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2524	18691603-1685	This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB2) cannabinoid receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2525	18691603-1685	This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB2) cannabinoid receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2526	18691603-1685	This signaling system is engaged by the active component of cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), which exerts its pharmacological effects by activation of G protein-coupled type-1 (CB1) and type-2 (CB2) cannabinoid receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2527	18691715-1342	Homocysteine stimulates antioxidant response element-mediated expression of glutamate-cysteine ligase in mouse macrophages.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2528	18691715-1343	The current study investigated whether homocysteine induces transcription of glutamate-cysteine ligase (Gcl), via ARE driven gene expression in mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2529	18691715-1343	The current study investigated whether homocysteine induces transcription of glutamate-cysteine ligase (Gcl), via ARE driven gene expression in mouse macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2530	18691715-1344	Treatment of mouse macrophages with d-/l-homocysteine (50microM) induced depletion of intracellular glutathione and a compensatory increase in Gcl activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2531	18691715-1344	Treatment of mouse macrophages with d-/l-homocysteine (50microM) induced depletion of intracellular glutathione and a compensatory increase in Gcl activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2532	18691715-1345	Real-time RT-PCR revealed increased mRNA-expression of the catalytic subunit of Gcl (Gclc) after treatment with homocysteine, and this occurred via increased transcription as demonstrated with luciferase promoter reporter constructs for Gclc.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2533	18691757-12	Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2534	18692155-570	Only EGF activated ERK signaling and up-regulated early gene expression, while DHT triggered the expression of classical AR-responsive genes with the exception of the EGF-induced PSA transcript in A549 cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2535	18692155-570	Only EGF activated ERK signaling and up-regulated early gene expression, while DHT triggered the expression of classical AR-responsive genes with the exception of the EGF-induced PSA transcript in A549 cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2536	18692155-570	Only EGF activated ERK signaling and up-regulated early gene expression, while DHT triggered the expression of classical AR-responsive genes with the exception of the EGF-induced PSA transcript in A549 cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2537	18692155-571	DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells, while in LNCaP cells each mitogen increased only CD1 protein expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2538	18692155-571	DHT and EGF up-regulated cyclinD1 (CD1) at both mRNA and protein levels in A549 cells, while in LNCaP cells each mitogen increased only CD1 protein expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2539	18692592-835	High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2540	18692592-835	High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2541	18692592-836	The influence of the prenylation status of Ras on the observed changes in endothelial cell growth under high glucose conditions has not previously been examined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2542	18692599-393	Calcineurin inhibitors (CsA, FK-506 and pimecrolimus) inhibited NO production and iNOS expression in a concentration-dependent manner, CsA being more potent than FK-506 and pimecrolimus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2543	18692599-393	Calcineurin inhibitors (CsA, FK-506 and pimecrolimus) inhibited NO production and iNOS expression in a concentration-dependent manner, CsA being more potent than FK-506 and pimecrolimus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2544	18692599-395	In conclusion, the results suggest that calcineurin inhibitors cyclosporin A, tacrolimus (FK-506) and pimecrolimus inhibit iNOS expression and NO production in response to inflammatory stimuli by enhancing the decay of iNOS mRNA by a 3'UTR-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2545	18692599-395	In conclusion, the results suggest that calcineurin inhibitors cyclosporin A, tacrolimus (FK-506) and pimecrolimus inhibit iNOS expression and NO production in response to inflammatory stimuli by enhancing the decay of iNOS mRNA by a 3'UTR-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2546	18692599-395	In conclusion, the results suggest that calcineurin inhibitors cyclosporin A, tacrolimus (FK-506) and pimecrolimus inhibit iNOS expression and NO production in response to inflammatory stimuli by enhancing the decay of iNOS mRNA by a 3'UTR-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2547	18692599-395	In conclusion, the results suggest that calcineurin inhibitors cyclosporin A, tacrolimus (FK-506) and pimecrolimus inhibit iNOS expression and NO production in response to inflammatory stimuli by enhancing the decay of iNOS mRNA by a 3'UTR-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2548	18692849-615	An increased activity of ATP-binding cassette transporter A1 (ABCA1) and ABCG5/G8 heterodimer has been proposed as a mechanism underlying the hypocholesterolaemic effect of phytosterols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2549	18692849-615	An increased activity of ATP-binding cassette transporter A1 (ABCA1) and ABCG5/G8 heterodimer has been proposed as a mechanism underlying the hypocholesterolaemic effect of phytosterols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2550	18692896-648	In sum, copper exposure lowered TOSC, a result that at least in part can be related to lowering of antioxidant enzymes like CAT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2551	18693051-793	Accumulation of glucose in PA was increased by insulin at 10nM and by IGF-I at 1 nM and 10nM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2552	18693051-793	Accumulation of glucose in PA was increased by insulin at 10nM and by IGF-I at 1 nM and 10nM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2553	18693094-1555	Glucagon is important to this response because it increases glutamine uptake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2554	18693095-825	It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2555	18693095-825	It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2556	18693100-829	Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2557	18693100-829	Biological testing of the compound demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and restoring the insulin levels in streptozotocin-induced diabetic rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2558	18693294-868	The activity of guanylyl cyclase was determined by the amount of cGMP generated in responses to sodium nitroprusside (SNP) or ANP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2559	18694296-116	Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2560	18694296-116	Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2561	18694296-116	Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2562	18694296-116	Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2563	18694429-208	Immunolocalization of androgen receptor in the boar epididymis: the effect of GnRH agonist deslorelin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2564	18694845-560	E(2) increased the expression of caveolin-1 and caveolin-2 mRNA and proteins, but pre-treatment with ICI 182,780 (an estrogen receptor (ER) antagonist) inhibited E(2)-induced increase in caveolin-1 and caveolin-2 proteins expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2565	18694845-560	E(2) increased the expression of caveolin-1 and caveolin-2 mRNA and proteins, but pre-treatment with ICI 182,780 (an estrogen receptor (ER) antagonist) inhibited E(2)-induced increase in caveolin-1 and caveolin-2 proteins expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2566	18694845-561	Phospho-caveolin-1 was significantly blocked by ICI 182,780 or pyrazolopyrimidine 2 (PP2 ; a Src-kinase inhibitor).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2567	18694845-561	Phospho-caveolin-1 was significantly blocked by ICI 182,780 or pyrazolopyrimidine 2 (PP2 ; a Src-kinase inhibitor).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2568	18694845-562	LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying ((3)H)-thymidine incorporation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2569	18694845-562	LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying ((3)H)-thymidine incorporation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2570	18694845-562	LY 294002 (a PI3K inhibitor) or PD 98059 (an ERK1/2 inhibitor) prevented E(2)-induced increase in caveolin-1 expression and the accompanying ((3)H)-thymidine incorporation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2571	18694845-563	Furthermore, inhibition of caveolin-1 expression using a caveolin-1 siRNA significantly attenuated E(2)-induced up-regulation of proto-oncogenes, cell cycle regulatory proteins, ((3)H)-thymidine incorporation, overall cell number, and percent of the cell population in S phase, while mediating a concomitant increase in the G0/G1 population.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2572	18694847-1230	Almost all Akt kinase that translocates to the nucleus shows a marked phosphorylation on serine 473.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2573	18695846-1364	During the early response in AR, histamine has been found to be the most abundant mediator and it is associated with many symptoms of this disease mediated through the histamine H1 receptor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2574	18695937-929	During the incubation of L-phenylalanine with para-hydroquinones using laccase as biocatalyst, one or two main products were formed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2575	18696104-1256	The effect on activation voltage but not that on amplitude was absent when expressing a cAMP-insensitive mutant (HCN2R/E), while a C-terminal truncated form of HCN2 (HCN2DeltaCx) exhibited only the voltage dependent but not the amplitude effect of erbstatin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2576	18696104-1257	Thus, the action of erbstatin on the activation relation and current amplitude are distinct and separable in newborn myocytes, and the effect on activation voltage depends on the cAMP status of HCN2 channels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2577	18696104-1257	Thus, the action of erbstatin on the activation relation and current amplitude are distinct and separable in newborn myocytes, and the effect on activation voltage depends on the cAMP status of HCN2 channels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2578	18696104-1258	In contrast to newborn myocytes, erbstatin had no effect on HCN2 under control conditions in adult myocytes but induced a negative shift with no change in amplitude when saturated cAMP was added to the pipette solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2579	18696104-1258	In contrast to newborn myocytes, erbstatin had no effect on HCN2 under control conditions in adult myocytes but induced a negative shift with no change in amplitude when saturated cAMP was added to the pipette solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2580	18696216-140	Arginine-specific ADP-ribosyltransferase (Art) catalyzes the mono-ADP-ribosylation, in which it transfers a single ADP-ribose moiety of NAD to the arginine residue(s) of target proteins, and may regulate the function of the proteins or peptides in cellular processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2581	18696216-140	Arginine-specific ADP-ribosyltransferase (Art) catalyzes the mono-ADP-ribosylation, in which it transfers a single ADP-ribose moiety of NAD to the arginine residue(s) of target proteins, and may regulate the function of the proteins or peptides in cellular processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2582	18696216-140	Arginine-specific ADP-ribosyltransferase (Art) catalyzes the mono-ADP-ribosylation, in which it transfers a single ADP-ribose moiety of NAD to the arginine residue(s) of target proteins, and may regulate the function of the proteins or peptides in cellular processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2583	18696261-327	A D-amino acid oxidase gene (dao) was ligated with the P(Hase) and cloned into pGEMKT to constitutively express protein of DAAO without the use of any inducer such as isopropyl beta-D-1-thiogalactopyranoside which is poisonous to the cells and environment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2584	18696261-327	A D-amino acid oxidase gene (dao) was ligated with the P(Hase) and cloned into pGEMKT to constitutively express protein of DAAO without the use of any inducer such as isopropyl beta-D-1-thiogalactopyranoside which is poisonous to the cells and environment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2585	18698091-1558	In response to a cholesterol-containing atherogenic diet, C57BL/6J mice significantly increased expression of UCP2 in the aorta, while mice lacking UCP2, in the absence of any other genetic modification, displayed significant endothelial dysfunction following the atherogenic diet.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2586	18698091-1559	These data establish that in the vasculature UCP2 functions as an adaptive antioxidant defense to protect against the development of atherosclerosis in response to a fat and cholesterol diet.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2587	18698130-1197	To confirm that mouse DMP1-PG possesses a single GAG chain attached to Ser (89), we substituted Ser (89) by Gly (89).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2588	18698132-1603	PC-1 is the primary generator of pyrophosphate in osteoblastic cells; therefore, regulated expression of PC-1 by FGFs may be a principal mechanism by which FGF signaling affects bone mineralization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2589	18698132-1603	PC-1 is the primary generator of pyrophosphate in osteoblastic cells; therefore, regulated expression of PC-1 by FGFs may be a principal mechanism by which FGF signaling affects bone mineralization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2590	18698333-75	In analogy to the reduction of Ca(2+) oscillation frequency, the blockers impaired HCEC contraction, NF-kappaB activation, and VCAM-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2591	18698333-76	Cisternal SAH-CSF induces cytosolic Ca(2+) oscillations in HCEC that results in cellular constriction, NF-kappaB activation, and VCAM-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2592	18698636-309	For proof of principle, we use L-lactate and D-lactate as representative pair of enantiomers, L-lactate oxidase as stereospecific signal generator, and cascade blue hydrazide as reactive signal amplifier to capture the produced pyruvate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2593	18698636-309	For proof of principle, we use L-lactate and D-lactate as representative pair of enantiomers, L-lactate oxidase as stereospecific signal generator, and cascade blue hydrazide as reactive signal amplifier to capture the produced pyruvate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2594	18698636-309	For proof of principle, we use L-lactate and D-lactate as representative pair of enantiomers, L-lactate oxidase as stereospecific signal generator, and cascade blue hydrazide as reactive signal amplifier to capture the produced pyruvate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2595	18698648-318	Escherichia coli strain PC09 (DeltaxylB, cAMP-independent CRP (crp *) mutant) expressing an NADPH-dependent xylose reductase from Candida boidinii (CbXR) was previously reported to produce xylitol from xylose while metabolizing glucose (Cirino et al.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2596	18698648-318	Escherichia coli strain PC09 (DeltaxylB, cAMP-independent CRP (crp *) mutant) expressing an NADPH-dependent xylose reductase from Candida boidinii (CbXR) was previously reported to produce xylitol from xylose while metabolizing glucose (Cirino et al.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2597	18698648-319	Studies in which the expression of CbXR or a xylose transporter was increased suggest that enzyme activity and xylose transport are not limiting xylitol production in PC09.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2598	18698648-321	For the case of xylose-proton symport, omitting the Zwf (glucose-6-phosphate dehydrogenase) or PntAB (membrane-bound transhydrogenase) reactions or TCA cycle activity from the model reduces the theoretical maximum yield from 9.2 to 8.8, 3.6, and 8.0 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2599	18698648-321	For the case of xylose-proton symport, omitting the Zwf (glucose-6-phosphate dehydrogenase) or PntAB (membrane-bound transhydrogenase) reactions or TCA cycle activity from the model reduces the theoretical maximum yield from 9.2 to 8.8, 3.6, and 8.0 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2600	18698648-322	Experimentally, deleting pgi (encoding phosphoglucose isomerase) from strain PC09 improves the yield from 3.4 to 4.0 mol xylitol (mol glucose)(-1), while deleting either or both E. coli transhydrogenases (sthA and pntA) has no significant effect on the measured yield.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2601	18698648-322	Experimentally, deleting pgi (encoding phosphoglucose isomerase) from strain PC09 improves the yield from 3.4 to 4.0 mol xylitol (mol glucose)(-1), while deleting either or both E. coli transhydrogenases (sthA and pntA) has no significant effect on the measured yield.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2602	18698648-322	Experimentally, deleting pgi (encoding phosphoglucose isomerase) from strain PC09 improves the yield from 3.4 to 4.0 mol xylitol (mol glucose)(-1), while deleting either or both E. coli transhydrogenases (sthA and pntA) has no significant effect on the measured yield.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2603	18698648-322	Experimentally, deleting pgi (encoding phosphoglucose isomerase) from strain PC09 improves the yield from 3.4 to 4.0 mol xylitol (mol glucose)(-1), while deleting either or both E. coli transhydrogenases (sthA and pntA) has no significant effect on the measured yield.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2604	18698648-323	Deleting either zwf or sucC (TCA cycle) significantly reduces the yield from 3.4 to 2.0 and 2.3 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2605	18698648-323	Deleting either zwf or sucC (TCA cycle) significantly reduces the yield from 3.4 to 2.0 and 2.3 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2606	18698648-323	Deleting either zwf or sucC (TCA cycle) significantly reduces the yield from 3.4 to 2.0 and 2.3 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2607	18698648-323	Deleting either zwf or sucC (TCA cycle) significantly reduces the yield from 3.4 to 2.0 and 2.3 mol xylitol (mol glucose)(-1), respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2608	18698649-324	In the process studied, the enzyme cellobiose dehydrogenase (CDH) oxidizes lactose at the C-1 position of the reducing sugar moiety to lactobionolactone, which spontaneously hydrolyzes to lactobionic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2609	18698649-324	In the process studied, the enzyme cellobiose dehydrogenase (CDH) oxidizes lactose at the C-1 position of the reducing sugar moiety to lactobionolactone, which spontaneously hydrolyzes to lactobionic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2610	18698649-326	Oxygen served as the terminal electron acceptor of the reaction and was fully reduced to water by laccase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2611	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2612	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2613	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2614	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2615	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2616	18699724-117	Immunocytochemical localization of cell surface markers like SSEA-3, SSEA-4, TRA-1-60, and TRA-1-81, staining for alkaline phosphatase and reverse transcriptase polymerase chain reaction (RT-PCR) analysis of pluripotency state markers viz.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2617	18699774-1334	Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2618	18699774-1334	Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2619	18699774-1334	Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2620	18699774-1334	Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2621	18699774-1335	SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2622	18699774-1335	SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2623	18699774-1335	SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2624	18699774-1335	SM (solamargine), a major steroidal alkaloid glycoside purified from Solanum incanum, triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2625	18700056-1486	Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2626	18700056-1486	Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2627	18700056-1486	Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2628	18700056-1486	Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2629	18700057-534	The effects of Ipt were reversed by the mitochondrial KATP blocker, 5-hydroxydecanoate, indicating that mitochondrial KATP channels participate in the regulation of astrocyte activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2630	18700809-895	The cell proliferation, the up-regulation of pS2, and the down-regulation of ERalpha and ERbeta gene expressions induced by the racemate and enantiomers of o,p'-DDT were all reversed by cotreatment with 10(-6) mol/L ICI 182,780.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2631	18700809-895	The cell proliferation, the up-regulation of pS2, and the down-regulation of ERalpha and ERbeta gene expressions induced by the racemate and enantiomers of o,p'-DDT were all reversed by cotreatment with 10(-6) mol/L ICI 182,780.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2632	18700818-411	While bass in all diazinon treatment groups had significantly inhibited brain AChE activity, only the medium and high treatment groups showed a dose- and time-dependent increase in time to capture prey.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2633	18701427-85	The aim of this phase 0 study was to investigate whether gemcitabine passes the blood-tumor barrier, and is phosphorylated in the tumor by deoxycytidine kinase (dCK) to gemcitabine nucleotides in order to enable radiosensitization, and whether it is deaminated by deoxycytidine deaminase (dCDA) to dFdU.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2634	18701427-85	The aim of this phase 0 study was to investigate whether gemcitabine passes the blood-tumor barrier, and is phosphorylated in the tumor by deoxycytidine kinase (dCK) to gemcitabine nucleotides in order to enable radiosensitization, and whether it is deaminated by deoxycytidine deaminase (dCDA) to dFdU.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2635	18701806-1254	The proline mutation at amino acid location 164 significantly reduced the initial hydrolysis of either the amelogenins in solution or the proteins bound on HAP, which was confirmed by amelogenin oligopeptide assays.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2636	18701809-777	In conclusion, dentin mineralization in a corrected phosphate and vitamin D environment compensates the adverse effect of PHEX mutation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2637	18701809-777	In conclusion, dentin mineralization in a corrected phosphate and vitamin D environment compensates the adverse effect of PHEX mutation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2638	18702173-1549	The considered biological model system consisted of a coating antibody (goat IgG), bovine serum albumin (BSA) as blocking agent, and a complementary antibody labelled with FITC (anti-goat IgG).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2639	18702173-1549	The considered biological model system consisted of a coating antibody (goat IgG), bovine serum albumin (BSA) as blocking agent, and a complementary antibody labelled with FITC (anti-goat IgG).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2640	18702613-201	Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2641	18702613-201	Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2642	18702613-203	Collectively, these results illustrate the phenomenon of beta-cell desensitization by amino acids, indicating that prolonged exposure to alanine can induce reversible alterations to metabolic flux, Ca(2+) handling and insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2643	18702613-203	Collectively, these results illustrate the phenomenon of beta-cell desensitization by amino acids, indicating that prolonged exposure to alanine can induce reversible alterations to metabolic flux, Ca(2+) handling and insulin secretion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2644	18702682-263	Acylation-stimulating protein (ASP) has been shown to positively stimulate fatty acid esterification and glucose uptake in adipocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2645	18703100-623	Using a set of experiments aimed at manipulate a putative l-glutamate/NMDA/NO signal transduction pathway, we have demonstrated, by quantitative real-time PCR, that NMDA enhances the expression of GnRH mRNA in a dose-response manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2646	18703100-623	Using a set of experiments aimed at manipulate a putative l-glutamate/NMDA/NO signal transduction pathway, we have demonstrated, by quantitative real-time PCR, that NMDA enhances the expression of GnRH mRNA in a dose-response manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2647	18703333-1701	Reaction parameters for the production of XOS from corncob using endoxylanase from Aspergillus oryzae MTCC 5154 were optimized and an XOS yield of 10.2+/-0.14 mg ml(-1) corresponding to 81+/-3.9% with 73.5% xylobiose was obtained.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2648	18703532-1538	Cilostazol inhibits cytokine-induced nuclear factor-kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2649	18703532-1539	Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A, thereby inhibiting platelet aggregation and inducing peripheral vasodilation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2650	18703532-1539	Cilostazol is a selective inhibitor of phosphodiesterase 3 that increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A, thereby inhibiting platelet aggregation and inducing peripheral vasodilation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2651	18703532-1540	We hypothesized that cilostazol may prevent inflammatory cytokine induced-nuclear factor (NF)-kappaB activation by activating AMP-activated protein kinase (AMPK) in vascular endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2652	18703532-1540	We hypothesized that cilostazol may prevent inflammatory cytokine induced-nuclear factor (NF)-kappaB activation by activating AMP-activated protein kinase (AMPK) in vascular endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2653	18703622-1294	Serum estradiol (E2) levels were not altered at any time point after IGF-I, demonstrating that the increased KiSS-1 expression observed was not caused by an elevation in E2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2654	18703794-1209	A2aR stimulation inhibits HA fragment-induced pro-fibrotic genes TNF-alpha, keratinocyte chemoattractant (KC), macrophage inflammatory protein (MIP)-2, and MIP-1alpha while simultaneously synergizing with hyaluronan fragments to up-regulate the TH1 cytokine IL-12.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2655	18703794-1209	A2aR stimulation inhibits HA fragment-induced pro-fibrotic genes TNF-alpha, keratinocyte chemoattractant (KC), macrophage inflammatory protein (MIP)-2, and MIP-1alpha while simultaneously synergizing with hyaluronan fragments to up-regulate the TH1 cytokine IL-12.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2656	18703794-1209	A2aR stimulation inhibits HA fragment-induced pro-fibrotic genes TNF-alpha, keratinocyte chemoattractant (KC), macrophage inflammatory protein (MIP)-2, and MIP-1alpha while simultaneously synergizing with hyaluronan fragments to up-regulate the TH1 cytokine IL-12.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2657	18703795-1210	In addition, treatment of primary mouse lung fibroblasts with ADMA stimulated arginase activity and collagen formation in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2658	18703795-1211	These data support the idea that ADMA may play a role in airway diseases, including asthma and pulmonary fibrosis, through NOS inhibition and enhancement of arginase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2659	18703795-1211	These data support the idea that ADMA may play a role in airway diseases, including asthma and pulmonary fibrosis, through NOS inhibition and enhancement of arginase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2660	18703867-1272	Osteopontin (OPN) inhibits the growth of calcium oxalate monohydrate (COM) and other crystal phases in a phosphorylation-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2661	18703992-1333	Prostaglandins D2, E2, and F2alpha were increased in the tissues from mouse pups exposed to >95% O2 at 7 d indicating a differential expression of cyclooxygenase-2 products.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2662	18704001-1340	Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2663	18704001-1341	Glucose stimulated insulin secretion (GSIS) was lower in the Glu group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2664	18704095-238	These data confirm that endogenous miR-34a regulates GRM7 levels and supports the notion that miR-34a contributes to the effects of lithium and VPA on GRM7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2665	18704096-1413	These results confirm the therapeutic potential of mGluR5 blockade on motor symptoms induced by reduced striatal dopamine function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2666	18704096-1414	Further, they demonstrate that mGluR5 blockade may also have beneficial effects on cognitive deficits induced by dopamine depletion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2667	18704103-600	Here, we found that the addition of glucocorticoids, such as dexamethasone and cortisol, to cultured human keratinocytes increased their TLR2 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2668	18704103-600	Here, we found that the addition of glucocorticoids, such as dexamethasone and cortisol, to cultured human keratinocytes increased their TLR2 gene expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2669	18704103-601	Gene expression of mitogen-activated protein kinase (MAPK) phosphatase-1 was also increased by the addition of dexamethasone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2670	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2671	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2672	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2673	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2674	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2675	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2676	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2677	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2678	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2679	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2680	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2681	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2682	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2683	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2684	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2685	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2686	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2687	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2688	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2689	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2690	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2691	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2692	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2693	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2694	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2695	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2696	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2697	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2698	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2699	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2700	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2701	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2702	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2703	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2704	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2705	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2706	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2707	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2708	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2709	18704264-1595	Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), gamma glutamyl transpeptidase (GGT), 5'nucleotidase (5'ND) and lactate dehydrogenase (LDH) with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin E and vitamin C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2710	18704417-141	Achieving CCgR within 12 months and maintaining it without an increase in BCR-ABL transcripts might indicate that low-dose imatinib therapy can produce acceptable outcomes without excess toxicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2711	18704417-141	Achieving CCgR within 12 months and maintaining it without an increase in BCR-ABL transcripts might indicate that low-dose imatinib therapy can produce acceptable outcomes without excess toxicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2712	18704487-89	Rac1 (-/-) platelets displayed defective thrombus formation on collagen under flow conditions which could be fully restored by co-infusion of ADP and the TxA(2) analog U46619, indicating that impaired GPVI-, but not G-protein signaling, was responsible for the observed defect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2713	18704487-89	Rac1 (-/-) platelets displayed defective thrombus formation on collagen under flow conditions which could be fully restored by co-infusion of ADP and the TxA(2) analog U46619, indicating that impaired GPVI-, but not G-protein signaling, was responsible for the observed defect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2714	18704543-120	LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2715	18704651-196	Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2716	18704651-196	Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2717	18704653-197	Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2718	18704653-197	Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2719	18704653-198	To explore the possibility of controlling cell interaction with biomaterials, tricalcium phosphate scaffolds were modified using the enzyme tissue transglutaminase (tTgase) in conjunction with fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2720	18704653-198	To explore the possibility of controlling cell interaction with biomaterials, tricalcium phosphate scaffolds were modified using the enzyme tissue transglutaminase (tTgase) in conjunction with fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2721	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2722	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2723	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2724	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2725	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2726	18704766-300	Four MPTP monkeys received L-DOPA/Benserazide plus CI-1041 an NMDA antagonist selective for NR1/NR2B and four were treated with L-DOPA/Benserazide plus a small dose of cabergoline ; one monkey of each group developed mild dyskinesias at the end of treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2727	18704766-304	Hence, MPTP lesion, L-DOPA treatment and prevention of LID with CI-1041 and cabergoline, or reduction with Ro 61-8048 were associated with modulation of NR2B/NMDA glutamate receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2728	18704766-304	Hence, MPTP lesion, L-DOPA treatment and prevention of LID with CI-1041 and cabergoline, or reduction with Ro 61-8048 were associated with modulation of NR2B/NMDA glutamate receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2729	18704766-304	Hence, MPTP lesion, L-DOPA treatment and prevention of LID with CI-1041 and cabergoline, or reduction with Ro 61-8048 were associated with modulation of NR2B/NMDA glutamate receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2730	18704940-430	MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase), a three-domain bacterial protein, catalyses a highly specific incorporation of D-glutamate to the cytoplasmic intermediate UDP-N-acetyl-muramoyl-L-alanine (UMA) utilizing ATP hydrolysis to ADP and P(i).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2731	18704940-431	On the basis of structural studies of MurD complexes, a stepwise catalytic mechanism was proposed that commences with a formation of the acyl-phosphate intermediate, followed by a nucleophilic attack of D-glutamate that, through the formation of a tetrahedral reaction intermediate and subsequent phosphate dissociation, affords the final product, UDP-N-acetyl-muramoyl-L-alanine-D-glutamate (UMAG).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2732	18704946-1065	Although the overall amino acid identity between SERTs and the LeuT(Aa) is only 17%, it increases to above 50% in the first shell of the putative 5-HT binding site, allowing de novo computational docking of tryptamine derivatives in atomic detail.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2733	18704953-1278	Mal-sCT, prepared by conjugating sCT via thio-ether bonds with aqueous-soluble palmitic acid derivative at Cys 1 and Cys 7, was reacted with mPEG-succinimide (mPEG-Suc, 5 kDa).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2734	18704953-1278	Mal-sCT, prepared by conjugating sCT via thio-ether bonds with aqueous-soluble palmitic acid derivative at Cys 1 and Cys 7, was reacted with mPEG-succinimide (mPEG-Suc, 5 kDa).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2735	18704953-1278	Mal-sCT, prepared by conjugating sCT via thio-ether bonds with aqueous-soluble palmitic acid derivative at Cys 1 and Cys 7, was reacted with mPEG-succinimide (mPEG-Suc, 5 kDa).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2736	18704955-1137	Our findings suggest that GLP-1 substituted with a PEG of an appropriate Mw at Lys (34) could be used as a promising type 2 anti-diabetic agent to timely control postprandial glucose levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2737	18706130-1404	The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2738	18706695-1298	Phosphatase activity was also inhibited for all the soils treated with triclosan (from 0.1 to 50mg/kg dry soil), but a declining inhibition was observed after 2 days of incubation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2739	18706940-826	The magnitude of autophagosome formation is tightly regulated by intracellular and extracellular amino acid concentrations and ATP levels via signaling pathways that include the nutrient sensing kinase TOR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2740	18707755-1088	Normoglycemic (4.72 mmol/L), moderate (11.1 mmol/L) or high grade (16.7 mmol/L) glucose clamps were maintained for 6 hours by infusion of glucose, insulin and somatostatin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2741	18707755-1088	Normoglycemic (4.72 mmol/L), moderate (11.1 mmol/L) or high grade (16.7 mmol/L) glucose clamps were maintained for 6 hours by infusion of glucose, insulin and somatostatin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2742	18707755-1088	Normoglycemic (4.72 mmol/L), moderate (11.1 mmol/L) or high grade (16.7 mmol/L) glucose clamps were maintained for 6 hours by infusion of glucose, insulin and somatostatin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2743	18708066-1324	or=6 ng/ml) was associated with increased expression of mrp-1 and pgp-1 and decreased glutathione, while higher level resistance (10 ng/ml) was primarily associated with the increased expression of P-glycoproteins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2744	18708066-1324	or=6 ng/ml) was associated with increased expression of mrp-1 and pgp-1 and decreased glutathione, while higher level resistance (10 ng/ml) was primarily associated with the increased expression of P-glycoproteins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2745	18708066-1324	or=6 ng/ml) was associated with increased expression of mrp-1 and pgp-1 and decreased glutathione, while higher level resistance (10 ng/ml) was primarily associated with the increased expression of P-glycoproteins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2746	18708157-1383	Co(2+) also induces the release of the pro-apoptotic factors, cytochrome c and AIF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2747	18708157-1383	Co(2+) also induces the release of the pro-apoptotic factors, cytochrome c and AIF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2748	18708157-1384	Incubation of rat hepatocyte primary cultures with Co(2+) results in apoptosis induction with caspase activation and increased level of expression of HIF-1alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2749	18708158-1385	Roscovitine reduced amounts of the caspase inhibitor XIAP, and API-2 increased amounts of the BH3-only protein Bim.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2750	18708158-1386	Bax accumulated in mitochondria in response to API-2, whereas release of cytochrome c from mitochondria required both API-2 and roscovitine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2751	18708158-1386	Bax accumulated in mitochondria in response to API-2, whereas release of cytochrome c from mitochondria required both API-2 and roscovitine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2752	18708158-1387	We suggest that roscovitine elicits events that activate Bax once it translocates to mitochondria and that inactivation of cdk9 signals these events and the down-regulation of XIAP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2753	18708158-1387	We suggest that roscovitine elicits events that activate Bax once it translocates to mitochondria and that inactivation of cdk9 signals these events and the down-regulation of XIAP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2754	18708191-1226	Intravenous glutamine enhances COX-2 activity giving cardioprotection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2755	18708191-1227	We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2756	18708191-1227	We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2757	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2758	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2759	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2760	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2761	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2762	18708284-1027	Islets from taurine-supplemented mice had: (i) significantly higher insulin content, (ii) increased insulin secretion at stimulatory glucose concentrations, (iii) significantly displaced the dose-response curve for glucose-induced insulin release to the left, (iv) increased glucose metabolism at 5.6 and 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ((Ca2+)i) oscillations in response to stimulatory glucose concentrations; (vi) increased insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase and pancreas duodenum homeobox-1 (PDX-1) gene expression and (vii) increased PDX-1 expression in the nucleus.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2763	18708284-1028	Moreover, taurine supplementation significantly increased both basal and insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle and liver tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2764	18708284-1028	Moreover, taurine supplementation significantly increased both basal and insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle and liver tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2765	18708284-1028	Moreover, taurine supplementation significantly increased both basal and insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle and liver tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2766	18708284-1028	Moreover, taurine supplementation significantly increased both basal and insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle and liver tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2767	18708284-1029	These results indicate that taurine controls glucose homeostasis by regulating the expression of genes required for glucose-stimulated insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2768	18708284-1029	These results indicate that taurine controls glucose homeostasis by regulating the expression of genes required for glucose-stimulated insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2769	18708284-1030	In addition, taurine enhances peripheral insulin sensitivity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2770	18708285-1040	Furthermore, treatment of lycopene and EPA also synergistically blocked the activation of downstream mTOR molecule.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2771	18708285-1041	Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2772	18708285-1041	Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2773	18709446-802	Amino acids (alanine, aspartic acid, glutamic acid) and glucose oxidase (GOx) were adsorbed on CNF and the results were compared with those obtained when activated carbon (AC) was used as support.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2774	18709446-802	Amino acids (alanine, aspartic acid, glutamic acid) and glucose oxidase (GOx) were adsorbed on CNF and the results were compared with those obtained when activated carbon (AC) was used as support.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2775	18709446-802	Amino acids (alanine, aspartic acid, glutamic acid) and glucose oxidase (GOx) were adsorbed on CNF and the results were compared with those obtained when activated carbon (AC) was used as support.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2776	18709646-694	The NSCs and neuroblasts had epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor alpha (PDGFRalpha) expressed on the ciliary apparatus and were the only cell types incorporating the proliferation marker BrdU.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2777	18709646-694	The NSCs and neuroblasts had epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor alpha (PDGFRalpha) expressed on the ciliary apparatus and were the only cell types incorporating the proliferation marker BrdU.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2778	18709646-694	The NSCs and neuroblasts had epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor alpha (PDGFRalpha) expressed on the ciliary apparatus and were the only cell types incorporating the proliferation marker BrdU.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2779	18709646-695	Ependymal and displaced ependymal cells also expressed EGFR and PDGFRalpha on their cilia but did not incorporate BrdU.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2780	18709646-695	Ependymal and displaced ependymal cells also expressed EGFR and PDGFRalpha on their cilia but did not incorporate BrdU.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2781	18709647-968	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2782	18709647-968	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2783	18709647-968	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2784	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2785	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2786	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2787	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2788	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2789	18709649-718	Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2790	18709661-989	Accordingly, the TLR3 agonist poly(I:C) (PIC) induced higher release of IFN-beta in primary and purified astroglia than in microglia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2791	18709661-989	Accordingly, the TLR3 agonist poly(I:C) (PIC) induced higher release of IFN-beta in primary and purified astroglia than in microglia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2792	18709661-990	As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2793	18709661-990	As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2794	18709661-990	As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2795	18709661-990	As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2796	18709661-990	As siRNA, PIC induced IP-10, Stat1, VCAM-1, and Cox-2 and increased TLR3 mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2797	18710402-1097	Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4 (+) T lymphocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2798	18710402-1097	Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4 (+) T lymphocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2799	18710402-1097	Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4 (+) T lymphocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2800	18710402-1097	Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4 (+) T lymphocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2801	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2802	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2803	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2804	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2805	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2806	18710402-1099	During activation with PMA and low amounts of I, intracellular concentrations of calcium ((Ca(2+))(i)) were greatly reduced upon CTLA-4-CD80/CD86 blockade.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2807	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2808	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2809	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2810	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2811	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2812	18710402-1100	Further experiments demonstrated that CTLA-4-CD80/CD86 interactions reduced cell cycling upon activation with PMA and high amounts of I or TG (high SOS) but the opposite occurred with PMA and low amounts of I or TG (low SOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2813	18710604-62	FSO decreased fasting glucose by 20 % and liver weights by 37 % compared with those in the CLA group; it maintained circulating insulin, HOMA1-IR and HOMA1 for beta cell function at levels found in the control group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2814	18710604-62	FSO decreased fasting glucose by 20 % and liver weights by 37 % compared with those in the CLA group; it maintained circulating insulin, HOMA1-IR and HOMA1 for beta cell function at levels found in the control group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2815	18710606-240	Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2816	18710606-240	Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2817	18710606-240	Animal evidence indicates that green tea may modulate insulin sensitivity, with epigallocatechin-3-gallate (EGCG) proposed as a likely health-promoting component.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2818	18710606-241	The purpose of this study was to investigate the effect of dietary supplementation with EGCG on insulin resistance and associated metabolic risk factors in man.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2819	18710606-242	EGCG treatment had no effect on insulin sensitivity, insulin secretion or glucose tolerance but did reduce diastolic blood pressure (mean change: placebo-0.058 (se 0.75) mmHg; EGCG-2.68 (se 0.72) mmHg; P = 0.014).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2820	18710606-242	EGCG treatment had no effect on insulin sensitivity, insulin secretion or glucose tolerance but did reduce diastolic blood pressure (mean change: placebo-0.058 (se 0.75) mmHg; EGCG-2.68 (se 0.72) mmHg; P = 0.014).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2821	18710606-243	In conclusion, regular intake of EGCG had no effect on insulin resistance but did result in a modest reduction in diastolic blood pressure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2822	18710702-125	We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ER (alpha), ER (beta)), P receptors (PR(B), PR(A+B)), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2823	18710702-125	We found that postovulatory administration of 1.5 mg of levonorgestrel to women with a subsequent or existing early pregnancy did not affect the immunohistochemical expressions of estrogen receptors (ER (alpha), ER (beta)), P receptors (PR(B), PR(A+B)), androgen receptor (AR), or proliferation index Ki67 in the first-trimester decidua and chorionic villi.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2824	18710819-1300	5-FU effect on HS cell viability was markedly reduced in hypoxic condition without an induction of chemoresistant related protein, P-glycoprotein.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2825	18710908-298	High-level toxin production occurred after detectable spore germination in all experiments except those with C. difficile PCR ribotype 027 and moxifloxacin, in which marked cytotoxin production preceded detectable germination, which coincided with isolate recovery on fluoroquinolone-containing medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2826	18711728-143	Furthermore, Ngb overexpression reduced superoxide anion generation after H/R, whereas glutathione levels were significantly improved compared with WT controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2827	18711728-143	Furthermore, Ngb overexpression reduced superoxide anion generation after H/R, whereas glutathione levels were significantly improved compared with WT controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2828	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2829	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2830	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2831	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2832	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2833	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2834	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2835	18711746-961	Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2836	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2837	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2838	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2839	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2840	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2841	18711746-962	The current study showed that alloxan-induced diabetic animals revealed hyperglycemia and was associated with an increase in the content of 5-HT, PKC-alpha expression and PKC 0.05) simultaneously in striatum (ST), midbrain (MB), pons medulla (PM), cerebellum (CB), and cerebral cortex (CCX) from 7 days to 60 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2842	18711746-963	Although the 5-HT levels in hippocampus (HC) and hypothalamus (HT) were not altered, the PKC-alpha expression and PKC 0.05) in level in HC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2843	18711746-963	Although the 5-HT levels in hippocampus (HC) and hypothalamus (HT) were not altered, the PKC-alpha expression and PKC 0.05) in level in HC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2844	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2845	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2846	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2847	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2848	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2849	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2850	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2851	18711749-1020	We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ neuroblast cell migration after stroke.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2852	18711749-1021	To elucidate whether SDF1/CXCR4 and Ang1/Tie2 pathways mediate DETA-NONOate-induced SVZ migration after stroke, SDF1alpha, Ang1 peptide, a specific antagonist of CXCR4 (AMD3100), and a neutralizing antibody of Tie2 (anti-Tie2) were used in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2853	18711749-1021	To elucidate whether SDF1/CXCR4 and Ang1/Tie2 pathways mediate DETA-NONOate-induced SVZ migration after stroke, SDF1alpha, Ang1 peptide, a specific antagonist of CXCR4 (AMD3100), and a neutralizing antibody of Tie2 (anti-Tie2) were used in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2854	18711749-1021	To elucidate whether SDF1/CXCR4 and Ang1/Tie2 pathways mediate DETA-NONOate-induced SVZ migration after stroke, SDF1alpha, Ang1 peptide, a specific antagonist of CXCR4 (AMD3100), and a neutralizing antibody of Tie2 (anti-Tie2) were used in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2855	18711749-1023	DETA-NONOate significantly increased the expression of SDF1 and Ang1 in the ischemic border and up-regulated CXCR4 and Tie2 in the SVZ compared with MCAo control.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2856	18711749-1023	DETA-NONOate significantly increased the expression of SDF1 and Ang1 in the ischemic border and up-regulated CXCR4 and Tie2 in the SVZ compared with MCAo control.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2857	18711749-1023	DETA-NONOate significantly increased the expression of SDF1 and Ang1 in the ischemic border and up-regulated CXCR4 and Tie2 in the SVZ compared with MCAo control.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2858	18711749-1023	DETA-NONOate significantly increased the expression of SDF1 and Ang1 in the ischemic border and up-regulated CXCR4 and Tie2 in the SVZ compared with MCAo control.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2859	18711749-1025	Our data indicate that treatment of stroke with a nitric oxide donor up-regulates SDF1/CXCR4 and Ang1/Tie2 pathways and thereby likely increases SVZ neuroblast cell migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2860	18711749-1025	Our data indicate that treatment of stroke with a nitric oxide donor up-regulates SDF1/CXCR4 and Ang1/Tie2 pathways and thereby likely increases SVZ neuroblast cell migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2861	18711749-1025	Our data indicate that treatment of stroke with a nitric oxide donor up-regulates SDF1/CXCR4 and Ang1/Tie2 pathways and thereby likely increases SVZ neuroblast cell migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2862	18711749-1025	Our data indicate that treatment of stroke with a nitric oxide donor up-regulates SDF1/CXCR4 and Ang1/Tie2 pathways and thereby likely increases SVZ neuroblast cell migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2863	18711750-1026	The MEK inhibitor PD98059 did not inhibit neurite outgrowth, and Y-27632 and staurosporine did not induce ERK phosphorylation, suggesting that the inhibitory effect of ODQ on neurite outgrowth is independent of the ERK signaling pathway.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2864	18711750-1026	The MEK inhibitor PD98059 did not inhibit neurite outgrowth, and Y-27632 and staurosporine did not induce ERK phosphorylation, suggesting that the inhibitory effect of ODQ on neurite outgrowth is independent of the ERK signaling pathway.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2865	18711750-1026	The MEK inhibitor PD98059 did not inhibit neurite outgrowth, and Y-27632 and staurosporine did not induce ERK phosphorylation, suggesting that the inhibitory effect of ODQ on neurite outgrowth is independent of the ERK signaling pathway.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2866	18712272-1403	We used this model to identify a potent competitive inhibitor, N1,N7-dihexyl-1,7-diamino-4-azaheptane, and to develop an affinity column, 1,16-diamino4,13-diazahexadecane-linked Sepharose, which was useful for the purification of PAO.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2867	18712288-246	Rapid determination of L-glutamine using engineered Escherichia coli overexpressing glutamine synthetase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2868	18712290-619	Purification, characterization, and preliminary X-ray diffraction analysis of a lactose-specific lectin from Cymbosema roseum seeds.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2869	18712290-620	Here, we report the purification, partial primary structure, carbohydrate affinity characterization, crystallization, and preliminary X-ray diffraction analysis of a lactose-specific lectin from Cymbosema roseum seeds (CRLII).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2870	18712361-637	Effects on haemolytic activity of single proline substitutions in the Bordetella pertussis CyaA pore-forming fragment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2871	18712381-639	Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human tumour xenografts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2872	18712381-640	The purpose of the study was to investigate the associations between uptake of (111)In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of human breast cancer (BC) xenografts in athymic mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2873	18712598-674	The adenosine (the final product of ATP hydrolysis by ectonucleotidases), have a recognized neuroprotective actions in the central nervous system (CNS) in pathological conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2874	18712838-744	To this end, the cultured fibroblasts were analyzed for very long chain fatty acid (VLCFA) concentrations, peroxisomal beta- and alpha-oxidation, dihydroxyacetone-phosphate acyltransferase (DHAPAT) activity, peroxisomal thiolase, and catalase immunofluorescence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2875	18712838-744	To this end, the cultured fibroblasts were analyzed for very long chain fatty acid (VLCFA) concentrations, peroxisomal beta- and alpha-oxidation, dihydroxyacetone-phosphate acyltransferase (DHAPAT) activity, peroxisomal thiolase, and catalase immunofluorescence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2876	18712838-744	To this end, the cultured fibroblasts were analyzed for very long chain fatty acid (VLCFA) concentrations, peroxisomal beta- and alpha-oxidation, dihydroxyacetone-phosphate acyltransferase (DHAPAT) activity, peroxisomal thiolase, and catalase immunofluorescence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2877	18712838-744	To this end, the cultured fibroblasts were analyzed for very long chain fatty acid (VLCFA) concentrations, peroxisomal beta- and alpha-oxidation, dihydroxyacetone-phosphate acyltransferase (DHAPAT) activity, peroxisomal thiolase, and catalase immunofluorescence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2878	18713274-881	Also, iNOS induction and concomitant nitric oxide generation appear to participate in the cytotoxicity of excessive portal pressure after extended hepatectomy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2879	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2880	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2881	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2882	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2883	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2884	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2885	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2886	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2887	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2888	18713277-882	Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme activities, antioxidant potential (AOP) value, malondialdehyde (MDA), cholesterol and triglyceride levels in the liver tissues and total cholesterol and triglyceride levels in serum samples were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2889	18714161-1109	Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2890	18715145-1378	Forced cytoplasmic overexpression of APE1 profoundly attenuated the upregulation of HMGB1-mediated reactive oxygen species generation, cytokine secretion, and cyclooxygenase-2 expression by primary monocytes and macrophage-like THP-1 cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2891	18715145-1378	Forced cytoplasmic overexpression of APE1 profoundly attenuated the upregulation of HMGB1-mediated reactive oxygen species generation, cytokine secretion, and cyclooxygenase-2 expression by primary monocytes and macrophage-like THP-1 cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2892	18715145-1378	Forced cytoplasmic overexpression of APE1 profoundly attenuated the upregulation of HMGB1-mediated reactive oxygen species generation, cytokine secretion, and cyclooxygenase-2 expression by primary monocytes and macrophage-like THP-1 cell lines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2893	18715148-1380	NO, a gas, is produced from L-arginine by different isoforms of nitric oxide synthase (NOS) and serves many normal physiologic purposes, such as promoting vasodilation of blood vessels and mediating communication between nervous system cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2894	18715148-1380	NO, a gas, is produced from L-arginine by different isoforms of nitric oxide synthase (NOS) and serves many normal physiologic purposes, such as promoting vasodilation of blood vessels and mediating communication between nervous system cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2895	18715149-1381	As one of the very few repair systems for oxidized proteins, MsrA and MsrB enzymes play a major role in protein homeostasis during aging and have also been involved in cellular defenses against oxidative stress, by scavenging reactive oxygen species.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2896	18715149-1381	As one of the very few repair systems for oxidized proteins, MsrA and MsrB enzymes play a major role in protein homeostasis during aging and have also been involved in cellular defenses against oxidative stress, by scavenging reactive oxygen species.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2897	18715284-1402	High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2898	18715284-1403	High-density lipoprotein (HDL) cholesterol is a powerful cardiovascular risk factor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2899	18715643-1517	Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2900	18715643-1517	Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2901	18715643-1517	Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2902	18715643-1517	Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2903	18715643-1518	Hepatoprotective potential of vitamin C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2904	18715643-1518	Hepatoprotective potential of vitamin C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2905	18715643-1518	Hepatoprotective potential of vitamin C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2906	18715643-1518	Hepatoprotective potential of vitamin C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2907	18715823-1582	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2908	18715823-1582	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2909	18715823-1582	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2910	18715823-1582	The interaction of quercetin, which is a bioflavonoid, with bovine serum albumin (BSA) was investigated under pseudo-physiological conditions by the application of UV-vis spectrometry, spectrofluorimetry and cyclic voltammetry (CV).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2911	18715823-1585	1x10(-5) mol L(-1)), most of the site marker reacted with the quercetin-BSA, but free warfarin was present at higher concentrations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2912	18715824-1587	Under optimum conditions, the fluorescence intensity of BSA-GNPs is linearly proportional to nickel concentration from 6.0x10(-8)mol/L to 8.0x10(-6)mol/L with a detection limit of 1.0x10(-8)mol/L.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2913	18716315-1771	C18 and C20Gb(3) were, in mixtures without C24 :1Gb(3), dominant negative for gp120 vesicle binding.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2914	18716315-1772	Gp120/VT1bound C18 and C24 :1Gb(3) mixtures, although neither isoform bound alone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2915	18716315-1773	Monolayer surface pressure measurement showed VT1, but not VT2, bound Gb(3) at cellular DRM surface pressures, and confirmed loss of VT1 and gp120 (but not VT2) specific C18Gb(3) binding.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2916	18716607-1835	Cholinesterase inhibition in chlorpyrifos workers: Characterization of biomarkers of exposure and response in relation to urinary TCPy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2917	18716607-1836	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2918	18716607-1836	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2919	18716607-1836	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2920	18716756-1877	Immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring Leu-Pro-X-Thr-Gly motif, muramidase-released protein and surface antigen one, were absent in the DeltasrtA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2921	18716756-1877	Immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring Leu-Pro-X-Thr-Gly motif, muramidase-released protein and surface antigen one, were absent in the DeltasrtA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2922	18716756-1877	Immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring Leu-Pro-X-Thr-Gly motif, muramidase-released protein and surface antigen one, were absent in the DeltasrtA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2923	18716756-1877	Immunofluorescence analysis revealed that two known virulence-associated surface proteins featuring Leu-Pro-X-Thr-Gly motif, muramidase-released protein and surface antigen one, were absent in the DeltasrtA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2924	18716761-1880	In addition, neuronal nitric oxide synthase, another component of the NMDA/nitric oxide/cGMP intracellular pathway, has been reported to be dysregulated in schizophrenia patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2925	18716761-1880	In addition, neuronal nitric oxide synthase, another component of the NMDA/nitric oxide/cGMP intracellular pathway, has been reported to be dysregulated in schizophrenia patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2926	18716782-1887	A role for natriuretic peptide in lipopolysaccharide-induced fever in Pekin ducks (Anas platyrhynchos): is natriuretic peptide an endogenous antipyretic in birds.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2927	18716782-1888	We induced fever in Pekin ducks with lipopolysaccharide and, at the same time, treated the animals with natriuretic peptide antiserum at a dose that effectively inhibited the known renal actions of endogenously secreted natriuretic peptide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2928	18716808-1894	Among the Gram-negative bacteria, 100% of the Escherichia coli isolates (including extended spectrum beta-lactamase (ESBL)-producers) were tigecycline-susceptible, while about 10% of the Enterobacter cloacae and Klebsiella pneumoniae isolates were resistant.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2929	18716864-1923	The data presented here show that NH4Cl (5 mM) mediates astroglial cell swelling, and that treatment with NH4Cl or lactate (25 mM) causes rearrangements of actin filaments and reduces astroglial glutamate uptake capacity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2930	18716881-1940	Here, we proposed that Lap4, a vacuolar amino peptidase, is involved in glutathione catabolism under cadmium stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2931	18716881-1942	Thus, under cadmium stress, Lap4 and gamma-glutamyl transferase seem to work together to assure an efficient glutathione turnover stored in the vacuole.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2932	18716881-1942	Thus, under cadmium stress, Lap4 and gamma-glutamyl transferase seem to work together to assure an efficient glutathione turnover stored in the vacuole.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2933	18716920-1959	In this research, the effects of pH, temperature, and oxygen on growth kinetics of a newly isolated strain of Bacillus circulans from the Amazon and their correlations with transglutaminase (TGase) production and cell sporulation were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2934	18716920-1959	In this research, the effects of pH, temperature, and oxygen on growth kinetics of a newly isolated strain of Bacillus circulans from the Amazon and their correlations with transglutaminase (TGase) production and cell sporulation were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2935	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2936	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2937	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2938	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2939	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2940	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2941	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2942	18717617-2177	No relationships were observed among mercury, selenium, and several other neurochemical biomarkers (dopamine-2, gamma-aminobutyric acid type A, muscarinic cholinergic, and nicotinic cholinergic receptors; cholinesterase and monoamine oxidase enzymes).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2943	18717625-2181	Despite responsive antioxidative defense (increased activities of superoxide dismutase, ascorbate peroxidase, and pyrogallol peroxidase), Tl+ caused oxidative damage to lipids and proteins as evaluated by malondialdehyde and carbonyl group levels, and induced DNA strand breaks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2944	18717625-2181	Despite responsive antioxidative defense (increased activities of superoxide dismutase, ascorbate peroxidase, and pyrogallol peroxidase), Tl+ caused oxidative damage to lipids and proteins as evaluated by malondialdehyde and carbonyl group levels, and induced DNA strand breaks.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2945	18717627-2182	However, Ref-1 inhibition followed by H2O2 treatment extensively induced the level of intracellular reactive oxygen species (ROS) through activation of the components of NADPH oxidase, like p22 (phox), p47 (phox), and Nox4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2946	18717627-2182	However, Ref-1 inhibition followed by H2O2 treatment extensively induced the level of intracellular reactive oxygen species (ROS) through activation of the components of NADPH oxidase, like p22 (phox), p47 (phox), and Nox4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2947	18717627-2182	However, Ref-1 inhibition followed by H2O2 treatment extensively induced the level of intracellular reactive oxygen species (ROS) through activation of the components of NADPH oxidase, like p22 (phox), p47 (phox), and Nox4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2948	18717628-2183	We conclude that mitochondrial dysfunction can induce alpha-synuclein oligomerization via ATP depletion-driven microtubule depolymerization and via ROS increase-driven protein oxidation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2949	18717715-2195	Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2950	18717715-2196	We previously showed that gene expression of synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug levetiracetam, is reduced during epileptogenesis in the rat.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2951	18717715-2196	We previously showed that gene expression of synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug levetiracetam, is reduced during epileptogenesis in the rat.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2952	18718549-2503	We also demonstrated that the deletion of the ptsG gene doubled ATP-driven glutathione synthesis and increased cellular ATP synthetic activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2953	18718551-2505	Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2954	18718551-2506	In the present study, we showed that selenocystine (SeC), a naturally occurring selenoamino acid, induced caspase-independent apoptosis in MCF-7 breast carcinoma cells, which was accompanied by poly(ADP-ribose) polymerase (PARP) cleavage, caspase activation, DNA fragmentation, phosphatidylserine exposure and nuclear condensation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2955	18718551-2506	In the present study, we showed that selenocystine (SeC), a naturally occurring selenoamino acid, induced caspase-independent apoptosis in MCF-7 breast carcinoma cells, which was accompanied by poly(ADP-ribose) polymerase (PARP) cleavage, caspase activation, DNA fragmentation, phosphatidylserine exposure and nuclear condensation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2956	18718551-2507	Silencing and attenuating of p53 activation with RNA interference and pifithrin-alpha treatment, respectively, partially suppressed SeC-induced cell apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2957	18718660-2524	Activation of c-Jun N-terminal kinase is essential for oxidative stress-induced Jurkat cell apoptosis by monochloramine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2958	18718660-2525	Within 10min of NH(2) Cl treatment, c-Jun N-terminal kinase (JNK) activation and elevation of cytosolic Ca(2+) were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2959	18718660-2525	Within 10min of NH(2) Cl treatment, c-Jun N-terminal kinase (JNK) activation and elevation of cytosolic Ca(2+) were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2960	18718660-2525	Within 10min of NH(2) Cl treatment, c-Jun N-terminal kinase (JNK) activation and elevation of cytosolic Ca(2+) were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2961	18718660-2525	Within 10min of NH(2) Cl treatment, c-Jun N-terminal kinase (JNK) activation and elevation of cytosolic Ca(2+) were observed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2962	18718713-2535	Induction in the activity of lignin peroxidase and azoreductase was observed during decolorization of Reactive Red 2 in the batch culture, which represented their role in degradation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2963	18718713-2535	Induction in the activity of lignin peroxidase and azoreductase was observed during decolorization of Reactive Red 2 in the batch culture, which represented their role in degradation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2964	18719855-2110	Treatment with nimbolide resulted in dose- and time-dependent inhibition of growth of BeWo cells with IC(50) values of 2.01 and 1.19 microM for 7 and 24 h respectively, accompanied by downregulation of proliferating cell nuclear antigen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2965	18719891-434	In all cases, the phenotype of SVQ524 was nearly overcome by the addition of methionine or cobalamin to the plant growth media or by the presence of a copy of the cobO gene in cosmid pMUS756.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2966	18719891-434	In all cases, the phenotype of SVQ524 was nearly overcome by the addition of methionine or cobalamin to the plant growth media or by the presence of a copy of the cobO gene in cosmid pMUS756.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2967	18719969-461	Obesity increases insulin resistance and glucose intolerance and also exacerbates metabolic abnormalities present in type 2 diabetes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2968	18720192-531	Inhibition of glycogen synthase kinase by curcumin : Investigation by simulated molecular docking and subsequent in vitro/in vivo evaluation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2969	18720192-532	The investigation included simulated docking experiments to fit curcumin within the binding pocket of GSK-3beta followed by experimental in vitro and in vivo validations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2970	18720192-533	Curcumin was found to optimally fit within the binding pocket of GSK-3beta via several attractive interactions with key amino acids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2971	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2972	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2973	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2974	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2975	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2976	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2977	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2978	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2979	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2980	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2981	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2982	18720446-603	A sample preparation protocol applying a binary matrix-assisted laser desorption/ionization(MALDI) matrix containing alpha-cyano-4-hydroxy cinnamic acid (CHCA) and 2,5-dihydroxy benzoic acid (DHB) on trifluoro acetic acid (TFA) etched latex glove surfaces allowed the direct determination (exact molecular weight) of Hevein, REF and a truncated form of REF (tREF) within nine different brands of natural latex gloves by means of MALDI-TOF-MS in the linear mode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2983	18721153-786	Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2984	18721153-787	Methods: We injected CD44 knock out (KO) or wild type mice with carbon tetrachloride (CCl(4)) and examined the difference of liver injury by immunological or histological analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2985	18721245-809	Studies using 1-methyl-tryptophan (1-MT), the specific inhibitor of IDO, showed that this enzyme is important in interferon-gamma (IFN-gamma)-dependent inhibition of allergic inflammation in the respiratory airway during immunotherapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2986	18721245-809	Studies using 1-methyl-tryptophan (1-MT), the specific inhibitor of IDO, showed that this enzyme is important in interferon-gamma (IFN-gamma)-dependent inhibition of allergic inflammation in the respiratory airway during immunotherapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2987	18721245-809	Studies using 1-methyl-tryptophan (1-MT), the specific inhibitor of IDO, showed that this enzyme is important in interferon-gamma (IFN-gamma)-dependent inhibition of allergic inflammation in the respiratory airway during immunotherapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2988	18721245-809	Studies using 1-methyl-tryptophan (1-MT), the specific inhibitor of IDO, showed that this enzyme is important in interferon-gamma (IFN-gamma)-dependent inhibition of allergic inflammation in the respiratory airway during immunotherapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2989	18721829-966	We examined the substrates of cannabinoid-mediated inhibition of both the emetic phases via immunolabeling for serotonin, Substance P, cannabinoid receptors 1 and 2 (CB(1), CB(2)), and the neuronal activation marker Fos in the least shrew (Cryptotis parva).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2990	18721829-966	We examined the substrates of cannabinoid-mediated inhibition of both the emetic phases via immunolabeling for serotonin, Substance P, cannabinoid receptors 1 and 2 (CB(1), CB(2)), and the neuronal activation marker Fos in the least shrew (Cryptotis parva).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2991	18721829-966	We examined the substrates of cannabinoid-mediated inhibition of both the emetic phases via immunolabeling for serotonin, Substance P, cannabinoid receptors 1 and 2 (CB(1), CB(2)), and the neuronal activation marker Fos in the least shrew (Cryptotis parva).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2992	18722097-1040	To observe the inhibitory effects of TSP-1 functional fragments, critical for CD36 binding, on the activation of L-TGF-beta1, we isolated alveolar macrophages from Wistar rat lungs 7 days after bleomycin administration (5mg/kg body weight) and cultured the cells with or without TSP-1 functional or control fragments.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2993	18722097-1040	To observe the inhibitory effects of TSP-1 functional fragments, critical for CD36 binding, on the activation of L-TGF-beta1, we isolated alveolar macrophages from Wistar rat lungs 7 days after bleomycin administration (5mg/kg body weight) and cultured the cells with or without TSP-1 functional or control fragments.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2994	18722097-1040	To observe the inhibitory effects of TSP-1 functional fragments, critical for CD36 binding, on the activation of L-TGF-beta1, we isolated alveolar macrophages from Wistar rat lungs 7 days after bleomycin administration (5mg/kg body weight) and cultured the cells with or without TSP-1 functional or control fragments.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2995	18722104-1045	The pEREGFP9 vector was delivered to a single MCF-7 using a nanoneedle and the effect of ICI 182,780, which is an antagonist of estrogen, was observed using the GFP expression level.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2996	18722104-1046	By ICI 182,780 treatment, the fluorescence intensity of the GFP was decreased by 30-50% within 24h.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2997	18722114-1051	Effect of different cellulase dosages on cell viability and ethanol production by Kluyveromyces marxianus in SSF processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2998	18722114-1052	This study was aimed to study the effect of commercial cellulases (Celluclast 1.5 LFG) on Kluyveromyces marxianus CECT 10875 growth and ethanol production in SSF processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
2999	18722490-1167	Crustacean hyperglycemic hormone (CHH) not only plays an important role in the modulation of hemolymph glucose level but also functions in other biological events including molting, reproduction and stress response.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3000	18722490-1167	Crustacean hyperglycemic hormone (CHH) not only plays an important role in the modulation of hemolymph glucose level but also functions in other biological events including molting, reproduction and stress response.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3001	18722763-1249	As a proof-of-concept, Concanavalin A-coated QDs (ConA-QDs) and dextran-coated AuNPs (Dex-AuNPs) were used to detect the mannosylated proteins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3002	18722763-1249	As a proof-of-concept, Concanavalin A-coated QDs (ConA-QDs) and dextran-coated AuNPs (Dex-AuNPs) were used to detect the mannosylated proteins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3003	18722763-1250	As a result, the PL intensity of QDs was found to be linearly correlated with the concentration and the number of glycan moiety of the glycoprotein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3004	18723022-1306	We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3005	18723022-1306	We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3006	18723022-1306	We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3007	18723107-1332	To overcome this limitation we turned to the yeast Pichia stipitis, which naturally produces xylitol, as a source of xylulokinase (Xyl3).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3008	18723107-1333	We examined the effects of plasmid-based expression of Xyl3 versus XylB on growth and xylitol production by engineered E. coli strains.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3009	18723121-1340	Behavioral and biochemical responses including filtering rates, key phase I, II and antioxidant enzymes and levels of metallothioneins, glutathione, lipid peroxidation and DNA strand breaks were determined in digestive glands of mussels after being exposed to sublethal levels of mercury chloride, methyl mercury, cadmium and Aroclor 1260 during 5 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3010	18723336-870	In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET(2) system (Renilla luciferase donor, green fluorescent protein (2) (GFP (2)) acceptor and coelenterazine 400a substrate).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3011	18723336-870	In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET(2) system (Renilla luciferase donor, green fluorescent protein (2) (GFP (2)) acceptor and coelenterazine 400a substrate).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3012	18723336-870	In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET(2) system (Renilla luciferase donor, green fluorescent protein (2) (GFP (2)) acceptor and coelenterazine 400a substrate).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3013	18723336-870	In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET(2) system (Renilla luciferase donor, green fluorescent protein (2) (GFP (2)) acceptor and coelenterazine 400a substrate).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3014	18723336-870	In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET(2) system (Renilla luciferase donor, green fluorescent protein (2) (GFP (2)) acceptor and coelenterazine 400a substrate).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3015	18723342-981	If no pretreatment applied, hydrolyses of the textiles by cellulase and beta-glucosidase for 24 h followed by simultaneous saccharification and fermentation (SSF) in 4 days, resulted in 0.140-0.145 g ethanol/g textiles, which was 25-26% of the corresponding theoretical yield.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3016	18723342-981	If no pretreatment applied, hydrolyses of the textiles by cellulase and beta-glucosidase for 24 h followed by simultaneous saccharification and fermentation (SSF) in 4 days, resulted in 0.140-0.145 g ethanol/g textiles, which was 25-26% of the corresponding theoretical yield.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3017	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3018	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3019	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3020	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3021	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3022	18723440-1394	In cystic fibrosis, this equilibrium is disrupted by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene resulting in the absence of functional CFTR protein, which in turn results in deficient cAMP-dependent Cl (-) secretion and predominant Na (+) absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3023	18723471-1399	Two patients presented a heterozygous T-to-G transversion in exon 2 (c.518T>G) of the PROKR2, which results in a leucine-to-arginine substitution at codon 173.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3024	18723471-1399	Two patients presented a heterozygous T-to-G transversion in exon 2 (c.518T>G) of the PROKR2, which results in a leucine-to-arginine substitution at codon 173.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3025	18723570-1420	Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3026	18723579-1422	Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3027	18723579-1422	Angiotensin II (AngII) stimulation of water and NaCl intake is a classic model of the behavioural effects of hormones.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3028	18723579-1423	Previous studies support the hypotheses that PKC is involved in AngII-induced water, but not NaCl intake and that MAP kinase plays a role in NaCl consumption, but not water intake, after injection of AngII.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3029	18723579-1424	Pretreatment with the PKC inhibitor chelerythrine attenuated AngII-induced water intake, but NaCl intake was unaffected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3030	18723579-1424	Pretreatment with the PKC inhibitor chelerythrine attenuated AngII-induced water intake, but NaCl intake was unaffected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3031	18723579-1425	In contrast, pretreatment with U0126, a MAP kinase inhibitor, had no effect on AngII-induced water intake, but attenuated NaCl intake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3032	18724397-1741	The prevalence rates of elevated blood pressure and hypertriglyceridemia were significantly higher among HCT recipients than among controls, but the prevalence rates of abdominal obesity, elevated blood glucose and low high-density lipoprotein cholesterol were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3033	18724397-1741	The prevalence rates of elevated blood pressure and hypertriglyceridemia were significantly higher among HCT recipients than among controls, but the prevalence rates of abdominal obesity, elevated blood glucose and low high-density lipoprotein cholesterol were not.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3034	18725236-2014	Specific neurochemical elements in these structures include not only decreases in reward neurotransmission, such as decreases in dopamine and opioid peptide function in the ventral striatum, but also recruitment of brain stress systems, such as corticotropin-releasing factor (CRF), in the extended amygdala.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3035	18725236-2014	Specific neurochemical elements in these structures include not only decreases in reward neurotransmission, such as decreases in dopamine and opioid peptide function in the ventral striatum, but also recruitment of brain stress systems, such as corticotropin-releasing factor (CRF), in the extended amygdala.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3036	18726068-972	Neither enzymatic activity of transaminases (AST and ALT) nor urea levels were significantly altered.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3037	18726117-2302	On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3038	18726117-2302	On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3039	18726675-2476	Although the TO2 hamster heart exhibits normal function at 1 month of age (presymptomatic stage), elevated levels of myeloperoxidase, monocyte chemotactic protein-1, malondialdehyde, osteopontin, and alkaline phosphatase were evident, indicating the presence of inflammation, oxidative stress, and osteogenic phenotype.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3040	18726675-2476	Although the TO2 hamster heart exhibits normal function at 1 month of age (presymptomatic stage), elevated levels of myeloperoxidase, monocyte chemotactic protein-1, malondialdehyde, osteopontin, and alkaline phosphatase were evident, indicating the presence of inflammation, oxidative stress, and osteogenic phenotype.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3041	18726677-2477	Transitions in the tryptophan microenvironment and secondary structure of two monocot lectins from Sauromatum guttatum and Arisaema tortuosum under different denaturing conditions were studied by steady state and time resolved fluorescence and CD spectroscopy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3042	18726677-2478	The lectins exist as tetramers with a single tryptophan residue estimated per monomer, present in a polar environment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3043	18726677-2479	Similarly, both the lectins showed a drastic loss of secondary structure in 5 M Gdn-HCl or 6 M Urea or at pH 2.0 and below.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3044	18726677-2479	Similarly, both the lectins showed a drastic loss of secondary structure in 5 M Gdn-HCl or 6 M Urea or at pH 2.0 and below.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3045	18726677-2479	Similarly, both the lectins showed a drastic loss of secondary structure in 5 M Gdn-HCl or 6 M Urea or at pH 2.0 and below.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3046	18726687-2490	In order to determine the possible effects of hemolysate on brain microvascular endothelial cells (BMECs), we examined the effects of hemolysate on the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1), generation of reactive oxygen species (ROS), and NF-kappaB activation in rat BMECs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3047	18726687-2490	In order to determine the possible effects of hemolysate on brain microvascular endothelial cells (BMECs), we examined the effects of hemolysate on the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1), generation of reactive oxygen species (ROS), and NF-kappaB activation in rat BMECs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3048	18726687-2490	In order to determine the possible effects of hemolysate on brain microvascular endothelial cells (BMECs), we examined the effects of hemolysate on the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1), generation of reactive oxygen species (ROS), and NF-kappaB activation in rat BMECs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3049	18726998-19	We examined 1,25 dihydroxyvitamin D (1,25(OH)(2)D(3))-induced expression of 25-hydroxyvitamin D(3) 24-hydroxylase (CYP24) and apical calcium channel (TRPV6) mRNA levels in 2-, 9-, and 15-day cultures Caco-2 cells that model proliferating, post-proliferative, and differentiated enterocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3050	18726998-19	We examined 1,25 dihydroxyvitamin D (1,25(OH)(2)D(3))-induced expression of 25-hydroxyvitamin D(3) 24-hydroxylase (CYP24) and apical calcium channel (TRPV6) mRNA levels in 2-, 9-, and 15-day cultures Caco-2 cells that model proliferating, post-proliferative, and differentiated enterocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3051	18727009-26	Here, we tested the hypothesis that interactions with DNA-topoisomerases play a role in the DNA-damaging properties of AOH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3052	18727009-27	Next, we selected AOH as the most DNA-damaging Alternaria metabolite for further studies of interactions with DNA topoisomerases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3053	18727009-28	Stabilisation of covalent topoisomerase II-DNA intermediates by AOH was also detectable in cell culture, and here, the IIalpha isoform was preferentially targeted.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3054	18727113-70	Bone formation and maturation processes were evaluated by double staining for alkaline phosphatase and tartrate-resistant acid phosphatase, immunohistochemistry for bone matrix proteins, vital staining with calcein, and elemental mapping with an electron probe microanalyzer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3055	18727113-70	Bone formation and maturation processes were evaluated by double staining for alkaline phosphatase and tartrate-resistant acid phosphatase, immunohistochemistry for bone matrix proteins, vital staining with calcein, and elemental mapping with an electron probe microanalyzer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3056	18727113-70	Bone formation and maturation processes were evaluated by double staining for alkaline phosphatase and tartrate-resistant acid phosphatase, immunohistochemistry for bone matrix proteins, vital staining with calcein, and elemental mapping with an electron probe microanalyzer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3057	18728222-493	Phosphorylation of insulin receptor substrate (IRS) proteins on serine residues has emerged as a key step in these control processes under both physiological and pathological conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3058	18728222-493	Phosphorylation of insulin receptor substrate (IRS) proteins on serine residues has emerged as a key step in these control processes under both physiological and pathological conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3059	18728345-519	In contrast, SKI-1 (S1P or site-1) is a membrane-bound serine protease inhibitable by AEBSF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3060	18728345-519	In contrast, SKI-1 (S1P or site-1) is a membrane-bound serine protease inhibitable by AEBSF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3061	18728345-519	In contrast, SKI-1 (S1P or site-1) is a membrane-bound serine protease inhibitable by AEBSF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3062	18728347-520	The progressive ankylosis gene (ank) is a transmembrane protein that transports intracellular pyrophosphate to the extracellular milieu.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3063	18728678-624	Tumor necrosis factor receptor-1 is essential for LPS-induced sensitization and tolerance to oxygen-glucose deprivation in murine neonatal organotypic hippocampal slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3064	18728678-624	Tumor necrosis factor receptor-1 is essential for LPS-induced sensitization and tolerance to oxygen-glucose deprivation in murine neonatal organotypic hippocampal slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3065	18728678-625	The role of tumor necrosis factor (TNF) receptors 1 and 2 in lipopolysaccharide (LPS)-induced sensitization and tolerance to oxygen-glucose deprivation (OGD) was evaluated in neonatal murine hippocampal organotypic slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3066	18728678-625	The role of tumor necrosis factor (TNF) receptors 1 and 2 in lipopolysaccharide (LPS)-induced sensitization and tolerance to oxygen-glucose deprivation (OGD) was evaluated in neonatal murine hippocampal organotypic slices.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3067	18729103-711	The immunoblot, ELISA and EMSA analysis demonstrated that the treatment of HCT116 cells with delphinidin resulted in the inhibition of (i) IKKalpha, (ii) phosphorylation and degradation of IkappaBalpha, (iii) phosphorylation of NF-kappaB/p65 at Ser (536), (iv) nuclear translocation of NF-kappaB/p65, (v) NF-kappaB/p65 DNA binding activity, and (vi) transcriptional activation of NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3068	18729103-711	The immunoblot, ELISA and EMSA analysis demonstrated that the treatment of HCT116 cells with delphinidin resulted in the inhibition of (i) IKKalpha, (ii) phosphorylation and degradation of IkappaBalpha, (iii) phosphorylation of NF-kappaB/p65 at Ser (536), (iv) nuclear translocation of NF-kappaB/p65, (v) NF-kappaB/p65 DNA binding activity, and (vi) transcriptional activation of NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3069	18729103-711	The immunoblot, ELISA and EMSA analysis demonstrated that the treatment of HCT116 cells with delphinidin resulted in the inhibition of (i) IKKalpha, (ii) phosphorylation and degradation of IkappaBalpha, (iii) phosphorylation of NF-kappaB/p65 at Ser (536), (iv) nuclear translocation of NF-kappaB/p65, (v) NF-kappaB/p65 DNA binding activity, and (vi) transcriptional activation of NF-kappaB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3070	18729824-936	Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3071	18729824-937	The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer's disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3072	18729824-937	The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer's disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3073	18729824-937	The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer's disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3074	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3075	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3076	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3077	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3078	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3079	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3080	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3081	18751681-68	Cells were grown for 24 h with APAP in the presence or absence of 4-methylpyrazole (4MP), L-arginine methyl ester (L-NAME), superoxide dismutase (SOD), or ruthenium red (RuR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3082	18751889-128	Synaptic vesicle-bound pyruvate kinase can support vesicular glutamate uptake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3083	18751889-129	We present evidence that ATP generated by synaptic vesicle-associated pyruvate kinase is harnessed to transport glutamate into synaptic vesicles.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3084	18751891-135	We examined the expression of Phgdh and ASCT1 in kainic acid (KA)-induced neurodegeneration of the mouse hippocampus using immunohistochemistry and Western blots.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3085	18751891-135	We examined the expression of Phgdh and ASCT1 in kainic acid (KA)-induced neurodegeneration of the mouse hippocampus using immunohistochemistry and Western blots.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3086	18751892-136	In the present study the effect of the convulsant drug 3-mercaptopropionic acid (MP) repetitive administration (4-7 days) on the hippocampal NR2B subunit was studied.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3087	18751892-137	A significant decrease in NR2B in the whole hippocampus was observed after MP4 with a tendency to recover to normal values in MP7 by western blot assay.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3088	18751894-139	Heart glycogen represents a store of glucosyl residues which are mobilized by the catalysis of glycogen phosphorylase (GP) and are mainly destined to serve as substrates for the generation of ATP.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3089	18752001-187	However, phenformin was equally effective in AMPKalpha1(-/-) and wild-type animals, suggesting additional AMPK-independent action of phenformin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3090	18752070-205	The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3091	18752070-205	The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3092	18752070-205	The relationship between prolactin (PRL), leptin, nitric oxide (NO), and cytokines in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3093	18752070-206	The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3094	18752070-206	The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3095	18752070-206	The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3096	18752070-206	The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3097	18752070-206	The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3098	18752089-210	Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3099	18752089-210	Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3100	18752284-283	Effect of cytochrome P450 3A5 *3 genotype on the stereoselective pharmacokinetics of amlodipine in healthy subjects.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3101	18752284-286	In conclusion, the present study showed that despite the evidence that amlodipine is stereoselectively metabolized, CYP3A5 *3 genotype did not affect stereoselective disposition of amlodipine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3102	18752284-287	It provides the evidence that CYP3A5 *3genotype plays a minor role in the interindividual variability of stereoselective disposition of amlodipine in humans.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3103	18752291-293	Tissues were stained for BrdU, Pax-7, vimentin, and haematoxylin and eosin staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3104	18752291-293	Tissues were stained for BrdU, Pax-7, vimentin, and haematoxylin and eosin staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3105	18752291-293	Tissues were stained for BrdU, Pax-7, vimentin, and haematoxylin and eosin staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3106	18752291-293	Tissues were stained for BrdU, Pax-7, vimentin, and haematoxylin and eosin staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3107	18752295-295	Differences in the expression of inwardly rectifying potassium channels (Kir4.1), glial fibrillary acidic protein (GFAP), and taurine levels in cortical astrocytes were detected using immunohistochemical methods.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3108	18752295-295	Differences in the expression of inwardly rectifying potassium channels (Kir4.1), glial fibrillary acidic protein (GFAP), and taurine levels in cortical astrocytes were detected using immunohistochemical methods.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3109	18752295-295	Differences in the expression of inwardly rectifying potassium channels (Kir4.1), glial fibrillary acidic protein (GFAP), and taurine levels in cortical astrocytes were detected using immunohistochemical methods.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3110	18752295-296	Immunohistochemical analysis suggests that the diverse expression of Kir4.1 channels and GFAP as well as differences in the accumulation of taurine might contribute to the distinct ability of astrocytes to regulate their volume.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3111	18752295-296	Immunohistochemical analysis suggests that the diverse expression of Kir4.1 channels and GFAP as well as differences in the accumulation of taurine might contribute to the distinct ability of astrocytes to regulate their volume.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3112	18752301-300	These evoked expressions at both molecular and cellular levels were significantly inhibited after TRPV(1) receptors were blocked by 5'-iodoresiniferatoxin (5 microg) or PKC was inhibited by chelerythrine chloride (5 microg).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3113	18752301-300	These evoked expressions at both molecular and cellular levels were significantly inhibited after TRPV(1) receptors were blocked by 5'-iodoresiniferatoxin (5 microg) or PKC was inhibited by chelerythrine chloride (5 microg).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3114	18752301-300	These evoked expressions at both molecular and cellular levels were significantly inhibited after TRPV(1) receptors were blocked by 5'-iodoresiniferatoxin (5 microg) or PKC was inhibited by chelerythrine chloride (5 microg).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3115	18752305-1438	Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3116	18752305-1439	Several growth factors, such as vascular endothelial growth factor, brain-derived neurotrophic factor, and insulin-like growth factor-I are involved in the actions of progesterone in the central nervous system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3117	18752305-1439	Several growth factors, such as vascular endothelial growth factor, brain-derived neurotrophic factor, and insulin-like growth factor-I are involved in the actions of progesterone in the central nervous system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3118	18752305-1440	Significant increases in the phosphorylation of ERK, in the expression of the catalytic (p110) and the regulatory (p85) subunits of PI3K and in the phosphorylation of Akt were observed in the hypothalamus, the hippocampus, and the cerebellum 24 hr after progesterone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3119	18752305-1440	Significant increases in the phosphorylation of ERK, in the expression of the catalytic (p110) and the regulatory (p85) subunits of PI3K and in the phosphorylation of Akt were observed in the hypothalamus, the hippocampus, and the cerebellum 24 hr after progesterone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3120	18752305-1440	Significant increases in the phosphorylation of ERK, in the expression of the catalytic (p110) and the regulatory (p85) subunits of PI3K and in the phosphorylation of Akt were observed in the hypothalamus, the hippocampus, and the cerebellum 24 hr after progesterone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3121	18752305-1440	Significant increases in the phosphorylation of ERK, in the expression of the catalytic (p110) and the regulatory (p85) subunits of PI3K and in the phosphorylation of Akt were observed in the hypothalamus, the hippocampus, and the cerebellum 24 hr after progesterone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3122	18752305-1440	Significant increases in the phosphorylation of ERK, in the expression of the catalytic (p110) and the regulatory (p85) subunits of PI3K and in the phosphorylation of Akt were observed in the hypothalamus, the hippocampus, and the cerebellum 24 hr after progesterone administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3123	18752414-337	In addition, we used PET to evaluate the striatal dopamine transporter availability (DAT) with ((11)C)d-threo-methylphenidate in the patient group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3124	18752468-361	Associated with the mitochondrial permeabilization, PdC also induced the release of cytochrome c, which is sensitive to inhibition by DTT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3125	18752565-399	Toll-like receptor 4 (TLR-4)/myeloid differentiation protein-2 complex ligation by lipopolysaccharide induces production of pro-inflammatory cytokines and co-stimulatory molecules on antigen presenting cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3126	18752565-399	Toll-like receptor 4 (TLR-4)/myeloid differentiation protein-2 complex ligation by lipopolysaccharide induces production of pro-inflammatory cytokines and co-stimulatory molecules on antigen presenting cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3127	18752633-420	Immunohistochemistry was performed on paraffin-embedded sections, using anti-5-methylcytosine (5mc) and anti-Acetyl-Histone H3 (Lys 9).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3128	18752635-423	Here, the NCX-mediated (45)Ca(2+) uptake was compared in Na (+)-loaded pig coronary artery smooth muscle and endothelial cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3129	18752635-425	The concept of a linkage between NCX and SERCA in smooth muscle was also confirmed by similar distribution of NCX and SERCA2 proteins when detergent-treated microsomes were fractionated by flotation on sucrose density gradients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3130	18752635-425	The concept of a linkage between NCX and SERCA in smooth muscle was also confirmed by similar distribution of NCX and SERCA2 proteins when detergent-treated microsomes were fractionated by flotation on sucrose density gradients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3131	18752971-536	The recent approval of sunitinib, sorafenib, temsirolimus and bevacizumab in combination with IFN-alpha has revolutionized the management of renal cell carcinoma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3132	18752971-536	The recent approval of sunitinib, sorafenib, temsirolimus and bevacizumab in combination with IFN-alpha has revolutionized the management of renal cell carcinoma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3133	18752971-536	The recent approval of sunitinib, sorafenib, temsirolimus and bevacizumab in combination with IFN-alpha has revolutionized the management of renal cell carcinoma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3134	18753126-578	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3135	18753126-578	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3136	18753126-578	Here we report identification of the first three in vivo non-histone protein substrates of lysine propionylation in eukaryotic cells: p53, p300, and CREB-binding protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3137	18753126-580	p300 was able to perform autopropionylation on lysine residues in cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3138	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3139	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3140	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3141	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3142	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3143	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3144	18753604-688	This study determined the effects of the estrous cycle, pregnancy, progesterone (P4), and interferon tau (IFNT) on expression of both facilitative (SLC2A1, SLC2A3, and SLC2A4) and sodium-dependent (SLC5A1 and SLC5A11) glucose transporters in ovine uterine endometria from Days 10 to 16 of the estrous cycle and Days 10 to 20 of pregnancy, as well as in conceptuses from Days 10 to 20 of pregnancy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3145	18753675-708	In CD36-D patients, plasma triglycerides, apolipoprotein B-48 (apoB-48), free fatty acids (FFAs), and free glycerol levels were much higher after OFL than those of controls, along with increases in chylomicron (CM) remnants and small dense low-density lipoprotein (sdLDL) particles.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3146	18753675-708	In CD36-D patients, plasma triglycerides, apolipoprotein B-48 (apoB-48), free fatty acids (FFAs), and free glycerol levels were much higher after OFL than those of controls, along with increases in chylomicron (CM) remnants and small dense low-density lipoprotein (sdLDL) particles.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3147	18753675-708	In CD36-D patients, plasma triglycerides, apolipoprotein B-48 (apoB-48), free fatty acids (FFAs), and free glycerol levels were much higher after OFL than those of controls, along with increases in chylomicron (CM) remnants and small dense low-density lipoprotein (sdLDL) particles.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3148	18753676-709	Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3149	18753676-710	Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3150	18753737-733	Testosterone is a strong correlate of ghrelin levels in men and postmenopausal women.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3151	18754081-829	Up to 72% hexose yield and 94% pentose yield were obtained using modified steam explosion with 2% sulfuric acid at 140 degrees C for 30 min and enzymatic hydrolysis with cellulase (15 filter per unit (FPU)/g cellulose) and beta-glucosidase (50 cellobiose units (CBU)/g cellulose).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3152	18754081-829	Up to 72% hexose yield and 94% pentose yield were obtained using modified steam explosion with 2% sulfuric acid at 140 degrees C for 30 min and enzymatic hydrolysis with cellulase (15 filter per unit (FPU)/g cellulose) and beta-glucosidase (50 cellobiose units (CBU)/g cellulose).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3153	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3154	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3155	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3156	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3157	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3158	18754092-832	Glutathione (GSH), catalase (CAT), and malondialdehyde (MDA) activities in blood were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3159	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3160	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3161	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3162	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3163	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3164	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3165	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3166	18754092-833	Catalase, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), glutathione reductase (GR), malondialdehyde, and nitric oxide (NO) activities were measured from tissue samples.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3167	18754101-836	In this study we examined the possible antigenotoxic effect of selenium (Se) in rats chronically exposed to low levels of methylmercury (MeHg) and the association between glutathione peroxidase (GSH-Px) activity and DNA lesions (via comet assay) in the same exposed animals.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3168	18754101-836	In this study we examined the possible antigenotoxic effect of selenium (Se) in rats chronically exposed to low levels of methylmercury (MeHg) and the association between glutathione peroxidase (GSH-Px) activity and DNA lesions (via comet assay) in the same exposed animals.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3169	18754103-838	To investigate any similarities in the inhibition of CYP2E1 by quinacrine and disulfiram, molecular modeling techniques were adopted and revealed that quinacrine molecule anchors inside the same binding pocket of the protein where disulfiram is also attached.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3170	18754105-839	administered during 7 days at 20 mg/kg per day (subacute treatment), resveratrol abrogated LPS-induced erythrocytes lipoperoxidation and catalase (CAT) activity depression to control levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3171	18754105-839	administered during 7 days at 20 mg/kg per day (subacute treatment), resveratrol abrogated LPS-induced erythrocytes lipoperoxidation and catalase (CAT) activity depression to control levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3172	18754702-986	H2S can be produced from cysteine by enzymes such as cystathionine beta-synthase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3173	18754757-1000	The influence of carbon sources on rhGH (recombinant human growth hormone) production by two Pichia pastoris strains having different methanol utilization phenotypes (P. pastoris-hGH-Mut (+) and P. pastoris-hGH-Mut (s)) was investigated using batch bioreactors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3174	18754816-1023	The present study was undertaken to test the hypothesis that PPARalpha activator fenofibrate plays a key role in left ventricular hypertrophic remodelling via the formation of c-fos/c-jun heterodimers in spontaneous hypertensive rats (SHRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3175	18754816-1023	The present study was undertaken to test the hypothesis that PPARalpha activator fenofibrate plays a key role in left ventricular hypertrophic remodelling via the formation of c-fos/c-jun heterodimers in spontaneous hypertensive rats (SHRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3176	18755047-1448	Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3177	18755047-1448	Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3178	18755047-1448	Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3179	18755051-1093	In the presence of AA (Fe:AA molar ratio of 1:20), significantly more Fe was absorbed from FeSO4 (about 303 %), HSF (about 454 %) and P-HSF (about 371 %) when compared with ferrous sulfate or ferritin without AA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3180	18755051-1093	In the presence of AA (Fe:AA molar ratio of 1:20), significantly more Fe was absorbed from FeSO4 (about 303 %), HSF (about 454 %) and P-HSF (about 371 %) when compared with ferrous sulfate or ferritin without AA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3181	18755266-1173	Insulin-like growth factor-I (IGF-I) is neuroprotective against ethanol-related toxicity and promotes white matter production following a number of insults.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3182	18755266-1173	Insulin-like growth factor-I (IGF-I) is neuroprotective against ethanol-related toxicity and promotes white matter production following a number of insults.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3183	18755266-1174	These data indicate that IGF-I may be a potential treatment for some of ethanol's damaging effects, a finding that has important implications for children of women who drink alcohol during pregnancy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3184	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3185	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3186	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3187	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3188	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3189	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3190	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3191	18755506-1246	This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3192	18755582-1265	SWCNT coatings were thus functionalized with poly(adamantane-pyrrole) and applied to the anchoring of glucose oxidase (GOX), modified with beta-cyclodextrin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3193	18755582-1265	SWCNT coatings were thus functionalized with poly(adamantane-pyrrole) and applied to the anchoring of glucose oxidase (GOX), modified with beta-cyclodextrin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3194	18755582-1266	This allows the immobilization of adamantane-tagged GOX.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3195	18755616-1270	Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3196	18755616-1270	Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3197	18755616-1271	The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3198	18755616-1271	The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3199	18755616-1271	The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3200	18755796-1307	cAMP, a second messenger in LH signaling, was identified as a factor in hCG-dependent regulation of Cdk5/p35.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3201	18755796-1307	cAMP, a second messenger in LH signaling, was identified as a factor in hCG-dependent regulation of Cdk5/p35.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3202	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3203	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3204	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3205	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3206	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3207	18755820-1310	Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3208	18756496-1463	Although we reported that 8-Cl-cAMP induces growth inhibition via p38 mitogen-activated protein kinase (MAPK) and a metabolite of 8-Cl-cAMP, 8-Cl-adenosine mediates this process, the action mechanism of 8-Cl-cAMP is still uncertain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3209	18756527-1486	Certain non-steroidal anti-inflammatory drugs, e.g., the cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs, celecoxib, raise Abeta(42) levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3210	18756589-1515	This was significantly in accordance with intracellular oxidative stress levels measured by glutathione depletion, malondialdehyde production, superoxide dismutase inhibition as well as reactive oxygen species generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3211	18756589-1515	This was significantly in accordance with intracellular oxidative stress levels measured by glutathione depletion, malondialdehyde production, superoxide dismutase inhibition as well as reactive oxygen species generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3212	18756589-1515	This was significantly in accordance with intracellular oxidative stress levels measured by glutathione depletion, malondialdehyde production, superoxide dismutase inhibition as well as reactive oxygen species generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3213	18757054-1690	Acrolein, IL-6 and CRP as markers of silent brain infarction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3214	18757054-1690	Acrolein, IL-6 and CRP as markers of silent brain infarction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3215	18757054-1691	We found previously that increased levels of polyamine oxidase (PAO) (acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)), and acrolein (CH(2)CHCHO) are good markers of stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3216	18757054-1691	We found previously that increased levels of polyamine oxidase (PAO) (acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)), and acrolein (CH(2)CHCHO) are good markers of stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3217	18757054-1691	We found previously that increased levels of polyamine oxidase (PAO) (acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)), and acrolein (CH(2)CHCHO) are good markers of stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3218	18757054-1691	We found previously that increased levels of polyamine oxidase (PAO) (acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)), and acrolein (CH(2)CHCHO) are good markers of stroke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3219	18757054-1692	We then investigated whether silent brain infarction (SBI) can be detected by measuring acrolein, PAO, or other biomarkers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3220	18757054-1693	It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3221	18757054-1693	It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3222	18757054-1693	It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal subjects.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3223	18757097-1716	Human skin keratinocytes HaCat attacked by Staphylococcus aureus alpha-toxin showed a transient drop of cellular ATP levels whereas in toxin-perforated bovine mammary epithelial cells (BMEC), the ATP levels dropped more slowly.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3224	18757185-1747	Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3225	18757188-1748	Estrogenic effect was determined by the change of uterine weight, and oxidant effects were determined by the content of SOD, GSH-Px, CAT and MDA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3226	18757188-1748	Estrogenic effect was determined by the change of uterine weight, and oxidant effects were determined by the content of SOD, GSH-Px, CAT and MDA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3227	18757188-1749	The intake of formononetin increased the uterine weight of the mice significantly as well as the content of SOD, GSH-Px, CAT, and reduced MDA in body.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3228	18757188-1749	The intake of formononetin increased the uterine weight of the mice significantly as well as the content of SOD, GSH-Px, CAT, and reduced MDA in body.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3229	18757189-1750	A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3230	18757189-1751	A novel lectin (PCL) with specificity towards sialic acid was purified from Phaseolus coccineus L. (P. multiflorus willd) seeds using ion exchange chromatography on CM and DEAE-Sepharose, and gel filtration on Sephacryl S-200 column.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3231	18757233-1762	The characterization for the binding of calcium and terbium to Euplotes octocarinatus centrin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3232	18757307-1779	We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3233	18757307-1779	We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3234	18757307-1779	We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3235	18757307-1779	We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3236	18757307-1779	We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3237	18757495-1808	Alkaline phosphatase activity and osteonectin expression of the osteoblasts cultured on the PLGA scaffolds remained stable over three weeks, whilst expression of collagen type I and osteopontin decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3238	18757495-1808	Alkaline phosphatase activity and osteonectin expression of the osteoblasts cultured on the PLGA scaffolds remained stable over three weeks, whilst expression of collagen type I and osteopontin decreased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3239	18757495-1809	The alkaline phosphatase activity of osteoblasts cultured on PLGA scaffolds is comparable with that from two commercially-available scaffolds-OPLA and collagen scaffolds (Becton-Dickinson (BD) Inc., Franklin Lakes, NJ, USA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3240	18757514-1816	The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3241	18757514-1816	The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3242	18757837-1932	The objective of the present study was to investigate the effects of a high-cholesterol diet on caveolin-1 expression and IR localization and activity in the rat liver.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3243	18758183-2073	P27 and P53 play important roles in the signal transduction leading to neointimal growth inhibition and induction of apoptosis of smooth muscle cells due to rapamycin and paclitaxel.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3244	18758183-2073	P27 and P53 play important roles in the signal transduction leading to neointimal growth inhibition and induction of apoptosis of smooth muscle cells due to rapamycin and paclitaxel.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3245	18758183-2073	P27 and P53 play important roles in the signal transduction leading to neointimal growth inhibition and induction of apoptosis of smooth muscle cells due to rapamycin and paclitaxel.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3246	18758183-2073	P27 and P53 play important roles in the signal transduction leading to neointimal growth inhibition and induction of apoptosis of smooth muscle cells due to rapamycin and paclitaxel.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3247	18758695-2200	Immobilization of hemoglobin on the gold colloid modified pretreated glassy carbon electrode for preparing a novel hydrogen peroxide biosensor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3248	18758695-2201	A novel hydrogen peroxide (H2O2) biosensor was developed by immobilizing hemoglobin on the gold colloid modified electrochemical pretreated glassy carbon electrode (PGCE) via the bridging of an ethylenediamine monolayer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3249	18758751-2238	Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3250	18758751-2239	To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied the effects of PKC pathway with an activator of the protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), during hemin-induced erythroid differentiation of K562 erythroleukemia cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3251	18758751-2239	To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied the effects of PKC pathway with an activator of the protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), during hemin-induced erythroid differentiation of K562 erythroleukemia cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3252	18758751-2244	Taken together, our results suggested the involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3253	18758757-2247	At glutamatergic synapses, increased binding to the glycine-B site located in the N-methyl-D-aspartate receptor (NMDAR) can enhance neurotransmission via NMDARs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3254	18758781-2256	The most common adverse events were mild and transient gastrointestinal disturbances, skin rash, nonprogressive transient increases in serum creatinine and urine beta2-microglobulin, and a temporary reduction of the creatinine clearance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3255	18758819-2275	In vitro effect of radiation, antibody to epidermal growth factor receptor and Docetaxel in human head and neck squamous carcinoma cells with mutant P53 and over-expressed EGFR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3256	18758819-2275	In vitro effect of radiation, antibody to epidermal growth factor receptor and Docetaxel in human head and neck squamous carcinoma cells with mutant P53 and over-expressed EGFR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3257	18758819-2275	In vitro effect of radiation, antibody to epidermal growth factor receptor and Docetaxel in human head and neck squamous carcinoma cells with mutant P53 and over-expressed EGFR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3258	18758925-2312	The optimal condition for the labeling of cypate to L-ASNase was 4 h reaction duration at 4 degrees C and pH 8.5 under catalysis by HOBt/HBTU.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3259	18758925-2312	The optimal condition for the labeling of cypate to L-ASNase was 4 h reaction duration at 4 degrees C and pH 8.5 under catalysis by HOBt/HBTU.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3260	18758938-2315	Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3261	18758938-2315	Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3262	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3263	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3264	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3265	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3266	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3267	18758940-2316	Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3268	18758940-2317	Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3269	18758940-2317	Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3270	18758940-2318	We here present the biofunctionalization of surfaces with poly-LacNAc structures and subsequent binding of ECM glycoproteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3271	18758940-2319	A mixture of poly-LacNAc-structures covalently coupled to functionalized microtiter plates were identified for best binding to our model galectin His(6) CGL2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3272	18758940-2319	A mixture of poly-LacNAc-structures covalently coupled to functionalized microtiter plates were identified for best binding to our model galectin His(6) CGL2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3273	18758940-2320	We further demonstrate for the first time that these poly-LacNAc surfaces are suitable for further galectin-mediated binding of the ECM glycoproteins laminin and fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3274	18758940-2320	We further demonstrate for the first time that these poly-LacNAc surfaces are suitable for further galectin-mediated binding of the ECM glycoproteins laminin and fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3275	18758940-2320	We further demonstrate for the first time that these poly-LacNAc surfaces are suitable for further galectin-mediated binding of the ECM glycoproteins laminin and fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3276	18758940-2320	We further demonstrate for the first time that these poly-LacNAc surfaces are suitable for further galectin-mediated binding of the ECM glycoproteins laminin and fibronectin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3277	18758978-2339	Seasonal variation of the metal (Zn, Fe, Mn) and metallothionein concentrations in the liver cytosol of the European chub (Squalius cephalus L.).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3278	18758978-2340	The specimens caught in the spring period had higher biometric (liver mass, condition and hepatosomatic indices) and some biochemical parameters (metallothionein (MT) and Mn) that are characteristic for the reproductive period.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3279	18758993-2343	Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3280	18758993-2343	Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3281	18758993-2343	Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3282	18758993-2343	Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3283	18758993-2344	These transcripts were predicted to synthesis of GAD proteins truncated of the binding site for pyridoxal phosphate, an essential cofactor, therefore cannot function as a decarboxylase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3284	18759148-2382	Loss-of-expression of SSTR2 in tumor tissues has been suggested to correlate with tumor progression and to the relatively poorer outcomes of somatostatin analog treatment in some clinical trials.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3285	18760301-213	Cobra venom factor (CVF) is a structural and functional analog of complement C3 isolated from cobra venom.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3286	18760497-301	Activities of malate- and succinate-dehydrogenases (MDH, SDH) and NADH- and succinate-cytochrome c reductases (NCCR, SCCR) were rapidly inhibited, while cytochrome c oxidase (CCO) was unaltered by cadmium treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3287	18760497-301	Activities of malate- and succinate-dehydrogenases (MDH, SDH) and NADH- and succinate-cytochrome c reductases (NCCR, SCCR) were rapidly inhibited, while cytochrome c oxidase (CCO) was unaltered by cadmium treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3288	18760497-302	However, this stimulated the NADPH-generating enzyme activities of the pentose phosphate pathway, glucose-6-phosphate- and 6-phosphogluconate-dehydrogenases (G6PDH, 6PGDH), as well as enzyme activity of fermentation, alcohol dehydrogenase (ADH), with concomitant inhibition in the capacity of enzyme inactivator (INADH).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3289	18760497-302	However, this stimulated the NADPH-generating enzyme activities of the pentose phosphate pathway, glucose-6-phosphate- and 6-phosphogluconate-dehydrogenases (G6PDH, 6PGDH), as well as enzyme activity of fermentation, alcohol dehydrogenase (ADH), with concomitant inhibition in the capacity of enzyme inactivator (INADH).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3290	18760497-302	However, this stimulated the NADPH-generating enzyme activities of the pentose phosphate pathway, glucose-6-phosphate- and 6-phosphogluconate-dehydrogenases (G6PDH, 6PGDH), as well as enzyme activity of fermentation, alcohol dehydrogenase (ADH), with concomitant inhibition in the capacity of enzyme inactivator (INADH).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3291	18760912-456	We also examined cellular impedance responsiveness of PC 12 cells in response to phenotypic alteration especially with regard to modulation of ion fluxes using nerve growth factor (NGF), dexamethasone and forskolin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3292	18760912-456	We also examined cellular impedance responsiveness of PC 12 cells in response to phenotypic alteration especially with regard to modulation of ion fluxes using nerve growth factor (NGF), dexamethasone and forskolin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3293	18760952-480	This paper investigates the effect of sterilisation by gamma irradiation (dose 2.5Mrad) on the following properties of polycaprolactone (PCL): (1) degradation rate (catalysed by lipase), (2) mechanical properties, (3) the ability of cells to attach and subsequently grow on its surface.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3294	18761029-495	Specifically, animals were exposed to one of five dipsetic stimuli: (1) 24-h water deprivation, (2) replacement of drinking water with 2.5% NaCl, (3) peripheral administration of hypertonic saline, (4) ICV injection of angiotensin II (AngII), or (5) the combination of peripheral hypertonic saline and central AngII.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3295	18761029-495	Specifically, animals were exposed to one of five dipsetic stimuli: (1) 24-h water deprivation, (2) replacement of drinking water with 2.5% NaCl, (3) peripheral administration of hypertonic saline, (4) ICV injection of angiotensin II (AngII), or (5) the combination of peripheral hypertonic saline and central AngII.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3296	18761103-512	We therefore propose copper-dependent homodimerization to be an essential step in the regulation of ATOX1-dependent transcription.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3297	18761380-599	In order to investigate the role of spinal opioid peptide in the phenomenon of naloxone-precipitated withdrawal we examined the effect of herpes simplex virus vector-mediated overexpression of proenkephalin in lumbar dorsal root ganglia in rats with neuropathic pain treated with morphine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3298	18761426-612	The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3299	18761603-651	One hundred and forty-four HCV-2- and HCV-3-infected patients initiated Peg-IFN alpha-2a (180 microg/week) and ribavirin (1000 or 1200 mg/day); those with viral clearance at week 4 were randomized to either Peg-IFN alpha-2a monotherapy (n = 59) or continuing combination therapy (n = 61) until week 12.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3300	18761603-652	Thus in HCV-2- and HCV-3-infected patients, withdrawal of ribavirin and continuation of Peg-IFN alpha-2a monotherapy may be appropriate to attain an SVR, providing viraemia is cleared early during therapy and associated with low baseline viral load.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3301	18761779-682	The apoE-deficient mouse, which develops atherosclerotic lesions rapidly when fed cholesterol, was used to determine the ability of dried plums to reduce atherosclerosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3302	18761779-683	Urinary thiobarbituric acid-reactive substances (TBARS) excretion and serum amyloid P-component (SAP) were measured as indicators of oxidative stress and inflammation, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3303	18761779-683	Urinary thiobarbituric acid-reactive substances (TBARS) excretion and serum amyloid P-component (SAP) were measured as indicators of oxidative stress and inflammation, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3304	18762200-801	Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3305	18762200-801	Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3306	18762201-805	Thus, in keeping with the ability of neurosteroids to potentiate GABA currents via a broad variety of GABA(A) receptor isoforms in neurons, the potentiation site is structurally highly conserved on this important neurotransmitter receptor family.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3307	18762202-807	The 5-HT2AR response dominated the MAPK signaling pathway when co-expressed with 5-HT1AR, and diminution of the response by the 5-HT2AR antagonist Ketanserin could not be rescued by the 5-HT1AR agonist.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3308	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3309	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3310	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3311	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3312	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3313	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3314	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3315	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3316	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3317	18762271-826	The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3318	18762369-869	Novel homo- and hetero-nuclear copper (II) complexes of tetradentate Schiff bases: synthesis, characterization, solvent-extraction and catalase-like activity studies.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3319	18762913-991	In streptozotocin-nicotinamide-induced diabetic mice, ASP8497 was administered orally for 3 weeks at 1, 3, or 10 mg/kg once daily, which improved the hemoglobin A (1c), non-fasting plasma insulin, fasting blood glucose levels, glucose intolerance, and lipid profiles (plasma triglyceride, non-esterified fatty acid and total cholesterol) with neutral effect on body weight.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3320	18762913-991	In streptozotocin-nicotinamide-induced diabetic mice, ASP8497 was administered orally for 3 weeks at 1, 3, or 10 mg/kg once daily, which improved the hemoglobin A (1c), non-fasting plasma insulin, fasting blood glucose levels, glucose intolerance, and lipid profiles (plasma triglyceride, non-esterified fatty acid and total cholesterol) with neutral effect on body weight.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3321	18762913-991	In streptozotocin-nicotinamide-induced diabetic mice, ASP8497 was administered orally for 3 weeks at 1, 3, or 10 mg/kg once daily, which improved the hemoglobin A (1c), non-fasting plasma insulin, fasting blood glucose levels, glucose intolerance, and lipid profiles (plasma triglyceride, non-esterified fatty acid and total cholesterol) with neutral effect on body weight.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3322	18762913-991	In streptozotocin-nicotinamide-induced diabetic mice, ASP8497 was administered orally for 3 weeks at 1, 3, or 10 mg/kg once daily, which improved the hemoglobin A (1c), non-fasting plasma insulin, fasting blood glucose levels, glucose intolerance, and lipid profiles (plasma triglyceride, non-esterified fatty acid and total cholesterol) with neutral effect on body weight.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3323	18762977-1011	The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5+/-1.9 mg/dL, PO4 4.4+/-1.3 mg/dL, alkaline phosphatase (ALP) 1,341+/-823, 25-hydroxyvitamin D (25 (OH) D) 5.8+/-2.9 ng/mL, intact parathyroid hormone (iPTH) 240+/-106 pg/mL.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3324	18762977-1011	The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5+/-1.9 mg/dL, PO4 4.4+/-1.3 mg/dL, alkaline phosphatase (ALP) 1,341+/-823, 25-hydroxyvitamin D (25 (OH) D) 5.8+/-2.9 ng/mL, intact parathyroid hormone (iPTH) 240+/-106 pg/mL.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3325	18762977-1011	The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5+/-1.9 mg/dL, PO4 4.4+/-1.3 mg/dL, alkaline phosphatase (ALP) 1,341+/-823, 25-hydroxyvitamin D (25 (OH) D) 5.8+/-2.9 ng/mL, intact parathyroid hormone (iPTH) 240+/-106 pg/mL.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3326	18762977-1011	The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5+/-1.9 mg/dL, PO4 4.4+/-1.3 mg/dL, alkaline phosphatase (ALP) 1,341+/-823, 25-hydroxyvitamin D (25 (OH) D) 5.8+/-2.9 ng/mL, intact parathyroid hormone (iPTH) 240+/-106 pg/mL.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3327	18763027-1031	There are no controlled trials comparing etanercept and acitretin efficacy and therapeutic mechanisms in psoriasis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3328	18763047-1035	Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3329	18763168-1076	Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3330	18763168-1076	Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3331	18764779-1509	The aqueous extract was found to be more effective than doxorubicin, a classical anticarcinogenic drug, with respect to its action on antioxidant enzymes and LDH in the liver of mice with developing lymphomas.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3332	18764780-1510	Cu,Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3333	18764780-1511	The understanding of the mechanism, oxidant(s) involved and how and what protein radicals are produced during the reaction of wild-type SOD1 (Cu,Zn-superoxide dismutase) with H2O2 and their fate is incomplete, but a better understanding of the role of this reaction is needed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3334	18764780-1511	The understanding of the mechanism, oxidant(s) involved and how and what protein radicals are produced during the reaction of wild-type SOD1 (Cu,Zn-superoxide dismutase) with H2O2 and their fate is incomplete, but a better understanding of the role of this reaction is needed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3335	18764780-1512	In the absence of (bi)carbonate, site-specific radical-mediated fragmentation is produced by SOD1 active-site copper.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3336	18764780-1513	Finally, we propose a biochemical mechanism to explain CO(*-) production from CO2, enhanced protein radical formation and protection by (bi)carbonate against H2O2-induced fragmentation of the SOD1 active site.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3337	18764784-1516	Furthermore, lysosomal integrity was disrupted after addition of clioquinol and zinc to the cells, as shown by redistribution of both Acridine Orange and cathepsin D. Clioquinol plus zinc resulted in a cleavage of Bid (BH3-interacting domain death agonist), a hallmark of lysosome-mediated apoptotic cell death.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3338	18764784-1516	Furthermore, lysosomal integrity was disrupted after addition of clioquinol and zinc to the cells, as shown by redistribution of both Acridine Orange and cathepsin D. Clioquinol plus zinc resulted in a cleavage of Bid (BH3-interacting domain death agonist), a hallmark of lysosome-mediated apoptotic cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3339	18764784-1516	Furthermore, lysosomal integrity was disrupted after addition of clioquinol and zinc to the cells, as shown by redistribution of both Acridine Orange and cathepsin D. Clioquinol plus zinc resulted in a cleavage of Bid (BH3-interacting domain death agonist), a hallmark of lysosome-mediated apoptotic cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3340	18764864-1538	Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3341	18764864-1538	Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3342	18764864-1538	Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3343	18764923-1564	The picture of signalling mechanisms underlying the wound-regulated FAD7 expression, and potential roles of CPL proteins as attenuators of wound-induced JA biosynthesis, are discussed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3344	18764923-1564	The picture of signalling mechanisms underlying the wound-regulated FAD7 expression, and potential roles of CPL proteins as attenuators of wound-induced JA biosynthesis, are discussed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3345	18765263-1705	KiSS-1 mRNA was significantly increased by seizure activity in rats and when neuronal activity in organotypic hippocampal slice cultures was enhanced by kainate or picrotoxin, while mRNA for GPR54 remained essentially unchanged.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3346	18765263-1705	KiSS-1 mRNA was significantly increased by seizure activity in rats and when neuronal activity in organotypic hippocampal slice cultures was enhanced by kainate or picrotoxin, while mRNA for GPR54 remained essentially unchanged.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3347	18765295-1718	In permeabilized muscle fibers, we observed, a strong inhibition of both state 3 mitochondrial respiration and functionally isolated maximal cytochrome c oxidase (COX) activity after 49 days of MeHg exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3348	18765295-1718	In permeabilized muscle fibers, we observed, a strong inhibition of both state 3 mitochondrial respiration and functionally isolated maximal cytochrome c oxidase (COX) activity after 49 days of MeHg exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3349	18765678-1803	The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3350	18765678-1803	The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3351	18765678-1804	In contrast, amino acids, especially leucine, regulate mTORC1 by controlling the ability of Rheb-GTP to activate mTORC1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3352	18765850-1867	Cortisol, hematocrit, blood urea nitrogen, total protein, albumin, aspartate aminotransferase 0.05) after transport regardless of space allowance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3353	18766172-2008	At 2 h in suspension, keratinocytes that had become committed to terminal differentiation had increased side scatter, were 7-aminoactinomycin D (7-AAD) positive and annexin V negative; they exhibited loss of mitochondrial membrane potential and increased cardiolipin oxidation, but with no increase in reactive oxygen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3354	18766172-2008	At 2 h in suspension, keratinocytes that had become committed to terminal differentiation had increased side scatter, were 7-aminoactinomycin D (7-AAD) positive and annexin V negative; they exhibited loss of mitochondrial membrane potential and increased cardiolipin oxidation, but with no increase in reactive oxygen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3355	18766385-2075	Iron uptake by the ubiquitous iron-storage protein ferritin involves the oxidation of two Fe(II) ions located at the highly conserved dinuclear " ferroxidase centre" in individual subunits.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3356	18766385-2075	Iron uptake by the ubiquitous iron-storage protein ferritin involves the oxidation of two Fe(II) ions located at the highly conserved dinuclear " ferroxidase centre" in individual subunits.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3357	18766385-2076	We have measured X-ray absorption spectra of four mutants (K86Q, K86Q/E27D, K86Q/E107D, and K86Q/E27D/E107D, involving variations of Glu to Asp on either or both sides of the dinuclear ferroxidase site) of recombinant human H-chain ferritin (rHuHF) in their complexes with reactive Fe(II) and redox-inactive Zn(II).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3358	18766385-2076	We have measured X-ray absorption spectra of four mutants (K86Q, K86Q/E27D, K86Q/E107D, and K86Q/E27D/E107D, involving variations of Glu to Asp on either or both sides of the dinuclear ferroxidase site) of recombinant human H-chain ferritin (rHuHF) in their complexes with reactive Fe(II) and redox-inactive Zn(II).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3359	18766385-2076	We have measured X-ray absorption spectra of four mutants (K86Q, K86Q/E27D, K86Q/E107D, and K86Q/E27D/E107D, involving variations of Glu to Asp on either or both sides of the dinuclear ferroxidase site) of recombinant human H-chain ferritin (rHuHF) in their complexes with reactive Fe(II) and redox-inactive Zn(II).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3360	18766385-2076	We have measured X-ray absorption spectra of four mutants (K86Q, K86Q/E27D, K86Q/E107D, and K86Q/E27D/E107D, involving variations of Glu to Asp on either or both sides of the dinuclear ferroxidase site) of recombinant human H-chain ferritin (rHuHF) in their complexes with reactive Fe(II) and redox-inactive Zn(II).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3361	18766955-2250	The aim of this study was to determine the effect of spironolactone on endothelial function in anti-tumour necrosis factor (TNF)-naive RA patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3362	18767058-2287	Compared with nonperfused constructs, flow perfused constructs demonstrated improved cells proliferation and differentiation according to cell viability, glucose consumption, alkaline phosphatase activity, and osteopontin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3363	18767059-2288	Behavior of rat periodontal ligament cells on fibroblast growth factor-2-immobilized titanium surfaces treated by plasma modification.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3364	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3365	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3366	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3367	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3368	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3369	18767059-2289	The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3370	18767059-2290	These were treated with oxygen plasma and dipped in FGF-2 solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3371	18767059-2291	Cells from fourth subculture were seeded onto the FGF-2-immobilized titanium surface.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3372	18767059-2292	These findings suggest that oxygen plasma modification can immobilize FGF-2 onto a titanium surface.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3373	18767059-2292	These findings suggest that oxygen plasma modification can immobilize FGF-2 onto a titanium surface.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3374	18767063-2297	One of the best triads for bone engineering is bone marrow stromal cells, calcium phosphate ceramics, and bone morphogenetic protein (BMP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3375	18767063-2297	One of the best triads for bone engineering is bone marrow stromal cells, calcium phosphate ceramics, and bone morphogenetic protein (BMP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3376	18767063-2298	The cells were mixed with beta-tricalcium phosphate (beta-TCP) granules followed by osteoblast induction with recombinant human BMP-2 (rhBMP-2) (first mixture), or were first induced with rhBMP-2 on plastic dishes and then mixed with the beta-TCP granules (last mixture) just prior to the operation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3377	18767136-1171	Effect of short-time exposures to nickel and lead on brain monoamine oxidase from Danio rerio and Poecilia reticulata.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3378	18767136-1172	The aim of this work was to verify, in two small size freshwater teleosts Danio rerio and Poecilia reticulata, the effects of short-time exposures (24 and 72 h) to a sublethal dose (500 microg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3379	18767136-1172	The aim of this work was to verify, in two small size freshwater teleosts Danio rerio and Poecilia reticulata, the effects of short-time exposures (24 and 72 h) to a sublethal dose (500 microg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3380	18767138-2325	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3381	18767138-2325	Methylenetetrahydrofolate dehydrogenasetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3382	18767138-2325	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3383	18767138-2325	Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3384	18767147-1187	An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3385	18767147-1187	An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3386	18767147-1187	An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3387	18767147-1187	An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3388	18767147-1187	An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3389	18767149-2331	We characterized this selenoprotein MsrA which had a single Sec residue at the catalytic site but no cysteine (Cys) residues in the protein sequence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3390	18767150-2332	Zn2+-linked dimerization of UreG from Helicobacter pylori, a chaperone involved in nickel trafficking and urease activation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3391	18767150-2332	Zn2+-linked dimerization of UreG from Helicobacter pylori, a chaperone involved in nickel trafficking and urease activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3392	18767150-2333	The biosynthesis of the active metal-bound form of the nickel-dependent enzyme urease involves the formation of a lysine-carbamate functional group concomitantly with the delivery of two Ni(2+) ions into the precast active site of the apoenzyme and with GTP hydrolysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3393	18767150-2333	The biosynthesis of the active metal-bound form of the nickel-dependent enzyme urease involves the formation of a lysine-carbamate functional group concomitantly with the delivery of two Ni(2+) ions into the precast active site of the apoenzyme and with GTP hydrolysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3394	18767150-2333	The biosynthesis of the active metal-bound form of the nickel-dependent enzyme urease involves the formation of a lysine-carbamate functional group concomitantly with the delivery of two Ni(2+) ions into the precast active site of the apoenzyme and with GTP hydrolysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3395	18767155-2335	Residue-wise conformational stability of DLC8 dimer from native-state hydrogen exchange.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3396	18767934-15	Whereas the role of locally produced 1, 25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid cell growth, so CYP27B1 can be considered a candidate parathyroid tumor suppressor gene in that its acquired inactivation in a parathyroid cell could confer a tumorigenic growth advantage.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3397	18767934-15	Whereas the role of locally produced 1, 25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid cell growth, so CYP27B1 can be considered a candidate parathyroid tumor suppressor gene in that its acquired inactivation in a parathyroid cell could confer a tumorigenic growth advantage.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3398	18768213-91	Mechanistically, we showed EphA2 knockdown suppressed thrombin-induced serine 536 phosphorylation of NFkappaB, an event critical of ICAM-1 transcriptional upregulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3399	18768213-91	Mechanistically, we showed EphA2 knockdown suppressed thrombin-induced serine 536 phosphorylation of NFkappaB, an event critical of ICAM-1 transcriptional upregulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3400	18768362-173	Total antioxidant capacity, catalase, thiobarbituric acid-reactive substances, hemoglobin, transferrin saturation and ferritin did not change significantly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3401	18768362-173	Total antioxidant capacity, catalase, thiobarbituric acid-reactive substances, hemoglobin, transferrin saturation and ferritin did not change significantly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3402	18768362-173	Total antioxidant capacity, catalase, thiobarbituric acid-reactive substances, hemoglobin, transferrin saturation and ferritin did not change significantly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3403	18768362-173	Total antioxidant capacity, catalase, thiobarbituric acid-reactive substances, hemoglobin, transferrin saturation and ferritin did not change significantly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3404	18768916-385	Considering the post-cAMP sites of HA action, it is shown herein that HA markedly inhibited db-cAMP-stimulated steroidogenic acute regulatory (STAR) protein expression, as well as steps catalyzed by P450-dependent enzymes, mainly the conversion of cholesterol to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3405	18768916-385	Considering the post-cAMP sites of HA action, it is shown herein that HA markedly inhibited db-cAMP-stimulated steroidogenic acute regulatory (STAR) protein expression, as well as steps catalyzed by P450-dependent enzymes, mainly the conversion of cholesterol to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3406	18768916-385	Considering the post-cAMP sites of HA action, it is shown herein that HA markedly inhibited db-cAMP-stimulated steroidogenic acute regulatory (STAR) protein expression, as well as steps catalyzed by P450-dependent enzymes, mainly the conversion of cholesterol to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3407	18768916-385	Considering the post-cAMP sites of HA action, it is shown herein that HA markedly inhibited db-cAMP-stimulated steroidogenic acute regulatory (STAR) protein expression, as well as steps catalyzed by P450-dependent enzymes, mainly the conversion of cholesterol to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3408	18768916-386	Finally, HA increased nitric oxide synthase (NOS) activity, and the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) markedly attenuated the effect of the amine on steroid synthesis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3409	18769443-565	LH, FSH, 17 beta-estradiol, progesterone, aldosterone and PRA were assayed at the seventh, fourteenth, twenty-first and twenty-eighth days of the cycle after 30 min of recumbency.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3410	18769443-565	LH, FSH, 17 beta-estradiol, progesterone, aldosterone and PRA were assayed at the seventh, fourteenth, twenty-first and twenty-eighth days of the cycle after 30 min of recumbency.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3411	18769443-566	Aldosterone was positively related to PRA and progesterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3412	18769474-571	COMT activity and proline levels may therefore be altered in 22q11DS individuals.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3413	18769474-572	COMT (158) genotype and plasma proline levels were determined in the 22q11DS children.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3414	18769875-666	We have investigated its antibacterial activity and binding activity to pathogenic whole cell antigens, lipopolysaccharide (LPS) and staphylococcal enterotoxin B.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3415	18770028-698	Quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases such as Parkinson's disease and methamphetamine-induced neurotoxicity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3416	18771337-1073	The effect of fenitrothion exposure on birds was examined by measuring aerobic metabolism, blood hemoglobin content, plasma cholinesterases, and body weight for up to 21 d postdose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3417	18771337-1073	The effect of fenitrothion exposure on birds was examined by measuring aerobic metabolism, blood hemoglobin content, plasma cholinesterases, and body weight for up to 21 d postdose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3418	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3419	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3420	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3421	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3422	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3423	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3424	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3425	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3426	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3427	18771515-1111	Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3428	18771515-1112	Of the 18 E. coli isolated from healthy calves, K99 (16.6%) and intimin (55.5%) genes were identified by PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3429	18771515-1112	Of the 18 E. coli isolated from healthy calves, K99 (16.6%) and intimin (55.5%) genes were identified by PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3430	18771515-1113	K99, F41, STa, Stx1 and Stx2 were found as the most common virulence gene markers of E. coli strains isolated from calves with diarrhoea.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3431	18771515-1113	K99, F41, STa, Stx1 and Stx2 were found as the most common virulence gene markers of E. coli strains isolated from calves with diarrhoea.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3432	18771570-1136	These agents possess a range of physiological effects that are associated with improved glycaemic control in diabetes including stimulation of glucose-dependent insulin secretion, suppression of glucagon secretion, slowing of gastric emptying, and reduction of food intake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3433	18771570-1136	These agents possess a range of physiological effects that are associated with improved glycaemic control in diabetes including stimulation of glucose-dependent insulin secretion, suppression of glucagon secretion, slowing of gastric emptying, and reduction of food intake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3434	18771604-1158	Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3435	18771604-1159	Induction of GRP94 by thapsigargin was also decreased in the BD group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3436	18771683-1179	Efforts in the field of synthetic vaccine carriers are focussing on decorating the particle surface with ligands for DC receptors such as heparan sulphate glycosaminoglycan structures, integrins, Siglecs, galectins, C-type lectins and toll-like receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3437	18771683-1179	Efforts in the field of synthetic vaccine carriers are focussing on decorating the particle surface with ligands for DC receptors such as heparan sulphate glycosaminoglycan structures, integrins, Siglecs, galectins, C-type lectins and toll-like receptors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3438	18771795-1211	Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3439	18771795-1211	Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3440	18771857-1234	It appears that GSTM1 null and GSTT1 null have a clear association with longer overall survival in patients with different malignancies who are treated with substrates for these GSTs (mostly alkylating agents and platinum compounds).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3441	18771857-1234	It appears that GSTM1 null and GSTT1 null have a clear association with longer overall survival in patients with different malignancies who are treated with substrates for these GSTs (mostly alkylating agents and platinum compounds).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3442	18771857-1234	It appears that GSTM1 null and GSTT1 null have a clear association with longer overall survival in patients with different malignancies who are treated with substrates for these GSTs (mostly alkylating agents and platinum compounds).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3443	18771904-1247	Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3444	18771904-1248	BALB/c mice were either left untreated or administered daily with vehicle (VH; saline) and/or silibinin (200 or 400 mg/kg) by gavage for 3 consecutive days prior to sensitization with ovalbumin (OVA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3445	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3446	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3447	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3448	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3449	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3450	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3451	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3452	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3453	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3454	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3455	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3456	18772236-1315	Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3457	18772236-1316	These results indicate that HG-induced TNF-alpha shedding could be attributed to TACE activation, which is regulated, in part, by PKC-delta and AR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3458	18772236-1316	These results indicate that HG-induced TNF-alpha shedding could be attributed to TACE activation, which is regulated, in part, by PKC-delta and AR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3459	18772236-1316	These results indicate that HG-induced TNF-alpha shedding could be attributed to TACE activation, which is regulated, in part, by PKC-delta and AR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3460	18772240-1321	We conclude that gastrocnemius, heart, and liver mitochondria of streptozotocin diabetic rats are not irrevocably altered toward excess superoxide production either by complex I or complex III.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3461	18772354-1356	Consequently, the primary mechanism of resistance to temozolomide is a function of the activity of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3462	18772354-1356	Consequently, the primary mechanism of resistance to temozolomide is a function of the activity of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3463	18772483-962	Despite their inhibitory effects on inflammatory gene expression, loss of PPARs or LXRs in macrophages did not exert major effects on obesity or glucose tolerance induced by a high-fat diet.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3464	18772483-964	Our results do not exclude a contribution of macrophage PPAR and LXR expression to systemic metabolism in certain contexts, but these factors do not appear to be dominant contributors to glucose tolerance in a high-fat-fed Th1-biased bone marrow transplant model.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3465	18772488-1372	The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3466	18772488-1373	A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3467	18772488-1376	Androgen therapy of hypogonadal men improves insulin sensitivity, fasting glucose, and HbA1c levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3468	18772894-1473	Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3469	18772894-1473	Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3470	18773149-1572	A mechanism for the bioreduction of H2PtCl6 and PtCl2 into platinum nanoparticles by a hydrogenase enzyme from Fusarium oxysporum is proposed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3471	18773198-1602	Responses of limbic and extrapyramidal substance P systems to nicotine treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3472	18773247-1624	Radioisotopic localization of (90) Yttrium-ibritumomab tiuxetan in patients with CD20+ non-Hodgkin's lymphoma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3473	18773910-1819	We solved the crystal structures of Aquifex aeolicus SPS and its complex with adenosine 5 '-(alpha,beta-methylene) triphosphate (AMPCPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3474	18773910-1819	We solved the crystal structures of Aquifex aeolicus SPS and its complex with adenosine 5 '-(alpha,beta-methylene) triphosphate (AMPCPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3475	18773910-1820	To identify the amino-acid residues that contribute to SPS activity, we prepared six mutants of SPS and examined their selenide-dependent ATP consumption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3476	18773910-1821	In SPS. AMPCPP, the N-terminal loop, including the two residues, assumes different conformations ("open" and "closed") between the two subunits.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3477	18773925-1827	The results indicated that CB1 receptors within the nucleus accumbens are involved in the acquisition and expression of morphine-induced CPP in sensitized rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3478	18773927-1828	Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3479	18773927-1828	Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3480	18773927-1828	Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3481	18773927-1829	The potentiated effect of obestatin on glucose-induced insulin output was not observed in the presence of diazoxide, an agent that activates ATP-dependent K(+) channels, thus suggesting that these channels might be sensitive to this peptide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3482	18773927-1829	The potentiated effect of obestatin on glucose-induced insulin output was not observed in the presence of diazoxide, an agent that activates ATP-dependent K(+) channels, thus suggesting that these channels might be sensitive to this peptide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3483	18773927-1829	The potentiated effect of obestatin on glucose-induced insulin output was not observed in the presence of diazoxide, an agent that activates ATP-dependent K(+) channels, thus suggesting that these channels might be sensitive to this peptide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3484	18773927-1829	The potentiated effect of obestatin on glucose-induced insulin output was not observed in the presence of diazoxide, an agent that activates ATP-dependent K(+) channels, thus suggesting that these channels might be sensitive to this peptide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3485	18773954-1841	Four brain areas (cortex, hippocampus, thalamus and hypothalamus) were analyzed for EB extravasation, water and electrolyte (Na (+), K(+), Cl (-)) contents, immunostained for albumin and glial fibrillary acidic protein (GFAP), and examined for neuronal, glial and axonal alterations using standard light and electron microscopy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3486	18773954-1841	Four brain areas (cortex, hippocampus, thalamus and hypothalamus) were analyzed for EB extravasation, water and electrolyte (Na (+), K(+), Cl (-)) contents, immunostained for albumin and glial fibrillary acidic protein (GFAP), and examined for neuronal, glial and axonal alterations using standard light and electron microscopy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3487	18773954-1841	Four brain areas (cortex, hippocampus, thalamus and hypothalamus) were analyzed for EB extravasation, water and electrolyte (Na (+), K(+), Cl (-)) contents, immunostained for albumin and glial fibrillary acidic protein (GFAP), and examined for neuronal, glial and axonal alterations using standard light and electron microscopy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3488	18773954-1841	Four brain areas (cortex, hippocampus, thalamus and hypothalamus) were analyzed for EB extravasation, water and electrolyte (Na (+), K(+), Cl (-)) contents, immunostained for albumin and glial fibrillary acidic protein (GFAP), and examined for neuronal, glial and axonal alterations using standard light and electron microscopy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3489	18773955-1842	We administered parathion to newborn rats on postnatal days (PN) 1-4 at doses spanning the threshold for detectable cholinesterase inhibition (0.1 mg/kg/day) and the first signs of loss of viability (0.2 mg/kg/day).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3490	18774132-1889	The Arg105 in GLUT10 is highly conserved across species and its replacement with cysteine is predicted to be pathogenic.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3491	18774203-1922	(Ofloxacin is contraindicated in case of G6PDG6PD deficiency: is it evidenced based?).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3492	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3493	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3494	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3495	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3496	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3497	18774319-1994	We also assess prostaglandin (PGE (2)) and thromboxane (TXB (2)) inhibition to establish the correlation between behavioural measures and the degree of selectivity for COX-1 and COX-2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3498	18774664-2104	High-dose steroid therapy for the former symptoms of AHS, and immunoglobulin, granulocyte colony-stimulating factor, and cefepime for the latter agranulocytosis were successfully performed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3499	18774689-2116	0.05 vs. aortic IR) plasma levels of malondialdehyde, P-selectin, intercellular adhesion molecule-1 (ICAM-I), and tissue levels of malondialdehyde and catalase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3500	18774957-2175	Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3501	18774957-2175	Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3502	18775028-2185	arginase-diminished arginine and indolamine 2,3-dioxygenase-diminished tryptophan) or nitric oxide (NO) production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3503	18775028-2185	arginase-diminished arginine and indolamine 2,3-dioxygenase-diminished tryptophan) or nitric oxide (NO) production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3504	18775028-2185	arginase-diminished arginine and indolamine 2,3-dioxygenase-diminished tryptophan) or nitric oxide (NO) production.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3505	18775088-2206	Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3506	18775088-2207	The aim of the present study was to determine whether memory impairments were present in young women at increased familial risk of depression and whether memory performance was related either to cortisol secretion or to allelic variation in the promoter region of the serotonin transporter gene (5-HTT).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3507	18775090-2208	The relative gene expression of cytochrome c 0.05) in-Cu calves compared with+ Cu or-Cu+Mn calves.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3508	18775100-2213	Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3509	18775100-2213	Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3510	18775100-2214	The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics, who have higher levels of these biomarkers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3511	18775100-2215	No between-treatment differences were found with regard to IL-6 or RBP4 ; though IL-6 0.001 following lignan and placebo treatments, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3512	18775100-2215	No between-treatment differences were found with regard to IL-6 or RBP4 ; though IL-6 0.001 following lignan and placebo treatments, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3513	18775460-2359	These include typical G-protein (Galphaq/11)-coupled cascades, such as activation of phospholipase C (PLC), and subsequent accumulation of inositol-(1,4,5)-triphosphate (IP3), intracellular Ca(2+) mobilization, and activation of protein kinase C.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3514	18775471-2362	Here we report the discovery of a series of novel adamantyl carboxamides as selective inhibitors of human 11beta-HSD1 in HEK-293 cells transfected with the HSD11B1 gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3515	18775538-2383	Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3516	18775538-2384	We investigated whether this allele was associated with elevated Lp(a) and cardiovascular risk in the Women's Health Study, a randomized trial of low-dose aspirin, and whether aspirin reduced cardiovascular risk in minor allele carriers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3517	18775593-2403	The study was prompted to characterize the B-type esterase activities in the terrestrial snail Xeropicta derbentina and to evaluate its sensitivity to organophosphorus and carbamate pesticides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3518	18775593-2404	Specific cholinesterase and carboxylesterase activities were mainly obtained with acetylthiocholine (K(m)=77.2 mM; V(max)=38.2 mU/mg protein) and 1-naphthyl acetate (K(m)=222 mM, V(max)=1095 mU/mg protein) substrates, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3519	18775593-2404	Specific cholinesterase and carboxylesterase activities were mainly obtained with acetylthiocholine (K(m)=77.2 mM; V(max)=38.2 mU/mg protein) and 1-naphthyl acetate (K(m)=222 mM, V(max)=1095 mU/mg protein) substrates, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3520	18775733-2451	To distinguish between isoform-specific and context-dependent modulation as possible explanations for this selectivity, the effects of penicillin were evaluated on recombinant GABA(A) receptors expressed in HEK293T cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3521	18775745-2455	Drosophila responds to detection of diamonopimelic-type microbial peptidoglycan through activation of the immune deficiency (Imd) pathway, a signaling pathway with numerous similarities to the mammalian pro-inflammatory TNF pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3522	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3523	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3524	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3525	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3526	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3527	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3528	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3529	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3530	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3531	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3532	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3533	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3534	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3535	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3536	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3537	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3538	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3539	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3540	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3541	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3542	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3543	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3544	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3545	18775894-2504	We measured serum high-sensitivity C-reactive protein (hs-CRP), fetuin-A, IL-6, IL-18, IL-10 (ELISA) and others (haemoglobin level, white blood cell count, serum calcium, phosphate, calcium-phosphate product, albumin, fibrinogen, cholesterol, high-density lipoprotein (HDL), triglycerides and parathormone).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3546	18775944-2518	Serum 25-hydroxyvitamin D (25-OHD), calcium, alkaline phosphatase and phosphorus were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3547	18775944-2518	Serum 25-hydroxyvitamin D (25-OHD), calcium, alkaline phosphatase and phosphorus were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3548	18776133-17	In the current study, we found that treatment of peripheral blood mononuclear cells with combination IL-2/IL-4 for 48 hours, but not with IL-2 or IL-4 alone, abrogated dexamethasone (DEX)-induced glucocorticoid receptor (GCR)-alpha nuclear translocation in both CD4 (+) and CD8(+) T cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3549	18776133-17	In the current study, we found that treatment of peripheral blood mononuclear cells with combination IL-2/IL-4 for 48 hours, but not with IL-2 or IL-4 alone, abrogated dexamethasone (DEX)-induced glucocorticoid receptor (GCR)-alpha nuclear translocation in both CD4 (+) and CD8(+) T cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3550	18776170-42	Linear regression analyses showed that cholesterol and phospholipid efflux and cellular apoA-I binding correlated significantly with the ability of ABCA1 to form cell surface lipid domains.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3551	18776170-42	Linear regression analyses showed that cholesterol and phospholipid efflux and cellular apoA-I binding correlated significantly with the ability of ABCA1 to form cell surface lipid domains.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3552	18776171-43	Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3553	18776171-43	Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3554	18776171-44	Inflammation plays a role in trans-10, cis-12 (10,12)-conjugated linoleic acid (CLA)-mediated delipidation and insulin resistance in adipocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3555	18776171-45	Given the anti-inflammatory role of resveratrol (RSV), we hypothesized that RSV would attenuate inflammation and insulin resistance caused by 10,12 CLA in human adipocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3556	18777013-349	Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3557	18777013-349	Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3558	18777014-352	Wheat germ lipase had a high activity and enantioselectivity only in n-hexane with a high initial water activity (alpha(w) = 0.97), especially with 1-phenylethanol (C 32%, E > 200).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3559	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3560	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3561	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3562	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3563	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3564	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3565	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3566	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3567	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3568	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3569	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3570	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3571	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3572	18777087-373	We determined effects of the vasopeptidase inhibitor (VPI) omapatrilat and angiotensin II type 1 receptor (AT(1)R) blocker (ARB) candesartan in rats during healing between day-2 and day-21 after reperfused myocardial infarction (RMI) on left ventricular (LV) remodeling and function, and regional matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-3, inducible-nitric-oxide-synthase (iNOS), oxidant-generating myeloperoxidase (MPO), and cytokines tumor-necrosis-factor (TNF)-alpha, interleukin (IL)-6 and IL-10, and transforming-growth-factor (TGF)-beta(1), and collagens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3573	18777087-374	The results suggest that modulation of matrix proteases, oxidants, cytokines, and NOSs with omapatrilat and candesartan contribute to reversal of adverse collagen and LV remodeling and attenuation of LV dysfunction during healing after RMI.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3574	18777087-374	The results suggest that modulation of matrix proteases, oxidants, cytokines, and NOSs with omapatrilat and candesartan contribute to reversal of adverse collagen and LV remodeling and attenuation of LV dysfunction during healing after RMI.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3575	18777088-375	We recently reported homocysteine (Hcy)-induced ERK-phosphorylation was suppressed by pertussis toxin (PTX), which suggested the involvement of GPCRs in initiating signal transduction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3576	18777110-388	Other factors prognostic for inferior survival were serum albumin 37 g/L (HR 3.22, 95% CI 1.11-13.22, p = 0.034) and treatment with non-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy (HR 4.89, 95% CI 1.67-14.36, p = 0.004).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3577	18777110-388	Other factors prognostic for inferior survival were serum albumin 37 g/L (HR 3.22, 95% CI 1.11-13.22, p = 0.034) and treatment with non-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy (HR 4.89, 95% CI 1.67-14.36, p = 0.004).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3578	18777110-388	Other factors prognostic for inferior survival were serum albumin 37 g/L (HR 3.22, 95% CI 1.11-13.22, p = 0.034) and treatment with non-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy (HR 4.89, 95% CI 1.67-14.36, p = 0.004).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3579	18777110-388	Other factors prognostic for inferior survival were serum albumin 37 g/L (HR 3.22, 95% CI 1.11-13.22, p = 0.034) and treatment with non-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy (HR 4.89, 95% CI 1.67-14.36, p = 0.004).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3580	18777117-392	Association between Val/Leu (247) polymorphism of apolipoprotein H and cerebral infarction in a Chinese population.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3581	18777117-393	The purpose of this study was to identify associations between the Val/Leu (247) polymorphism of apoH gene and CI in a Chinese cohort.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3582	18777136-397	We have discovered multiple genetic and biochemical differences between humans and these other hominids, in relation to sialic acids and in Siglecs (Sia-recognizing Ig superfamily lectins).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3583	18777160-404	Possible binding site for the substrate, prostaglandin H(2) (PGH(2)), was identified by systematically probing the refined molecular structure of mPGES-1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3584	18777180-406	We cloned the zGCAP4 gene, purified non-myristoylated and myristoylated forms of the protein after heterologous expression in Escherichia coli and studied its properties: zGCAP4 was a strong activator of membrane-bound guanylate cyclases from bovine and zebrafish retina, showing half-maximal activation at 520-570 nM free Ca(2+) concentration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3585	18777180-408	Thus, expression and biochemical properties of zGCAP4 are in agreement with its function as an efficient Ca(2+)-sensitive regulator of guanylate cyclase activity in cone vision.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3586	18777181-411	The results of the present work show that this replacement does not considerably affect the DNA modifications by this drug, recognition of these modifications by HMGB1 protein, their repair, and reactivity of the platinum complex with GSH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3587	18777181-411	The results of the present work show that this replacement does not considerably affect the DNA modifications by this drug, recognition of these modifications by HMGB1 protein, their repair, and reactivity of the platinum complex with GSH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3588	18778244-705	However, in addition to GST activity, we discovered that EGST also possesses thiol : disulfide oxidoreductase activity, for which the residue Cys (10) plays an essential role.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3589	18778244-705	However, in addition to GST activity, we discovered that EGST also possesses thiol : disulfide oxidoreductase activity, for which the residue Cys (10) plays an essential role.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3590	18778281-720	Anti-P mAb promoted IL-10 overproduction in a dose- and time-dependent manner in both lipopolysaccharide (LPS)-activated RAW 264.7 cells and primary human macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3591	18778289-732	Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40-activated human B cells in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3592	18778316-735	The addition of a bisecting N-acetylglucosamine residue by beta(1,4)-N-acetylglucosaminyltransferase III (GnTIII) is known to control the processing of N-linked glycans in mammals, for example by preventing alpha(1,6)-fucosylation of the core glycan.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3593	18778316-736	Both CTSs targeted enhanced yellow fluorescent protein (eYFP) to a brefeldin A-sensitive compartment, indicative of Golgi localization.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3594	18778748-865	We have investigated the pre-receptor metabolism of progesterone in primary hOSE cells and an immortalised hOSE cell line, OSE-C2, focusing on transcriptional regulation of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) by inflammatory, anti-inflammatory and apoptotic factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3595	18778748-865	We have investigated the pre-receptor metabolism of progesterone in primary hOSE cells and an immortalised hOSE cell line, OSE-C2, focusing on transcriptional regulation of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) by inflammatory, anti-inflammatory and apoptotic factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3596	18778749-866	Coexpression with H6PDH potentiated 11beta-HSD1 reductase activity at high glucose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3597	18778749-867	11beta-HSD1 dehydrogenase activity was observed in H4IIE cells only at subphysiological glucose levels, indicating a highly efficient supply of substrate for H6PDH and NADPH generation in the ER-lumen.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3598	18778768-874	There are data to suggest that psychological intervention can influence neuroendocrine (e.g., cortisol) and immune function indicators, especially lymphocyte proliferation and TH1 cytokine production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3599	18778874-903	The proteins identified belong to the photosynthesis, carbohydrate and nitrogen metabolism, and stress-related protein functional categories.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3600	18778892-914	In the present study, we investigated whether CD147/basigin is involved, via its association with MCT1 and 4 to transport lactate, in glycolysis and then contributes to the progression of A375 melanoma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3601	18778892-914	In the present study, we investigated whether CD147/basigin is involved, via its association with MCT1 and 4 to transport lactate, in glycolysis and then contributes to the progression of A375 melanoma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3602	18779389-1017	TCblR belongs to the low-density lipoprotein receptor family, with 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3603	18779389-1017	TCblR belongs to the low-density lipoprotein receptor family, with 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3604	18780301-1284	Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3605	18780301-1284	Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3606	18780301-1284	Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3607	18780301-1284	Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3608	18780328-1293	Extended-release PEG-luciferin allows for long-term imaging of firefly luciferase activity in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3609	18780332-1296	Spectrofluorimetric determination of vitamin B(1) using horseradish peroxidase as catalyst in the presence of hydrogen peroxide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3610	18780332-1297	In this work a new spectrofluorimetric method for the determination of vitamin B(1), based on the catalytic activity of horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2), has been developed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3611	18780332-1297	In this work a new spectrofluorimetric method for the determination of vitamin B(1), based on the catalytic activity of horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2), has been developed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3612	18780332-1297	In this work a new spectrofluorimetric method for the determination of vitamin B(1), based on the catalytic activity of horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2), has been developed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3613	18780332-1297	In this work a new spectrofluorimetric method for the determination of vitamin B(1), based on the catalytic activity of horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H2O2), has been developed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3614	18780360-1305	Electrospun polyglyconate (Maxon) and its blends with proteins such as gelatin and elastin, with a spatially designed layer structure, were prepared as potential scaffolds for vascular tissue engineering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3615	18780360-1305	Electrospun polyglyconate (Maxon) and its blends with proteins such as gelatin and elastin, with a spatially designed layer structure, were prepared as potential scaffolds for vascular tissue engineering.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3616	18781168-1823	So far, in maize, three classes of mutants involved in phytic acid biosynthesis have been isolated: lpa1, lpa2 and lpa3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3617	18781168-1823	So far, in maize, three classes of mutants involved in phytic acid biosynthesis have been isolated: lpa1, lpa2 and lpa3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3618	18781168-1823	So far, in maize, three classes of mutants involved in phytic acid biosynthesis have been isolated: lpa1, lpa2 and lpa3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3619	18781316-1566	Bevacizumab (Avastin), ranibizumab (Lucentis) and pegaptanib sodium (Macugen) are anti-VEGF medications that have been used in the treatment of CNV.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3620	18781316-1566	Bevacizumab (Avastin), ranibizumab (Lucentis) and pegaptanib sodium (Macugen) are anti-VEGF medications that have been used in the treatment of CNV.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3621	18781338-1571	Blood samples were collected to assay for biomarkers of oxidative stress (malondialdehyde and carbonyl groups) and antioxidants (glutathione peroxidase, reduced glutathione, alpha-tocopherol, and beta-carotene).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3622	18781338-1571	Blood samples were collected to assay for biomarkers of oxidative stress (malondialdehyde and carbonyl groups) and antioxidants (glutathione peroxidase, reduced glutathione, alpha-tocopherol, and beta-carotene).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3623	18781385-1599	The low content of sphingomyelin, sulfatide and galactosylceramide is consistent with the immunohistochemical results showing that in the grey-lethal brain significant depletion and disorganization of the myelinated fibres is present, thus supporting the hypothesis that loss of function of the OSTM1 causes neuronal impairment and myelin deficit.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3624	18781596-1677	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70 (S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3625	18781596-1677	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70 (S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3626	18781596-1677	Finally and most importantly, our data indicate that a decrease in AKT activity followed by a total decrease in p70 (S6K) phosphorylation reflecting a decrease in mTOR activity occurs during high oxygen consumption, resulting from high cell density.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3627	18781650-1708	Some of the peptide derivatives inhibited PEPT1-mediated uptake of ((3)H) Gly-Sar.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3628	18781688-1721	Effect of enzyme supplementation at moderate cellulase loadings on initial glucose and xylose release from corn stover solids pretreated by leading technologies.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3629	18781688-1722	For a combined mass loading of cellulase and beta-glucosidase of 16.1 mg/g original glucan (about 7.5 FPU/g), glucose release from pretreated solids ranged from 50% to75% of the theoretical maximum and was greater for all pretreatments at all protein loadings compared to pure Avicel cellulose except for solids from controlled pH pretreatment and from dilute acid pretreatment by the Sunds pilot unit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3630	18781688-1722	For a combined mass loading of cellulase and beta-glucosidase of 16.1 mg/g original glucan (about 7.5 FPU/g), glucose release from pretreated solids ranged from 50% to75% of the theoretical maximum and was greater for all pretreatments at all protein loadings compared to pure Avicel cellulose except for solids from controlled pH pretreatment and from dilute acid pretreatment by the Sunds pilot unit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3631	18781688-1722	For a combined mass loading of cellulase and beta-glucosidase of 16.1 mg/g original glucan (about 7.5 FPU/g), glucose release from pretreated solids ranged from 50% to75% of the theoretical maximum and was greater for all pretreatments at all protein loadings compared to pure Avicel cellulose except for solids from controlled pH pretreatment and from dilute acid pretreatment by the Sunds pilot unit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3632	18781688-1722	For a combined mass loading of cellulase and beta-glucosidase of 16.1 mg/g original glucan (about 7.5 FPU/g), glucose release from pretreated solids ranged from 50% to75% of the theoretical maximum and was greater for all pretreatments at all protein loadings compared to pure Avicel cellulose except for solids from controlled pH pretreatment and from dilute acid pretreatment by the Sunds pilot unit.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3633	18782461-1964	PCFT/HCP1 could therefore play a physiological role in Fe nutrition and the data highlight the potential for the interaction of folate and haem at the level of intestinal absorption.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3634	18782463-1965	Following an oral glucose challenge, there was a weak trend for glucose-stimulated insulin release to be increased in the offspring of dams fed the folate-deficient diet.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3635	18782570-2009	Association between serum retinol-binding protein 4 and small dense low-density lipoprotein cholesterol levels in young adult women.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3636	18782588-2018	Adult female X. laevis were injected three times at weekly intervals with the hapten-carrier complex, trinitrophenylated bovine serum albumin (TNP-BSA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3637	18782588-2018	Adult female X. laevis were injected three times at weekly intervals with the hapten-carrier complex, trinitrophenylated bovine serum albumin (TNP-BSA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3638	18782661-2054	By using the system, we obtained four event timing data sets (stimulation by NGF with and without staurosporine at the concentrations of 0.01, 0.1, and 1 microM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3639	18783254-2198	First, R-state, or allosteric, autocatalysis of nitrite reduction increases the rate of NO generation by deoxyhemoglobin and results in maximal NO production at approximately 50% hemoglobin oxygen saturation, which is physiologically associated with greatest NO-dependent vasodilation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3640	18783311-2231	Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3641	18783311-2234	Downregulation of Nox4, or pretreatment with N-acetylcysteine, attenuated hyperoxia-induced cell migration and capillary tube formation, suggesting that ROS generated by Nox4 regulate endothelial cell motility.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3642	18783384-2267	Using newly designed degenerate primers targeting the phnA gene we analysed the potential for phosphonoacetate utilization in DNA and cDNA libraries constructed from a phytoplankton bloom in the Western English Channel during July 2006.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3643	18783774-2396	Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3644	18783774-2397	Only a small number of population-based cohort studies have directly compared the predictive value of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDLC) for coronary artery disease in Asian populations, such as Japan.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3645	18783827-2422	Finally, we show that Vcx1 helps return cytosolic Ca(2+) toward resting levels after shock with high extracellular Ca(2+) much more effectively than Pmc1 and that calcineurin, a protein phosphatase regulator of Vcx1 and Pmc1, had no detectable effects on these factors within the first few minutes of its activation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3646	18783828-2424	It is a serious problem that effective treatment choices to T315I, in the ABL kinase domain that shows a strong tolerance in imatinib do not exist clinically.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3647	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3648	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3649	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3650	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3651	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3652	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3653	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3654	18783846-2433	Moreover, diacylgycerol-dependent protein kinase C isoenzymes and activation of extracellular signal-regulated protein kinase (ERK) are required for glucose-, tolbutamide- and KCl-induced Egr-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3655	18784063-2498	Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3656	18784063-2498	Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3657	18784648-124	Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3658	18784734-168	The study aim was to determine whether urine albumin/creatinine ratio (UACR), high-sensitivity C-reactive protein (hsCRP) or N-terminal pro-brain natriuretic peptide (Nt-proBNP) added to risk prediction based on HeartScore and history of diabetes or cardiovascular disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3659	18784749-176	Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3660	18784906-222	Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3661	18784908-224	Cu concentration in the liver and in plasma alanine aminotransferase (ALT) and aspartate transaminase (AST) activities were determined.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3662	18784908-225	In brain tissue, Cu concentration, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and glutathione (GSH) concentrations were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3663	18784908-225	In brain tissue, Cu concentration, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and glutathione (GSH) concentrations were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3664	18784908-225	In brain tissue, Cu concentration, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and glutathione (GSH) concentrations were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3665	18784908-225	In brain tissue, Cu concentration, superoxide dismutase (SOD) activities, malondialdehyde (MDA) levels and glutathione (GSH) concentrations were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3666	18785000-243	We previously reported that inhibition of Rho-kinase (ROCK) by hydroxyl fasudil improves cognitive deficit and neuronal damage in rats with chronic cerebral ischemia (Huang et al., Cell Mol Neurobiol 28:757-768, 2008).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3667	18785000-244	Finally, in the presence of OGD and fasudil mesylate, superoxide dismutase (SOD) activity was increased by 50% for cortex and by 58% for hippocampus, compared to OGD only group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3668	18785000-244	Finally, in the presence of OGD and fasudil mesylate, superoxide dismutase (SOD) activity was increased by 50% for cortex and by 58% for hippocampus, compared to OGD only group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3669	18785066-298	Na+/H+ exchanger isoform 3 (NHE-3) is responsible for net uptake of NaCl and water from the gastrointestinal (GI) tract.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3670	18785206-418	PDE4B is also important in the regulation of cAMP signaling, a second messenger implicated in learning, memory, and mood.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3671	18785212-354	Elevated amounts of PGK1, one of the ATP-generating reactions of glycolysis, in wood frog brain during freezing would enhance the glycolytic capacity of the organ and support the maintenance of cellular energetics under the ischemic conditions of the frozen state.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3672	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3673	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3674	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3675	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3676	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3677	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3678	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3679	18785685-518	SNs and SMs were exposed to macrophages with and without addition of endotoxin lipopolysaccharide (LPS), a positive inducer of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and nitric oxide (NO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3680	18785878-575	We therefore hypothesized that a diffusible product of the GPI-PLC enzyme reaction (possibly DAG (diacylglycerol)) mediated the biological effects of the protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3681	18786000-610	Silencing of chalcone synthase, the key entry-point enzyme for flavonoid biosynthesis led to flavonoid-deficient roots.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3682	18786181-656	Nitrilase enzymes have been characterised in plants, bacteria and fungi and are thought to be important in detoxification of nitriles, utilisation of nitrogen and synthesis of plant hormones.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3683	18786181-657	In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic acid and ammonia by NIT4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3684	18786181-657	In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic acid and ammonia by NIT4.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3685	18786182-658	The mitochondrial membrane potential (Delta psi (mit)) was also tested with rhodamine 123 30 min after SI challenge, and was shown to have collapsed in the incompatible pollen tubes after exposure to S-RNase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3686	18786279-668	In conclusion, female rats undernourished in utero had normophagic obesity as adults but had an absence of serotonin-induced hypophagia and low hypothalamic levels of the 5-HT 2C receptor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3687	18786279-669	Compensatory adaptations for the functional serotonergic impairment were evidenced, such as an enhanced release of serotonin in response to a meal allied to up-regulated hypothalamic 5-HT1B and transporter expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3688	18786604-753	The proliferation of the parental cell line was most efficiently stimulated by 5alpha-dihydrotestosterone (DHT), but the LNCaP(17beta-HSD3) cells were equally stimulated by Adione, indicating that 17beta-HSD3 efficiently converts Adione to T in this model.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3689	18786604-753	The proliferation of the parental cell line was most efficiently stimulated by 5alpha-dihydrotestosterone (DHT), but the LNCaP(17beta-HSD3) cells were equally stimulated by Adione, indicating that 17beta-HSD3 efficiently converts Adione to T in this model.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3690	18786605-754	They potentiate glucose-induced insulin secretion and may be responsible for up to 70% of postprandial insulin secretion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3691	18786605-755	However, in supraphysiological doses, GLP-1 administration may completely normalize beta as well as alpha cell sensitivity to glucose.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3692	18786649-767	The induction of signal transduction by serum and growth factors significantly increases the level of S6K ubiquitination, while the treatment of cells with UV and staurosporine has the opposite effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3693	18786760-796	Interaction of malachite green with bovine serum albumin : determination of the binding mechanism and binding site by spectroscopic methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3694	18786760-797	The interaction between malachite green (MG) and bovine serum albumin (BSA) under simulative physiological conditions was investigated by the methods of fluorescence spectroscopy, UV-vis absorption and circular dichroism (CD) spectroscopy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3695	18786760-797	The interaction between malachite green (MG) and bovine serum albumin (BSA) under simulative physiological conditions was investigated by the methods of fluorescence spectroscopy, UV-vis absorption and circular dichroism (CD) spectroscopy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3696	18786760-798	The binding distance (r) between MG and the tryptophan residue of BSA was obtained to be 4.79 nm according to Förster theory of non-radioactive energy transfer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3697	18786974-878	Unlike creatinine, Cystatin C (CysC) is believed to be independent of body composition in both adults and children.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3698	18786974-878	Unlike creatinine, Cystatin C (CysC) is believed to be independent of body composition in both adults and children.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3699	18787021-886	Levels of endothelial nitric oxide synthase and inducible nitric oxide synthase did not differ among the groups, nor did total nitrite plus nitrate levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3700	18787024-887	Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3701	18787024-887	Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3702	18787032-890	Thereafter we determined that hCG effect could be partially blocked by pharmacologic inhibition of MAPK pathway with 50 microM PD98059 but not by the inhibition of the phosphatidylinositol 3-kinase pathway with 0.1 microm wortmannin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3703	18787032-890	Thereafter we determined that hCG effect could be partially blocked by pharmacologic inhibition of MAPK pathway with 50 microM PD98059 but not by the inhibition of the phosphatidylinositol 3-kinase pathway with 0.1 microm wortmannin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3704	18787174-941	Lung injury was assessed by measuring vascular permeability (via Evans blue dye), edema, neutrophil infiltration (via myeloperoxidase (MPO), and expression of proinflammatory cytokines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3705	18787236-950	Cholesterol efflux from ((3)H) cholesterol-oleate-acetyl-LDL-loaded monocyte-derived macrophages to standard apolipoprotein A-I (apoA-I), HDL(2), and serum was measured.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3706	18787236-950	Cholesterol efflux from ((3)H) cholesterol-oleate-acetyl-LDL-loaded monocyte-derived macrophages to standard apolipoprotein A-I (apoA-I), HDL(2), and serum was measured.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3707	18787236-950	Cholesterol efflux from ((3)H) cholesterol-oleate-acetyl-LDL-loaded monocyte-derived macrophages to standard apolipoprotein A-I (apoA-I), HDL(2), and serum was measured.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3708	18787236-950	Cholesterol efflux from ((3)H) cholesterol-oleate-acetyl-LDL-loaded monocyte-derived macrophages to standard apolipoprotein A-I (apoA-I), HDL(2), and serum was measured.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3709	18787236-952	Cholesterol efflux to apoA-I, HDL(2), and serum from macrophage foam cells derived from low- and high-HDL subjects was similar.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3710	18787236-954	Cholesterol efflux from THP-1 macrophages to serum from study subjects correlated with serum apoB (P = 0.033), apoA-I (P = 0.004), apoA-II 0.0001), and the percentage of apoA-I present in the form of prebeta-HDL (P = 0.0001).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3711	18787236-954	Cholesterol efflux from THP-1 macrophages to serum from study subjects correlated with serum apoB (P = 0.033), apoA-I (P = 0.004), apoA-II 0.0001), and the percentage of apoA-I present in the form of prebeta-HDL (P = 0.0001).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3712	18787748-1079	In this study, the degradation of Rac- and R-metalaxyl under anaerobic conditions was studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3713	18787757-1084	Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3714	18787837-1099	Studies of HeLa cells and serum- and glucocorticoid-regulated kinase 1 (SGK1) knockout mice identified threonine residues in the n-myc downstream-regulated gene 1 protein (NDRG1-Thr (346/356/366)) that are phosphorylated by SGK1 but not by related kinases (Murray et al., Biochem J 385:1-12, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3715	18787837-1099	Studies of HeLa cells and serum- and glucocorticoid-regulated kinase 1 (SGK1) knockout mice identified threonine residues in the n-myc downstream-regulated gene 1 protein (NDRG1-Thr (346/356/366)) that are phosphorylated by SGK1 but not by related kinases (Murray et al., Biochem J 385:1-12, 2005).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3716	18787837-1100	Although G (Na) is negligible in hormone-deprived cells, these cells displayed basal SGK1 activity that was sensitive to LY294002, an inhibitor of 3-phosphatidylinositol phosphate kinase (PI3K).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3717	18787840-1103	Epidermal growth factor receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell lung cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3718	18787967-1145	The present investigation was carried out to assess the erythrocytic oxidative stress indices such as lipid peroxides level and activities of antioxidant enzymes such as superoxide dismutase and catalase, and some hematological parameters after treatment of subclinically ketotic lactating cows with antioxidants, vitamin E and selenium, incorporated in conventional treatment regimen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3719	18787967-1145	The present investigation was carried out to assess the erythrocytic oxidative stress indices such as lipid peroxides level and activities of antioxidant enzymes such as superoxide dismutase and catalase, and some hematological parameters after treatment of subclinically ketotic lactating cows with antioxidants, vitamin E and selenium, incorporated in conventional treatment regimen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3720	18787967-1145	The present investigation was carried out to assess the erythrocytic oxidative stress indices such as lipid peroxides level and activities of antioxidant enzymes such as superoxide dismutase and catalase, and some hematological parameters after treatment of subclinically ketotic lactating cows with antioxidants, vitamin E and selenium, incorporated in conventional treatment regimen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3721	18787967-1145	The present investigation was carried out to assess the erythrocytic oxidative stress indices such as lipid peroxides level and activities of antioxidant enzymes such as superoxide dismutase and catalase, and some hematological parameters after treatment of subclinically ketotic lactating cows with antioxidants, vitamin E and selenium, incorporated in conventional treatment regimen.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3722	18787973-1149	This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3723	18787973-1149	This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3724	18787978-1152	Candida albicans and C. tropicalis obtained from whole saliva of patients presenting signs of oral candidosis were assayed for quantification of colony forming units, exoenzyme activity (phospholipase and proteinase) and antifungal drug sensitivity (amphotericin B, fluconazole and itraconazole) by the reference method of the Clinical and Laboratory Standards Institute.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3725	18787978-1152	Candida albicans and C. tropicalis obtained from whole saliva of patients presenting signs of oral candidosis were assayed for quantification of colony forming units, exoenzyme activity (phospholipase and proteinase) and antifungal drug sensitivity (amphotericin B, fluconazole and itraconazole) by the reference method of the Clinical and Laboratory Standards Institute.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3726	18787978-1152	Candida albicans and C. tropicalis obtained from whole saliva of patients presenting signs of oral candidosis were assayed for quantification of colony forming units, exoenzyme activity (phospholipase and proteinase) and antifungal drug sensitivity (amphotericin B, fluconazole and itraconazole) by the reference method of the Clinical and Laboratory Standards Institute.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3727	18788036-1175	To achieve sustained delivery of a novel bone-induced growth factor, chitosan microspheres loaded with synthetic oligopeptide (S((PO4))KIPKASSVPTELSAISTLYLDDD, P24) were prepared by an emulsion-ionic cross-linking method in the presence of tripolyphosphate, with bovine serum albumin (BSA) as a control.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3728	18788036-1175	To achieve sustained delivery of a novel bone-induced growth factor, chitosan microspheres loaded with synthetic oligopeptide (S((PO4))KIPKASSVPTELSAISTLYLDDD, P24) were prepared by an emulsion-ionic cross-linking method in the presence of tripolyphosphate, with bovine serum albumin (BSA) as a control.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3729	18789002-1201	Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3730	18789002-1201	Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3731	18789002-1204	This process is associated with an increase in intracellular levels of pyruvate, increase in the acetylation status of histone H4, and enhanced cell death.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3732	18789341-1500	The cAMP/protein kinase A (PKA) signaling cascade is crucial for synaptic plasticity in a wide variety of species.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3733	18789398-1523	Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3734	18789440-1646	In the present study, we have investigated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3735	18789440-1646	In the present study, we have investigated the effect of IFN-gamma on ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3736	18789466-1548	Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3737	18789466-1548	Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3738	18789466-1548	Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3739	18789466-1548	Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3740	18789492-1558	As such, the aim of the present study was to investigate whether CETP-inhibition with JTT-705, a molecule distinctly different from torcetrapib, impacts on vascular function, a well-established surrogate of atherosclerotic vascular disease, as well as markers of inflammation and oxidative stress in patients with type II hyperlipidemia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3741	18789529-1570	In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3742	18789530-2169	Pathways involved in the hydrolysis of nitrile pollutants (aliphatic nitriles, benzonitrile analogues) and the corresponding enzymes (nitrilase, nitrile hydratase) are described in detail.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3743	18789597-659	Since stellate cells have been found to express the beta but not the alpha isoform of the estrogen receptor, it can be predicted that nutritional intakes of the soy isoflavone genistein-a selective agonist for ERbeta in the low nanomolar plasma concentrations achievable with these intakes-have potential for suppressing hepatic fibrosis, in both men and women.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3744	18789597-659	Since stellate cells have been found to express the beta but not the alpha isoform of the estrogen receptor, it can be predicted that nutritional intakes of the soy isoflavone genistein-a selective agonist for ERbeta in the low nanomolar plasma concentrations achievable with these intakes-have potential for suppressing hepatic fibrosis, in both men and women.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3745	18789664-1638	We report that the PP inhibition of proteolysis in young rats was mediated by the increased INS secretion and resulted from a down-regulation of both lysosomal and Ca(2+)-dependent proteolysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3746	18789666-1639	Aqueous extract of cumin was tested for its antiglycating ability against fructose-induced glycation of goat lens total soluble protein (TSP), alpha-crystallin from goat lens and a nonlenticular protein bovine serum albumin (BSA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3747	18789666-1639	Aqueous extract of cumin was tested for its antiglycating ability against fructose-induced glycation of goat lens total soluble protein (TSP), alpha-crystallin from goat lens and a nonlenticular protein bovine serum albumin (BSA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3748	18789666-1639	Aqueous extract of cumin was tested for its antiglycating ability against fructose-induced glycation of goat lens total soluble protein (TSP), alpha-crystallin from goat lens and a nonlenticular protein bovine serum albumin (BSA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3749	18789669-1641	To investigate the effects of selenium on mRNA expressions of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in the pancreas of streptozotocin-induced diabetic mice, the animals were divided into three groups in this study: a normal control group, an untreated diabetes mellitus group and a selenite-treated diabetes mellitus group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3750	18789669-1641	To investigate the effects of selenium on mRNA expressions of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in the pancreas of streptozotocin-induced diabetic mice, the animals were divided into three groups in this study: a normal control group, an untreated diabetes mellitus group and a selenite-treated diabetes mellitus group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3751	18789669-1641	To investigate the effects of selenium on mRNA expressions of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in the pancreas of streptozotocin-induced diabetic mice, the animals were divided into three groups in this study: a normal control group, an untreated diabetes mellitus group and a selenite-treated diabetes mellitus group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3752	18789669-1641	To investigate the effects of selenium on mRNA expressions of proinflammatory cytokines and inducible nitric oxide synthase (iNOS) in the pancreas of streptozotocin-induced diabetic mice, the animals were divided into three groups in this study: a normal control group, an untreated diabetes mellitus group and a selenite-treated diabetes mellitus group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3753	18789669-1642	The results showed that pancreatic selenium content and glutathione peroxidase.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3754	18789669-1642	The results showed that pancreatic selenium content and glutathione peroxidase.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3755	18789669-1643	Meanwhile, pancreatic mRNA expressions of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma ; mRNA expression and activity of iNOS.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3756	18789669-1643	Meanwhile, pancreatic mRNA expressions of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma ; mRNA expression and activity of iNOS.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3757	18789669-1643	Meanwhile, pancreatic mRNA expressions of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma ; mRNA expression and activity of iNOS.05), respectively, in selenite-treated diabetes mellitus group compared with untreated diabetes mellitus group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3758	18789733-21	Decreases in PNNs, aggrecan and hyaluronic acid were observed only in the terminal stages and correlated with the distribution of PrP (BSE) and activated glial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3759	18789733-22	This study suggests that the loss of PNNs, aggrecan and hyaluronic acid is a consequence of PrP (BSE) accumulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3760	18789733-22	This study suggests that the loss of PNNs, aggrecan and hyaluronic acid is a consequence of PrP (BSE) accumulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3761	18789802-1681	Cells were exposed to native low-density lipoprotein (LDL), acetylated LDL, and LDL that had been modified by oxidation with copper or ferrous ions or by exposure to auto-oxidation products of arachidonic acid for 16h, and VEGF was then assayed in medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3762	18789802-1681	Cells were exposed to native low-density lipoprotein (LDL), acetylated LDL, and LDL that had been modified by oxidation with copper or ferrous ions or by exposure to auto-oxidation products of arachidonic acid for 16h, and VEGF was then assayed in medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3763	18789802-1681	Cells were exposed to native low-density lipoprotein (LDL), acetylated LDL, and LDL that had been modified by oxidation with copper or ferrous ions or by exposure to auto-oxidation products of arachidonic acid for 16h, and VEGF was then assayed in medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3764	18789953-507	In hypersensitive alpha4L9'A mice, injections of a low dose of nicotine (0.1 mg/kg) led to strong c-fos expression in only the ventrolateral region of the MHb, but not in the MHb of wild-type (WT) mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3765	18790021-1764	To address this issue, we have examined the effects of excitotoxic lesion of CM/Pf and of 6-hydroxydopamine-induced lesion of nigral dopamine neurons, separately or in association, on gene expression of markers of neuronal activity in the rat basal ganglia (striatal neuropeptide precursors, GAD67, cytochrome oxidase subunit I) by quantitative in situ hybridization histochemistry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3766	18790021-1764	To address this issue, we have examined the effects of excitotoxic lesion of CM/Pf and of 6-hydroxydopamine-induced lesion of nigral dopamine neurons, separately or in association, on gene expression of markers of neuronal activity in the rat basal ganglia (striatal neuropeptide precursors, GAD67, cytochrome oxidase subunit I) by quantitative in situ hybridization histochemistry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3767	18790021-1764	To address this issue, we have examined the effects of excitotoxic lesion of CM/Pf and of 6-hydroxydopamine-induced lesion of nigral dopamine neurons, separately or in association, on gene expression of markers of neuronal activity in the rat basal ganglia (striatal neuropeptide precursors, GAD67, cytochrome oxidase subunit I) by quantitative in situ hybridization histochemistry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3768	18790083-1786	Participating in a significant fraction of the fundamental paths connecting the ligands to the phenotypes, cofactor GTP and complex Gbeta/Ggamma were identified as "housekeeping" molecules, through which all pathways of EGFR network are cross-talking.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3769	18790533-1437	These effects were probably associated with the increase of intracellular superoxide in mitochondrial signaling pathway which attributed to the down-regulation of superoxide dismutase (SOD).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3770	18790533-1437	These effects were probably associated with the increase of intracellular superoxide in mitochondrial signaling pathway which attributed to the down-regulation of superoxide dismutase (SOD).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3771	18790812-2041	This initiates a cAMP signalling cascade resulting in the translocation of AQP2-bearing vesicles to the apical membrane.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3772	18790996-2085	The formation and trafficking of autophagic vesicles are directed in part by associated conjugation cascades that couple the AUTOPHAGY-RELATED8 (ATG8) and ATG12 proteins to their respective targets, phosphatidylethanolamine and the ATG5 protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3773	18790996-2085	The formation and trafficking of autophagic vesicles are directed in part by associated conjugation cascades that couple the AUTOPHAGY-RELATED8 (ATG8) and ATG12 proteins to their respective targets, phosphatidylethanolamine and the ATG5 protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3774	18790996-2085	The formation and trafficking of autophagic vesicles are directed in part by associated conjugation cascades that couple the AUTOPHAGY-RELATED8 (ATG8) and ATG12 proteins to their respective targets, phosphatidylethanolamine and the ATG5 protein.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3775	18790996-2086	Levels of Atg transcripts and/or the ATG8-phosphatidylethanolamine adduct increase during leaf senescence and nitrogen and fixed-carbon limitations, indicating that autophagy plays a key role in nutrient remobilization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3776	18791141-99	This study confirmed QTL previously identified for pH except those on SSC1, 11, 12, and X, and found 11 new 5% genome-wise significant QTL for glycogen-related traits.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3777	18791145-109	The objective of this study was to examine the effect of level and duration of feeding of an n-3 PUFA-enriched fish oil (FO) supplement in combination with soybean oil (SO) on the transcriptional regulation of Delta(9)-desaturase gene expression in bovine muscle.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3778	18791154-2132	Whole blood and plasma were analyzed for total Se, glutathione peroxidase activity in whole blood (GPX-1) and plasma, and thyroid hormones (thyroxine and triiodothyronine) in plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3779	18791154-2132	Whole blood and plasma were analyzed for total Se, glutathione peroxidase activity in whole blood (GPX-1) and plasma, and thyroid hormones (thyroxine and triiodothyronine) in plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3780	18791154-2132	Whole blood and plasma were analyzed for total Se, glutathione peroxidase activity in whole blood (GPX-1) and plasma, and thyroid hormones (thyroxine and triiodothyronine) in plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3781	18791154-2132	Whole blood and plasma were analyzed for total Se, glutathione peroxidase activity in whole blood (GPX-1) and plasma, and thyroid hormones (thyroxine and triiodothyronine) in plasma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3782	18791496-2222	Studies have shown that administration of 17beta-estradiol (estrogen) after trauma-hemorrhage normalized cardiac IL-6 levels and restored cardiac functions under those conditions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3783	18791811-2349	Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3784	18791821-2351	Epirubicin plus low-dose trastuzumab in HER2 positive metastatic breast cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3785	18791821-2352	This phase II study, evaluated the activity and cardiotoxicity of first-line epirubicin plus low-dose trastuzumab (LD-T) in patients with HER2 positive MBC.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3786	18791914-2380	The DEP-induced increases in peribronchial eosinophils and mucous goblet cells in the lung tissues, and of IL-5 and IL-13 in the BAL fluid, were significantly attenuated by the antioxidant N-acetylcysteine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3787	18791914-2380	The DEP-induced increases in peribronchial eosinophils and mucous goblet cells in the lung tissues, and of IL-5 and IL-13 in the BAL fluid, were significantly attenuated by the antioxidant N-acetylcysteine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3788	18792056-2438	Each of the developed consortium has a phosphate solubilizer, nitrogen fixer, growth hormone producer, heterotrophic member and an antagonist.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3789	18792056-2438	Each of the developed consortium has a phosphate solubilizer, nitrogen fixer, growth hormone producer, heterotrophic member and an antagonist.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3790	18792785-89	Using cannabinoid receptor antagonists and cannabinoid receptor gene deficient mice (CB(1) (-/-) and CB(2) (-/-)), we showed that both CB(1) and CB(2) receptors were involved in the THC-induced attenuation of serum IL-12 and IFNgamma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3791	18792801-694	Promoter analysis of the PSG1, 4, and 11 genes in HeLa cells did not reveal a cis-regulatory element responsive to 5-bromodeoxyuridine in their 5'-flanking sequences.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3792	18792915-162	p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3793	18793216-256	In vivo administration of a synthetic phospholipid, named hereafter phospho-ceramide analogue-1 (PCERA-1), was previously found to suppress lipopolysaccharide (LPS)-induced TNF-alpha blood levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3794	18793216-258	In conclusion, the anti-inflammatory activity of PCERA-1 seems to be mediated by a cell membrane receptor, upstream of cAMP production, and eventually TNF-alpha suppression and IL-10 induction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3795	18793216-258	In conclusion, the anti-inflammatory activity of PCERA-1 seems to be mediated by a cell membrane receptor, upstream of cAMP production, and eventually TNF-alpha suppression and IL-10 induction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3796	18793341-327	Acylated ghrelin and TNF α, IFN γ, IL-1β and IL-6 were measured with bioplex.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3797	18793341-327	Acylated ghrelin and TNF α, IFN γ, IL-1β and IL-6 were measured with bioplex.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3798	18793341-327	Acylated ghrelin and TNF α, IFN γ, IL-1β and IL-6 were measured with bioplex.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3799	18793341-327	Acylated ghrelin and TNF α, IFN γ, IL-1β and IL-6 were measured with bioplex.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3800	18793347-2512	Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy : the role of insulin sensitivity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3801	18793347-2513	Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3802	18793351-330	Inhibition of autophagy by treating rats with Wortmannin (15 microg/kg; intraperitoneally) abolished the ischaemic adaptation-induced induction of LC3-II, Beclin-1, BAG-1 and cardioprotection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3803	18793351-330	Inhibition of autophagy by treating rats with Wortmannin (15 microg/kg; intraperitoneally) abolished the ischaemic adaptation-induced induction of LC3-II, Beclin-1, BAG-1 and cardioprotection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3804	18793351-330	Inhibition of autophagy by treating rats with Wortmannin (15 microg/kg; intraperitoneally) abolished the ischaemic adaptation-induced induction of LC3-II, Beclin-1, BAG-1 and cardioprotection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3805	18793694-459	When myosin molecules work as an aggregate, the sliding movement of a myosin filament driven by the power strokes of some myosin heads makes other myosin heads that have completed their power strokes detach from the actin without consuming ATP.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3806	18793694-460	A critical requirement for this mechanism is that ATP must preferentially facilitate the detachment of myosins that have completed their power strokes, but are still strongly attached to the actin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3807	18794178-604	Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3808	18794178-605	To determine the efficacy and safety of etanercept and etanercept plus sulfasalazine versus sulfasalazine in patients with rheumatoid arthritis (RA) despite sulfasalazine therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3809	18794865-1914	A randomized trial of etoposide and G-CSF with or without rituximab for PBSC mobilization in B-cell non-Hodgkin's lymphoma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3810	18794865-1915	Twenty seven patients were mobilized with etoposide and G-CSF and 28 with etoposide, G-CSF and rituximab.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3811	18795231-893	Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene is a predictive marker for the response to chemotherapy with alkylating agents (e.g., temozolomide) in malignant gliomas.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3812	18795240-896	This work describes the influence of two polar lipids, Sn-1/3 and Sn-2 monopalmitin, on the activity of lipase in biphasic systems and in microemulsions.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3813	18795240-897	In previous communications, we have shown that Sn-2 monoglycerides can replace Sn-1,3 regiospecific lipases at the oil-water interface, causing a drastically reduced rate of lipolysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3814	18795263-905	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3815	18795263-905	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3816	18795263-905	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3817	18795263-905	Depletion of tungsten and/or molybdenum, however, did not affect the growth of the pure culture of S. fumaroxidans on propionate plus fumarate significantly, although the specific activities of hydrogenase and especially formate dehydrogenase were influenced by the absence of Mo and W. This indicates that the organism has a low W or Mo requirement under these conditions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3818	18795263-906	Our results suggest a more prominent role for H2 as electron carrier in the syntrophic conversion of propionate, when the essential trace metals W and Mo for the functioning of formate dehydrogenase are depleted.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3819	18795264-907	Previous studies have demonstrated an association between genetic polymorphisms of the mu opioid receptor gene (OPRM1) and response to naltrexone treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3820	18795290-925	Based on the preclinical evidence of topoisomerase I (Topo-1) upregulation by mitomycin C (MMC) and decreased NF-kappaB activation by celecoxib, we evaluated combinations of irinotecan/MMC and irinotecan/MMC/celecoxib in patients with advanced solid malignancies.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3821	18795320-932	The cells expressed aquaporin-1 sensitive to HgCl (2) and decreased by siRNA, which both reduced fast volume changes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3822	18795889-1063	Two conserved leucine repeats within the COMM domain were found to be critically required for XIAP binding.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3823	18795892-1064	Functional analysis of rat liver citrate carrier promoter: differential responsiveness to polyunsaturated fatty acids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3824	18795918-1074	Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3825	18795918-1074	Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3826	18795969-1090	The use of low-dose COCs is preferable in PCOS, especially among patients with glucose intolerance, insulin resistance and uncomplicated diabetes mellitus.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3827	18796314-1192	Due to its faculty to protect cholinesterase (ChE) activity against irreversible inactivation by OP, pyridostigmine bromide (PB) was used as a prophylaxis treatment during the first Persian Gulf War.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3828	18796403-1220	Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1 (-/-)mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3829	18796403-1222	In this study, we examined the role of NPC1L1 in phytosterol and cholesterol trafficking in mice lacking ATP-binding cassette (ABC) transporters G5 and G8 (G5/G8(-/-) mice).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3830	18796403-1223	We found that mice lacking ABCG5/G8 and NPC1L1 (triple knockout (TKO) mice) did not accumulate phytosterols in plasma and the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3831	18796403-1223	We found that mice lacking ABCG5/G8 and NPC1L1 (triple knockout (TKO) mice) did not accumulate phytosterols in plasma and the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3832	18796403-1224	In conclusion, NPC1L1 is essential for phytosterols to enter the body in mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3833	18796561-1268	The slow BSO-induced GSH depletion allows separation of two redox-related phases, namely, early thiol disequilibrium and late frank oxidative stress; each phase contributes to the progressive activation of a p50-p50 homodimer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3834	18796623-1276	In contrast, Notch-signaling inhibition by the gamma-secretase inhibitor I (GSI ; z-Leu-Leu-Nle-CHO) and the specific Notch2 down-regulation by small-interfering RNA accelerate spontaneous B-CLL cell apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3835	18797825-1625	Effects of exhaustion and calcium supplementation on adrenocorticotropic hormone and cortisol levels in athletes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3836	18797825-1626	The present study was performed to investigate the effects of strenuous exercise and calcium supplementation on cortisol and adrenocorticotropic hormone levels in athletes at rest and exhaustion.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3837	18797825-1627	One-month supplementation with calcium does not influence the cortisol and adrenocorticotropic hormone 0.05).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3838	18797870-1649	Effects of nonspecific targeting of FLT3 were evaluated with addition of imatinib (Gleevec) to cell cultures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3839	18797914-1664	In the pericentral necrotic zone after CCl4-treatment, no induction of Thy-1 was found.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3840	18797943-1672	Sixty-one percent of the isolates were beta-lactamase producers, which explains the poor activity of penicillin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3841	18798281-1790	In contrast, chelating intracellular calcium ((Ca(2+))(i)) by BAPTA-AM abolished BDNF-mediated Arc up-regulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3842	18798281-1790	In contrast, chelating intracellular calcium ((Ca(2+))(i)) by BAPTA-AM abolished BDNF-mediated Arc up-regulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3843	18798281-1791	These data suggested novel functions of (Ca(2+))(i) and CaM in BDNF signaling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3844	18798281-1791	These data suggested novel functions of (Ca(2+))(i) and CaM in BDNF signaling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3845	18798281-1792	Comparison of the Arc transcription profiles between Ca(2+)-stimulated and BDNF-stimulated neurons demonstrated that the regulatory mechanisms were distinctively tailored to the complex features of neuronal activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3846	18798567-1853	Bark of elderberry (Sambucus nigra) contains a galactose (Gal)/N-acetylgalactosamine (GalNAc)-specific lectin (SNA-II) corresponding to slightly truncated B-chains of a genuine Type-II ribosome-inactivating protein (Type-II RIPs, SNA-V), found in the same species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3847	18798567-1853	Bark of elderberry (Sambucus nigra) contains a galactose (Gal)/N-acetylgalactosamine (GalNAc)-specific lectin (SNA-II) corresponding to slightly truncated B-chains of a genuine Type-II ribosome-inactivating protein (Type-II RIPs, SNA-V), found in the same species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3848	18798567-1853	Bark of elderberry (Sambucus nigra) contains a galactose (Gal)/N-acetylgalactosamine (GalNAc)-specific lectin (SNA-II) corresponding to slightly truncated B-chains of a genuine Type-II ribosome-inactivating protein (Type-II RIPs, SNA-V), found in the same species.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3849	18798730-1896	Infusion of each receptor antagonist alone similarly reduced basal unstressed volume and blood flow in ACEI-treated CHF patients, but not in healthy volunteers or ARB-treated CHF patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3850	18798730-1897	In ARB-treated heart failure, venous responses to bradykinin are preserved but arterial responses are reduced compared with healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3851	18798833-1679	Later-onset congenital central hypoventilation syndrome due to a heterozygous 24-polyalanine repeat expansion mutation in the PHOX2B gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3852	18798833-1680	to describe a family with later onset congenital central hypoventilation syndrome (LO-CCHS) and heterozygosity for a 24-polyalanine repeat expansion mutation in the PHOX2B gene, rendered phenotypically apparent with exposure to anesthetics.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3853	18798864-1974	Effects of raloxifene on breast cancer cell migration and invasion through the actin cytoskeleton.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3854	18798867-1982	High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3855	18798867-1982	High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3856	18798867-1982	High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3857	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3858	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3859	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3860	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3861	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3862	18798867-1983	This study was to investigate the effect of high glucose (HG) on vascular endothelial growth factor (VEGF) expression in bone marrow stem cells and JAK2/STAT-3 signalling.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3863	18799187-2083	Hepatic stellate cell activation in focal nodular hyperplasia with a central scar was accompanied by the expression of 8-hydroxy-2'-deoxyguanosine and inducible nitric oxide synthase in the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3864	18799187-2084	Expression of 8-hydroxy-2'-deoxyguanosine and inducible nitric oxide synthase was rarely seen in focal nodular hyperplasia without a central scar, focal nodular hyperplasia-like nodules, or nodular regenerative hyperplasia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3865	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3866	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3867	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3868	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3869	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3870	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3871	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3872	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3873	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3874	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3875	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3876	18799201-2087	The main purpose of this study was to evaluate the regional distribution pattern and relative frequency of some endocrine cells in the three portions of the gastrointestinal tract (GIT)--the proventriculus, gizzard and duodenum-of the rufous-collared sparrow (Zonotrichia capensis subtorquata), by immunohistochemical methods using six types of polyclonal antisera, specific for serotonin (5-HT), somatostatin (D cells), glucagon, motilin, polypeptide YY (PYY) and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3877	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3878	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3879	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3880	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3881	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3882	18799201-2088	In the gizzard, endocrine cells secreting somatostatin, 5-HT and PYY were detected, while those secreting glucagon and insulin were not.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3883	18799201-2089	In the final part of the gizzard, endocrine cells secreting 5-HT were more frequent, and cells secreting somatostatin and insulin were not detected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3884	18799201-2089	In the final part of the gizzard, endocrine cells secreting 5-HT were more frequent, and cells secreting somatostatin and insulin were not detected.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3885	18799634-2193	Cell fractionation by sucrose gradient and differential centrifugation demonstrated that in bradykinin-stimulated cells, TRPM7 localized in fractions corresponding to caveolae.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3886	18799753-2260	However, there are conflicting data regarding the role of Gpr30 as an estrogen receptor (ER): several laboratories were unable to demonstrate estradiol binding to GPR30 or estradiol-activated signal transduction in Gpr30-expressing cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3887	18799753-2261	Our data demonstrate that in vivo Gpr30 is dispensable for the mediation of estradiol effects in reproductive organs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3888	18799757-2262	Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3889	18799757-2262	Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3890	18799757-2263	Here we characterize Sord mRNA and SORD expression during mouse spermatogenesis and examine the ability of sorbitol to support epididymal sperm motility and tyrosine phosphorylation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3891	18799757-2263	Here we characterize Sord mRNA and SORD expression during mouse spermatogenesis and examine the ability of sorbitol to support epididymal sperm motility and tyrosine phosphorylation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3892	18799757-2263	Here we characterize Sord mRNA and SORD expression during mouse spermatogenesis and examine the ability of sorbitol to support epididymal sperm motility and tyrosine phosphorylation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3893	18799757-2263	Here we characterize Sord mRNA and SORD expression during mouse spermatogenesis and examine the ability of sorbitol to support epididymal sperm motility and tyrosine phosphorylation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3894	18800037-1366	Increase in sildenafil clearance in the early postnatal period likely reflects maturation of CYP-mediated N-demethylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3895	18800064-2365	Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3896	18800064-2365	Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3897	18800064-2366	The NET-selective antidepressant desipramine (DMI) was chronically administered for 14 days to WKY rats and the strain from which it was outbred that does not show depressive-like behavior, the Wistar rat.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3898	18800198-2413	The present study was designed to evaluate the impact of zinc status before burn on the recovery of injury with focus on plasma insulin and glucose levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3899	18800198-2414	Blood and tissue samples were collected 3, 6, and 24 h after injury in order to study biochemical parameters and the glucose/insulin response in relation with the zinc status.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3900	18800198-2415	In addition, the burn-induced insulin resistance, leading to protein catabolism, was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3901	18800198-2415	In addition, the burn-induced insulin resistance, leading to protein catabolism, was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3902	18800204-2418	methoxyphenoxy)benzyl) morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical studies of norepinephrine transporters (NETs) in the human brain in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3903	18800204-2418	methoxyphenoxy)benzyl) morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical studies of norepinephrine transporters (NETs) in the human brain in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3904	18800231-631	The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3905	18800231-631	The most predictive model of EPO response for the pediatric cohort had, as the major variables, urea clearance x dialysis duration/total body water (Kt/V), urea reduction ratio (URR), intact parathyroid hormone (iPTH), blood loss, normalized protein catabolic rates (nPCR) and indices of malnutrition and inflammation, whereas adults had iron and folate deficiencies as the dominant variables.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3906	18800231-632	In summary EPO resistance in the pediatric dialysis cohort was predicted by nutritional deficits, inflammation, poor dialysis, and hyperparathyroidism, while iron and folate deficits were the major determinants in adults.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3907	18800351-2001	Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3908	18800351-2001	Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3909	18800351-2002	The DATS-mediated G2-M phase cell cycle arrest was explained by down-regulation of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C protein expression leading to accumulation of Tyr15 phosphorylated (inactive) Cdk1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3910	18800351-2002	The DATS-mediated G2-M phase cell cycle arrest was explained by down-regulation of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C protein expression leading to accumulation of Tyr15 phosphorylated (inactive) Cdk1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3911	18800351-2003	Knockdown of Bax and Bak proteins conferred significant protection against DATS-induced apoptotic cytoplasmic histone-associated DNA fragmentation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3912	18800351-2003	Knockdown of Bax and Bak proteins conferred significant protection against DATS-induced apoptotic cytoplasmic histone-associated DNA fragmentation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3913	18800985-2514	In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3914	18800985-2514	In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3915	18800985-2514	In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3916	18800985-2514	In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3917	18800985-2514	In the present work, we showed for the first time that synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG) are able to stimulate, in the presence of interferon-gamma (IFN-gamma), both arginase and inducible nitric oxide synthase (iNOS) in murine Mphi.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3918	18800985-2515	A significant increase in arginase activity was observed upon a short pre-incubation (1 hr) with IFN-gamma and subsequent CpG stimulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3919	18800985-2515	A significant increase in arginase activity was observed upon a short pre-incubation (1 hr) with IFN-gamma and subsequent CpG stimulation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3920	18800985-2516	Therefore, a very interesting observation of this study was that the CpG-mediated arginase activity is dependent on IFN-gamma priming.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3921	18800985-2516	Therefore, a very interesting observation of this study was that the CpG-mediated arginase activity is dependent on IFN-gamma priming.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3922	18800985-2517	This report reveals a singular effect of the combination of CpG and IFN-gamma, one of the mayor cytokines produced in response to CpG administration in vivo.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3923	18801207-197	Bakuchiol has a three-fold higher binding affinity for ERalpha than for ERbeta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3924	18801207-197	Bakuchiol has a three-fold higher binding affinity for ERalpha than for ERbeta.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3925	18801483-309	In the present study, we examined the effect of gliclazide, a second generation sulfonylurea with antioxidant properties, on LOX-1 expression and LOX-1-mediated MMP-9 expression and apoptosis in oxLDL-treated human aortic endothelial cells (HAECs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3926	18801483-309	In the present study, we examined the effect of gliclazide, a second generation sulfonylurea with antioxidant properties, on LOX-1 expression and LOX-1-mediated MMP-9 expression and apoptosis in oxLDL-treated human aortic endothelial cells (HAECs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3927	18801483-309	In the present study, we examined the effect of gliclazide, a second generation sulfonylurea with antioxidant properties, on LOX-1 expression and LOX-1-mediated MMP-9 expression and apoptosis in oxLDL-treated human aortic endothelial cells (HAECs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3928	18801483-309	In the present study, we examined the effect of gliclazide, a second generation sulfonylurea with antioxidant properties, on LOX-1 expression and LOX-1-mediated MMP-9 expression and apoptosis in oxLDL-treated human aortic endothelial cells (HAECs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3929	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3930	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3931	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3932	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3933	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3934	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3935	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3936	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3937	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3938	18801573-338	The phenolics: anthocyanin (ATH), sinapoyl esters and activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POX), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and glutathione reductase (GR), in red cabbage seedlings subjected to Cu2+ stress were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3939	18801573-339	It could results from the fact that phenolic compounds (PhC), which could be also substrates for different peroxidases, were the first line of defence against metal stress.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3940	18801652-367	The affinity characteristics of developed immunosensors were investigated in reaction with microcystin-LR, and PSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3941	18801652-368	The detection limit for microcystin-LR was 10 ngmL(-1) and for PSA 0.01 ngmL(-1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3942	18801682-382	This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3943	18801682-382	This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3944	18801682-382	This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3945	18801682-382	This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3946	18801682-383	Following formalin injection, ASIC1 (-/-) and ASIC2 (-/-), but not ASIC3 (-/-) or TRPV1 (-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3947	18801682-383	Following formalin injection, ASIC1 (-/-) and ASIC2 (-/-), but not ASIC3 (-/-) or TRPV1 (-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3948	18801682-383	Following formalin injection, ASIC1 (-/-) and ASIC2 (-/-), but not ASIC3 (-/-) or TRPV1 (-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3949	18801682-383	Following formalin injection, ASIC1 (-/-) and ASIC2 (-/-), but not ASIC3 (-/-) or TRPV1 (-/-), mice showed enhanced pain behaviour, predominantly in the second phase of the test.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3950	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3951	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3952	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3953	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3954	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3955	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3956	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3957	18801894-463	The biochemical parameters studied are: albumin (ALB), alanine aminotransferase (ALT), amylase (AMY), total bilirubin (TBI), blood urea nitrogen (BUN), creatinine (CRE), glucose, globulin, total proteins (TP), and the ions calcium, phosphorus, sodium, and potassium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3958	18801899-465	In addition, serum levels of glucose, adiponectin, and insulin were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3959	18801899-466	In addition, adenosine monophosphate-activated protein kinase levels were high during fasting and low during HF diet.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3960	18801901-901	This action of IGF-I was abolished by SB 212090 but not by wortmannin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3961	18801905-473	After 7 d central leptin treatment, the total content of ceramides was analyzed by quantitative shotgun lipidomics mass spectrometry.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3962	18801908-476	Previously we have shown that rosiglitazone has antiinflammatory actions not explicable by activation of PPARgamma,but possibly by the glucocorticoid receptor (GR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3963	18801908-476	Previously we have shown that rosiglitazone has antiinflammatory actions not explicable by activation of PPARgamma,but possibly by the glucocorticoid receptor (GR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3964	18801908-477	Rosiglitazone drives luciferase expression from a simple glucocorticoid-response element containing reporter gene in a GR-dependent manner (EC50 4 microm), with a similar amplitude response to the partial GR agonist RU486.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3965	18801909-478	To begin to understand the mechanisms for the development of acute insulin resistance, serine phosphorylation of insulin receptor substrate (IRS)-1 and c-Jun N-terminal kinase phosphorylation/activation was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3966	18801909-478	To begin to understand the mechanisms for the development of acute insulin resistance, serine phosphorylation of insulin receptor substrate (IRS)-1 and c-Jun N-terminal kinase phosphorylation/activation was investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3967	18801909-478	To begin to understand the mechanisms for the development of acute insulin resistance, serine phosphorylation of insulin receptor substrate (IRS)-1 and c-Jun N-terminal kinase phosphorylation/activation was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3968	18802196-558	Circulating oxidized LDL (oxLDL) levels are strongly correlated to LDL-cholesterol (LDL-c) and apolipoprotein-B100 (apoB100), making it difficult to disentangle their independent contributions to cardiovascular risk.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3969	18802196-559	FMD of the brachial artery and plasma concentrations of oxLDL, LDL-cholesterol, and apoB100 were measured in 624 men and women (age range 50 to 87 years), participating in a population-based cohort study.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3970	18802196-560	After adjustment for age, sex, glucose tolerance status, and Framingham risk score, the oxLDL/apoB100 ratio was negatively related to FMD (P = 0.017).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3971	18802325-593	The fibrillin-1 isolated from the youngest group had the highest capacity to form fructosamine and AGEs under glycation in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3972	18802724-681	The patterns of nerves immunoreactive (IR) to antibodies towards serotonin (5-HT) and the invertebrate neuropeptide FMRFamide are described in relation to the musculature.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3973	18802724-681	The patterns of nerves immunoreactive (IR) to antibodies towards serotonin (5-HT) and the invertebrate neuropeptide FMRFamide are described in relation to the musculature.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3974	18802724-681	The patterns of nerves immunoreactive (IR) to antibodies towards serotonin (5-HT) and the invertebrate neuropeptide FMRFamide are described in relation to the musculature.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3975	18802724-681	The patterns of nerves immunoreactive (IR) to antibodies towards serotonin (5-HT) and the invertebrate neuropeptide FMRFamide are described in relation to the musculature.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3976	18802750-687	Based on these results we analyzed the expression of either M1 receptors or BDNF following PMA treatment of retinal cell cultures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3977	18802816-701	Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3978	18803227-822	Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3979	18803284-847	The results obtained from the Fluo-3 image experiments showed that VEGF pretreatment of cultured neurons at a final concentration of 50, 100, or 200 ng/ml acutely and dose dependently attenuated the Ca(2+) influx induced by application of KCl (60 mM) or glutamate (50 microM).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3980	18803284-847	The results obtained from the Fluo-3 image experiments showed that VEGF pretreatment of cultured neurons at a final concentration of 50, 100, or 200 ng/ml acutely and dose dependently attenuated the Ca(2+) influx induced by application of KCl (60 mM) or glutamate (50 microM).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3981	18803286-849	5-Bromo-2'-deoxyuridine (BrdU) was injected into pregnant mice 3 hr after the NT3 administration to label the neural progenitor cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3982	18803297-852	A vitreous fraction showing growth-promoting activity 1000 Da, consistent with ascorbic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3983	18803462-1385	The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3984	18803462-1385	The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3985	18803582-1273	A specific digoxigenin-labelled probe, obtained by PCR amplification of a 270-bp fragment of the gene coding the LCDV major capsid protein, was used for ISH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3986	18803655-955	In particular, a Cimicifuga heracleifolia extract (CHE) was reported to inhibit the formation of glutamate and the glutamate dehydrogenase activity in cultured rat islet.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3987	18804292-1116	No differences in estradiol, testosterone, or vitellogenin plasma concentrations were observed in exposed males or females compared to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3988	18804292-1116	No differences in estradiol, testosterone, or vitellogenin plasma concentrations were observed in exposed males or females compared to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3989	18804314-557	Macrophages located in the media differentiate into giant cells and/or produce reactive oxygen species, nitric oxide and matrix metallo-proteinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3990	18804314-557	Macrophages located in the media differentiate into giant cells and/or produce reactive oxygen species, nitric oxide and matrix metallo-proteinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3991	18804365-1156	Having compared four kinds of antibody immobilizations on Au surface, an optimized mAb 8G3 was immobilized onto the Au electrode with protein A on a mixed self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (11-MUA) and 6-mercaptohexan-1-ol (6-MHO) as adhesive layer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3992	18804365-1156	Having compared four kinds of antibody immobilizations on Au surface, an optimized mAb 8G3 was immobilized onto the Au electrode with protein A on a mixed self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (11-MUA) and 6-mercaptohexan-1-ol (6-MHO) as adhesive layer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3993	18804365-1156	Having compared four kinds of antibody immobilizations on Au surface, an optimized mAb 8G3 was immobilized onto the Au electrode with protein A on a mixed self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (11-MUA) and 6-mercaptohexan-1-ol (6-MHO) as adhesive layer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3994	18804365-1156	Having compared four kinds of antibody immobilizations on Au surface, an optimized mAb 8G3 was immobilized onto the Au electrode with protein A on a mixed self-assembled monolayer (SAM) of 11-mercaptoundecanoic acid (11-MUA) and 6-mercaptohexan-1-ol (6-MHO) as adhesive layer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3995	18804521-2419	Budesonide is a potent glucocorticoid with high affinity for the glucocorticoid receptor, which is now used for the treatment of inflammatory bowel diseases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3996	18804525-2139	Studies on the antioxidant effect and interaction of diphenyl diselenide and dicholesteroyl diselenide with hepatic delta-aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3997	18804525-2140	Studies on the interaction of dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) with hepatic delta-aminolevulinic acid dehydratase (ALA-D) and different isoforms of lactate dehydrogenase (LDH) from different tissues were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3998	18804525-2140	Studies on the interaction of dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) with hepatic delta-aminolevulinic acid dehydratase (ALA-D) and different isoforms of lactate dehydrogenase (LDH) from different tissues were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
3999	18804848-1280	A single guanosine insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene, may play an important role in the regulation of PAI-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4000	18804848-1280	A single guanosine insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene, may play an important role in the regulation of PAI-1 expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4001	18804908-377	Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4002	18804908-379	Glucosamine also recovered the depletion of I-kappaBalpha via TGase 2 inhibition, which resulted in a decrease of NF-kappaB activity in EcR293/TG cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4003	18804908-379	Glucosamine also recovered the depletion of I-kappaBalpha via TGase 2 inhibition, which resulted in a decrease of NF-kappaB activity in EcR293/TG cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4004	18804927-1300	Influence of IGF-I on buffalo (Bubalus bubalis) spermatozoa motility, membrane integrity, lipid peroxidation and fructose uptake in vitro.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4005	18804927-1301	The objective of the present experiment was to examine the influence of mean physiological concentration of insulin-like growth factor-I (IGF-I) on frozen-thawed Surti buffalo (Bubalus bubalis) spermatozoa functional parameters, i.e., motility, plasmalemma integrity, acrosomal integrity, functional membrane integrity, lipid peroxidation and fructose uptake in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4006	18804927-1302	Frozen-thawed semen samples (n=6) were washed in tris buffer and divided into two equal parts (control and IGF-I groups).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4007	18804927-1303	Fructose utilization was significantly higher in IGF-I 0.01) of incubation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4008	18804950-1309	This diagnosis was confirmed by genetic testing, which revealed a novel point mutation in the COL3A1 gene, c.2545G-->C, leading to a codon encoding for arginine instead of glycine (p.Gly849Arg).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4009	18804950-1309	This diagnosis was confirmed by genetic testing, which revealed a novel point mutation in the COL3A1 gene, c.2545G-->C, leading to a codon encoding for arginine instead of glycine (p.Gly849Arg).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4010	18804984-1311	Animal studies show that ecosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are effective for the prevention and treatment of insulin resistance (IR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4011	18805402-1407	Signaling involving cAMP is organized in subcellular compartments and a distinct cAMP compartment might be required for proper AHR mobility and function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4012	18805433-1411	We also found an inhibitory effect of lenalidomide on the associations between cadherin 5, beta-catenin and CD31, adherens junction proteins whose interaction is critical for endothelial cell cord formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4013	18805433-1412	We also found a strong inhibitory effect of lenalidomide on hypoxia-induced endothelial cell formation of cords and HIF-1 alpha expression, the main mediator of hypoxia-mediated effects and a key driver of angiogenesis and metastasis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4014	18805442-1416	Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4015	18805484-1419	Control loperamide-loaded HSA nanoparticles with IgG2a antibodies yielded only marginal effects.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4016	18805505-1370	Engineered selenium-containing glutaredoxin displays strong glutathione peroxidase activity rivaling natural enzyme.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4017	18805505-1370	Engineered selenium-containing glutaredoxin displays strong glutathione peroxidase activity rivaling natural enzyme.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4018	18805505-1371	The use of a common thioredoxin fold with a high affinity for glutathione in glutaredoxin (Grx) and glutathione peroxidase (GPx) suggests a possibility of engineering Grx into GPx and vice versa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4019	18805505-1371	The use of a common thioredoxin fold with a high affinity for glutathione in glutaredoxin (Grx) and glutathione peroxidase (GPx) suggests a possibility of engineering Grx into GPx and vice versa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4020	18805508-1434	The potassium channels blockade by either tetraethylammonium or charybdotoxin also resulted in a potent inhibition of HEDS-induced aortic relaxation, whereas apamine only slightly reduced it.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4021	18805508-1434	The potassium channels blockade by either tetraethylammonium or charybdotoxin also resulted in a potent inhibition of HEDS-induced aortic relaxation, whereas apamine only slightly reduced it.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4022	18805632-1457	ROS activated almost immediately in a time- and concentration-dependent manner the MAPK pathways p38, ERK and JNK (their activation was abrogated by the antioxidant N-acetylcysteine).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4023	18805632-1457	ROS activated almost immediately in a time- and concentration-dependent manner the MAPK pathways p38, ERK and JNK (their activation was abrogated by the antioxidant N-acetylcysteine).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4024	18805632-1457	ROS activated almost immediately in a time- and concentration-dependent manner the MAPK pathways p38, ERK and JNK (their activation was abrogated by the antioxidant N-acetylcysteine).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4025	18805632-1457	ROS activated almost immediately in a time- and concentration-dependent manner the MAPK pathways p38, ERK and JNK (their activation was abrogated by the antioxidant N-acetylcysteine).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4026	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4027	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4028	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4029	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4030	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4031	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4032	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4033	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4034	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4035	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4036	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4037	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4038	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4039	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4040	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4041	18805639-1461	Multiple linear regression (MLR), radial basis network (RB), and multilayer perceptron (MLP) neural network (NN) models have been explored for the estimation of toxicity of ammonium, imidazolium, morpholinium, phosphonium, piperidinium, pyridinium, pyrrolidinium and quinolinium ionic liquid salts in the Leukemia Rat Cell Line (IPC-81) and Acetylcholinesterase (AChE) using only their empirical formulas (elemental composition) and molecular weights.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4042	18805685-1489	The beneficial effect of DHA on the treatment groups was accompanied by decreases in blood-brain barrier disruption, brain edema, malondialdehyde (MDA) production, inflammatory cell infiltration, interleukin-6 (IL-6) expression and caspase-3 activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4043	18805685-1489	The beneficial effect of DHA on the treatment groups was accompanied by decreases in blood-brain barrier disruption, brain edema, malondialdehyde (MDA) production, inflammatory cell infiltration, interleukin-6 (IL-6) expression and caspase-3 activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4044	18805685-1490	Elevation of antioxidative capacity, as evidenced by decreased MDA level and increased superoxide dismutase activity and glutathione level, was detected only in the chronic daily-administration group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4045	18806218-232	Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4046	18806296-1733	Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: role of NADPH oxidase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4047	18806930-1949	TKTL 1 was highest expressed in cell lines derived from more invasive tumors but the expression level was not strongly correlated to proliferation rate, to GLUT-1 expression or to the response to oxythiamine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4048	18806932-1906	Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4049	18806932-1906	Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4050	18806932-1906	Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4051	18806932-1906	Magnesium (Mg), interleukin 8 (IL-8), and malondialdehyde levels were analyzed in blood, while edema, neutrophil infiltration, eosinophilia, loss of striation, and nucleolization were evaluated in histopathological examination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4052	18807018-1954	Study of multiple binding constants of dexamethasone with human serum albumin by capillary electrophoresis-frontal analysis and multivariate regression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4053	18807018-1955	In this paper, to evaluate the pharmacokinetic and pharmacodynamic properties of dexamethasone (DXM), the interaction between DXM and HSA was studied by capillary electrophoresis-frontal analysis (CE-FA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4054	18807050-1745	Arthropod hemocyanins transport and store oxygen and are composed of six subunits, or multiples thereof depending on the species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4055	18807050-1746	The protein is insensitive to lactate, but affected by urate which markedly increased hemocyanin-oxygen affinity, acting as the physiological major positive effector.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4056	18807177-2028	The estrogen-induced increase in CXCR4 protein in MCF-7-HER2 cells was abrogated by the antiestrogen ICI 182780 and by gefitinib (Iressa ; a phospho-tyrosine kinase inhibitor), indicating an ER-mediated effect and confirming involvement of receptor tyrosine kinases, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4057	18807177-2028	The estrogen-induced increase in CXCR4 protein in MCF-7-HER2 cells was abrogated by the antiestrogen ICI 182780 and by gefitinib (Iressa ; a phospho-tyrosine kinase inhibitor), indicating an ER-mediated effect and confirming involvement of receptor tyrosine kinases, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4058	18807177-2028	The estrogen-induced increase in CXCR4 protein in MCF-7-HER2 cells was abrogated by the antiestrogen ICI 182780 and by gefitinib (Iressa ; a phospho-tyrosine kinase inhibitor), indicating an ER-mediated effect and confirming involvement of receptor tyrosine kinases, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4059	18807200-2046	Enzymatic activities of an H(2)O(2) independent oxidase along with laccase and an azoreductase suggest their prominent role during the decolorization of reactive yellow 84A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4060	18807200-2046	Enzymatic activities of an H(2)O(2) independent oxidase along with laccase and an azoreductase suggest their prominent role during the decolorization of reactive yellow 84A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4061	18807200-2047	Azoreductase activity was prominent in presence of cofactors NADH and NADP in mineral salt medium.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4062	18807200-2047	Azoreductase activity was prominent in presence of cofactors NADH and NADP in mineral salt medium.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4063	18807214-2051	The increase of oxygen availability caused the induction of the antioxidant enzyme superoxide dismutase, which indicates that the defensive mechanisms of the cells against oxidative stress were effective and cells could cope with increased pressure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4064	18808217-2356	Concentrations of aqueous-phase perfluorooctanoic acid (PFOA), a representative perfluorinated aliphatic (PFA) compound, are shown to be reduced effectively via reaction with horseradish peroxidase (HRP), hydrogen peroxide, and a phenolic cosubstrate (4-methoxyphenol).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4065	18808217-2356	Concentrations of aqueous-phase perfluorooctanoic acid (PFOA), a representative perfluorinated aliphatic (PFA) compound, are shown to be reduced effectively via reaction with horseradish peroxidase (HRP), hydrogen peroxide, and a phenolic cosubstrate (4-methoxyphenol).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4066	18808217-2356	Concentrations of aqueous-phase perfluorooctanoic acid (PFOA), a representative perfluorinated aliphatic (PFA) compound, are shown to be reduced effectively via reaction with horseradish peroxidase (HRP), hydrogen peroxide, and a phenolic cosubstrate (4-methoxyphenol).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4067	18808217-2356	Concentrations of aqueous-phase perfluorooctanoic acid (PFOA), a representative perfluorinated aliphatic (PFA) compound, are shown to be reduced effectively via reaction with horseradish peroxidase (HRP), hydrogen peroxide, and a phenolic cosubstrate (4-methoxyphenol).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4068	18808217-2357	Approximately 68% depletion of the parent compound and 98% depletion of its related acute aquatic toxicity are achieved in 6 h. Because no PFOA removal is observed in the absence of cosubstrate and/or following consumption thereof, we conclude that radical intermediate species generated during reaction between HRP and 4-methoxyphenol mediate nonspecific depletion of PFOA and that these intermediates may be sufficiently reactive to sever the extremely stable C-F bonds of PFOA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4069	18808365-2406	In the present study, the mRNA expression and promoter CpG methylation of ERalpha isoforms (i.e.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4070	18808365-2407	The present study is the first report that demonstrates selective inactivation of ERalpha isoforms through the promoter CpG methylation pathway in leukaemias.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4071	18808455-2441	Type-B monogalactosyldiacylglycerol synthases are involved in phosphate starvation-induced lipid remodeling, and are crucial for low-phosphate adaptation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4072	18809244-141	This study was performed to evaluate the effects of imatinib on breast cancer cell lines with respect to the activity of PDGFR beta and Akt : a downstream modulator of cell growth and survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4073	18809244-141	This study was performed to evaluate the effects of imatinib on breast cancer cell lines with respect to the activity of PDGFR beta and Akt : a downstream modulator of cell growth and survival.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4074	18809262-150	The mechanisms may include the recently revealed anti-inflammatory effects of insulin as well as its conventional glucose and free fatty acids lowering effects, and possibly may also include changes in body fat distribution and plasma adiponectin level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4075	18809347-188	Recently, we reported stimulatory effect of ghrelin alone and in combination with growth hormone (GH) on estradiol secretion, aromatase activity in parallel with inhibitory effect on cell apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4076	18809347-188	Recently, we reported stimulatory effect of ghrelin alone and in combination with growth hormone (GH) on estradiol secretion, aromatase activity in parallel with inhibitory effect on cell apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4077	18809347-188	Recently, we reported stimulatory effect of ghrelin alone and in combination with growth hormone (GH) on estradiol secretion, aromatase activity in parallel with inhibitory effect on cell apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4078	18809347-189	In cultures treated together ghrelin and (D-Lys-3)-GHRP-6, estradiol secretion, aromatase activity and cell proliferation returned to control levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4079	18809347-189	In cultures treated together ghrelin and (D-Lys-3)-GHRP-6, estradiol secretion, aromatase activity and cell proliferation returned to control levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4080	18809364-192	Expression levels of the functional activities (albumin secretion and ammonia removal) and the cell-cell adhesion molecules (cadherin and connexin-32) were higher in the hepatocytes that formed spheroids compared to those which assumed a monolayer configuration, and these levels were maintained for at least 10 days.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4081	18809367-193	Nevertheless, certain clinical cases manifest themselves with the onset of acute renal failure bought upon by the administration of blockers of the rennin-angiotensin-aldosterone system, or by some other causes responsible for a sudden drop in renal plasma flow (e.g., thrombosis of the renal artery).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4082	18809432-1105	The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4083	18809432-1106	This is the first finding that Gb3 plays a role in innate immunity by cooperating with natural ligands, RBLs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4084	18809481-220	Effect of polyols on the solubility of bovine serum albumin (BSA) in the presence of polyethylene glycols (PEGs) was investigated in order to strengthen the understanding of the observed effects of polyols and PEGs on protein properties in solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4085	18809481-220	Effect of polyols on the solubility of bovine serum albumin (BSA) in the presence of polyethylene glycols (PEGs) was investigated in order to strengthen the understanding of the observed effects of polyols and PEGs on protein properties in solution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4086	18810331-544	After 2 and 6 weeks of treatment, parotid gland was removed and total protein and sialic acid (free and total) concentration and amylase and peroxidase activities were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4087	18810331-545	At week 2 of the study, parotid gland of diabetic rats presented a reduction of total protein concentration (55%) and an increase of amylase (120%) and peroxidase (160%) activities, free (150%) and total (170%) sialic acid concentration.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4088	18810466-577	To investigate the change pattern of substance P (SP) and nitric oxide (NO) in the portal vein during the recto-anal inhibitory reflex (RAIR), and its physiological significance; the influence of external splanchnic nerve (ESN) of rectum and anus to the RAIR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4089	18810510-591	Considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4090	18810510-591	Considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4091	18810510-591	Considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4092	18810510-591	Considering the common metabolic pathway and synergism between dopamine and serotonin, the role of dopamine transporter (SLC6A3, DAT) and monoamine oxidase A (MAOA) genes in SIDS and stillbirth (sudden intrauterine unexplained death, SIUD) was investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4093	18810517-648	A lipase (F2) and lipase-like materials (F1) were purified from the culture supernatant of P. monteilii TKU009 with soybean powder as the sole carbon/nitrogen source.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4094	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4095	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4096	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4097	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4098	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4099	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4100	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4101	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4102	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4103	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4104	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4105	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4106	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4107	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4108	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4109	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4110	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4111	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4112	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4113	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4114	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4115	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4116	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4117	18810712-643	DHEA, DHEA-S, dihydrotestosterone, total testosterone, free testosterone, sex hormone-binding globulin, estrone, estradiol, cortisol, insulin, IGF-1, IGFBP-1, IGFBP-3, and adiponectin in plasma or serum were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4118	18812013-984	Our data indicate that genetic differences in S100B gene expression may predispose individual differences in the responsivity to repeated intake of MDMA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4119	18812209-396	Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4120	18812209-396	Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4121	18812209-396	Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4122	18812209-396	Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4123	18812225-1232	The enzyme responsible for D-serine biosynthesis, serine racemase (SR), is therefore a promising target for treatment of neuropathologies related to glutamate receptor excitotoxicity, such as stroke or Alzheimer's disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4124	18812229-1054	Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4125	18812229-1054	Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4126	18812233-1056	To investigate the metabolism of NADA through the cytochrome P450 (CYP450) metabolic pathway, we studied the in vitro rat liver microsomal production of hydroxylated metabolites and their activity at recombinant human TRPV(1) receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4127	18812596-1164	The FFA fractions elicited pro-inflammatory responses inducing TNFalpha and intracellular adhesion molecule expression and reactive oxygen species (ROS) production in human aortic endothelial cells (HAECs).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4128	18812689-1190	MDR1 single nucleotide polymorphism G2677T/A and haplotype are correlated with response to docetaxel-cisplatin chemotherapy in patients with non-small-cell lung cancer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4129	18814142-2252	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4130	18814142-2252	Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4131	18814142-2253	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4132	18814142-2253	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4133	18814142-2254	These results suggest that adrenaline may selectively protect mesenchymal C3H10T1/2 cells from oxidative stress through a mechanism related to the promoted biosynthesis of glutathione in association with transient Nrf2 expression after activation of beta(2)AdR.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4134	18814181-1610	Two principal signaling pathways that regulate proliferation are PI3K/PI(3,4,5)P3/Akt and Shc/Ras/ERK1/2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4135	18814181-1610	Two principal signaling pathways that regulate proliferation are PI3K/PI(3,4,5)P3/Akt and Shc/Ras/ERK1/2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4136	18814181-1610	Two principal signaling pathways that regulate proliferation are PI3K/PI(3,4,5)P3/Akt and Shc/Ras/ERK1/2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4137	18814181-1610	Two principal signaling pathways that regulate proliferation are PI3K/PI(3,4,5)P3/Akt and Shc/Ras/ERK1/2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4138	18814181-1610	Two principal signaling pathways that regulate proliferation are PI3K/PI(3,4,5)P3/Akt and Shc/Ras/ERK1/2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4139	18814266-2509	However, lovastatin treatment resulted in intracellular accumulation of PLP and prevented its translocation to the cell surface.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4140	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4141	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4142	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4143	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4144	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4145	18814279-1660	Imatinib mesylate (imatinib) is a potent and selective inhibitor of the tyrosine kinases, Bcr-Abl, c-Kit and platelet-derived growth factor receptors (PDGFRs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4146	18814300-1665	The large and diverse family of cytochrome P450 monooxygenases (CYPs) was systematically analyzed to identify selectivity- and specificity-determining residues in the substrate recognition site 5, which is located in close vicinity to the heme center.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4147	18814300-1665	The large and diverse family of cytochrome P450 monooxygenases (CYPs) was systematically analyzed to identify selectivity- and specificity-determining residues in the substrate recognition site 5, which is located in close vicinity to the heme center.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4148	18814300-1666	In 98.4% of all CYP sequences a preferentially hydrophobic residue is located at position 5 after the ExxR motif that is predicted to point close to the heme center.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4149	18814316-53	We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4150	18814316-53	We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4151	18814316-53	We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4152	18814316-53	We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4153	18814316-54	The observed fluorescence quenching of HSA by IOC is due to a complex formation by a static quenching process with a quenching constant of the order of 10(5) M(-1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4154	18814316-55	From the observed Förster-type fluorescence resonance energy transfer (FRET), the donor (Trp 214 in HSA) to acceptor (IOC) distance is calculated to be 3.2 nm.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4155	18814316-56	The preferred binding site of IOC was analyzed by ligand displacement experiments with 1-anilino-8-naphthalenesulfonate (ANS) and warfarin-bound HSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4156	18814316-56	The preferred binding site of IOC was analyzed by ligand displacement experiments with 1-anilino-8-naphthalenesulfonate (ANS) and warfarin-bound HSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4157	18814316-56	The preferred binding site of IOC was analyzed by ligand displacement experiments with 1-anilino-8-naphthalenesulfonate (ANS) and warfarin-bound HSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4158	18814864-1818	A number of site-specific modifications of the nucleosome core histones-including the trimethylated forms of histone H3 lysines K4, K9, and K27-are of particular interest for postmortem research, because these marks differentiate between active and inactive chromatin and seem to remain relatively stable during tissue autolysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4159	18814910-1833	We here demonstrate that TRPA1 confers a sensitivity towards near ultraviolet (UVA) light, which rapidly causes Ca(2+) entry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4160	18814910-1834	In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4161	18814910-1834	In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4162	18814934-1845	To verify the possible involvement of lipids and several other compounds including hydrogen peroxide (H(2)O(2)) and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) in the response of Hordeum vulgare to early potassium deprivation, plants were grown in hydroponic conditions for 30d with a modified Hewitt nutrient solution containing 3mM K(+).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4163	18814934-1845	To verify the possible involvement of lipids and several other compounds including hydrogen peroxide (H(2)O(2)) and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) in the response of Hordeum vulgare to early potassium deprivation, plants were grown in hydroponic conditions for 30d with a modified Hewitt nutrient solution containing 3mM K(+).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4164	18815024-1868	A new biosensor for trehalose determination has been realized by means of a flow system, based on a reactor in which the trehalase enzyme catalyses its hydrolysis into two alpha,d-glucose molecules, and a GOD (glucose oxidase) amperometric biosensor is employed for the glucose determination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4165	18815024-1868	A new biosensor for trehalose determination has been realized by means of a flow system, based on a reactor in which the trehalase enzyme catalyses its hydrolysis into two alpha,d-glucose molecules, and a GOD (glucose oxidase) amperometric biosensor is employed for the glucose determination.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4166	18815084-1886	The angiogenic potential of vascular endothelial growth factor (VEGF) and its oxygen pressure-dependent regulation suggest a strong connection between this growth factor and the 'delay phenomenon'.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4167	18815123-1901	Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4168	18815141-1912	Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4169	18815243-1973	After serum creatinine reached a stable nadir in the transplant recipients, GFR and its hemodynamic determinants were evaluated and the whole allograft K(f) was computed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4170	18815356-1953	Lower expression of IGFBP1 and prolactin mRNA and protein was observed in hESF from women with vs. those without endometriosis in response to 8-Br-cAMP, but not P4, suggesting a blunted response of these decidual biomarkers to activation of the PKA pathway in eutopic endometrium in women with disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4171	18815356-1953	Lower expression of IGFBP1 and prolactin mRNA and protein was observed in hESF from women with vs. those without endometriosis in response to 8-Br-cAMP, but not P4, suggesting a blunted response of these decidual biomarkers to activation of the PKA pathway in eutopic endometrium in women with disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4172	18815358-2022	Furthermore, constitutive expression of an oxygen-insensitive, active form of HIF1A protein mimicked the effects of low oxygen, inhibiting the differentiation of trophoblast giant cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4173	18815782-2147	Finally, the results showed that the lipase covalently attached onto epoxy resin exhibited the highest enantioselectivity and operational stability.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4174	18815831-2150	Effect of the inoculum size on carbapenem susceptibilities of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4175	18815831-2151	However, the effect of inoculum size of beta-lactamase-negative, ampicillin-resistant H. influenzae (BLNAR) on MICs for carbapenems has not been investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4176	18815849-2155	It has been proposed that there is improvement in glucose and insulin metabolism after weight loss in patients who underwent diet restriction and bariatric surgery.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4177	18815869-2158	Folate deficiency due to the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) variants leads to carcinogenesis by affecting DNA synthesis, repair, and methylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4178	18815869-2158	Folate deficiency due to the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) variants leads to carcinogenesis by affecting DNA synthesis, repair, and methylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4179	18815869-2158	Folate deficiency due to the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) variants leads to carcinogenesis by affecting DNA synthesis, repair, and methylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4180	18815881-2160	Tamoxifen has been the mainstay of endocrine therapy for estrogen receptor-positive breast cancer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4181	18815882-2164	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of physiological and pathological processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4182	18815882-2164	The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids, terminal components of glycoconjugates associated with a variety of physiological and pathological processes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4183	18816186-2283	A subthreshold stimulation by acute pathological threatening conditions (e.g., global ischemia subthreshold for cell death) enhances neuronal Cx36 and glial Cx43 hemichannel activity, favoring ATP release and generation of preconditioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4184	18816186-2283	A subthreshold stimulation by acute pathological threatening conditions (e.g., global ischemia subthreshold for cell death) enhances neuronal Cx36 and glial Cx43 hemichannel activity, favoring ATP release and generation of preconditioning.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4185	18816698-2452	A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4186	18816698-2452	A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4187	18816698-2452	A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4188	18816790-2482	4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4189	18816790-2483	5) After PKA inhibition with H-89, PKC stimulation with PMA (or inhibition with CaC) does not lead to any change in evoked ACh release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4190	18816790-2484	In contrast, PKA inhibition prevent PKC stimulation (with the phorbol ester) and coupling to ACh output.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4191	18817778-252	The inhibition of female rabbit sexual behavior by progesterone : progesterone receptor-dependent and-independent effects.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4192	18817795-259	Reproductive experience alters corticosterone and CBG levels in the rat dam.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4193	18817795-260	The present study investigated whether the levels of circulating corticosterone and its binding protein, corticosteroid binding globulin (CBG), are altered with reproductive experience and pup-exposure during late pregnancy and the postpartum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4194	18817795-260	The present study investigated whether the levels of circulating corticosterone and its binding protein, corticosteroid binding globulin (CBG), are altered with reproductive experience and pup-exposure during late pregnancy and the postpartum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4195	18817795-261	Total serum corticosterone and CBG were assayed from five groups; multiparous, primiparous, nulliparous, primip-no-pups, and sensitized rats during gestation (days 14 and 19) and the postpartum period (days 1, 5, 14, 21, and 35).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4196	18817797-263	The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4197	18817797-263	The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4198	18817816-1059	The expressions of serotonin receptors (5-hydroxytryptamine receptor), corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the hypothalamus were detected by real time PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4199	18817816-1059	The expressions of serotonin receptors (5-hydroxytryptamine receptor), corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the hypothalamus were detected by real time PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4200	18817816-1059	The expressions of serotonin receptors (5-hydroxytryptamine receptor), corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the hypothalamus were detected by real time PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4201	18817816-1059	The expressions of serotonin receptors (5-hydroxytryptamine receptor), corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the hypothalamus were detected by real time PCR.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4202	18817841-391	After incubation with 4- androstene-3,17-dione (4-dione), there are no estrogens, estrone (E1) and estradiol (E2), detected suggesting that the pathway of aromatase is not important in these cell lines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4203	18817841-391	After incubation with 4- androstene-3,17-dione (4-dione), there are no estrogens, estrone (E1) and estradiol (E2), detected suggesting that the pathway of aromatase is not important in these cell lines.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4204	18817845-305	The aim of this study was to investigate the effects of acute and chronic exercise on thiobarbituric acid reactive substances, as an indicator of lipid peroxidation, in the hippocampus, which has a high concentration of glucocorticoid receptors, and prefrontal cortex and striatum, which have high dopamine content.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4205	18817845-305	The aim of this study was to investigate the effects of acute and chronic exercise on thiobarbituric acid reactive substances, as an indicator of lipid peroxidation, in the hippocampus, which has a high concentration of glucocorticoid receptors, and prefrontal cortex and striatum, which have high dopamine content.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4206	18817845-306	Additionally we examined antioxidant enzyme activities, superoxide dismutase and glutathione peroxidase and nitrite-nitrate levels to assess the effects of reactive oxygen and nitrogen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4207	18817845-306	Additionally we examined antioxidant enzyme activities, superoxide dismutase and glutathione peroxidase and nitrite-nitrate levels to assess the effects of reactive oxygen and nitrogen species.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4208	18818063-283	Oral administration of (PhSe)(2) in rats did not change plasma alanine and aspartate aminotransferase activities (AST and ALT) as well as urea and creatinine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4209	18818063-283	Oral administration of (PhSe)(2) in rats did not change plasma alanine and aspartate aminotransferase activities (AST and ALT) as well as urea and creatinine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4210	18818063-283	Oral administration of (PhSe)(2) in rats did not change plasma alanine and aspartate aminotransferase activities (AST and ALT) as well as urea and creatinine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4211	18818063-283	Oral administration of (PhSe)(2) in rats did not change plasma alanine and aspartate aminotransferase activities (AST and ALT) as well as urea and creatinine levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4212	18818229-311	Total plasma homocysteine level, MTHFR C677T polymorphism, inherited abnormalities of the natural anticoagulant system as well as plasma folate and cobalamin levels were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4213	18818229-311	Total plasma homocysteine level, MTHFR C677T polymorphism, inherited abnormalities of the natural anticoagulant system as well as plasma folate and cobalamin levels were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4214	18818229-311	Total plasma homocysteine level, MTHFR C677T polymorphism, inherited abnormalities of the natural anticoagulant system as well as plasma folate and cobalamin levels were determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4215	18818289-2648	Immunohistochemical colabeling for nesfatin-1 and ghrelin, histidine decarboxylase, or somatostatin revealed two subtypes of nesfatin-1-positive endocrine cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4216	18818289-2648	Immunohistochemical colabeling for nesfatin-1 and ghrelin, histidine decarboxylase, or somatostatin revealed two subtypes of nesfatin-1-positive endocrine cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4217	18818289-2649	Cells in the midportion of the glands coexpressed nesfatin-1 and ghrelin, whereas few cells in the glandular base coexpressed nesfatin-1 and somatostatin or histidine decarboxylase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4218	18818289-2649	Cells in the midportion of the glands coexpressed nesfatin-1 and ghrelin, whereas few cells in the glandular base coexpressed nesfatin-1 and somatostatin or histidine decarboxylase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4219	18818294-345	Importantly, tPA and PAI-1 proteins and tPA activity were low/nondetectable in granulosa cells obtained after treatment with hCG and the PG synthesis inhibitor celecoxib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4220	18818294-345	Importantly, tPA and PAI-1 proteins and tPA activity were low/nondetectable in granulosa cells obtained after treatment with hCG and the PG synthesis inhibitor celecoxib.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4221	18818294-346	To determine whether hCG stimulation of tPA and PAI-1 requires PGE2, granulosa cells obtained at 0 h were cultured with hCG plus indomethacin to inhibit PG production; some cells also received PGE2 or an agonist selective for one PGE2 receptor (EP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4222	18818294-346	To determine whether hCG stimulation of tPA and PAI-1 requires PGE2, granulosa cells obtained at 0 h were cultured with hCG plus indomethacin to inhibit PG production; some cells also received PGE2 or an agonist selective for one PGE2 receptor (EP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4223	18818299-354	The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4224	18818375-367	In conclusion, the enhanced H(2)O(2) contraction in resistance arteries from SHRs seems to be mediated by increased TXA(2) release from COX-1 followed by elevations in vascular smooth muscle (Ca(2+))(i) levels and O(2)(.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4225	18818396-379	The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4226	18818396-380	Herein we show that c-Myb expression is subject to posttranscriptional regulation by microRNA (miRNA)-15a.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4227	18818396-381	Exogenous expression of c-myb mRNA lacking the 3'-UTR partially rescued the miR-15a induced cell-cycle block.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4228	18818396-382	Occupancy of one canonical c-Myb binding site was demonstrated by chromatin immunoprecipitation analysis and shown to be required for miR-15a expression in K562 cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4229	18818396-384	In aggregate, these findings suggest the presence of a c-Myb-miR-15a autoregulatory feedback loop of potential importance in human hematopoiesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4230	18818486-396	The central homeostasis is characterized by increased cerebrocortical synaptosomal T(3) content, deiodinase type II (DII) activity, and cAMP content.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4231	18818687-454	This review provides an introduction to epigenetic concepts for renal investigators and an overview of our work detailing an epigenetic pathway for aldosterone signaling and the control of epithelial Na(+) channel-alpha (ENaCalpha) subunit gene expression in the collecting duct.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4232	18818710-2729	We aim to evaluate whether an E1A, E1B double-restricted oncolytic adenovirus, AxdAdB-3, can improve the efficacy for gallbladder cancers (GBCs) of the replication-deficient adenovirus-based herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) therapy directed by the carcinoembryonic antigen (CEA) promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4233	18818710-2729	We aim to evaluate whether an E1A, E1B double-restricted oncolytic adenovirus, AxdAdB-3, can improve the efficacy for gallbladder cancers (GBCs) of the replication-deficient adenovirus-based herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) therapy directed by the carcinoembryonic antigen (CEA) promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4234	18818710-2729	We aim to evaluate whether an E1A, E1B double-restricted oncolytic adenovirus, AxdAdB-3, can improve the efficacy for gallbladder cancers (GBCs) of the replication-deficient adenovirus-based herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) therapy directed by the carcinoembryonic antigen (CEA) promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4235	18818710-2729	We aim to evaluate whether an E1A, E1B double-restricted oncolytic adenovirus, AxdAdB-3, can improve the efficacy for gallbladder cancers (GBCs) of the replication-deficient adenovirus-based herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) therapy directed by the carcinoembryonic antigen (CEA) promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4236	18818710-2730	Cytopathic effects of AxdAdB-3 plus AxCEAprTK (an adenovirus expressing HSVtk directed by CEA promoter) or AxCAHSVtk (an adenovirus expressing HSVtk directed by a nonspecific CAG promoter) with GCV administration were examined in several GBC lines and normal cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4237	18818946-557	This mutation in the SLC2A10 gene replaces a cysteine encoding codon with a stop signal.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4238	18819019-595	Cyclophilin A (CypA), a receptor for the immunosuppressive agent cyclosporin A (CsA), is a cis-trans peptidyl-prolyl isomerase (PPIase) which accelerates the cis-trans isomerization of prolyl-peptide bonds, interacts with a variety of proteins and therefore regulates their activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4239	18819019-595	Cyclophilin A (CypA), a receptor for the immunosuppressive agent cyclosporin A (CsA), is a cis-trans peptidyl-prolyl isomerase (PPIase) which accelerates the cis-trans isomerization of prolyl-peptide bonds, interacts with a variety of proteins and therefore regulates their activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4240	18819019-595	Cyclophilin A (CypA), a receptor for the immunosuppressive agent cyclosporin A (CsA), is a cis-trans peptidyl-prolyl isomerase (PPIase) which accelerates the cis-trans isomerization of prolyl-peptide bonds, interacts with a variety of proteins and therefore regulates their activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4241	18819053-613	While studies have shown that eplerenone does not exhibit nonspecific actions on androgen receptor, its effects on steroid hormone production have not been reported.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4242	18819705-825	New treatments for type 2 diabetes mellitus are needed to retain insulin-glucose coupling and lower the risk of weight gain and hypoglycaemia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4243	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4244	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4245	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4246	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4247	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4248	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4249	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4250	18819713-827	The parameters measured in E. albidus whole body were: lipid peroxidation (LPO), total glutathione (TG), as well as the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione S-transferase (GST).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4251	18819820-872	Augmentation of antibody responses by retinoic acid and costimulatory molecules.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4252	18820127-944	In accord with published results, we could show that treatment with 17AAG resulted in depletion of Chk1, a known Hsp90 client protein.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4253	18820127-944	In accord with published results, we could show that treatment with 17AAG resulted in depletion of Chk1, a known Hsp90 client protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4254	18820127-945	In addition, we observed a time- and dose-dependent decrease in Wee1 kinase level, a negative regulator of mitosis, after 17AAG treatment in gastrointestinal cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4255	18820134-953	Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4256	18820153-959	A small cytoplasmic protein, MURR1, has been identified in human hepatic tissue, but its role in Cu metabolism is unknown.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4257	18820153-962	As with CCS, they are involved in making Cu available to apo-enzymes inside the cell.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4258	18820175-973	BrdU proliferation assays showed that in vivo proliferation of CD8+ T cells was reduced in ethanol-fed mice, and IL-2-dependent in vitro proliferation of naive CD8+ T cells was also reduced.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4259	18820241-987	Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7alpha-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4260	18820241-987	Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7alpha-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4261	18820279-997	Therefore, we queried whether rosuvastatin is prosurvival in podocytes through a p21-dependent pathway.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4262	18820825-2189	Treatment with pioglitazone, associated with metformin, showed a reduction of IL-6 monocyte production after their in vitro activation with LPS.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4263	18820838-1229	Regulation of T-type Cav3.1 channels expression by synthetic glucocorticoid dexamethasone in neonatal cardiac myocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4264	18820905-1243	The supernatant of the majority of the strains did not release the aglycone from daidzin, suggesting that cell-associated beta-glucosidases (beta-Glu) are mainly responsible for the metabolism of soybean glyco-conjugates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4265	18820905-1243	The supernatant of the majority of the strains did not release the aglycone from daidzin, suggesting that cell-associated beta-glucosidases (beta-Glu) are mainly responsible for the metabolism of soybean glyco-conjugates.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4266	18820913-1250	Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4267	18821018-1286	Acute regulation is mediated by the steroidogenic acute regulatory protein (StAR), which facilitates the rapid influx of cholesterol into mitochondria, where P450scc resides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4268	18821018-1286	Acute regulation is mediated by the steroidogenic acute regulatory protein (StAR), which facilitates the rapid influx of cholesterol into mitochondria, where P450scc resides.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4269	18821018-1287	In the absence of P450c17 in the zona glomerulosa, C21 deoxy steroids are produced, leading to the mineralocorticoid, aldosterone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4270	18821018-1288	In the presence of the 17alpha-hydroxylase but not the 17,20 lyase activity of P450c17 in the zona fasciculata, C21, 17-hydroxy steroids are produced, leading to the glucocorticoid, cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4271	18821018-1289	When both the 17alpha-hydroxylase and 17,20 lyase activities of P450c17 are present in the zona reticularis, the androgen precursor DHEA is produced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4272	18821018-1291	In the adrenal zona reticularis, the abundant expression of P450 oxidoreductase and cytochrome b5, and the low expression of 3beta-hydroxysteroid dehydrogenase (HSD3B2) result in the production of the large amounts of DHEA that characterize adrenarche.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4273	18821018-1291	In the adrenal zona reticularis, the abundant expression of P450 oxidoreductase and cytochrome b5, and the low expression of 3beta-hydroxysteroid dehydrogenase (HSD3B2) result in the production of the large amounts of DHEA that characterize adrenarche.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4274	18821018-1291	In the adrenal zona reticularis, the abundant expression of P450 oxidoreductase and cytochrome b5, and the low expression of 3beta-hydroxysteroid dehydrogenase (HSD3B2) result in the production of the large amounts of DHEA that characterize adrenarche.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4275	18821058-2709	These were mutated in onion vacuolar invertase (acINV) according to the residue in festuca sucrose : sucrose 1-fructosyltransferase (saSST) and vice versa.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4276	18821058-2709	These were mutated in onion vacuolar invertase (acINV) according to the residue in festuca sucrose : sucrose 1-fructosyltransferase (saSST) and vice versa.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4277	18821127-1366	Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4278	18821127-1367	The relative pharmacological efficacy for chitosan phthalate and chitosan succinate microspheres (18.66+/-3.84%, 16.24+/-4%) was almost three-fold higher than the efficacy of the oral insulin administration (4.68+/-1.52%).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4279	18821579-1511	Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4280	18821579-1513	FK228 converted unconjugated microtubule-associated protein light chain 3 (LC3-I) to conjugated light chain 3 (LC3-II) and induced localization of LC3 to autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4281	18821579-1513	FK228 converted unconjugated microtubule-associated protein light chain 3 (LC3-I) to conjugated light chain 3 (LC3-II) and induced localization of LC3 to autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4282	18821579-1513	FK228 converted unconjugated microtubule-associated protein light chain 3 (LC3-I) to conjugated light chain 3 (LC3-II) and induced localization of LC3 to autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4283	18821579-1513	FK228 converted unconjugated microtubule-associated protein light chain 3 (LC3-I) to conjugated light chain 3 (LC3-II) and induced localization of LC3 to autophagosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4284	18821579-1514	Apoptosis inducing factor (AIF), which plays a role in caspase-independent cell death, translocated to the nucleus in response to FK228 treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4285	18821579-1514	Apoptosis inducing factor (AIF), which plays a role in caspase-independent cell death, translocated to the nucleus in response to FK228 treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4286	18821853-1612	Furthermore, the effect of HBO on DDR2 has not been reported previously.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4287	18821853-1613	In the present study, we investigated the cellular and molecular mechanisms of DDR2 regulation by HBO in VSMCs (vascular SMCs).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4288	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4289	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4290	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4291	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4292	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4293	18822099-1671	The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4294	18822105-1672	Pretransplant conditioning consisted of fludarabine, l-PAM and TBI (2 Gy).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4295	18822107-1673	Despite pre- and post-operative PP and immunosuppressive treatment consisting of steroids, CycA, daclizumab, and MMF, daily protein excretion and serum creatinine increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4296	18822107-1673	Despite pre- and post-operative PP and immunosuppressive treatment consisting of steroids, CycA, daclizumab, and MMF, daily protein excretion and serum creatinine increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4297	18822278-1745	Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4298	18822413-1812	High-density-lipoproteins-cholesterol (HDL-C) is invertedly related to the incidence of cardiovascular events.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4299	18823071-2096	An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4300	18823430-2181	Effects of CYP2C19 and MDR1 genotype on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4301	18823430-2181	Effects of CYP2C19 and MDR1 genotype on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4302	18823436-2183	Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4303	18823687-2243	Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4304	18823722-2255	Among the R-Nx strains, a substitution of Gly to Cys at position 81 (Gly81à Cys) of the gyrA gene in 10 strains isolated from wild birds and ovine foetuses, and of Asp to Tyr at position 87 (Asp87à Tyr) in one strain isolated from ewe faeces, were revealed by sequencing the gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4305	18823727-2261	Expansion of the first polyalanine tract of the ARX gene in a boy presenting with generalized dystonia in the absence of infantile spasms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4306	18823727-2262	Gene sequencing detected an additional seven GCG repeats in the first polyalanine tract of the ARX gene, a mutation which leads to an expansion of the normal 16 alanine residues to 23.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4307	18823877-2298	Emerging evidence that both brain-derived neurotrophic factor (BDNF) and lithium suppress FoxO activity suggests a potential role of FoxOs in regulating mood-relevant behavior.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4308	18823877-2298	Emerging evidence that both brain-derived neurotrophic factor (BDNF) and lithium suppress FoxO activity suggests a potential role of FoxOs in regulating mood-relevant behavior.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4309	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4310	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutaseperoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4311	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4312	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4313	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4314	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4315	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4316	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4317	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4318	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4319	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4320	18823890-2301	We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKYN); two distinct SOX markers: Cu/Zn superoxide dismutase (Cu/Zn SOD) and total peroxide ; and high sensitivity C-reactive protein (hs CRP) as a indicator of inflammation in 146 ESRD patients and healthy controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4321	18823890-2304	ESRD patients showed a significant increase in Cu/Zn SOD, total peroxide and hs CRP levels between controls and all patients group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4322	18823890-2304	ESRD patients showed a significant increase in Cu/Zn SOD, total peroxide and hs CRP levels between controls and all patients group.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4323	18823964-2330	Diabetes is characterized by elevated fasting blood glucose (FBG) resulting from improper insulin regulation and/or insulin resistance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4324	18823964-2332	THII significantly diminished these changes in glucose and insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4325	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4326	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4327	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4328	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4329	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4330	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4331	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4332	18824011-260	Using HPLC techniques we evaluated the electrical field stimulation-evoked overflow of noradrenaline (NA), adenosine 5 '-triphosphate (ATP), and beta-nicotinamide adenine dinucleotide (beta-NAD) in the presence of low nanomolar concentrations of omega-conotoxin GVIA or omega-agatoxin IVA in the canine mesenteric arteries and veins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4333	18824106-2403	An extensive kinetic profile towards a plethora of purines and mutational analyses have established models on how UapA recognizes the purine ring and revealed specific amino acid residues involved in proper folding, topogenesis, function and specificity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4334	18824106-2404	The present work describes for the first time the purification of the UapA transporter of A. nidulans through overexpression via the strong, ethanol-inducible, glucose-repressible, alcA promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4335	18824106-2404	The present work describes for the first time the purification of the UapA transporter of A. nidulans through overexpression via the strong, ethanol-inducible, glucose-repressible, alcA promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4336	18824106-2404	The present work describes for the first time the purification of the UapA transporter of A. nidulans through overexpression via the strong, ethanol-inducible, glucose-repressible, alcA promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4337	18824106-2404	The present work describes for the first time the purification of the UapA transporter of A. nidulans through overexpression via the strong, ethanol-inducible, glucose-repressible, alcA promoter.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4338	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4339	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4340	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4341	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4342	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4343	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4344	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4345	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4346	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4347	18824121-2411	Three enzymes function in biosynthesis of GDP-mannose from the glycolytic intermediate fructose 6-phosphate : phosphomannose isomerase (PMI), phosphomannomutase (PMM) and GDP-mannose pyrophosphorylase (GMPP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4348	18824121-2412	Synthesis of GDP-mannose from exogenous mannose requires hexokinase or phosphotransferase enzymes together with PMM and GMPP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4349	18824121-2412	Synthesis of GDP-mannose from exogenous mannose requires hexokinase or phosphotransferase enzymes together with PMM and GMPP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4350	18824341-1648	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4351	18824341-1648	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4352	18824341-1648	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4353	18824341-1648	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4354	18824415-2564	Thrombin, vascular endothelial growth factor, and hydrogen peroxide increased EC permeability, disrupted cell junctions, and induced stress fiber formation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4355	18824476-2583	Clarified glycomic and protemic information combined with publicly available microarray data sets allowed us to identify galectin-3 as a receptor of Galalpha1-3Gal epitope.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4356	18824496-2592	Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by polyglutamine expansion mutation in the androgen receptor (AR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4357	18824518-2598	Also, our previous studies implicated the SphK1/S1P pathway in the induction of the arachidonic acid cascade, a major inflammatory pathway involved in colon carcinogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4358	18824518-2599	In the azoxymethane (AOM) murine model of colon cancer, SphK1 and S1P were significantly elevated in colon cancer tissues compared to normal mucosa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4359	18824518-2599	In the azoxymethane (AOM) murine model of colon cancer, SphK1 and S1P were significantly elevated in colon cancer tissues compared to normal mucosa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4360	18824524-2604	Uptake of valsartan, losartan, and cefadroxil was quantified in HeLa cells after heterologous expression of human PEPT1 (hPEPT1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4361	18824524-2604	Uptake of valsartan, losartan, and cefadroxil was quantified in HeLa cells after heterologous expression of human PEPT1 (hPEPT1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4362	18824524-2604	Uptake of valsartan, losartan, and cefadroxil was quantified in HeLa cells after heterologous expression of human PEPT1 (hPEPT1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4363	18824524-2605	In contrast to cefadroxil, no PEPT1-specific uptake of valsartan and losartan was found.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4364	18824524-2605	In contrast to cefadroxil, no PEPT1-specific uptake of valsartan and losartan was found.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4365	18824524-2605	In contrast to cefadroxil, no PEPT1-specific uptake of valsartan and losartan was found.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4366	18824527-2607	The 2-(acylamino)-3-thiophenecarboxylates suppressed CFTR-mediated Cl (-) current in T84 colonic cells in response to cholera and Escherichia coli (STa) toxins, and prevented intestinal fluid accumulation in a closed-loop mouse model of secretory diarrhea.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4367	18824596-2638	We investigated the hypothesis that modulation of EPC biology and attenuation of allograft vasculopathy by increased high-density lipoprotein cholesterol after human apo A-I (AdA-I) transfer requires scavenger receptor (SR)-BI expression in bone marrow-derived EPCs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4368	18824635-2654	Hormone-sensitive lipase (HSL) is a key regulator of cholesterol esters metabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4369	18824635-2654	Hormone-sensitive lipase (HSL) is a key regulator of cholesterol esters metabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4370	18825162-2817	We found associations between the midazolam phenotype and age, diagnosis of hypertension and one htSNP (141689) located upstream of CYP3A4.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4371	18825163-2818	Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4372	18825163-2819	The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4373	18825163-2820	Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (beta=0.200, P=0.028), free oestradiol (beta=0.233, P=0.008) and lean body mass (beta=0.257, P=0.034).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4374	18825163-2821	Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4375	18825163-2821	Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4376	18825302-18	Repaglinide plus single-dose insulin glargine: a safe regimen for low-risk type 2 diabetic patients who insist on fasting in Ramadan.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4377	18825335-25	Much interest has been directed to the study of the TRPV1, because capsaicin has been instrumental in discovering the unique role of a subset of primary sensory neurons in causing nociceptive responses, in activating reflex pathways including cough, and in producing neurogenic inflammation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4378	18825368-41	To evaluate arginine vasopressin (AVP) and copeptin plasma concentrations in patients with vasodilatory shock after cardiac surgery.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4379	18825380-47	In this study, we report a novel GPIbbeta defect in a Tunisian family, in which Serine 23 is substituted by a Stop codon causing a premature termination of translation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4380	18825527-114	Eight newly synthesized carbacylamidophosphates with the general formula RC(O) NHP (O) Cl2 with R = pCl-C6H4 1a, pBr-C6H4 2a, C6H5 3a, and pMe-C6H4 4a and RC(O) NHP (O)(NC4H8O)2 R = pCl-C6H4 1b, pBr-C6H4 2b, C6H5 3b, pMe-C6H4 4b, were selected to compare the inhibition kinetic parameters, IC50, Ki, kp and KD, on human erythrocyte acetylcholinesterase (hAChE) and bovine serum butyrylcholinesterase (BuChE), Also, the in vivo inhibition potency of compound 2a, 2b and 3a, were studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4381	18825527-114	Eight newly synthesized carbacylamidophosphates with the general formula RC(O) NHP (O) Cl2 with R = pCl-C6H4 1a, pBr-C6H4 2a, C6H5 3a, and pMe-C6H4 4a and RC(O) NHP (O)(NC4H8O)2 R = pCl-C6H4 1b, pBr-C6H4 2b, C6H5 3b, pMe-C6H4 4b, were selected to compare the inhibition kinetic parameters, IC50, Ki, kp and KD, on human erythrocyte acetylcholinesterase (hAChE) and bovine serum butyrylcholinesterase (BuChE), Also, the in vivo inhibition potency of compound 2a, 2b and 3a, were studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4382	18825527-114	Eight newly synthesized carbacylamidophosphates with the general formula RC(O) NHP (O) Cl2 with R = pCl-C6H4 1a, pBr-C6H4 2a, C6H5 3a, and pMe-C6H4 4a and RC(O) NHP (O)(NC4H8O)2 R = pCl-C6H4 1b, pBr-C6H4 2b, C6H5 3b, pMe-C6H4 4b, were selected to compare the inhibition kinetic parameters, IC50, Ki, kp and KD, on human erythrocyte acetylcholinesterase (hAChE) and bovine serum butyrylcholinesterase (BuChE), Also, the in vivo inhibition potency of compound 2a, 2b and 3a, were studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4383	18825527-114	Eight newly synthesized carbacylamidophosphates with the general formula RC(O) NHP (O) Cl2 with R = pCl-C6H4 1a, pBr-C6H4 2a, C6H5 3a, and pMe-C6H4 4a and RC(O) NHP (O)(NC4H8O)2 R = pCl-C6H4 1b, pBr-C6H4 2b, C6H5 3b, pMe-C6H4 4b, were selected to compare the inhibition kinetic parameters, IC50, Ki, kp and KD, on human erythrocyte acetylcholinesterase (hAChE) and bovine serum butyrylcholinesterase (BuChE), Also, the in vivo inhibition potency of compound 2a, 2b and 3a, were studied.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4384	18825528-117	The presented study is aimed at reactivation of trichlorfon-inhibited butyrylcholinesterase since this enzyme play an important role in Alzheimer's disease as deputy for acetylcholinesterase and furthermore it could be applied as a scavenger in case of overdosing.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4385	18825531-118	Among them, compound 3 and 5 had significant calpain inhibitory activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4386	18825537-122	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4387	18825537-122	Here we report the docking study of four green tea catechins and four alkylating anticancer drugs into the GST P1-1 model, as GSTs were found to be affected by tea catechins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4388	18825553-139	The protein glycation inhibitory activity of ethanolic extract of Lawsonia inermis (henna) plant tissues was evaluated in vitro using the model system of bovine serum albumin and glucose.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4389	18825555-141	In vitro effects of peroxynitrite treatment on fish liver catalase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4390	18825555-142	The effect of peroxynitrite (PN), a highly toxic agent, on catalase (CAT) activity in fish liver microsomal homogenates was determined.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4391	18825555-142	The effect of peroxynitrite (PN), a highly toxic agent, on catalase (CAT) activity in fish liver microsomal homogenates was determined.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4392	18825778-209	NMR-derived folate-bound structure of dihydrofolate reductase 1 from the halophile Haloferax volcanii.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4393	18826375-301	Histidine-regulated activity of M-ficolin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4394	18826375-305	The biological roles of the histidine-regulated conformational equilibrium of M-ficolin are discussed in terms of the self and non-self discrimination mechanism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4395	18826425-314	The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4396	18826485-2656	These results underscore the differential regulation of GPX expression in response to cadmium, aluminium and nitric oxide, and strongly support a role for GPX6 and possibly other GPX genes in stress and/or metabolic signalling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4397	18826485-2656	These results underscore the differential regulation of GPX expression in response to cadmium, aluminium and nitric oxide, and strongly support a role for GPX6 and possibly other GPX genes in stress and/or metabolic signalling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4398	18826485-2656	These results underscore the differential regulation of GPX expression in response to cadmium, aluminium and nitric oxide, and strongly support a role for GPX6 and possibly other GPX genes in stress and/or metabolic signalling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4399	18826485-2656	These results underscore the differential regulation of GPX expression in response to cadmium, aluminium and nitric oxide, and strongly support a role for GPX6 and possibly other GPX genes in stress and/or metabolic signalling.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4400	18827283-620	Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4401	18827283-621	Among the known mechanisms of reverse cholesterol transport (RCT), ATP binding cassette transporter G1 (ABCG1)-mediated free cholesterol (FC) transport is the most recent and least studied.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4402	18827283-622	Here, we have characterized the efficiencies of different acceptors using baby hamster kidney (BHK) cells transfected with human ABCG1 cDNA, which is inducible upon treatment with mifepristone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4403	18827741-766	Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4404	18827741-766	Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4405	18827741-766	Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4406	18827742-767	Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4407	18827742-767	Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4408	18827746-775	Reduced responses of alpha-MSH or Nac-beta-END IRM to CRH and the invalid suppression by dexamethasone reflect a state of dysfunction of the melanotroph-type POMC system in nonsurvivors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4409	18827746-775	Reduced responses of alpha-MSH or Nac-beta-END IRM to CRH and the invalid suppression by dexamethasone reflect a state of dysfunction of the melanotroph-type POMC system in nonsurvivors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4410	18827746-775	Reduced responses of alpha-MSH or Nac-beta-END IRM to CRH and the invalid suppression by dexamethasone reflect a state of dysfunction of the melanotroph-type POMC system in nonsurvivors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4411	18827746-775	Reduced responses of alpha-MSH or Nac-beta-END IRM to CRH and the invalid suppression by dexamethasone reflect a state of dysfunction of the melanotroph-type POMC system in nonsurvivors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4412	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4413	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4414	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4415	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4416	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4417	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4418	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4419	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4420	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4421	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4422	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4423	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4424	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4425	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4426	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4427	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4428	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4429	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4430	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4431	18827747-776	Systemic, hepatosplanchnic, and renal hemodynamics; oxygen exchange; energy metabolism (lactate/pyruvate and ketone body ratios); ileal mucosal and renal cortex microcirculation; systemic inflammation (TNF-alpha, IL-6); nitrosative/oxidative stress (thiobarbituric acid reactive species, nitrates+ nitrites); and endothelial/coagulation dysfunction (asymmetric dimethylarginine, von Willebrand factor, thrombin-antithrombin complexes, platelet count) were assessed before and 12, 18, and 22 h of peritonitis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4432	18827975-862	The purpose of this retrospective study was to compare the effects of lepirudin and argatroban in the management of HIT.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4433	18828007-864	The outer membrane TolC is involved in cysteine tolerance and overproduction in Escherichia coli.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4434	18828007-866	Gene expression analysis revealed that the tolC gene encoding the outer membrane channel is essential for L-cysteine tolerance in E. coli cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4435	18828019-168	The present study was performed to elucidate the relationship between the expression of ABCB1/MDR1 and ABCC1/MRP1 with resistance to either ET-743 or PM00104.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4436	18828019-168	The present study was performed to elucidate the relationship between the expression of ABCB1/MDR1 and ABCC1/MRP1 with resistance to either ET-743 or PM00104.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4437	18828019-168	The present study was performed to elucidate the relationship between the expression of ABCB1/MDR1 and ABCC1/MRP1 with resistance to either ET-743 or PM00104.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4438	18828019-168	The present study was performed to elucidate the relationship between the expression of ABCB1/MDR1 and ABCC1/MRP1 with resistance to either ET-743 or PM00104.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4439	18828793-1124	The previous amphotericin B, granulocyte colony-stimulating factor, hyperbaric oxygen and nasal and left maxillary sinus surgical debridement therapy was ineffective in stopping the progression of the infection to the brain.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4440	18828793-1124	The previous amphotericin B, granulocyte colony-stimulating factor, hyperbaric oxygen and nasal and left maxillary sinus surgical debridement therapy was ineffective in stopping the progression of the infection to the brain.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4441	18829132-1261	Bacterial strains differed in their ability to synthesize auxin and hydrogen cyanide compounds, as well as in their ACC deaminase activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4442	18829132-1261	Bacterial strains differed in their ability to synthesize auxin and hydrogen cyanide compounds, as well as in their ACC deaminase activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4443	18829266-1329	Toll-like receptor (TLR) 4 is a critical receptor and signal transducer for lipopolysaccharide (LPS), a major component of Gram-negative bacteria.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4444	18829281-1345	Postprandial glucose and CRP.05) in HTAG.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4445	18829286-1353	Colonization of germ-free (GF) mice has been shown to induce the gastrointestinal form of the selenium-dependent glutathione peroxidases, GPx2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4446	18829286-1353	Colonization of germ-free (GF) mice has been shown to induce the gastrointestinal form of the selenium-dependent glutathione peroxidases, GPx2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4447	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4448	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4449	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4450	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4451	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4452	18829287-2771	The purpose of this study was to investigate whether or not the role of docosahexaenoic acid (DHA) supplementation on cognitive capability was related with brain-derived neurotrophic factor (BDNF), nitric oxide (NO) and dopamine (DA) in aged mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4453	18829372-151	Model analysis of local oxygen delivery with liposome-encapsulated hemoglobin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4454	18829372-152	Liposome-encapsulated hemoglobins (LHs) are comparable to red blood cells (RBCs) in terms of oxygen (O(2))-carrying capacity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4455	18829677-1475	Moreover, both lung and plasma concentrations of the pro-inflammatory cytokines tumour necrosis factor-alpha and interferon-gamma were higher in nicotine-treated animals at this time-point.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4456	18829704-1495	The role of Hg(2+)-insensitive AQP7, if any, in sperm volume regulation was studied in transgenic mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4457	18829704-1496	Therefore, the Hg(2+)-sensitive AQP8, which was localized in elongated spermatids and spermatozoa, is a likely candidate for a water channel responsible for physiological sperm volume regulation crucial to in vivo fertilization.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4458	18829979-1580	Increased intrahepatic vascular tone in cirrhosis has been attributed to a decrease of hepatic nitric oxide (NO) secondary to disturbances in the post-translational regulation of the enzyme eNOS.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4459	18830228-1650	Adenylosuccinate lyase deficiency is a rare autosomal disorder of de novo purine synthesis, which results in the accumulation of succinylpurines in body fluids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4460	18830228-1651	Both patients had an increased succinyladenosine/SAICAr ratio of 1.6, and exhibited a novel homozygous missense mutation (c.674T>C; p.Met225Thr) in the exon 6 of the ADSL gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4461	18830381-1696	The profile of global DNA and estrogen receptor (ER)-alpha gene methylation during cancer development was determined by analysis of 5-methylcytosine (5-MeC) using immunohistochemical (IHC) staining, dot blot analysis or a quantitative gene methylation assay (QGMA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4462	18830381-1696	The profile of global DNA and estrogen receptor (ER)-alpha gene methylation during cancer development was determined by analysis of 5-methylcytosine (5-MeC) using immunohistochemical (IHC) staining, dot blot analysis or a quantitative gene methylation assay (QGMA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4463	18830594-1807	Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4464	18830594-1807	Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4465	18830620-1813	Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4466	18830680-1821	Donor testicular cells were prepared from heterozygous chicken beta actin (CAG)/enhanced green fluorescent protein (EGFP)-transgenic rats (EGFP Tg rats) during the second week after birth and injected into the seminiferous tubules of the MT-myc Tg rats (line-A and-B; both subfertile) or rats pretreated with busulfan to remove endogenous spermatogonia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4467	18830680-1821	Donor testicular cells were prepared from heterozygous chicken beta actin (CAG)/enhanced green fluorescent protein (EGFP)-transgenic rats (EGFP Tg rats) during the second week after birth and injected into the seminiferous tubules of the MT-myc Tg rats (line-A and-B; both subfertile) or rats pretreated with busulfan to remove endogenous spermatogonia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4468	18830680-1821	Donor testicular cells were prepared from heterozygous chicken beta actin (CAG)/enhanced green fluorescent protein (EGFP)-transgenic rats (EGFP Tg rats) during the second week after birth and injected into the seminiferous tubules of the MT-myc Tg rats (line-A and-B; both subfertile) or rats pretreated with busulfan to remove endogenous spermatogonia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4469	18830721-1832	Models of noncoupled dinuclear copper centers in azurin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4470	18830721-1833	Toward this goal, models of the noncoupled copper centers found in the enzymes peptidyl alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DBM), and nitrite reductase (NiR) were designed into the small soluble protein azurin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4471	18830721-1833	Toward this goal, models of the noncoupled copper centers found in the enzymes peptidyl alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DBM), and nitrite reductase (NiR) were designed into the small soluble protein azurin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4472	18830721-1833	Toward this goal, models of the noncoupled copper centers found in the enzymes peptidyl alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DBM), and nitrite reductase (NiR) were designed into the small soluble protein azurin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4473	18830721-1833	Toward this goal, models of the noncoupled copper centers found in the enzymes peptidyl alpha-hydroxylating monooxygenase (PHM), dopamine beta-monooxygenase (DBM), and nitrite reductase (NiR) were designed into the small soluble protein azurin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4474	18830721-1834	The models are significant because they maintain the existing type 1 (T1) copper, electron transfer site of azurin while including the second designed type 2 (T2) copper center that mimics the T2 catalytic sites in the target enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4475	18830722-1835	Intraprotein electron transfer (IET) from flavin mononucleotide (FMN) to heme is essential in NO synthesis by NO synthase (NOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4476	18830722-1835	Intraprotein electron transfer (IET) from flavin mononucleotide (FMN) to heme is essential in NO synthesis by NO synthase (NOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4477	18830722-1835	Intraprotein electron transfer (IET) from flavin mononucleotide (FMN) to heme is essential in NO synthesis by NO synthase (NOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4478	18830729-1841	The esterase and lipase activities were determined by the hydrolysis of pNPB and pNPP, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4479	18830729-1841	The esterase and lipase activities were determined by the hydrolysis of pNPB and pNPP, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4480	18830730-1843	In the present work, the activity of the enzymes xylose reductase (XR); xylitol dehydrogenasexylitol dehydrogenase (XD); and glucose-6-phosphate dehydrogenase (G6PD) during cultivation of Candida guilliermondii on rice straw hemicellulosic hydrolysate was measured and correlated with xylitol production under different pH values (around 4.5 and 7.5) and initial xylose concentration (around 30 and 70 g l(-1)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4481	18830730-1843	In the present work, the activity of the enzymes xylose reductase (XR); xylitol dehydrogenase (XD); and glucose-6-phosphate dehydrogenase (G6PD) during cultivation of Candida guilliermondii on rice straw hemicellulosic hydrolysate was measured and correlated with xylitol production under different pH values (around 4.5 and 7.5) and initial xylose concentration (around 30 and 70 g l(-1)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4482	18830730-1843	In the present work, the activity of the enzymes xylose reductase (XR); xylitol dehydrogenase (XD); and glucose-6-phosphate dehydrogenase (G6PD) during cultivation of Candida guilliermondii on rice straw hemicellulosic hydrolysate was measured and correlated with xylitol production under different pH values (around 4.5 and 7.5) and initial xylose concentration (around 30 and 70 g l(-1)).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4483	18830873-1896	QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4484	18830873-1897	QSAR studies for the inhibition of isozyme XIV of human carbonic anhydrase (CA, EC 4.2.1.1) by a series of sulfonamides including clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and zonisamide) are presented.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4485	18830874-1898	Inhibition of human muscle-specific enolase by methylglyoxal and irreversible formation of advanced glycation end products.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4486	18830874-1900	The affinity of enolase for gluconeogenic substrate phosphoenolpyruvate altered after preincubation with MG in the same manner, but less intensively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4487	18830875-307	Inhibitory effects of Cefazolin and Cefodizime on the activity of mushroom tyrosinase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4488	18830875-307	Inhibitory effects of Cefazolin and Cefodizime on the activity of mushroom tyrosinase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4489	18830876-308	The order of the cytotoxicity of the compounds was; IV > III > II > I > V. Compound IV, had the highest Hammett and log P values (0.23 and 4.21, respectively) and exerted both highest cytotoxicity and strongest DNA topoisomerase I inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4490	18830877-1907	Tests were carried out on cell cultures of human keratinocytes and mouse 3T3 fibroblasts incubated with radiolabeled acetate, and on homogenates prepared from yeast cells expressing human lanosterol synthase, incubated with radiolabeled oxidosqualene.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4491	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4492	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4493	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4494	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4495	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4496	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4497	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4498	18830880-1910	Hepatic antioxidant status viz, reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT 0.001).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4499	18830882-1911	Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4500	18830882-1913	The concentration required for 50% inhibition (IC(50)) by ZLLLal was 88 nM for cathepsin B and 163 nM for cathepsin L.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4501	18830882-1913	The concentration required for 50% inhibition (IC(50)) by ZLLLal was 88 nM for cathepsin B and 163 nM for cathepsin L.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4502	18830885-1914	Preliminary structure-activity relationships and a molecular modeling study for 9a have revealed that the isoflavone moiety plays a key role in the interaction of this series of derivatives with AChE by acting as an anchor in its peripheral anionic site.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4503	18830972-1951	Heme oxygenase-1 (HO-1) and Nitric oxide (NO) which may play an important role in regulatory and protective processes in cells were assayed upon nickel treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4504	18830972-1951	Heme oxygenase-1 (HO-1) and Nitric oxide (NO) which may play an important role in regulatory and protective processes in cells were assayed upon nickel treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4505	18831007-1971	One potential target for reducing T cell migration is inhibition of the Ca(2+)-activated neutral protease calpain.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4506	18831007-1971	One potential target for reducing T cell migration is inhibition of the Ca(2+)-activated neutral protease calpain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4507	18831010-1974	A shift toward proinflammatory microglial activation is indicated by the release of interleukin-6, tumor necrosis factor-alpha, and nitric oxide and the oxidative burst in rat primary microglial cells, an activation and differentiation process similar to the proinflammatory response of microglia to exposure to lipopolysaccharide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4508	18831010-1974	A shift toward proinflammatory microglial activation is indicated by the release of interleukin-6, tumor necrosis factor-alpha, and nitric oxide and the oxidative burst in rat primary microglial cells, an activation and differentiation process similar to the proinflammatory response of microglia to exposure to lipopolysaccharide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4509	18831033-1984	Levetiracetam, a newer anticonvulsant, does not undergo CYP metabolism and does not alter the pharmacokinetics of chemotherapy, antiemetics, and corticosteroids, which are metabolized by the liver.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4510	18831052-2002	The human AU RNA binding protein/enoyl-Coenzyme A hydratase (AUH) is a 3-hydroxy-3-methylglutaconyl-CoA dehydratase in the leucine degradation pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4511	18831052-2002	The human AU RNA binding protein/enoyl-Coenzyme A hydratase (AUH) is a 3-hydroxy-3-methylglutaconyl-CoA dehydratase in the leucine degradation pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4512	18831980-2703	SULT1E1 is responsible for the sulfation and inactivation of beta-estradiol (E2) at physiological concentrations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4513	18832050-2295	The main mechanism of resistance to methotrexate was extra-chromosomal amplification of the dihydrofolate reductase gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4514	18832097-2311	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished ((3)H) 1,25-dihydroxy vitamin D (3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4515	18832097-2311	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished ((3)H) 1,25-dihydroxy vitamin D (3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4516	18832102-2313	The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein receptors (very-low-density lipoprotein receptor (VLDLR), low-density lipoprotein receptor (LDLR), and scavenger receptor-BI (SR-BI 12 h) has not been characterized.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4517	18832102-2313	The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein receptors (very-low-density lipoprotein receptor (VLDLR), low-density lipoprotein receptor (LDLR), and scavenger receptor-BI (SR-BI 12 h) has not been characterized.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4518	18832102-2313	The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein receptors (very-low-density lipoprotein receptor (VLDLR), low-density lipoprotein receptor (LDLR), and scavenger receptor-BI (SR-BI 12 h) has not been characterized.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4519	18832102-2313	The use of lipoproteins as a substrate for progesterone synthesis remains unclear, and the expression of lipoprotein receptors (very-low-density lipoprotein receptor (VLDLR), low-density lipoprotein receptor (LDLR), and scavenger receptor-BI (SR-BI 12 h) has not been characterized.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4520	18832102-2314	These data suggest that an ovulatory stimulus rapidly mobilizes stored cholesterol esters for use as a progesterone substrate and that as these are depleted, new cholesterol esters are obtained through an LDLR- and/or SR-BI-mediated mechanism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4521	18832102-2314	These data suggest that an ovulatory stimulus rapidly mobilizes stored cholesterol esters for use as a progesterone substrate and that as these are depleted, new cholesterol esters are obtained through an LDLR- and/or SR-BI-mediated mechanism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4522	18832185-2341	The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4523	18832185-2343	As this effect might be related to deregulation of connexin 43 (Cx43) synthesis, trafficking, or degradation, we investigated the impact of PCB 153 on these events.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4524	18832185-2343	As this effect might be related to deregulation of connexin 43 (Cx43) synthesis, trafficking, or degradation, we investigated the impact of PCB 153 on these events.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4525	18832185-2345	Inhibition of either proteasomes or lysosomes with their specific inhibitors largely restored total Cx43 protein levels, thus suggesting that both proteasomes and lysosomes may participate in the PCB 153-enhanced Cx43 internalization and degradation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4526	18832185-2346	Finally, PCB 153 also interfered with restoration of gap junction plaques following the inhibition of Cx43 transport to plasma membrane.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4527	18832185-2347	Taken together, multiple modes of action seem to contribute to downregulation of Cx43 in PCB 153-treated rat liver epithelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4528	18832295-2399	Vildagliptin demonstrates potent inhibition of DPP-4 activity with excellent tolerability at doses of up to and including 200 mg qd.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4529	18832330-479	The accelerated rate of kindling was partially repressed by inhibiting N-methyl-D-aspartic acid receptor (NMDAR) with MK-801 or mGluR5 receptor with 2-methyl-6-(phenylethynyl)-pyridine (MPEP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4530	18832330-479	The accelerated rate of kindling was partially repressed by inhibiting N-methyl-D-aspartic acid receptor (NMDAR) with MK-801 or mGluR5 receptor with 2-methyl-6-(phenylethynyl)-pyridine (MPEP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4531	18832330-479	The accelerated rate of kindling was partially repressed by inhibiting N-methyl-D-aspartic acid receptor (NMDAR) with MK-801 or mGluR5 receptor with 2-methyl-6-(phenylethynyl)-pyridine (MPEP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4532	18832453-2471	Here, PCA is applied to three problems in GAG research: (i) distinguishing origins of heparin preparations, (ii) structural analysis of heparin derivatives, and (iii) classification of chondroitin sulfates (CS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4533	18832476-2484	The CL(int) was obtained using either individual or combined cofactors for cytochrome P450 (P450) and UGT enzymes with alamethicin activation and in the presence and absence of 2% bovine serum albumin (BSA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4534	18832476-2484	The CL(int) was obtained using either individual or combined cofactors for cytochrome P450 (P450) and UGT enzymes with alamethicin activation and in the presence and absence of 2% bovine serum albumin (BSA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4535	18832480-801	By using purified bovine xanthine oxidase, the reduction was observed in the presence of NAD (P)H. These results suggest that FLU-1 N-OH is involved in flutamide-induced hepatotoxicity and that cytosolic reduction of FLU-1 N-OH plays a major role in protection against flutamide-induced hepatotoxicity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4536	18832589-2551	Recent studies have provided important insight into the homeoprotein LIM homeobox transcription factor 1alpha (Lmx1a) and its role in the commitment of cells to a midbrain dopamine (mDA) fate in the developing mouse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4537	18832589-2551	Recent studies have provided important insight into the homeoprotein LIM homeobox transcription factor 1alpha (Lmx1a) and its role in the commitment of cells to a midbrain dopamine (mDA) fate in the developing mouse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4538	18832593-1025	An acute increase in oxygen tension led to Smad activation within 30 minutes, even in the absence of exogenous BMP treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4539	18832596-2558	Recognition of galactan components of pectin by galectin-3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4540	18832596-2559	By using a combination of fluorescence microscopy, flow cytometry, and force spectroscopy, it has been possible to demonstrate, for the first time, specific binding of a pectin galactan to the recombinant form of human Gal3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4541	18832659-2578	STIM1 has been identified as an endoplasmic reticulum (ER)-resident Ca(2+) sensor that regulates store-operated calcium entry (SOCE) in immune cells and platelets, but the identity of the platelet SOC channel has remained elusive.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4542	18832772-2632	A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4543	18832772-2633	A wide range of reactive intermediates oxidizes methionine residues to methionine sulfoxide (MetO) in apolipoprotein A-I (apoA-I), the major HDL protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4544	18832772-2633	A wide range of reactive intermediates oxidizes methionine residues to methionine sulfoxide (MetO) in apolipoprotein A-I (apoA-I), the major HDL protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4545	18832826-1553	The renin-angiotensin-aldosterone system: approaches to guide angiotensin-converting enzyme inhibition in patients with coronary artery disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4546	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4547	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4548	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4549	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4550	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4551	18834674-2651	It was identified as producer of extended-spectrum beta-lactamases (ESBL) by double-disk synergy test between amoxicillin-clavulanate and cefotaxime, ceftriaxone, ceftazidime and aztreonam.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4552	18834690-355	The binding of diazepam to human serum albumin was used as the model system in order to evaluate the performance of automated SPME.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4553	18834707-357	Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4554	18834868-391	Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4555	18834868-391	Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4556	18834868-391	Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4557	18834868-391	Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4558	18834868-392	According to the oxidative stress concept, increased vascular superoxide and peroxynitrite production as well as an increased sensitivity to vasoconstrictors secondary to activation of protein kinase C as well as vascular NADPH oxidases contribute to the development of tolerance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4559	18834868-392	According to the oxidative stress concept, increased vascular superoxide and peroxynitrite production as well as an increased sensitivity to vasoconstrictors secondary to activation of protein kinase C as well as vascular NADPH oxidases contribute to the development of tolerance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4560	18834868-393	mitochondrial aldehyde dehydrogenase (ALDH-2)) and mitochondria as potential sources of reactive oxygen species (ROS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4561	18834868-393	mitochondrial aldehyde dehydrogenase (ALDH-2)) and mitochondria as potential sources of reactive oxygen species (ROS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4562	18834868-395	Finally, we will address the question whether ALDH-2 inactivation by nitroglycerin could be a useful marker for clinical nitrate tolerance and discuss the redox-regulation of this enzyme by oxidative stress and dihydrolipoic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4563	18834868-395	Finally, we will address the question whether ALDH-2 inactivation by nitroglycerin could be a useful marker for clinical nitrate tolerance and discuss the redox-regulation of this enzyme by oxidative stress and dihydrolipoic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4564	18834868-395	Finally, we will address the question whether ALDH-2 inactivation by nitroglycerin could be a useful marker for clinical nitrate tolerance and discuss the redox-regulation of this enzyme by oxidative stress and dihydrolipoic acid.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4565	18834871-397	Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4566	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4567	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4568	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4569	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4570	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4571	18834871-398	The present study was designed to assess the effect of sex steroids (testosterone and 17beta-estradiol) on insulin receptor expression, insulin binding and glucose oxidation in human liver cell line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4572	18834900-402	It is predicted to possess all the expected features of proPO members, including two putative tyrosinase copper-binding motifs with six histidine residues and a thiol ester-like motif, sharing 67% amino acid sequence identity with PmproPO1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4573	18834900-402	It is predicted to possess all the expected features of proPO members, including two putative tyrosinase copper-binding motifs with six histidine residues and a thiol ester-like motif, sharing 67% amino acid sequence identity with PmproPO1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4574	18834946-408	Examination of cadmium-induced expression of the small heat shock protein gene, hsp30, in Xenopus laevis A6 kidney epithelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4575	18834946-409	In the present study, we have characterized the effect of cadmium on the accumulation of the small heat shock protein (HSP), HSP30, in Xenopus laevis A6 kidney epithelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4576	18834946-409	In the present study, we have characterized the effect of cadmium on the accumulation of the small heat shock protein (HSP), HSP30, in Xenopus laevis A6 kidney epithelial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4577	18834946-410	Immunocytochemical analysis of cadmium chloride-treated A6 cells revealed HSP30 accumulation primarily in the cytoplasm in a punctate pattern supplemented with larger HSP30 staining structures.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4578	18834946-411	Also, HSP30 co-localized with the F-actin cytoskeleton at higher cadmium chloride concentrations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4579	18834946-411	Also, HSP30 co-localized with the F-actin cytoskeleton at higher cadmium chloride concentrations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4580	18834950-413	In order to suppress the emergence of such resistant variants, we introduced charged and hydrophilic amino acids, glutamic acid (E) and lysine (K), at the solvent accessible site of C34.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4581	18834950-413	In order to suppress the emergence of such resistant variants, we introduced charged and hydrophilic amino acids, glutamic acid (E) and lysine (K), at the solvent accessible site of C34.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4582	18834958-415	Cloning, expression, and characterization of cadmium-induced metallothionein-2 from the earthworms Metaphire posthuma and Polypheretima elongata.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4583	18834958-416	In this study we report the sequences of MT-2 cDNA from two species of Megascoleidae earthworms, Metaphire posthuma and Polypheretima elongata, by mRNA differential display after exposure of the organisms to cadmium.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4584	18834958-417	Complementary (c)DNA was verified as the MT-2 gene by the characteristics of its predicted translation product, namely a high cysteine content, conserved CXC motifs, and a molecular weight of around 8 kDa.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4585	18834958-420	These earthworms could be used to evaluate heavy-metal pollution in soil due to the inducible MT-2 by cadmium exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4586	18834983-429	Despite the reciprocal relationship that exists between inflammation and thrombosis, we asked whether thrombosis can develop without inflammation, and whether stress-related hormones (ACTH and cortisol) influence platelet-mediated thrombosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4587	18835067-453	The most active compound to emerge from the in vitro and in vivo murine studies was 2b, suggesting an antimalarial activity via inhibition of hemoglobin hydrolysis, however, not as efficient as chloroquine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4588	18835228-501	The culture medium was analyzed for pH value, concentration of free calcium and phosphate ions and osteocalcin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4589	18835260-516	Surprisingly, no role of ERK1/2 or STAT-3 was found in the protein-mediated protection of hepatocytes during acetaminophen exposure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4590	18835260-516	Surprisingly, no role of ERK1/2 or STAT-3 was found in the protein-mediated protection of hepatocytes during acetaminophen exposure.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4591	18835277-527	Mutations at M57 (M57L) and H210 (H210G, H210M, and H210N), both of which are involved in interactions with the C2 carbonyl oxygen in uracil or xanthine, cause substantial reductions in XDG and UDG activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4592	18835277-527	Mutations at M57 (M57L) and H210 (H210G, H210M, and H210N), both of which are involved in interactions with the C2 carbonyl oxygen in uracil or xanthine, cause substantial reductions in XDG and UDG activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4593	18835277-527	Mutations at M57 (M57L) and H210 (H210G, H210M, and H210N), both of which are involved in interactions with the C2 carbonyl oxygen in uracil or xanthine, cause substantial reductions in XDG and UDG activities.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4594	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4595	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4596	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4597	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4598	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4599	18835277-528	Most interestingly, a proline substitution at the G63 position switches the Gme SMUG1 enzyme to an exclusive UDG as demonstrated by the uniform excision of uracil in both double-stranded and single-stranded DNA and the complete loss of XDG activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4600	18835344-566	Serum albumin-alginate coated microspheres: role of the inner gel in binding and release of the KRFK peptide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4601	18835350-570	Furthermore, increased production of high inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expressions were detected in the hippocampus and cerebral cortex of copper and cholesterol co-treated mice by immunohistochemical analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4602	18835350-570	Furthermore, increased production of high inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expressions were detected in the hippocampus and cerebral cortex of copper and cholesterol co-treated mice by immunohistochemical analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4603	18835350-570	Furthermore, increased production of high inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expressions were detected in the hippocampus and cerebral cortex of copper and cholesterol co-treated mice by immunohistochemical analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4604	18835350-570	Furthermore, increased production of high inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expressions were detected in the hippocampus and cerebral cortex of copper and cholesterol co-treated mice by immunohistochemical analysis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4605	18835362-575	We report herein some novel phenomena between hemin-H(2)O(2)-NO(2)(-) and 3-morpholinosydnonimine hydrochloride (SIN-1)-mediated oxidation and nitration reactions of glutamate dehydrogenase (GDH).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4606	18835362-575	We report herein some novel phenomena between hemin-H(2)O(2)-NO(2)(-) and 3-morpholinosydnonimine hydrochloride (SIN-1)-mediated oxidation and nitration reactions of glutamate dehydrogenase (GDH).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4607	18835442-614	After intravenous administration of either DOTAP/cholesterol or DOTMA/cholesterol liposomes, serum TNFalpha and ALT levels were normal, suggesting that liver injury as well as cytokine production was caused by lipoplexes, but not by cationic liposomes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4608	18835442-614	After intravenous administration of either DOTAP/cholesterol or DOTMA/cholesterol liposomes, serum TNFalpha and ALT levels were normal, suggesting that liver injury as well as cytokine production was caused by lipoplexes, but not by cationic liposomes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4609	18835442-614	After intravenous administration of either DOTAP/cholesterol or DOTMA/cholesterol liposomes, serum TNFalpha and ALT levels were normal, suggesting that liver injury as well as cytokine production was caused by lipoplexes, but not by cationic liposomes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4610	18835585-659	GTP was the most potent regulator of hemoglobin affinity, with concentrations of 5 mmol L(-1) causing an increase in p(50) from 5 to 19 mm Hg at pH 7.5, while the order of potency of the other phosphates was IHP>ATP>BPG.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4611	18835652-693	Functional inactivation of NF2/merlin in human mesothelioma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4612	18835652-694	The tumor suppressor merlin is encoded by the neurofibromatosis type 2 gene (NF2) which is located on chromosome 22q12 and mutations in this gene have been found in 40% of mesothelioma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4613	18835662-698	No main effect of group assignment on TSST responses was found for IL-6, cortisol or POMS scores.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4614	18835763-723	The objective of this study was to determine: (i) the prevalence of resistance in current clinical isolates of Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis and Klebsiella pneumoniae; (ii) the prevalence of production of extended-spectrum beta-lactamases (ESBLs) and methicillin resistance in S. aureus; and (iii) regional differences in the prevalence of ESBL production and clonality of K. pneumoniae isolates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4615	18835829-730	cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4616	18835829-730	cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4617	18835829-731	In Leydig cells, androgen biosynthesis is controlled primarily by the pituitary gonadotropin luteinizing hormone (LH) acting via its receptor (LH-R), which in turn activates the adenylate cyclase/cyclic adenosine monophosphate (cAMP) signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4618	18835829-731	In Leydig cells, androgen biosynthesis is controlled primarily by the pituitary gonadotropin luteinizing hormone (LH) acting via its receptor (LH-R), which in turn activates the adenylate cyclase/cyclic adenosine monophosphate (cAMP) signaling pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4619	18835829-732	Here, we report that cAMP-mediated induction of Nur77 expression at the protein, mRNA, and promoter levels in MA-10 cells involves different mechanisms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4620	18835829-733	In addition, our detailed analysis of the Nur77 promoter in MA-10 cells revealed that distinct regulatory elements are involved in basal and cAMP-induced Nur77 transcription.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4621	18835830-734	Expression of nitric oxide synthase during germ cell apoptosis in testis of cynomolgus monkey after testosterone and heat treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4622	18835831-735	Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4623	18835926-762	Together, these results provide compelling evidence that Fgf23 does not have a klotho-independent role in the regulation of systemic phosphate and vitamin D homeostasis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4624	18835976-780	Based on fasting insulin and glucose, several indices of insulin sensitivity have been developed in adults.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4625	18835979-782	LDL from all subjects stimulated both the basal and AngII-induced aldosterone and cortisol release from adrenocortical cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4626	18835979-782	LDL from all subjects stimulated both the basal and AngII-induced aldosterone and cortisol release from adrenocortical cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4627	18835981-786	Here we present evidence of distinct STI571-induced modulation of abl functions using high-resolution live-cell imaging approaches.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4628	18835981-787	Quantitative analysis yielded 0.81 and 1.8 microM for EC(50) values of STI571-induced cell edge translocation of abl-KD-green fluorescent protein (GFP) and wild-type abl-GFP, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4629	18836089-2732	Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4630	18836089-2733	We evaluated the association between clinical outcome (safety and efficacy) of paclitaxel monotherapy in metastatic breast cancer patients with ABCB1 gene polymorphisms 2677G>T/A or 3435C>T.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4631	18836137-847	CXCL1/KC was detected as early as 6 hours after bleomycin instillation and returned to basal levels after Day 8.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4632	18836137-848	DF2162 treatment reduced bleomycin-induced expression of von Willebrand Factor, a marker of angiogenesis, in the lung.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4633	18836482-927	This was prevented by pretreatment of cells with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or pharmacological inhibition of PKB.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4634	18836482-927	This was prevented by pretreatment of cells with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or pharmacological inhibition of PKB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4635	18836681-1004	Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4636	18836681-1004	Kynurenic acid (KYNA) is an agonist of the G-protein-coupled receptor GPR35, which is predominantly expressed in gastrointestinal tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4637	18836710-1021	Molecular dynamics simulation techniques have been used to study the unbinding pathways of 1alpha,25-dihydroxyvitamin D(3) from the ligand-binding pocket of the vitamin D receptor (VDR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4638	18836740-1043	Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4639	18836740-1046	Inhibiting insulin signalling in SUR1 (-/-) beta-cells blunted the glucose-induced decrease of (Ca(2+))(c).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4640	18836843-1091	Relaxation to CGRP (10(-8) M) was unaffected by L-NAME (3 x 10(-4) M) and indomethacin (10(-6) M) suggesting no involvement of nitric oxide or prostaglandins in the CGRP-induced relaxation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4641	18836843-1091	Relaxation to CGRP (10(-8) M) was unaffected by L-NAME (3 x 10(-4) M) and indomethacin (10(-6) M) suggesting no involvement of nitric oxide or prostaglandins in the CGRP-induced relaxation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4642	18836851-1099	In the mouse model of demyelination-remyelination induced by oral administration of cuprizone, in situ hybridization showed an upregulation of the DDR1 gene in three different white matter areas (corpus callosum, dorsal fornix, and external capsule) during the remyelination period.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4643	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4644	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4645	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4646	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4647	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4648	18836851-1100	Cells positive for DDR1 mRNA were also positive for oligodendrocyte markers (OLIG2, carnosine, and APC) but not for markers of oligodendrocyte precursors (NG2), myelin markers (CNPase), microglia (CD11b), or reactive glia (GFAP).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4649	18836996-1126	By conducting this initial screen on EMT6 cells and applying protein function and genomic structure criteria to genes identified as upregulated in response to 5-azadC/TSA, we were able to identify two characterized breast cancer TSGs (Timp3 and Rprm) and four putative TSGs (Atp1B2, Dusp2, FoxJ1 and Smpd3) silenced in this line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4650	18836996-1126	By conducting this initial screen on EMT6 cells and applying protein function and genomic structure criteria to genes identified as upregulated in response to 5-azadC/TSA, we were able to identify two characterized breast cancer TSGs (Timp3 and Rprm) and four putative TSGs (Atp1B2, Dusp2, FoxJ1 and Smpd3) silenced in this line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4651	18836996-1126	By conducting this initial screen on EMT6 cells and applying protein function and genomic structure criteria to genes identified as upregulated in response to 5-azadC/TSA, we were able to identify two characterized breast cancer TSGs (Timp3 and Rprm) and four putative TSGs (Atp1B2, Dusp2, FoxJ1 and Smpd3) silenced in this line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4652	18836996-1126	By conducting this initial screen on EMT6 cells and applying protein function and genomic structure criteria to genes identified as upregulated in response to 5-azadC/TSA, we were able to identify two characterized breast cancer TSGs (Timp3 and Rprm) and four putative TSGs (Atp1B2, Dusp2, FoxJ1 and Smpd3) silenced in this line.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4653	18837008-1129	Therapeutic strategy to rescue mutation-induced exon skipping in rhodopsin by adaptation of U1 snRNA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4654	18837008-1130	As a therapeutic strategy, U1 snRNAs were adapted to the novel RHO mutation and tested for its potential to reverse missplicing.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4655	18837469-2746	Urinary concentrations of dihydrodaidzein, dihydrogenistein, O-desmethylangolensin, and equol exceeded IFN aglycone equivalents.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4656	18837469-2746	Urinary concentrations of dihydrodaidzein, dihydrogenistein, O-desmethylangolensin, and equol exceeded IFN aglycone equivalents.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4657	18837469-2746	Urinary concentrations of dihydrodaidzein, dihydrogenistein, O-desmethylangolensin, and equol exceeded IFN aglycone equivalents.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4658	18837469-2746	Urinary concentrations of dihydrodaidzein, dihydrogenistein, O-desmethylangolensin, and equol exceeded IFN aglycone equivalents.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4659	18837470-2752	Concentrations of glucose, insulin, C-peptide, nonesterified fatty acids, triacylglycerol, total and exogenous glucose kinetics were assessed for 6 h postprandially.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4660	18837470-2754	After 120 min, glucose and insulin responses declined, but remained higher after the Pol 0.05) in parallel to the inhibition of lipolysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4661	18837522-1374	Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4662	18837522-1375	To prevent uracil incorporation into DNA, representatives of the dUTP nucleotidohydrolase (dUTPase) enzyme family eliminate excess dUTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4663	18837522-1376	The dUTPase binding pocket is highly specific for uracil.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4664	18837522-1377	Phosphate chain coordination involves Mg2+ and is analogous to that of DNA polymerases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4665	18837522-1378	In these respective pathogens, Plasmodium falciparum and Mycobacterium tuberculosis, the biosynthesis of dTMP relies exclusively on dUTPase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4666	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4667	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4668	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4669	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4670	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4671	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4672	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4673	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4674	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4675	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4676	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4677	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4678	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4679	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4680	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4681	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4682	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4683	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4684	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4685	18837652-1413	Furthermore, NaHS enhanced inhibitory effects of apocynin, N-acetyl-l-cysteine (NAC), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), Nomega-nitro-l-arginine methyl ester (L-NAME) on ROS production and redox enzymes levels induced by Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4686	18837698-1429	It controls the expression of a total of 11 genes, the CopR regulon, in a copper-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4687	18838074-1535	In this article, the intracellular signal transduction mechanisms mediating the actions of some of these regulators, including GTH-releasing hormones, pituitary adenylate cyclase-activating polypeptide, dopamine, ghrelin, sex steroids, activin, and follistatin from experiments with goldfish are reviewed and discussed in relation with recent findings.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4688	18838074-1535	In this article, the intracellular signal transduction mechanisms mediating the actions of some of these regulators, including GTH-releasing hormones, pituitary adenylate cyclase-activating polypeptide, dopamine, ghrelin, sex steroids, activin, and follistatin from experiments with goldfish are reviewed and discussed in relation with recent findings.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4689	18838074-1535	In this article, the intracellular signal transduction mechanisms mediating the actions of some of these regulators, including GTH-releasing hormones, pituitary adenylate cyclase-activating polypeptide, dopamine, ghrelin, sex steroids, activin, and follistatin from experiments with goldfish are reviewed and discussed in relation with recent findings.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4690	18838074-1536	Goldfish gonadotropes possess multiple pharmacologically distinct intracellular Ca2+ stores that together with voltage-sensitive Ca2+ channels, Na+/H+ exchangers, protein kinase C, arachidonic acid, NO, protein kinase A, ERK/MAPK, and Smads allows for integrated control by different neuroendocrine factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4691	18838074-1536	Goldfish gonadotropes possess multiple pharmacologically distinct intracellular Ca2+ stores that together with voltage-sensitive Ca2+ channels, Na+/H+ exchangers, protein kinase C, arachidonic acid, NO, protein kinase A, ERK/MAPK, and Smads allows for integrated control by different neuroendocrine factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4692	18838074-1536	Goldfish gonadotropes possess multiple pharmacologically distinct intracellular Ca2+ stores that together with voltage-sensitive Ca2+ channels, Na+/H+ exchangers, protein kinase C, arachidonic acid, NO, protein kinase A, ERK/MAPK, and Smads allows for integrated control by different neuroendocrine factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4693	18838074-1536	Goldfish gonadotropes possess multiple pharmacologically distinct intracellular Ca2+ stores that together with voltage-sensitive Ca2+ channels, Na+/H+ exchangers, protein kinase C, arachidonic acid, NO, protein kinase A, ERK/MAPK, and Smads allows for integrated control by different neuroendocrine factors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4694	18838089-1541	An enzymatic reaction between hydrogen peroxide and catalase produced oxygen bubbles and thus many internal pores within microsphere were naturally developed.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4695	18838102-1545	The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4696	18838102-1545	The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4697	18838102-1545	The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4698	18838102-1545	The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4699	18838266-1623	We present a robust and simple method for the direct detection of multiple point mutations in the Mycobacterium tuberculosis rpoB gene during the development of rifampin (RIF) resistance using an electrochemical genosensor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4700	18838482-1670	The main source of extracellular adenosine stems from a coordinated two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4701	18838482-1670	The main source of extracellular adenosine stems from a coordinated two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4702	18838482-1670	The main source of extracellular adenosine stems from a coordinated two-step enzymatic conversion of precursor nucleotides via the ecto-apyrase (CD39) and the ecto-5'-nucleotidase (CD73).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4703	18838483-2012	Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4704	18838483-2012	Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4705	18838483-2013	We aimed at evaluating the relative contribution of cyclooxygenase (COX)-1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4706	18838483-2013	We aimed at evaluating the relative contribution of cyclooxygenase (COX)-1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4707	18838483-2013	We aimed at evaluating the relative contribution of cyclooxygenase (COX)-1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4708	18838483-2013	We aimed at evaluating the relative contribution of cyclooxygenase (COX)-1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4709	18838503-1683	In contrast, CYP2D6.24, CYP2D6.26, and CYP2D6.27 allelic isoforms all showed active drug-metabolizing activities toward both codeine and dextromethorphan O-demethylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4710	18838503-1683	In contrast, CYP2D6.24, CYP2D6.26, and CYP2D6.27 allelic isoforms all showed active drug-metabolizing activities toward both codeine and dextromethorphan O-demethylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4711	18838506-1689	Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen : a comparison of kinetics and probe substrate selection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4712	18838506-1689	Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen : a comparison of kinetics and probe substrate selection.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4713	18838506-1690	In vitro experiments were conducted to compare k(inact), K(I) and inactivation efficiency (k(inact)/K(I)) of cytochrome P450 (P450) 2C9 by tienilic acid and (+/-)-suprofen using (S)-flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4714	18838506-1690	In vitro experiments were conducted to compare k(inact), K(I) and inactivation efficiency (k(inact)/K(I)) of cytochrome P450 (P450) 2C9 by tienilic acid and (+/-)-suprofen using (S)-flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4715	18838523-1691	Leukotoxin activity was evaluated by measuring Ca(2+) entry or pore formation using spectrofluorometry or flow cytometry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4716	18838739-1780	These Ca2+-independent phospholipases A2 display remarkable specificity for the length of the sn-2 residue, but this selectivity is lost as the residue gains oxygen functions.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4717	18839053-1886	At the end of treatment, BMI, WHR, HbA1c, fasting glucose, leptin, HOMA-IR, alanine aminotransferase values decreased in both groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4718	18839068-1905	Among these indicators is phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane, which can be detected by annexinV (ANXA5) conjugation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4719	18839068-1905	Among these indicators is phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane, which can be detected by annexinV (ANXA5) conjugation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4720	18839150-1938	Effects of chronic inflammation and morphine tolerance on the expression of phospho-ERK 1/2 and phospho-P38 in the injured tissue.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4721	18839150-1938	Effects of chronic inflammation and morphine tolerance on the expression of phospho-ERK 1/2 and phospho-P38 in the injured tissue.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4722	18839150-1940	The results of the present study show that ERKs phosphorylation is unaltered by inflammation or morphine tolerance, each one individually, in the plantar tissue.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4723	18839150-1941	In contrast, no significant differences in phospho-p38 expression were observed between naïve and tolerant animals acutely injected with saline or morphine in presence of CFA inflammation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4724	18839150-1942	These results suggest that ERK but not p38 could be implicated in the development of morphine tolerance during peripheral inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4725	18839155-1946	The anterior pituitary gland contains five types of cells secreting specific hormones (growth hormone, adrenocorticotropic hormone (ACTH), gonadotropic hormone, prolactin, and thyroid-stimulating hormone), and the double staining results indicated that D:-Ala is localized to the ACTH-secreting cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4726	18839155-1946	The anterior pituitary gland contains five types of cells secreting specific hormones (growth hormone, adrenocorticotropic hormone (ACTH), gonadotropic hormone, prolactin, and thyroid-stimulating hormone), and the double staining results indicated that D:-Ala is localized to the ACTH-secreting cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4727	18839155-1946	The anterior pituitary gland contains five types of cells secreting specific hormones (growth hormone, adrenocorticotropic hormone (ACTH), gonadotropic hormone, prolactin, and thyroid-stimulating hormone), and the double staining results indicated that D:-Ala is localized to the ACTH-secreting cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4728	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4729	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4730	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4731	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4732	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4733	18839173-1953	In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4734	18839216-1978	A comprehensive literature review of clinical studies in children evaluating s-CysC or CysC-based formulas and plasma creatinine or creatinine-based formulas against an exogenous reference method using receiver operating characteristics (ROC) curves or Bland-Altman plots is presented.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4735	18839216-1979	The comparison of s-CysC with plasma creatinine indicated that s-CysC was superior to plasma creatinine in five of 13 studies; four studies showed no difference, and, in four studies, no statistical comparison was made.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4736	18839216-1980	S-CysC is most likely superior to plasma creatinine and at least equal to creatinine-based formulas.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4737	18839216-1981	CysC-based prediction equations are at least as good as creatinine-based formulas but cannot replace exogenous methods.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4738	18839315-2028	By combining endosperm LKR/SDH suppression with embryo LKR/SDH suppression through crosses, the saccharopine level in embryo was reduced and resulted in higher lysine accumulation in mature kernels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4739	18839315-2028	By combining endosperm LKR/SDH suppression with embryo LKR/SDH suppression through crosses, the saccharopine level in embryo was reduced and resulted in higher lysine accumulation in mature kernels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4740	18839328-2042	We examined the relationship between FGF23 and serum calcium, phosphate, 1,25(OH)(2)D(3), and PTH levels in haemodialysis patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4741	18839335-2050	Resistin, an adipokine-linked obesity with type 2 diabetes, impairs glucose-stimulated insulin secretion (GSIS) in beta-cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4742	18839360-2057	Intracellular Cl (-) is required for the motor function of prestin, a unique plasma membrane molecular motor of these cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4743	18839361-2058	Prestin was immunostained with mouse anti-FLAG primary antibody and FITC-conjugated goat anti-mouse IgG secondary antibody.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4744	18839419-2085	Intramuscular triacylglycerol does not appear to be a ubiquitous marker of insulin resistance, although specific IMCL intermediates such as long-chain fatty acyl-CoAs, ceramide, and diacylglycerol may inhibit insulin signal transduction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4745	18840097-2250	Light stimulates cGMP hydrolysis via the G-protein transducin, which directly binds to and activates phosphodiesterase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4746	18840413-2365	Inhibition of gamma-glutamyl transferase (GGT1, EC 2.3.2.2)-catalyzed extracellular GSH degradation with acivicin significantly blocked GSH efflux, suggesting that GSH breakdown is a driving force for GSH export.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4747	18840446-2377	We injected females with human chorionic gonadotropin (HCG), estradiol, estradiol plus progesterone, saline, or HCG plus fadrozole (an aromatase blocker) and tested their responses to mating calls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4748	18840446-2377	We injected females with human chorionic gonadotropin (HCG), estradiol, estradiol plus progesterone, saline, or HCG plus fadrozole (an aromatase blocker) and tested their responses to mating calls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4749	18840446-2377	We injected females with human chorionic gonadotropin (HCG), estradiol, estradiol plus progesterone, saline, or HCG plus fadrozole (an aromatase blocker) and tested their responses to mating calls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4750	18840462-2386	Here we use an array of flow cytometric analyses to characterize silkworm hemocytes with various molecular probes, such as propidium iodide, green fluorescence protein, monoclonal antibodies, and fluorescent lectins.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4751	18840470-2387	Amino acid 1092 (AA1092) in capsid protein 1 of coxsackievirus B3 (CVB3) is located in close vicinity to the central phenoxy group of capsid binders (i.e.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4752	18840474-2388	Insulin is a polypeptide hormone that is present in mammals and its main function is the maintenance of adequate blood sugar level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4753	18840497-2407	In vivo assays confirmed that the three resulting genotypes differed in their ability to produce cortisol in response to intravenous insulin injection implicating CYP17 as the primary cause of the observed hypocortisolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4754	18840497-2407	In vivo assays confirmed that the three resulting genotypes differed in their ability to produce cortisol in response to intravenous insulin injection implicating CYP17 as the primary cause of the observed hypocortisolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4755	18840501-434	In addition, SR-BI facilitates bi-directional flux of cholesterol by modifying the phospholipid content of the plasma membrane.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4756	18840501-435	Overall, SR-BI is the cell surface receptor responsible for selective uptake of lipoprotein cholesterol and its ultimate delivery to sites of hormone synthesis in steroidogenic tissues.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4757	18840514-2413	Susceptibility to esophageal cancer may be modified by functional polymorphisms in genes along the folate metabolic pathway, such as methylenetetrahydrofolate reductase (MTHFR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4758	18840514-2413	Susceptibility to esophageal cancer may be modified by functional polymorphisms in genes along the folate metabolic pathway, such as methylenetetrahydrofolate reductase (MTHFR).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4759	18840516-2417	We looked at the toxicity of non-drug-containing liposomes on (3)H-thymidine incorporation by concanavalin A (Con A)-stimulated human lymphocytes, splenocytes and Epstein-Barr virus (EBV)-transformed human B-cell lymphoblastoid cell line (LCL).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4760	18840516-2417	We looked at the toxicity of non-drug-containing liposomes on (3)H-thymidine incorporation by concanavalin A (Con A)-stimulated human lymphocytes, splenocytes and Epstein-Barr virus (EBV)-transformed human B-cell lymphoblastoid cell line (LCL).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4761	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4762	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4763	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4764	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4765	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4766	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4767	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4768	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4769	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4770	18840548-2430	The anti-inflammatory effect of these compounds and a coumarin control, scopoletin, on interleukin-6 (IL-6), tumor necrosis factor (TNF), and macrophage chemotactic protein-1 (MCP-1) release was studied using lipopolysaccharide (LPS)-stimulated alveolar macrophages.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4771	18840610-2455	We previously determined that BLIP Tyr51 is a canonical and Trp150 an anti-canonical TEM-1-contact residue, where canonical refers to the alanine substitution resulting in a matched change in the hydrophobicity of binding free energy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4772	18840610-2455	We previously determined that BLIP Tyr51 is a canonical and Trp150 an anti-canonical TEM-1-contact residue, where canonical refers to the alanine substitution resulting in a matched change in the hydrophobicity of binding free energy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4773	18840610-2456	This explains the anti-canonical nature of the Trp150 to alanine substitution, and also reveals a strong long distance coupling between Trp150 and Asp49 of BLIP, because these two residues are more than 25 angstroms apart.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4774	18840670-2486	This effect is independent of any change in neutrophil adhesion or adhesion molecule expression but is related to the ability of statins to reduce fMLP-induced Rho activity in neutrophils.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4775	18840670-2487	This was confirmed by the ability of the Rho precursor geranylgeranyl pyrophosphate to rescue the statin-mediated reduction in neutrophil transendothelial migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4776	18840677-1304	Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4777	18840677-1304	Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4778	18840759-2541	We hypothesized that conditioned medium from macrophages pretreated with palmitate or LPS would directly affect insulin action and glucose uptake in muscle cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4779	18840759-2542	Surprisingly, and opposite to its effects on adipose cells, conditioned medium from LPS-treated macrophages stimulated myoblast insulin-stimulated glucose uptake, GLUT4 translocation, and Akt phosphorylation without affecting stress kinases or inflammation indexes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4780	18840759-2542	Surprisingly, and opposite to its effects on adipose cells, conditioned medium from LPS-treated macrophages stimulated myoblast insulin-stimulated glucose uptake, GLUT4 translocation, and Akt phosphorylation without affecting stress kinases or inflammation indexes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4781	18840759-2542	Surprisingly, and opposite to its effects on adipose cells, conditioned medium from LPS-treated macrophages stimulated myoblast insulin-stimulated glucose uptake, GLUT4 translocation, and Akt phosphorylation without affecting stress kinases or inflammation indexes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4782	18840763-2544	The essential role of glucagon and insulin and the importance of distributed control of glucose fluxes are highlighted in this review.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4783	18840763-2544	The essential role of glucagon and insulin and the importance of distributed control of glucose fluxes are highlighted in this review.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4784	18840765-2545	Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz(a) anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4785	18840765-2545	Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz(a) anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4786	18840783-2553	Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4787	18840783-2554	Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4788	18840785-2556	This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4789	18840785-2556	This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4790	18840785-2556	This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4791	18840785-2556	This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4792	18840785-2556	This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4793	18840785-2557	The primary aims were to determine the effects of DPP-4 inhibition on GLP-1 clearance and on hepatic glucose uptake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4794	18840785-2557	The primary aims were to determine the effects of DPP-4 inhibition on GLP-1 clearance and on hepatic glucose uptake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4795	18840871-2587	In the present study we determined the effect of insulin on the secretome by comparing incorporation rates of (13)C-labeled lysine in the presence and absence of insulin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4796	18840995-2643	Chromogranin A as an alternative to 5-hydroxyindoleacetic acid in the evaluation of symptoms during treatment of patients with neuroendocrine Tumors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4797	18841321-2736	Th1 cytokine profile may be related to the risk of the vaginal erosions following placement of polypropylene meshes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4798	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4799	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4800	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4801	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4802	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4803	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4804	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4805	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4806	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4807	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4808	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4809	18841385-2745	However, compared to osmotic stress alone, in the seedlings treated with microwave irradiation plus osmotic stress the concentration of malondialdehyde decreased, while the activities of nitricoxide synthase, catalase, peroxidase, superoxide dismutase and the concentration of nitric oxide, ascorbic acid and glutathione increased.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4810	18841409-2761	The oxidative stress in the mollusk was observed at the U site during spring and at the R site during summer and autumn according to the differences in Mn-superoxide dismutase and catalase activities, O (2) (*-) production, lipid peroxidation, and glutathione levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4811	18841409-2761	The oxidative stress in the mollusk was observed at the U site during spring and at the R site during summer and autumn according to the differences in Mn-superoxide dismutase and catalase activities, O (2) (*-) production, lipid peroxidation, and glutathione levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4812	18841465-2774	These results suggest that ugonin K by activation of ERK1/2 and PI3K/Akt signal pathways protects SH-SY5Y cells from H(2)O(2)-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4813	18841465-2774	These results suggest that ugonin K by activation of ERK1/2 and PI3K/Akt signal pathways protects SH-SY5Y cells from H(2)O(2)-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4814	18841465-2774	These results suggest that ugonin K by activation of ERK1/2 and PI3K/Akt signal pathways protects SH-SY5Y cells from H(2)O(2)-induced apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4815	18841468-2776	This decrease was not modified by catalase or Trolox, demonstrating that ONOO (-) was responsible for the effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4816	18841468-2776	This decrease was not modified by catalase or Trolox, demonstrating that ONOO (-) was responsible for the effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4817	18841470-2778	Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN (3); neither nuclear fragmentation by DAPI, nor Annexin V positivity by flow cytometry were detected, ruling out the occurrence of apoptosis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4818	18841471-2779	Plasma homovanillic acid and prolactin in Huntington's disease.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4819	18841471-2780	We assessed plasma homovanillic acid (pHVA) and plasma prolactin (pPRL), two correlates of dopaminergic activity, in 116 subjects with CAG repeats expansion in the HD gene, 26 presymptomatic (18 females) and 90 with overt symptomatology (43 females).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4820	18841529-2811	Profile of serum IL-1beta and IL-10 shortly after ovariectomy and estradiol replacement in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4821	18841529-2811	Profile of serum IL-1beta and IL-10 shortly after ovariectomy and estradiol replacement in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4822	18842264-225	A low plasma high-density lipoprotein cholesterol (HDL-c) concentration is an important risk factor for the development of atherosclerotic cardiovascular disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4823	18842297-227	A hydrogel was fabricated by chemically crosslinking alpha-elastin with glutaraldehyde at high pressure CO(2).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4824	18842335-233	We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation of signal transducers that drive cancer cell growth and thereby promote apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4825	18842335-233	We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation of signal transducers that drive cancer cell growth and thereby promote apoptosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4826	18842348-234	The cancer cells could find an alternate pathway to make this protein that does not require progesterone secretion, or the cancer cells may actually utilize progesterone and thus make PIBF in a similar fashion to normal pregnancy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4827	18842620-268	Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4828	18842620-268	Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4829	18842620-268	Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4830	18842620-269	Dioxin treatment leads to recruitment of the aryl hydrocarbon receptor to the enhancer regions but not to the proximal promoter regions of both the CYP1A1 and CYP1B1 genes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4831	18842620-269	Dioxin treatment leads to recruitment of the aryl hydrocarbon receptor to the enhancer regions but not to the proximal promoter regions of both the CYP1A1 and CYP1B1 genes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4832	18842620-269	Dioxin treatment leads to recruitment of the aryl hydrocarbon receptor to the enhancer regions but not to the proximal promoter regions of both the CYP1A1 and CYP1B1 genes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4833	18842620-270	These results suggest that nucleosomal remodeling is less significant for dioxin-mediated induction of CYP1B1 than that of CYP1A1 and may be related to the more modest inducibility of the former.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4834	18842620-270	These results suggest that nucleosomal remodeling is less significant for dioxin-mediated induction of CYP1B1 than that of CYP1A1 and may be related to the more modest inducibility of the former.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4835	18842620-271	These observations provide novel insights into the functional roles of the endogenous coactivators in dioxin induction of the human CYP1A1 and CYP1B1 genes in their natural chromosomal configurations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4836	18842620-271	These observations provide novel insights into the functional roles of the endogenous coactivators in dioxin induction of the human CYP1A1 and CYP1B1 genes in their natural chromosomal configurations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4837	18842703-297	Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4838	18842954-373	The different mechanisms might be explained by the different sensitivity of synaptotagmin isoforms to Ca2+, Sr2+, and Ba2+.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4839	18842962-374	Each residue was modified with one to three hexose units, and the most dominant SodC glycoform was modified with nine hexose units.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4840	18843259-489	Following dDAVP there was a time-dependent redistribution of total aquaporin-2 from predominantly intracellular vesicles to the apical plasma membrane, clathrin-coated vesicles, early endosomal compartments, and lysosomes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4841	18843273-456	The relationships among obesity, metabolic syndrome, ED, sex hormone-binding globulin (SHBG) and serum total and free testosterone levels are complex and often confusing to the physician.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4842	18843482-535	The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4843	18844213-796	We now show that treatment of cells with phosphomimic uPA (uPA138E/303E, serine 138 and 303 substituted with glutamic acid) strongly inhibits matrix-induced cell migration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4844	18844219-799	When cells were subjected to hypoxia (1% O2), the expression of HSP70-2 had a significant increase in cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4845	18844235-806	We further demonstrate that loss of actin stress fibers is due to a cyclic adenosine monophosphate, protein kinase A-mediated pathway that results in Rho inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4846	18844235-806	We further demonstrate that loss of actin stress fibers is due to a cyclic adenosine monophosphate, protein kinase A-mediated pathway that results in Rho inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4847	18844235-806	We further demonstrate that loss of actin stress fibers is due to a cyclic adenosine monophosphate, protein kinase A-mediated pathway that results in Rho inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4848	18844240-810	The nuclear NF-kappaB p65 expression after treatment with the SFN-5-Fu combination was also evaluated by western blot analysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4849	18844240-812	Treatment ACCs cells with SFN and 5-Fu in combination, led to synergistic inhibition on cell growth and a decreased expression in nuclear NF-kappaB p65 protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4850	18844240-813	Our results demonstrate synergism between SFN and 5-Fu at higher doses against the ACC-M and ACC-2 cells, which was associated with the decreased expression of nuclear NF-kappaB p65 protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4851	18844290-828	In order to further analyse the protective mode of action, the superoxide anion scavenging activity of two extracts was evaluated in a xanthine/xanthine oxidase system.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4852	18844290-828	In order to further analyse the protective mode of action, the superoxide anion scavenging activity of two extracts was evaluated in a xanthine/xanthine oxidase system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4853	18844296-833	Human genetic diseases that affect N-glycosylation result from the defective synthesis of the N-linked sugar moiety (glycan) of glycoproteins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4854	18844325-840	Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4855	18844325-840	Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4856	18844325-840	Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4857	18844325-840	Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities/levels of mitochondrial antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reduced glutathione).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4858	18844326-841	Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4859	18844326-841	Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4860	18844326-842	This inhibitory effect of ginsenoside Rg3 on adipocyte differentiation was accompanied by PPAR-gamma inhibition in rosiglitazone-treated cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4861	18844326-843	Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-gamma inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4862	18844326-843	Taken together, these results suggest that the antiobesity effect of red ginseng rich constituent, ginsenoside Rg3, involves the AMPK signaling pathway and PPAR-gamma inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4863	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4864	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4865	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4866	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4867	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4868	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4869	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4870	18845121-1115	They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and ammonia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4871	18845132-1120	Selenocystine is taken up well by the b(0,+) rBAT system, while selenobetaine is a low-affinity substrate only for SIT1 and PAT1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4872	18845132-1120	Selenocystine is taken up well by the b(0,+) rBAT system, while selenobetaine is a low-affinity substrate only for SIT1 and PAT1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4873	18845148-1121	Experiments using a classical inhibitor of phosphotyrosine phosphatase, sodium orthovanadate, also showed that the ecto-phosphatase activity was inhibited in a dose-dependent manner.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4874	18845237-1145	Both promoters are partially regulated by all-trans retinoic acid via RARA and other RARs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4875	18845277-1178	Our data suggest a developmental role of PBRs in erythropoiesis in chickens, possibly via the regulation of heme availability for the assembly of functional hemoglobins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4876	18845277-1178	Our data suggest a developmental role of PBRs in erythropoiesis in chickens, possibly via the regulation of heme availability for the assembly of functional hemoglobins.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4877	18845302-1193	Circulating apelin, adiponectin, leptin, TNF-alpha, hsCRP and insulin levels were determined both at baseline and after TLC intervention and statin treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4878	18845302-1193	Circulating apelin, adiponectin, leptin, TNF-alpha, hsCRP and insulin levels were determined both at baseline and after TLC intervention and statin treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4879	18845302-1193	Circulating apelin, adiponectin, leptin, TNF-alpha, hsCRP and insulin levels were determined both at baseline and after TLC intervention and statin treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4880	18845357-1202	VEGF, TNF-alpha and 8-isoprostane levels in exhaled breath condensate and serum of patients with lung cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4881	18845357-1202	VEGF, TNF-alpha and 8-isoprostane levels in exhaled breath condensate and serum of patients with lung cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4882	18845357-1203	The aim of the present study was to evaluate the levels of VEGF, 8-isoprostane and TNF-alpha in EBC and serum of patients with primary lung cancer prior to the initiation of any treatment, in order to evaluate their possible diagnostic role.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4883	18845357-1203	The aim of the present study was to evaluate the levels of VEGF, 8-isoprostane and TNF-alpha in EBC and serum of patients with primary lung cancer prior to the initiation of any treatment, in order to evaluate their possible diagnostic role.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4884	18845357-1204	Furthermore, associations between VEGF, 8-isoprostane and TNF-alpha levels in EBC and serum with clinicopathologic factors were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4885	18845357-1204	Furthermore, associations between VEGF, 8-isoprostane and TNF-alpha levels in EBC and serum with clinicopathologic factors were investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4886	18845357-1205	TNF-alpha, VEGF and 8-isoprostane levels in EBC and serum were analyzed by an immunoenzymatic method (ELISA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4887	18845357-1205	TNF-alpha, VEGF and 8-isoprostane levels in EBC and serum were analyzed by an immunoenzymatic method (ELISA).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4888	18845383-1219	Currently, adreno-corticotrophic hormone (ACTH), steroids and vigabatrin (VGB) form the mainstay of its treatment.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4889	18845389-1221	The addition of a protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, rescued PhIP-inhibited TNF-alpha expression in LTA-stimulated cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4890	18845486-1248	Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3 (-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin content of islets and expression of the proinflammatory cytokines, TNF-alpha, IFN-gamma, IL-17, and iNOS in pancreatic lymph nodes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4891	18845486-1248	Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3 (-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin content of islets and expression of the proinflammatory cytokines, TNF-alpha, IFN-gamma, IL-17, and iNOS in pancreatic lymph nodes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4892	18845486-1248	Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3 (-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin content of islets and expression of the proinflammatory cytokines, TNF-alpha, IFN-gamma, IL-17, and iNOS in pancreatic lymph nodes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4893	18845486-1248	Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3 (-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin content of islets and expression of the proinflammatory cytokines, TNF-alpha, IFN-gamma, IL-17, and iNOS in pancreatic lymph nodes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4894	18845486-1248	Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3 (-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin content of islets and expression of the proinflammatory cytokines, TNF-alpha, IFN-gamma, IL-17, and iNOS in pancreatic lymph nodes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4895	18845629-1303	They secreted insulin in response to glucose and could correct hyperglycemia in vivo when cotransplanted with vascular cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4896	18845633-1305	This action was mimicked solely by 100 nm CH-275, a selective agonist at the somatostatin type 1 receptor (SSTR1), but not by 100 nm BIM-23027, L-362855, or NNC-269100 ; agonists selective for the other four SSTRs known to exist in MIN6.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4897	18845634-1306	A functional leptin system is essential for sodium tungstate antiobesity action.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4898	18845638-1311	Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4899	18845639-1312	The aim of this study was to assess in rats the effect of protein feeding on the: 1) distribution of endogenous glucose production (EGP) among gluconeogenic organs, and 2) repercussion on the insulin sensitivity of glucose metabolism.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4900	18845640-1315	Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4901	18845640-1316	The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol side-chain cleavage cytochrome P450 (CYP11A1) enzyme complex takes place in the inner mitochondrial membranes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4902	18845640-1316	The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol side-chain cleavage cytochrome P450 (CYP11A1) enzyme complex takes place in the inner mitochondrial membranes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4903	18845643-1319	Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D (3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4904	18845645-1323	Direct mineralocorticoid receptor (MR) activation with deoxycorticosterone acetate has deleterious effects on the cerebral vasculature.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4905	18845645-1325	Therefore, we hypothesized that systemic 11betaHSD2 inhibition with carbenoxolone (CBX) would cause remodeling of the middle cerebral artery (MCA) and increase the damage caused by cerebral ischemia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4906	18845661-1336	In this study, we attempted to evaluate the effects of ketamine on F-actin and microtubular cytoskeletons in human hepatoma HepG2 cells and its possible molecular mechanisms.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4907	18845661-1337	Consequently, ketamine-caused cytoskeletal interruption led to suppression of CYP3A4 expression and its metabolizing activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4908	18845662-1339	Because many drug-drug interactions may occur at the level of drug transporting proteins, we studied interactions of diclofenac with apical ATP-binding cassette (ABC) multidrug efflux transporters.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4909	18845662-1341	Furthermore, in Sf9-BCRP membrane vesicles diclofenac inhibited transport of methotrexate in a concentration-dependent manner.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4910	18845675-1354	To test this hypothesis, we measured the effect of AMT on RyR2 channels from mice and sheep and on intact mouse cardiomyocytes loaded with the Ca(2+) fluorescent indicator Fura-2 acetoxymethyl ester.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4911	18845675-1354	To test this hypothesis, we measured the effect of AMT on RyR2 channels from mice and sheep and on intact mouse cardiomyocytes loaded with the Ca(2+) fluorescent indicator Fura-2 acetoxymethyl ester.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4912	18845675-1354	To test this hypothesis, we measured the effect of AMT on RyR2 channels from mice and sheep and on intact mouse cardiomyocytes loaded with the Ca(2+) fluorescent indicator Fura-2 acetoxymethyl ester.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4913	18845675-1354	To test this hypothesis, we measured the effect of AMT on RyR2 channels from mice and sheep and on intact mouse cardiomyocytes loaded with the Ca(2+) fluorescent indicator Fura-2 acetoxymethyl ester.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4914	18845767-1393	Most cells contain methionine sulfoxide reductases, which catalyze a thioredoxin-dependent reduction of methionine sulfoxide back to methionine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4915	18845767-1394	The intracellular free methionine and S-adenosylmethionine pools were not altered, nor was the specific activity of the key enzyme, glutamine synthetase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4916	18845767-1394	The intracellular free methionine and S-adenosylmethionine pools were not altered, nor was the specific activity of the key enzyme, glutamine synthetase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4917	18845781-1399	Activity of muscle citrate synthase and 3-hydroxyacyl-CoA dehydrogenase, as well as maximal oxygen uptake and 10-km performance time, remained unaltered in both groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4918	18845781-1399	Activity of muscle citrate synthase and 3-hydroxyacyl-CoA dehydrogenase, as well as maximal oxygen uptake and 10-km performance time, remained unaltered in both groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4919	18845907-1434	MIN6 cells excreted insulin, glucagon, somatostatin and ghrelin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4920	18845907-1434	MIN6 cells excreted insulin, glucagon, somatostatin and ghrelin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4921	18845907-1435	They expressed mRNAs of insulin I and II, proglucagon, somatostatin, pancreatic polypeptide (PP) and ghrelin which were shown in the mouse pancreatic islet core and periphery obtained by LCM.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4922	18845907-1435	They expressed mRNAs of insulin I and II, proglucagon, somatostatin, pancreatic polypeptide (PP) and ghrelin which were shown in the mouse pancreatic islet core and periphery obtained by LCM.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4923	18845907-1435	They expressed mRNAs of insulin I and II, proglucagon, somatostatin, pancreatic polypeptide (PP) and ghrelin which were shown in the mouse pancreatic islet core and periphery obtained by LCM.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4924	18845907-1436	Glucagon, somatostatin and ghrelin were detectable in the culture medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4925	18845907-1436	Glucagon, somatostatin and ghrelin were detectable in the culture medium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4926	18846314-1555	Metallothioneins (MTs) are cysteine-rich, metal-binding proteins that are useful biomarkers for monitoring pollution by heavy metals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4927	18846314-1558	The deduced amino acid sequence has 18 cysteine residues, implying that S. henanense CdMT binds six equivalents of bivalent metal ions (Cd) as opposed to the seven in its mammalian counterparts.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4928	18846317-1559	Their health status was assessed by medical conditions, family history, BMI, past or present clinical manifestations, 25 (OH)D, Calcium, alkaline phosphatase, phosphorus, HbA1C, PTH, Mg and creatinine analysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4929	18846317-1559	Their health status was assessed by medical conditions, family history, BMI, past or present clinical manifestations, 25 (OH)D, Calcium, alkaline phosphatase, phosphorus, HbA1C, PTH, Mg and creatinine analysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4930	18846317-1559	Their health status was assessed by medical conditions, family history, BMI, past or present clinical manifestations, 25 (OH)D, Calcium, alkaline phosphatase, phosphorus, HbA1C, PTH, Mg and creatinine analysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4931	18846317-1559	Their health status was assessed by medical conditions, family history, BMI, past or present clinical manifestations, 25 (OH)D, Calcium, alkaline phosphatase, phosphorus, HbA1C, PTH, Mg and creatinine analysis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4932	18846318-1561	Treatment of Platelet Rich Plasma (PRP) with the dialyzed supernatant from the leucocyte suspension incubated with 80 microM aspirin resulted in parallel syntheses of NO and IFN-alpha as determined by methemoglobin assay and enzyme linked immunosorbent assay respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4933	18846383-1582	Muscular oxidative stress and inflammation induced by H2O2 or MS were assessed by measurements of isoprostanes and IL-6 levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4934	18846383-1583	In control rats, H2O2, bradykinin and MS significantly enhanced the HFV response.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4935	18846383-1584	Pre-treatment with SOD abolished the post-MS-enhanced HFV response whereas diclofenac lowered the peak HFV response to MS and H2O2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4936	18846383-1584	Pre-treatment with SOD abolished the post-MS-enhanced HFV response whereas diclofenac lowered the peak HFV response to MS and H2O2.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4937	18846383-1585	H2O2 injection and MS elicited significant and similar increases in isoprostanes and IL-6.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4938	18846462-1626	The decreased level of GSH as well as SOD and GSH-Px activities in haloperidol-treated mice were significantly increased by NTA pretreatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4939	18847291-1916	In this study, fluorescence microscopy and elemental analysis were exploited to show that the 3,4-dihydroxyphenyl-L-alanine (dopa) residues of mussel foot protein-1 colocalize with Fe and Ca distributions in the cuticle of Mytilus galloprovincialis mussel byssal threads.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4940	18847329-1933	We measured pain using a visual analog pain scale at five time points in 0-48 h, oxycodone use for pain, acetaminophen for fever, C-reactive protein (CRP), and total and percent gammadeltaT-cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4941	18847384-1963	Association between insulin resistance, glucose intolerance, and hypertension in pregnancy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4942	18847384-1966	These results suggest that insulin resistance and relative glucose intolerance are associated with an increased risk of new-onset hypertension in pregnancy, particularly preeclampsia, and support the hypothesis that insulin resistance may play a role in the pathogenesis of this disorder.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4943	18848532-2325	These ADHs are likely to perform similar functions to those reported for other mammalian ADHs in the metabolism of ingested and endogenous alcohols and aldehydes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4944	18848584-2351	Glyoxalase I and II form a ubiquitous glutathione-dependent pathway for the detoxification of reactive and mutagenic ketoaldehydes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4945	18848601-2359	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent 17beta-estradiol (E2).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4946	18848601-2359	17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent 17beta-estradiol (E2).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4947	18848620-2373	Blood was collected before and repeatedly afterward for determination of NF-kappaB activity, leukocyte subset numbers, cortisol, norepinephrine, and in vitro-stimulated IL-6 production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4948	18848620-2373	Blood was collected before and repeatedly afterward for determination of NF-kappaB activity, leukocyte subset numbers, cortisol, norepinephrine, and in vitro-stimulated IL-6 production.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4949	18848620-2374	Higher NF-kappaB stress responses were associated with lower cortisol stress responses (beta=-.37, p=.05), higher pre-stress IL-6 production (beta=.38, p=.043), and high chronic in combination with low acute stress, or vice versa (beta=-.61, p=.06).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4950	18848646-2382	The combination of leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domains is found in the domain architecture of the Trk neurotrophin receptor protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4951	18848646-2383	Given the significant biological roles of Trk and such newly identified proteins, we have searched the public database for human proteins with LRR and Ig domains (collectively termed the leucine-rich repeat and Ig domain-containing protein, LRRIG protein, in this study), and have analyzed the mRNA expression pattern of mouse orthologs of obtained human LRRIG proteins at embryonic day 10.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4952	18848727-2425	Quantum chemical studies for oxidation of morpholine by Cytochrome P450.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4953	18848727-2426	Since morpholine oxidation has recently been shown to involve Cytochrome P450, the study on its mechanism at molecular level using quantum chemical calculations for the model of cytochrome active site is reported here.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4954	18848748-2442	Pretreatment with oligonol diminished the levels of proliferating cell nuclear antigen and expression of COX-2 in papillomas and carcinomas, respectively, as compared to DMBA plus TPA treatment alone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4955	18848748-2442	Pretreatment with oligonol diminished the levels of proliferating cell nuclear antigen and expression of COX-2 in papillomas and carcinomas, respectively, as compared to DMBA plus TPA treatment alone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4956	18848782-2443	TnBP (tri-n-butyl phosphate) and polysorbate 20 during the manufacture of the factor VIII/VWF concentrate Optivate has been investigated.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4957	18848797-2450	Euthyroid animals with a palpation score >or=3 were significantly older, had higher body weights, lower alkaline phosphatase, alanine aminotransferase, phosphate, and urine specific gravity, but higher lipase and creatinine concentrations than hyperthyroid cats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4958	18848797-2450	Euthyroid animals with a palpation score >or=3 were significantly older, had higher body weights, lower alkaline phosphatase, alanine aminotransferase, phosphate, and urine specific gravity, but higher lipase and creatinine concentrations than hyperthyroid cats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4959	18848797-2450	Euthyroid animals with a palpation score >or=3 were significantly older, had higher body weights, lower alkaline phosphatase, alanine aminotransferase, phosphate, and urine specific gravity, but higher lipase and creatinine concentrations than hyperthyroid cats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4960	18848797-2450	Euthyroid animals with a palpation score >or=3 were significantly older, had higher body weights, lower alkaline phosphatase, alanine aminotransferase, phosphate, and urine specific gravity, but higher lipase and creatinine concentrations than hyperthyroid cats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4961	18848818-2462	A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4962	18848878-2491	2-Deoxyglucose decreased NADH/NAD (+) and NADPH/NADP(+) ratios by 59 and 50%, respectively, and intact cell NQO1 activity by 74%; lactate restored NADH/NAD (+), but not NADPH/NADP(+) or NQO1 activity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4963	18848894-880	We propose that the coordinated regulation of actin cytoskeletal reorganization and macropinocytosis-mediated retrograde membrane trafficking may contribute to Ca(2+)-induced axon growth inhibition.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4964	18848957-982	Cocaine stimulated ACTH, cortisol, and LH, whereas cocaine+nalbuphine in combination produced a smaller increase in ACTH, and decreased cortisol and LH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4965	18848957-983	Thus it appears that nalbuphine attenuated cocaine's effects on ACTH, cortisol, and LH.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4966	18848961-2547	In this work we show that in FaO rat hepatoma cells inhibition of the epidermal growth factor receptor (EGFR) with the tyrphostin AG1478 enhances TGF-beta-induced cell death, coincident with an elevated increase in ROS production and GSH depletion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4967	18848961-2547	In this work we show that in FaO rat hepatoma cells inhibition of the epidermal growth factor receptor (EGFR) with the tyrphostin AG1478 enhances TGF-beta-induced cell death, coincident with an elevated increase in ROS production and GSH depletion.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4968	18848984-2561	Membrane inlet mass spectrometry was used to observe nitric oxide in the well-studied reaction of nitrite with hemoglobin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4969	18849028-2571	Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4970	18849028-2571	Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4971	18849028-2571	Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4972	18849028-2571	Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4973	18849030-2572	Serum testosterone, estradiol, sex hormone binding globulin (SHBG), and dehydroepiandrosterone levels were measured in 1947 postmenopausal women aged 45-84 years (30% White, 14% Chinese-American, 31% Black, and 25% Hispanic) and not on hormone therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4974	18849030-2572	Serum testosterone, estradiol, sex hormone binding globulin (SHBG), and dehydroepiandrosterone levels were measured in 1947 postmenopausal women aged 45-84 years (30% White, 14% Chinese-American, 31% Black, and 25% Hispanic) and not on hormone therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4975	18849030-2573	Total and bioavailable testosterone were positively associated with common cIMT independent of age, BMI, hypertension, smoking, HDL-cholesterol, LDL-cholesterol and insulin sensitivity (p=0.009 and p=0.002, respectively).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4976	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4977	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4978	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4979	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4980	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4981	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4982	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4983	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4984	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4985	18849055-2585	In addition to lipid peroxidation, the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and two non-enzymatic antioxidants (ascorbic acid and reduced glutathione) were investigated in order to understand their variation with respect to pollution status of the sampling locations.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4986	18849055-2586	This study shows that changes in lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase and reduced glutathione in tissues of P. viridis can be used as molecular biomarkers in environmental monitoring programs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4987	18849055-2586	This study shows that changes in lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase and reduced glutathione in tissues of P. viridis can be used as molecular biomarkers in environmental monitoring programs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4988	18849055-2586	This study shows that changes in lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase and reduced glutathione in tissues of P. viridis can be used as molecular biomarkers in environmental monitoring programs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4989	18849055-2586	This study shows that changes in lipid peroxidation, superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase and reduced glutathione in tissues of P. viridis can be used as molecular biomarkers in environmental monitoring programs.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4990	18849069-2591	At the same time, both types of conduits were permeable to three compounds tested including glucose, lysozyme and bovine serum albumin, indicating the suitability of the conduits for free exchanges of nutrients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4991	18849069-2591	At the same time, both types of conduits were permeable to three compounds tested including glucose, lysozyme and bovine serum albumin, indicating the suitability of the conduits for free exchanges of nutrients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4992	18849110-2608	The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4993	18849110-2609	This inhibitory effect is possibly mediated by a cAMP-dependent activation of the small GTPase Rap1 via Epac.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4994	18849110-2609	This inhibitory effect is possibly mediated by a cAMP-dependent activation of the small GTPase Rap1 via Epac.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4995	18849120-2614	Gender differences in corticotropin and corticosterone secretion and corticotropin-releasing factor mRNA expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala in response to footshock stress or psychological stress in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4996	18849120-2614	Gender differences in corticotropin and corticosterone secretion and corticotropin-releasing factor mRNA expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala in response to footshock stress or psychological stress in rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4997	18849120-2615	Although females in both proestrus and diestrus showed significant increases in plasma ACTH and corticosterone and CRF mRNA expression in the PVN in response to PS, no significant responses of the HPA axis to PS were found in males.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4998	18849120-2615	Although females in both proestrus and diestrus showed significant increases in plasma ACTH and corticosterone and CRF mRNA expression in the PVN in response to PS, no significant responses of the HPA axis to PS were found in males.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
4999	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5000	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5001	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5002	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5003	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5004	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5005	18849121-2616	BDNF, NGF, adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) were determined at baseline on postnatal days (PND) 14, 30 and 60 by means of specific ELISA and RIA procedures.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5006	18849159-2635	A substrate regeneration cycle coupling GOD with l-ascorbic acid (AsA: 0, 1.0, 3.0, 10.0 and 50.0 mmol/l; as reducing reagent system) was applied to the chemo-mechanical reaction unit in order to amplify the output signal of the tonometric biosensor.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5007	18849171-2637	In vitro and in vivo models simulating the bee sting have been developed using live honeybees and, as the envenomation sites, pig ears and rat legs; MALDI MSI has been used to map, over time, the diffusion and distribution of three venom allergens (Api m 1, Api m 4, and Api m 6) and two venom toxins (apamine and mast cell degranulating peptide).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5008	18849325-2674	The effect was lactose-inhibitable and required galectin-3 affinity for N-acetyllactosamine, a saccharide typically found on cell surface glycoproteins, since a mutant lacking this activity was without effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5009	18849325-2674	The effect was lactose-inhibitable and required galectin-3 affinity for N-acetyllactosamine, a saccharide typically found on cell surface glycoproteins, since a mutant lacking this activity was without effect.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5010	18849352-2679	Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase inhibitors (TKIs) such as gefitinib exhibit limited activity in this cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5011	18849352-2679	Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase inhibitors (TKIs) such as gefitinib exhibit limited activity in this cancer.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5012	18849352-2680	It is noteworthy that FGF2 and FGF9 as well as FGFR1 IIIc and/or FGFR2 IIIc mRNA and protein are frequently coexpressed in NSCLC cell lines, especially those that are insensitive to gefitinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5013	18849352-2680	It is noteworthy that FGF2 and FGF9 as well as FGFR1 IIIc and/or FGFR2 IIIc mRNA and protein are frequently coexpressed in NSCLC cell lines, especially those that are insensitive to gefitinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5014	18849352-2680	It is noteworthy that FGF2 and FGF9 as well as FGFR1 IIIc and/or FGFR2 IIIc mRNA and protein are frequently coexpressed in NSCLC cell lines, especially those that are insensitive to gefitinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5015	18849352-2680	It is noteworthy that FGF2 and FGF9 as well as FGFR1 IIIc and/or FGFR2 IIIc mRNA and protein are frequently coexpressed in NSCLC cell lines, especially those that are insensitive to gefitinib.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5016	18849389-2687	Preprandial concentrations of glucose, NEFA, lactate, and IGF-I fluctuated over time without significant treatment effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5017	18849389-2687	Preprandial concentrations of glucose, NEFA, lactate, and IGF-I fluctuated over time without significant treatment effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5018	18849389-2687	Preprandial concentrations of glucose, NEFA, lactate, and IGF-I fluctuated over time without significant treatment effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5019	18849389-2687	Preprandial concentrations of glucose, NEFA, lactate, and IGF-I fluctuated over time without significant treatment effect.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5020	18849389-2688	In late gestation, the postprandial increases in glucose and insulin were delayed, and smaller, after a high-fiber meal than after a control meal.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5021	18849389-2689	During lactation, glucose and insulin profiles after a standard meal did not differ between sows from treatment groups.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5022	18849391-1967	Effects of gram-negative bacterial lipopolysaccharide (LPS) and supplemental dietary Met on N balance, serum hormones and haptoglobin, and plasma urea-N and AA were evaluated in 20 Angus-cross steers (BW = 262+/-6.3 kg).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5023	18849391-1967	Effects of gram-negative bacterial lipopolysaccharide (LPS) and supplemental dietary Met on N balance, serum hormones and haptoglobin, and plasma urea-N and AA were evaluated in 20 Angus-cross steers (BW = 262+/-6.3 kg).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5024	18849391-1968	Diet samples, feed refusals, feces, and urine were collected daily for 5 d. Rectal temperature and serum concentrations of cortisol, prolactin, tumor necrosis factor-alpha, and haptoglobin 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5025	18849391-1968	Diet samples, feed refusals, feces, and urine were collected daily for 5 d. Rectal temperature and serum concentrations of cortisol, prolactin, tumor necrosis factor-alpha, and haptoglobin 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5026	18849391-1968	Diet samples, feed refusals, feces, and urine were collected daily for 5 d. Rectal temperature and serum concentrations of cortisol, prolactin, tumor necrosis factor-alpha, and haptoglobin 0.01).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5027	18849391-1969	Plasma urea-N was greater for+LPS than-LPS steers (LPS; P = 0.03), and serum IGF-1 was not affected (P > or = 0.26) by LPS or Met.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5028	18849413-2041	Domain shape annealing is observed from branched to rounded shapes after SMase activity quenching by EDTA, with a decay halftime of approximately 10 min.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5029	18849420-2060	Using neighborhood approaches, we were able to assign seven novel functional partners in luciferase synthesis, nitrogen metabolism, and quorum sensing to BLUF domain-containing proteins (involved in light sensing).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5030	18849565-2744	Chondroitin lyases (or chondroitinases) are a family of enzymes that depolymerize chondroitin sulfate (CS) and dermatan sulfate (DS) galactosaminoglycans, which have gained prominence as important players in central nervous system biology.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5031	18849890-22	We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5032	18849890-22	We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5033	18850007-61	This downregulation was abolished following treatment with the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) and cytosine methylation inhibitor 5-aza-2-deoxycytidine (5-Aza), suggesting that an epigenetic regulatory mechanism may be involved in RUNX3 silencing by hypoxia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5034	18850007-61	This downregulation was abolished following treatment with the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) and cytosine methylation inhibitor 5-aza-2-deoxycytidine (5-Aza), suggesting that an epigenetic regulatory mechanism may be involved in RUNX3 silencing by hypoxia.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5035	18850009-63	Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5036	18850074-89	Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5037	18850074-90	The purpose of this study was to examine the distribution and action of doxorubicin-transferrin conjugate (DOXTRF) in a leukaemia cell line (HL60), a multidrug-resistant leukaemia cell line (HL60ADR) and a normal tissue cell line (human fibroblasts).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5038	18850096-105	Purification of an alcohol dehydrogenase involved in the conversion of methional to methionol in Oenococcus oeni IOEB 8406.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5039	18850096-105	Purification of an alcohol dehydrogenase involved in the conversion of methional to methionol in Oenococcus oeni IOEB 8406.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5040	18850096-106	An NAD (P)H-dependent ADH involved in the reduction of methional was then purified to homogeneity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5041	18850096-106	An NAD (P)H-dependent ADH involved in the reduction of methional was then purified to homogeneity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5042	18850096-107	Sequencing of the purified enzyme and amino acid sequence comparison with the database revealed the presence of a conserved sequence motif specific to the medium-chain zinc-containing NAD (P)H-dependent ADHs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5043	18850096-108	The purified ADH does not seem to be involved in the modification of buttery and lactic notes or to be involved in the specific formation of volatile alcohols during MLF.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5044	18850096-109	The function of the purified ADH remains unclear, although the role of the sulfur atom in methional molecules in the interaction between enzyme and substrate was evidenced.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5045	18850096-109	The function of the purified ADH remains unclear, although the role of the sulfur atom in methional molecules in the interaction between enzyme and substrate was evidenced.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5046	18850241-169	All strains tested positive for cellulase activity while none where capable of xylan degradation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5047	18850267-174	In the present work we studied the effect of endothelin-1 and-3 on neuronal norepinephrine release and the short-term regulation of tyrosine hydroxylase in the olfactory bulb.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5048	18850267-175	Results showed that both endothelins increased tyrosine hydroxylase activity through the activation of a non-conventional endothelin G-protein coupled receptor, coupled to the stimulation of protein kinase A and C, as well as Ca(2+)/calmodulin-dependent protein kinase II.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5049	18850267-175	Results showed that both endothelins increased tyrosine hydroxylase activity through the activation of a non-conventional endothelin G-protein coupled receptor, coupled to the stimulation of protein kinase A and C, as well as Ca(2+)/calmodulin-dependent protein kinase II.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5050	18850267-175	Results showed that both endothelins increased tyrosine hydroxylase activity through the activation of a non-conventional endothelin G-protein coupled receptor, coupled to the stimulation of protein kinase A and C, as well as Ca(2+)/calmodulin-dependent protein kinase II.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5051	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5052	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5053	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5054	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5055	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5056	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5057	18850490-228	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5058	18851707-551	P2X receptors are membrane cation channels gated by extracellular ATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5059	18851710-552	End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers (hsCRP (high-sensitivity C-reactive protein)) and endothelial function (FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5060	18851710-552	End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers (hsCRP (high-sensitivity C-reactive protein)) and endothelial function (FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5061	18851713-556	Addition of SOD (superoxide dismutase) doubled the amount of HOBr detected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5062	18851713-556	Addition of SOD (superoxide dismutase) doubled the amount of HOBr detected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5063	18851895-635	Drug-resistant cancer cells became sensitive to doxorubicin treatment when nucleophosmin was expressed in cytosol.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5064	18851927-647	All the analyzed resistant mutants exhibited both increased econazole efflux and increased transcription of mmpS5-mmpL5 genes, encoding a hypothetical efflux system belonging to the resistance-nodulation-division (RND) family of transporters.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5065	18851927-647	All the analyzed resistant mutants exhibited both increased econazole efflux and increased transcription of mmpS5-mmpL5 genes, encoding a hypothetical efflux system belonging to the resistance-nodulation-division (RND) family of transporters.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5066	18851956-1598	This study investigated the effects of atorvastatin on ABCB1 and ABCC1 mRNA expression on peripheral blood mononuclear cells (PBMC) and their relationship with gene polymorphisms and lowering-cholesterol response.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5067	18851956-1598	This study investigated the effects of atorvastatin on ABCB1 and ABCC1 mRNA expression on peripheral blood mononuclear cells (PBMC) and their relationship with gene polymorphisms and lowering-cholesterol response.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5068	18851994-2766	While the three SAT isotypes showed comparable Km and k(cat) for L-serine and acetyl-CoA, they showed remarkable differences in their sensitivity to inhibition by L-cysteine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5069	18851994-2766	While the three SAT isotypes showed comparable Km and k(cat) for L-serine and acetyl-CoA, they showed remarkable differences in their sensitivity to inhibition by L-cysteine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5070	18851994-2767	We propose that multiple SAT isotypes with different properties may play complementary roles in the regulation of the cysteine biosynthetic pathway in E. histolytica under different conditions, e.g.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5071	18852015-684	At 1 min before the exposure rats were treated with one of the following: intravenous aprotinin, 4.4 mg/kg; intraperitoneal (ip) ilomastat, 25mg/kg; or ip trolox, 500 microg/kg.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5072	18852015-684	At 1 min before the exposure rats were treated with one of the following: intravenous aprotinin, 4.4 mg/kg; intraperitoneal (ip) ilomastat, 25mg/kg; or ip trolox, 500 microg/kg.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5073	18852015-685	Treatment with aprotinin or ilomastat eliminated these PF changes, yielding results comparable with controls for each of these parameters.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5074	18852015-686	While aprotinin and ilomastat both alleviated the PF perturbations, surprisingly only aprotinin reduced the observed pathology, both grossly and histologically.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5075	18852015-687	These early results indicate that treatment with aprotinin and to a lesser extent ilomastat reduces some of the direct inflammatory response and damage associated with SM-induced lung injury.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5076	18852063-706	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5077	18852063-706	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5078	18852217-740	Pretreatment with DEX abrogated calcitonin inhibition by sst (2)-preferring analogue octreotide in TT.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5079	18852255-2230	Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5080	18853098-1027	Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5081	18853098-1028	The aim of this study was to evaluate the activity of semicarbazide-sensitive amine oxidase (SSAO) and the total nitrite and nitrate (NO(x)) concentrations in serum from type 2 diabetic patients and control subjects in order to evaluate if they could be used as novel diabetic markers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5082	18853098-1028	The aim of this study was to evaluate the activity of semicarbazide-sensitive amine oxidase (SSAO) and the total nitrite and nitrate (NO(x)) concentrations in serum from type 2 diabetic patients and control subjects in order to evaluate if they could be used as novel diabetic markers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5083	18853099-1030	Serum lipid, creatinine, uric acid, CRP, HbA(1C) and urinary albumin concentration were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5084	18853099-1030	Serum lipid, creatinine, uric acid, CRP, HbA(1C) and urinary albumin concentration were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5085	18853102-1107	Cryptolepine activity showed highest correlations to topoisomerase II and microtubule targeting drugs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5086	18853145-1060	Ulcerated tissues were processed to assess ulcer area, malondialdehyde, proliferating cell nuclear antigen (PCNA) and cleaved caspase-3.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5087	18853145-1060	Ulcerated tissues were processed to assess ulcer area, malondialdehyde, proliferating cell nuclear antigen (PCNA) and cleaved caspase-3.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5088	18853166-1068	Serum NO, catalase and glutathione were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5089	18853166-1069	Serum glutathione and catalase levels were significantly lower in FM patients than controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5090	18853182-1073	This article discusses the physiology of proximal Na (+)/H(+) exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5091	18853182-1073	This article discusses the physiology of proximal Na (+)/H(+) exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5092	18853185-1077	Cortisol and DHEA-sulfate response to rapid adrenocorticotropic hormone (ACTH) stimulation was inadequate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5093	18853185-1077	Cortisol and DHEA-sulfate response to rapid adrenocorticotropic hormone (ACTH) stimulation was inadequate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5094	18853185-1077	Cortisol and DHEA-sulfate response to rapid adrenocorticotropic hormone (ACTH) stimulation was inadequate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5095	18853185-1077	Cortisol and DHEA-sulfate response to rapid adrenocorticotropic hormone (ACTH) stimulation was inadequate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5096	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5097	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5098	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5099	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5100	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5101	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5102	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5103	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5104	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5105	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5106	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5107	18853207-1083	The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5108	18853207-1084	The intracellular levels of ADH and G6PDH after permeabilization of these stored cells with cetyltrimetylammonium bromide (CTAB) were much higher, which showed only slight decrease within 2 weeks during the industrial storage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5109	18853207-1084	The intracellular levels of ADH and G6PDH after permeabilization of these stored cells with cetyltrimetylammonium bromide (CTAB) were much higher, which showed only slight decrease within 2 weeks during the industrial storage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5110	18853234-1098	Streptokinase (SK), glucose oxidase (GOx) and phosphorylcholine (PC) were immobilized onto PGLD to obtain a blood compatible bioconjugate with glucose sensing properties.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5111	18854222-1462	Treatment of RPE cells with high glucose-induced a significant increased of iNOS, accompanied by an increase in cell damage, NO and nitrotyrosine levels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5112	18854222-1464	High glucose causes increased cell damage and NO generation in RPE cells by a process of iNOS expression that requires the activation of p38MAPK and ERK.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5113	18854222-1464	High glucose causes increased cell damage and NO generation in RPE cells by a process of iNOS expression that requires the activation of p38MAPK and ERK.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5114	18854222-1464	High glucose causes increased cell damage and NO generation in RPE cells by a process of iNOS expression that requires the activation of p38MAPK and ERK.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5115	18854226-1467	A crude peel extract and purified fraction of Flemingia vestita, as well as a crude rhizome extract of Stephania glabra and fractions were tested with respect to the activity of NOS, NO efflux and cGMP concentration in the cestode Raillietina echinobothrida in order to find out the possible mode of anthelmintic action of these plant-derived components.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5116	18854307-761	Our data suggest that PKCalpha translocates to the contractile system and anchors to TnI in a Ca(2+)-dependent manner in the human heart, contributing to the maintenance of contractile force.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5117	18854307-761	Our data suggest that PKCalpha translocates to the contractile system and anchors to TnI in a Ca(2+)-dependent manner in the human heart, contributing to the maintenance of contractile force.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5118	18854368-1518	In this study, we describe the crystal structure of yeast PNGase in complex with N,N'-diacetylchitobiose (chitobiose).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5119	18854368-1519	Mutagenesis studies confirm the critical role of the chitobiose-interacting residues in substrate binding and suggest that efficient oligosaccharide binding is required for PNGase activity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5120	18854379-1521	Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5121	18854379-1521	Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5122	18854401-1524	Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5123	18854401-1524	Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5124	18854401-1525	This condition is caused by mutations in the PTH/PTHrP receptor that result in ligand-independent cAMP accumulation, thus rendering the receptor constitutively active.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5125	18854401-1525	This condition is caused by mutations in the PTH/PTHrP receptor that result in ligand-independent cAMP accumulation, thus rendering the receptor constitutively active.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5126	18854421-1530	Adiponectin, an adipokine secreted by the white adipose tissue, plays an important role in regulating glucose and lipid metabolism and controlling energy homeostasis in insulin-sensitive tissues.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5127	18854429-993	Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5128	18854429-994	Both Epac and PKA are effectors of the second messenger cAMP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5129	18854435-1007	Since a polypeptide lacking the proline-rich region (P-region) of huntingtin (103Q) cannot form aggresomes, this domain serves as an aggresome-targeting signal.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5130	18854599-1421	Expression of UDP-N-acetyl-D-galactosamine : polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5131	18854599-1422	UDP-N-acetyl-d-galactosamine : polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6) is one of the enzymes responsible for the initial step in O-glycosylation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5132	18854840-1661	In addition, SAH caused large increases in markers of inflammation, including TNFalpha and NFkappaB, and markers of cell injury or cell death, including IgG endocytosis and caspase-3 activation, with glibenclamide significantly reducing these effects.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5133	18854840-1662	We conclude that block of SUR1 by glibenclamide may ameliorate several pathologic effects associated with inflammation that lead to cortical dysfunction after SAH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5134	18854981-1711	Intrinsic fluorescence of tryptophan-214 in HSA was monitored upon addition of the chemicals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5135	18854987-1716	The COMT enzyme breaks down extracellular dopamine (DA) and has a particularly important role in the prefrontal cortex (PFC) where DA transporters are sparse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5136	18854987-1716	The COMT enzyme breaks down extracellular dopamine (DA) and has a particularly important role in the prefrontal cortex (PFC) where DA transporters are sparse.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5137	18854999-1723	CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5138	18855021-1734	The metal-thiolate connectivity of recombinant Cd(7)-MT10 metallothionein from the sea mussel Mytilus galloprovincialis has been investigated for the first time by means of multinuclear, multidimensional NMR spectroscopy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5139	18855035-1741	Radical scavenging activity of lipophilized products from lipase-catalyzed transesterification of triolein with cinnamic and ferulic acids.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5140	18855035-1742	Lipase-catalyzed transesterification of triolein with cinnamic and ferulic acids using an immobilized lipase from Candida antarctica (E.C.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5141	18855035-1742	Lipase-catalyzed transesterification of triolein with cinnamic and ferulic acids using an immobilized lipase from Candida antarctica (E.C.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5142	18855107-1775	Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5143	18855190-2056	Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5144	18855521-439	The study established that SPZ attenuated myocardial I/R injury through overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5145	18855521-439	The study established that SPZ attenuated myocardial I/R injury through overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5146	18855522-1934	Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5147	18855911-2115	The purpose of this study was to propose a new preparation method to fabricate insulin-loaded poly(lactic-coglycolic acid) (PLGA) microparticles satisfying protein loading, release profiles, burst release, and particularly stability of the encapsulated protein.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5148	18855936-2128	This injury induces central sensitization leading to tactile allodynia and is mediated by activation of Ca(2+) permeable AMPA/kainate receptors through PKC and PKA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5149	18855942-2132	Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5150	18855943-2134	Transport properties of PIs by the drug efflux transporters P-gp and multidrug resistance protein 1 (MRP1) were assessed by measuring the cellular uptake of (3)H-atazanavir or (3)H-ritonavir in P-gp and MRP1 overexpressing cells as well as hCMEC/D3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5151	18855943-2134	Transport properties of PIs by the drug efflux transporters P-gp and multidrug resistance protein 1 (MRP1) were assessed by measuring the cellular uptake of (3)H-atazanavir or (3)H-ritonavir in P-gp and MRP1 overexpressing cells as well as hCMEC/D3.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5152	18922131-2288	Incubation of L6 myotubes with palmitate (for 16 h) increases intramyocellular ceramide and reduces insulin-stimulated PKB activation and glucose uptake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5153	18922131-2288	Incubation of L6 myotubes with palmitate (for 16 h) increases intramyocellular ceramide and reduces insulin-stimulated PKB activation and glucose uptake.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5154	18922514-2447	This is the first cyclodextrin glycosyltransferase with a known primary structure and a glutamine instead of glycine residue at position 179 in the highly conserved-6 subsite, shown to be involved in substrate binding.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5155	18922514-2447	This is the first cyclodextrin glycosyltransferase with a known primary structure and a glutamine instead of glycine residue at position 179 in the highly conserved-6 subsite, shown to be involved in substrate binding.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5156	18922527-2451	Functional LCAT is not required for macrophage cholesterol efflux to human serum.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5157	18922794-2589	The AbfR/S two-component system is required to activate the expression of the suite of enzymes that remove the numerous side chains from xylan, but not the xylanases that hydrolyze the beta1,4-linked xylose polymeric backbone of this polysaccharide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5158	18922879-2629	In agreement with molecular modeling predictions, the inhibitory action of pPTME and PTME toward intracellular ODC of LN229 cells exceeded that of the previous designed lead compound POB.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5159	18922958-2662	Treatment with acidified saline reduced fetal basal pH from 7.35+/-0.01 to 7.29+/-0.01 but did not alter basal cardiovascular variables, blood glucose, or plasma concentrations of catecholamines, ACTH, and cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5160	18922958-2662	Treatment with acidified saline reduced fetal basal pH from 7.35+/-0.01 to 7.29+/-0.01 but did not alter basal cardiovascular variables, blood glucose, or plasma concentrations of catecholamines, ACTH, and cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5161	18922958-2663	During hypoxemia, treatment with acidified saline increased the magnitude of the fetal bradycardia and femoral vasoconstriction and concomitantly increased chemoreflex function and enhanced the increments in plasma concentrations of catecholamines, ACTH, and cortisol.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5162	18923065-2678	The induction of HO-1 by YC-1 was unchanged by the sGC inhibitor, 1H-(1,2,4)oxadiazolo(4,3-alpha)quinozalin-1-one (ODQ) or by the protein kinase pyrimidin-4-ylamine (BAY 41-2272).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5163	18923065-2678	The induction of HO-1 by YC-1 was unchanged by the sGC inhibitor, 1H-(1,2,4)oxadiazolo(4,3-alpha)quinozalin-1-one (ODQ) or by the protein kinase pyrimidin-4-ylamine (BAY 41-2272).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5164	18923065-2678	The induction of HO-1 by YC-1 was unchanged by the sGC inhibitor, 1H-(1,2,4)oxadiazolo(4,3-alpha)quinozalin-1-one (ODQ) or by the protein kinase pyrimidin-4-ylamine (BAY 41-2272).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5165	18923065-2678	The induction of HO-1 by YC-1 was unchanged by the sGC inhibitor, 1H-(1,2,4)oxadiazolo(4,3-alpha)quinozalin-1-one (ODQ) or by the protein kinase pyrimidin-4-ylamine (BAY 41-2272).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5166	18923087-1871	The potentiation was not altered by the beta(1) subunit or mediated by ARA-S metabolites, stimulation of known cannabinoid receptors, G proteins, protein kinases, or Ca(2+)-dependent processes; it was lost after patch excision or after membrane cholesterol depletion but was restored after cholesterol reconstitution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5167	18923087-1871	The potentiation was not altered by the beta(1) subunit or mediated by ARA-S metabolites, stimulation of known cannabinoid receptors, G proteins, protein kinases, or Ca(2+)-dependent processes; it was lost after patch excision or after membrane cholesterol depletion but was restored after cholesterol reconstitution.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5168	18923147-2705	Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5169	18923147-2705	Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5170	18923157-2713	Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5171	18923157-2713	Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5172	18923157-2714	In this study we evaluated OVGP1 and steroid receptor expression in oviducts of baboons with endometriosis during the midsecretory phase and determined whether progesterone resistance associated with endometriosis also occurs in the oviduct.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5173	18923157-2715	These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5174	18923157-2715	These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5175	18923162-2719	In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5176	18923162-2719	In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5177	18923162-2719	In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5178	18923162-2719	In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5179	18923387-2775	Transgenic mice that overexpress rat angiotensinogen in their proximal tubule cells were given either apocynin, perindopril, or hydralazine while untreated or apocynin-treated non-transgenic littermates served as controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5180	18923387-2775	Transgenic mice that overexpress rat angiotensinogen in their proximal tubule cells were given either apocynin, perindopril, or hydralazine while untreated or apocynin-treated non-transgenic littermates served as controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5181	18923387-2775	Transgenic mice that overexpress rat angiotensinogen in their proximal tubule cells were given either apocynin, perindopril, or hydralazine while untreated or apocynin-treated non-transgenic littermates served as controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5182	18923397-2783	Requirement of AQP4 for antidepressive efficiency of fluoxetine : implication in adult hippocampal neurogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5183	18923397-2785	Collectively, these findings suggest that AQP4 is required for the antidepressive action of fluoxetine via regulating adult hippocampal neurogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5184	18923398-2787	Although no significant change in the apparent K(m) was revealed in animals that exhibited an escalation in the rate of cocaine intake, an increased dopamine uptake rate was found suggesting an upregulation of DAT number in response to a history of high cocaine intake.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5185	18923402-2788	Previous work has shown that repeated desipramine treatment causes downregulation of the norepinephrine transporter (NET) and persistent antidepressant-like effects on behavior, ie effects observed 2 days after discontinuation of drug treatment when acute effects are minimized.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5186	18923402-2788	Previous work has shown that repeated desipramine treatment causes downregulation of the norepinephrine transporter (NET) and persistent antidepressant-like effects on behavior, ie effects observed 2 days after discontinuation of drug treatment when acute effects are minimized.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5187	18923402-2790	Treatment for 14 days with 70 mg/kg per day venlafaxine, which inhibits both the NET and SERT, or 10 mg/kg per day phenelzine, a monoamine oxidase inhibitor, produced antidepressant-like effects on behavior without altering NET or SERT expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5188	18923402-2790	Treatment for 14 days with 70 mg/kg per day venlafaxine, which inhibits both the NET and SERT, or 10 mg/kg per day phenelzine, a monoamine oxidase inhibitor, produced antidepressant-like effects on behavior without altering NET or SERT expression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5189	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5190	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5191	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5192	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5193	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5194	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5195	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5196	18923405-2791	Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5197	18923405-2792	Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5198	18923405-2792	Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5199	18923405-2792	Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5200	18923823-499	However, detection of Cu and Zn in superoxide dismutase after PAGE-LA-ICP-MS depends on the conditions of the PAGE method because possible metal losses can occur (either with SDS-PAGE or with native PAGE).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5201	18923827-111	Recent studies have suggested that a decrease in the specific activity of the 2-oxoglutarate dehydrogenase complex (ODHC) is important for glutamate overproduction by Corynebacterium glutamicum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5202	18923851-130	To evaluate the potential of using heme-containing lipocalin nitrophorin 1 (NP1) as a template for protein engineering, we have replaced the native axial heme-coordinating histidine residue with glycine, alanine, and cysteine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5203	18923851-130	To evaluate the potential of using heme-containing lipocalin nitrophorin 1 (NP1) as a template for protein engineering, we have replaced the native axial heme-coordinating histidine residue with glycine, alanine, and cysteine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5204	18923851-130	To evaluate the potential of using heme-containing lipocalin nitrophorin 1 (NP1) as a template for protein engineering, we have replaced the native axial heme-coordinating histidine residue with glycine, alanine, and cysteine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5205	18923851-130	To evaluate the potential of using heme-containing lipocalin nitrophorin 1 (NP1) as a template for protein engineering, we have replaced the native axial heme-coordinating histidine residue with glycine, alanine, and cysteine.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5206	18923851-133	Two crystal structures of the H60C_ NP1 in complex with imidazole and histamine were solved to 1.7- and 1.96-A resolution, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5207	18923851-133	Two crystal structures of the H60C_ NP1 in complex with imidazole and histamine were solved to 1.7- and 1.96-A resolution, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5208	18923851-134	Both structures show that the H60C mutation is well tolerated by the protein scaffold and suggest that heme-thiolate coordination in H60C_ NP1 requires some movement of the heme within its binding cavity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5209	18923851-134	Both structures show that the H60C mutation is well tolerated by the protein scaffold and suggest that heme-thiolate coordination in H60C_ NP1 requires some movement of the heme within its binding cavity.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5210	18923901-159	Anticancer effect of celecoxib via COX-2 dependent and independent mechanisms in human gastric cancers cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5211	18924134-216	Real-time polymerase chain reaction analysis of hypoxic, NO-sulindac treated PC-3 cells showed downregulation of lysyl oxidase and carbonic anhydrase IX mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5212	18924134-216	Real-time polymerase chain reaction analysis of hypoxic, NO-sulindac treated PC-3 cells showed downregulation of lysyl oxidase and carbonic anhydrase IX mRNA expression.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5213	18925358-887	Established risk cardiovascular factors like hypertension, atherogenic dyslipidaemia, and glucose intolerance occur in the setting of insulin resistance and central adiposity, with genetic and environmental influences modulating the ultimate risk.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5214	18925359-508	Despite this lack of oxidative and cytotoxic action, exposure of hepatoma cells to Ni(2+) resulted in a significant activation of Akt that was abrogated by inhibitors of PI3K.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5215	18925413-539	Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5216	18925413-539	Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5217	18925413-539	Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5218	18925413-539	Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5219	18925649-643	The chimera was at least fourfold less sensitive to inhibition by okadaic acid, but was stimulated by nickel ions and chlorogenic acid, characteristics of PP2B not of PP1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5220	18925649-643	The chimera was at least fourfold less sensitive to inhibition by okadaic acid, but was stimulated by nickel ions and chlorogenic acid, characteristics of PP2B not of PP1.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5221	18925649-643	The chimera was at least fourfold less sensitive to inhibition by okadaic acid, but was stimulated by nickel ions and chlorogenic acid, characteristics of PP2B not of PP1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5222	18925649-643	The chimera was at least fourfold less sensitive to inhibition by okadaic acid, but was stimulated by nickel ions and chlorogenic acid, characteristics of PP2B not of PP1.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5223	18925653-646	Because o-quinones are very unstable, we used an oxymetric method to characterize the kinetics of this substrate, based on measurements of the oxygen consumed in the tyrosinase reaction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5224	18925655-1527	Plasma levels of citalopram, cortisol, and prolactin were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5225	18925655-1527	Plasma levels of citalopram, cortisol, and prolactin were measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5226	18925655-1528	An increase in cortisol and prolactin concentrations was observed from the EOI until 60 min after the EOI.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5227	18925830-712	Different lag-time of pulse-released nerve growth factor (NGF) from genipin-crosslinked gelatin within polycaprolactone (PCL) conduits was evaluated in large-gap peripheral nerve repair.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5228	18925830-712	Different lag-time of pulse-released nerve growth factor (NGF) from genipin-crosslinked gelatin within polycaprolactone (PCL) conduits was evaluated in large-gap peripheral nerve repair.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5229	18925830-713	In this study, 10% (w/v) gelatin was mixed with NGF, crosslinked with 0%, 0.1%, 0.5%, and 1% (w/v) genipin, and then sucked into the wall of PCL conduits.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5230	18926542-922	It was found from this group that 4-hydroxycoumarin was the best alternative to warfarin for examining the interactions of drugs at Sudlow site I on HSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5231	18926547-923	Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5232	18926547-923	Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5233	18926641-955	The majority of patients with acute depression shows an exaggerated plasma corticotrophin (ACTH) and cortisol response to this test that normalizes gradually during successful antidepressant therapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5234	18926641-956	We examined plasma ACTH and cortisol responses to the dex/CRH test in acutely depressed inpatients treated either with mirtazapine (n=55) or a monoamine reuptake inhibitor (n=105) according to doctor's choice and compared the test results with healthy controls (n=40).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5235	18926682-975	Both extracts increased AMP-kinase phosphorylation and HMG-CoA reductase phosphorylation by 2.5-to 4-fold, but with different time courses: maximal phosphorylation with green tea was evident within 30 min of treatment, whereas with black tea phosphorylation was slower to develop, with maximal phosphorylation occurring > or =3 hours after treatment.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5236	18926687-978	However, the ethyl ester of commipheric acid (150 mg/kg, twice daily) lowered fasting blood glucose and plasma insulin, and plasma triglycerides without affecting food intake or body weight.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5237	18926804-1008	This finding led the authors to propose that RDH-E2 may be involved in the pathogenesis of psoriasis through its potential role in retinoic acid biosynthesis and stimulation of keratinocyte proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5238	18926804-1010	In this study, we began the characterization of RDH-E2 protein in order to determine whether it might play a role in retinoic acid biosynthesis.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5239	18926804-1011	The preference for NAD(+) suggests that RDH-E2 is likely to function in the oxidative direction in vivo, further supporting its potential role in the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in human keratinocytes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5240	18926806-1012	Identification of Aldh1a, Cyp26 and RAR orthologs in protostomes pushes back the retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5241	18926807-1161	As release of NADH can be a rate-limiting step for ALDH activity, NADH binding was evaluated for R166wt and R166H enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5242	18926849-1039	GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5243	18926849-1039	GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5244	18926849-1039	GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5245	18926859-1152	Peripheral GLP-1 gastroprotection against ethanol : the role of exendin, NO, CGRP, prostaglandins and blood flow.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5246	18926859-1152	Peripheral GLP-1 gastroprotection against ethanol : the role of exendin, NO, CGRP, prostaglandins and blood flow.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5247	18926859-1154	Absolute ethanol was administered through an orogastric cannula right after the injection of GLP-1 (1, 10, 100, 1000 or 10,000 ng/kg; i.p.).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5248	18926889-1065	It inhibited Trypanosoma brucei GAPDH with an IC(50) value of 240 microM and has been shown to be a competitive reversible inhibitor (Ki=200+/-10 microM) of this enzyme with respect to its cofactor NAD (+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5249	18926911-1076	We have also described LD between HLA-G alleles and HLA class II DRB1 allelic groups and found significant LD between DRB104-G01B, DRB113-G010401, DRB114-G010108, DRB115-G0103, DRB103-G0101A and DRB103-G01B.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5250	18926911-1076	We have also described LD between HLA-G alleles and HLA class II DRB1 allelic groups and found significant LD between DRB104-G01B, DRB113-G010401, DRB114-G010108, DRB115-G0103, DRB103-G0101A and DRB103-G01B.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5251	18927146-1139	Morpholino oligonucleotide-induced expression of truncated dystrophin in the brains of mdx mice, but not in the muscle, ameliorated the abnormal freezing response to restraint.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5252	18927216-1186	It is suggested that in this animal model, characterized by TSH elevation and low-grade inflammation, an increased expression and function of iNOS, resulting in superoxide generation, accounts for an impaired NO availability.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5253	18927219-1190	Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5254	18927219-1192	These changes were associated with an alleviation of hyperglycemia, glucose intolerance, and insulin resistance.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5255	18927241-1195	Vernakalant was metabolized rapidly via 4-O-demethylation by cytochrome P450 (CYP)2D6 to its major metabolite RSD1385, which then circulated predominantly as an inactive glucuronide conjugate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5256	18927241-1195	Vernakalant was metabolized rapidly via 4-O-demethylation by cytochrome P450 (CYP)2D6 to its major metabolite RSD1385, which then circulated predominantly as an inactive glucuronide conjugate.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5257	18927268-1200	We assessed in vivo carotid sinus nerve activity (CSNA) at baseline, in response to acute hypoxia, in response to infused NMDA, and in response to infused endothelin-1 (ET-1) with and without MK-801, an NMDA receptor blocker.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5258	18927268-1200	We assessed in vivo carotid sinus nerve activity (CSNA) at baseline, in response to acute hypoxia, in response to infused NMDA, and in response to infused endothelin-1 (ET-1) with and without MK-801, an NMDA receptor blocker.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5259	18927347-1235	Thus, CS-mediated down-regulation of HDAC2 in human macrophages and lung epithelial cells in vitro and in mouse lung in vivo involves the induction of serine/threonine phosphorylation and proteasomal degradation, which may have implications for steroid resistance and abnormal inflammation caused by cigarette smoke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5260	18927347-1235	Thus, CS-mediated down-regulation of HDAC2 in human macrophages and lung epithelial cells in vitro and in mouse lung in vivo involves the induction of serine/threonine phosphorylation and proteasomal degradation, which may have implications for steroid resistance and abnormal inflammation caused by cigarette smoke.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5261	18927433-1257	Immunofluorescence microscopy of live human umbilical vein endothelial cells showed that VWF multimers rapidly formed strings several hundred micrometers long on the cell surface after stimulation with histamine.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5262	18927433-1258	Soluble P-selectin reduced the number of platelet-decorated VWF strings in the absence of Ca(2+) and Mg(2+) but had no effect in the presence of these cations.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5263	18927435-1259	To examine the relationship of functional expression of VLA-4 to prognosis in AML, we studied marrow samples from 175 adult AML patients who underwent induction chemotherapy with anthracycline and cytarabine on Southwest Oncology Group trials.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5264	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5265	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5266	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5267	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5268	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5269	18928402-1632	Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5270	18929413-2021	Inhibition of GSK3beta by lithium in vivo suppressed the inflammatory response in mice infected with F. tularensis LVS and conferred a survival advantage.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5271	18929429-2031	The capacity for osmotic adjustment, superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities and proline content were also elevated in the transgenic Arabidopsis plants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5272	18929429-2031	The capacity for osmotic adjustment, superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities and proline content were also elevated in the transgenic Arabidopsis plants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5273	18929429-2031	The capacity for osmotic adjustment, superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities and proline content were also elevated in the transgenic Arabidopsis plants.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5274	18929477-2059	To prevent the effects of interfering anionic species, such as uric acid and ascorbic acid, on the sensor response, the Pt-Ir electrode was coated with Nafion, and then glucose oxidase was immobilized on the coated electrode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5275	18929477-2059	To prevent the effects of interfering anionic species, such as uric acid and ascorbic acid, on the sensor response, the Pt-Ir electrode was coated with Nafion, and then glucose oxidase was immobilized on the coated electrode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5276	18929477-2059	To prevent the effects of interfering anionic species, such as uric acid and ascorbic acid, on the sensor response, the Pt-Ir electrode was coated with Nafion, and then glucose oxidase was immobilized on the coated electrode.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5277	18929666-2130	A naturally occurring glycine to aspartic acid mutation at position 169 (G169D) in the putative transmembrane domain 4 (TM4) makes mice susceptible to Salmonella typhimurim, Leishmania donovani, and Mycobacterium bovis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5278	18929666-2130	A naturally occurring glycine to aspartic acid mutation at position 169 (G169D) in the putative transmembrane domain 4 (TM4) makes mice susceptible to Salmonella typhimurim, Leishmania donovani, and Mycobacterium bovis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5279	18930039-2213	Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5280	18930039-2214	The aim of this study was to monitor the level of serum free L-carnitine in combination with myoglobin (Myo) and creatine kinase (total activity and CK-MB level) for usefulness as a predictor of AMI in ICU patients.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5281	18930076-2223	Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5282	18930084-2225	L-penetratin was the most effective promoter of insulin absorption compared with others CPPs.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5283	18930084-2226	A dose-dependent relationship of L-penetratin and insulin bioavailability was statically significant.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5284	18930084-2227	There was no significant difference in the release of LDH in nasal lavage fluid and the integrity of nasal respiratory epithelium when L-penetratin was present.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5285	18930122-2233	Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5286	18930149-2366	Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny neurons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5287	18930149-2367	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5288	18930149-2367	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5289	18930149-2367	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5290	18930149-2368	The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5291	18930149-2368	The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5292	18930149-2369	Finally, we provided evidence for anandamide as an endovanilloid substance in the striatum, since genetic inhibition of anandamide degradation resulted in a tonic activation of TRPV1 channels modulating glutamate but not GABA release.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5293	18930474-2338	With the exception of significantly elevated serum prolactin after escitalopram, no effects in the secondary outcome measures were detected.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5294	18930547-2375	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5295	18930547-2375	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5296	18930547-2375	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5297	18930547-2375	The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5298	18930565-2381	Primaquine toxicity is aggravated in people deficient of 6-glucose phosphate dehydrogenase or glutathione synthetase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5299	18930648-795	Levels of interleukin-8 (IL-8) and 8-isoprostane were measured in epithelial lining fluid (ELF) from central and peripheral airways separately collected using a bronchoscopic microsampling technique.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5300	18930648-795	Levels of interleukin-8 (IL-8) and 8-isoprostane were measured in epithelial lining fluid (ELF) from central and peripheral airways separately collected using a bronchoscopic microsampling technique.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5301	18930650-823	Fluoroimmunoassay based on the fluorescent property of quantum dot was used along with immunoassay to detect 2,4-D. CdTe capped with mercaptopropionic acid, was conjugated using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC) and a coupling reagent like N-hydroxysuccinimide (NHS) to alkaline phosphatase (ALP) which was in turn conjugated to 2,4-D molecule.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5302	18930650-823	Fluoroimmunoassay based on the fluorescent property of quantum dot was used along with immunoassay to detect 2,4-D. CdTe capped with mercaptopropionic acid, was conjugated using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC) and a coupling reagent like N-hydroxysuccinimide (NHS) to alkaline phosphatase (ALP) which was in turn conjugated to 2,4-D molecule.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5303	18930705-2444	The SoxN protein is proposed to harbor the heme b of lower reduction potential and the heme a (s), and CbsA the other heme b.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5304	18930712-2448	Seleno-L-methionine (SeMet) can be oxidized to L-methionine selenoxide (MetSeO) by flavin-containing monooxygenase 3 (FMO3) and rat liver microsomes in the presence of NADPH.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5305	18930714-667	Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5306	18930714-667	Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5307	18930714-667	Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5308	18930714-668	Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion (GSIS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5309	18930714-668	Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion (GSIS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5310	18930714-668	Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion (GSIS).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5311	18930714-670	GTP-bound form) and membrane association of Rac1 in INS 832/13 cells and rat islets.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5312	18930714-671	Interestingly, however, in contrast to the inhibitory effects of NSC23766, Tiam1 gene depletion potentiated GSIS in these cells; such a potentiation of GSIS was sensitive to extracellular calcium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5313	18930760-2475	This vector allows the co-expression of alpha-Hb as a fusion protein with Glutathione S-Transferase (GST-alpha-Hb) and beta-Hb with an additional methionine at the N-terminal extremity (rbeta-Hb).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5314	18930760-2475	This vector allows the co-expression of alpha-Hb as a fusion protein with Glutathione S-Transferase (GST-alpha-Hb) and beta-Hb with an additional methionine at the N-terminal extremity (rbeta-Hb).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5315	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5316	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5317	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5318	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5319	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5320	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5321	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5322	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5323	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5324	18930779-791	Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5325	18930779-793	The erythrocyte CAT activity was higher in erdosteine group and there was a statistically significant increase, when compared with the erdosteine plus ischemia/reperfusion group.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5326	18930802-2496	The ethidium bromide (EB) demyelinating model was associated with vitamin E (Vit E) and ebselen (Ebs) treatment to evaluate acetylcholinesterase (AChE) activity in the striatum (ST), hippocampus (HP), cerebral cortex (CC) and erythrocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5327	18930802-2496	The ethidium bromide (EB) demyelinating model was associated with vitamin E (Vit E) and ebselen (Ebs) treatment to evaluate acetylcholinesterase (AChE) activity in the striatum (ST), hippocampus (HP), cerebral cortex (CC) and erythrocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5328	18930802-2496	The ethidium bromide (EB) demyelinating model was associated with vitamin E (Vit E) and ebselen (Ebs) treatment to evaluate acetylcholinesterase (AChE) activity in the striatum (ST), hippocampus (HP), cerebral cortex (CC) and erythrocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5329	18930802-2496	The ethidium bromide (EB) demyelinating model was associated with vitamin E (Vit E) and ebselen (Ebs) treatment to evaluate acetylcholinesterase (AChE) activity in the striatum (ST), hippocampus (HP), cerebral cortex (CC) and erythrocytes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5330	18930813-875	A search of publicly available microarray data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O(2)(-)) to hydrogen peroxide (H(2)O(2)), is consistently increased in high-grade and advanced-stage bladder tumors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5331	18930813-875	A search of publicly available microarray data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O(2)(-)) to hydrogen peroxide (H(2)O(2)), is consistently increased in high-grade and advanced-stage bladder tumors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5332	18930826-2517	In vivo TASK blockade by anandamide significantly increased infarct volumes at 24 h in mice undergoing 30 min of transient middle cerebral artery occlusion (tMCAO).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5333	18930833-2520	Glutathione S-transferases (GSTs) are multifunctional phase II detoxification enzymes that catalyze the attachment of electrophilic substrates to glutathione.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5334	18930833-2520	Glutathione S-transferases (GSTs) are multifunctional phase II detoxification enzymes that catalyze the attachment of electrophilic substrates to glutathione.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5335	18930846-916	It can use a dithiol-disulfide active-site to transfer reducing equivalents from NADPH to thioredoxin (Trx), via the cofactor FAD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5336	18930846-916	It can use a dithiol-disulfide active-site to transfer reducing equivalents from NADPH to thioredoxin (Trx), via the cofactor FAD.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5337	18930903-626	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that plays an essential role in oxygen homeostasis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5338	18930903-626	Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that plays an essential role in oxygen homeostasis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5339	18930948-1088	However, transferrin, a protein with no active site serine, was covalently modified in vitro by 0.5mM 10-fluoroethoxyphosphinyl-N-biotinamido pentyldecanamide, chlorpyrifos oxon, diisopropylfluorophosphate, dichlorvos, sarin, and soman.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5340	18931035-2612	The mechanism of lysoPAF-mediated inhibition of neutrophils involves an elevation in the intracellular cAMP level, and pharmacological blockade of adenylyl cyclase completely reverses the inhibitory effect of lysoPAF.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5341	18931047-2620	Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5342	18931047-2620	Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5343	18931108-2645	DnaB (BA) demonstrated a strong DNA helicase activity that required ATP or dATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5344	18931108-2645	DnaB (BA) demonstrated a strong DNA helicase activity that required ATP or dATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5345	18931108-2645	DnaB (BA) demonstrated a strong DNA helicase activity that required ATP or dATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5346	18931108-2645	DnaB (BA) demonstrated a strong DNA helicase activity that required ATP or dATP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5347	18931130-230	MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5348	18931136-2657	HmuY and HmuR are hemin binding proteins required for P. gingivalis growth.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5349	18931257-1820	The effect of tropomyosin on actin filaments was independent of ionic strength, but became stronger as the magnesium concentration increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5350	18931257-1820	The effect of tropomyosin on actin filaments was independent of ionic strength, but became stronger as the magnesium concentration increased.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5351	18931328-2696	We showed that, compared with the untreated CF serous cells, a 24-hour pre-incubation period with 200 nM salmeterol induced an 83% increase in delF508-CFTR-mediated chloride efflux.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5352	18931344-2072	Activation of Bax and Bak was demonstrated in peripheral blood mononuclear cells, and induction of apoptosis was related to overall obatoclax exposure, as monitored by the plasma concentration of oligonucleosomal DNA/histone complexes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5353	18931344-2072	Activation of Bax and Bak was demonstrated in peripheral blood mononuclear cells, and induction of apoptosis was related to overall obatoclax exposure, as monitored by the plasma concentration of oligonucleosomal DNA/histone complexes.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5354	18931380-2724	Liver glycidamide DNA adducts and acrylamide and glycidamide N-terminal valine hemoglobin adducts were also determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5355	18931380-2724	Liver glycidamide DNA adducts and acrylamide and glycidamide N-terminal valine hemoglobin adducts were also determined.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5356	18931380-2724	Liver glycidamide DNA adducts and acrylamide and glycidamide N-terminal valine hemoglobin adducts were also determined.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5357	18931475-2743	The acyl ghrelin peptide features a unique post-translational modification of O-n-octanoylation at serine 3, and is the only gastrointestinal signal that increases meal size.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5358	18931618-2800	Tests of the blood samples obtained at the ED revealed leucocytosis (11 070.6+/-4302.5/microl), increased blood glucose, LDH, CK and CK-MB levels.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5359	18931836-26	Molecular and biochemical characterization of a distinct tyrosinase involved in melanin production from Aeromonas media.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5360	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5361	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5362	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5363	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5364	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5365	18931836-28	TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5366	18931836-29	EDTA or glutathione notably inhibited the enzymatic activities of TyrA, whereas Triton X-100 and SDS activated them.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5367	18931836-30	These results suggest that TyrA is the first reported distinct tyrosinase involved in melanin production in the genus Aeromonas.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5368	18931836-30	These results suggest that TyrA is the first reported distinct tyrosinase involved in melanin production in the genus Aeromonas.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5369	18931932-360	AMP-deaminase from goldfish white muscle: regulatory properties and redistribution under exposure to high environmental oxygen level.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5370	18931932-361	Both sodium and potassium ions activated goldfish AMPD at low concentrations, with maximal activation at about 80 mM of each chloride salt, whereas higher concentrations became inhibitory.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5371	18931932-362	Magnesium and calcium ions also inhibited goldfish muscle AMPD, as did phosphate and fluoride ; at a concentration of 8 mM, each anion reduced activity by about 66%.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5372	18931932-362	Magnesium and calcium ions also inhibited goldfish muscle AMPD, as did phosphate and fluoride ; at a concentration of 8 mM, each anion reduced activity by about 66%.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5373	18931933-364	Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5374	18931933-364	Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5375	18931933-364	Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5376	18931933-364	Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5377	18931946-74	Unfolding and inactivation of abalone (Haliotis diversicolor) alkaline phosphatase during denaturation by guanidine hydrochloride.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5378	18931946-75	Unfolding and inactivation of ALPase from abalone (Haliotis diversicolor) during denaturation by guanidine hydrochloride (GuHCl) of different concentrations has first been studied.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5379	18931948-76	We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil (N-(2-hydroxyethyl) nicotinamide nitrate ester), in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5380	18931948-76	We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil (N-(2-hydroxyethyl) nicotinamide nitrate ester), in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5381	18932012-102	NADH/NAD (+) ratio can be normalized by the activation or overexpression of nicotinamide nucleotide transhydrogenase (NNT--> NADPH+ NAD (+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5382	18932012-102	NADH/NAD (+) ratio can be normalized by the activation or overexpression of nicotinamide nucleotide transhydrogenase (NNT--> NADPH+ NAD (+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5383	18932012-102	NADH/NAD (+) ratio can be normalized by the activation or overexpression of nicotinamide nucleotide transhydrogenase (NNT--> NADPH+ NAD (+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5384	18932012-102	NADH/NAD (+) ratio can be normalized by the activation or overexpression of nicotinamide nucleotide transhydrogenase (NNT--> NADPH+ NAD (+).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5385	18932024-913	An efficient electrocatalytic biosensor for sulfite detection was developed by co-immobilizing sulfite oxidase and cytochrome c with polyaniline sulfonic acid in a layer-by-layer assembly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5386	18932024-913	An efficient electrocatalytic biosensor for sulfite detection was developed by co-immobilizing sulfite oxidase and cytochrome c with polyaniline sulfonic acid in a layer-by-layer assembly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5387	18932046-599	After 10 days of treatment, otomicroscopic evaluation of tympanic membranes and measurement of anti-inflammatory mediators such as superoxide dismutase, nitrite/nitrate, glutathione peroxidase and malondialdehyde were performed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5388	18932046-599	After 10 days of treatment, otomicroscopic evaluation of tympanic membranes and measurement of anti-inflammatory mediators such as superoxide dismutase, nitrite/nitrate, glutathione peroxidase and malondialdehyde were performed.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5389	18932046-600	The levels of malondialdehyde and superoxide dismutase were lower in ginkgo groups but not significantly.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5390	18932201-188	These results indicate that cloned embryos have aberrant DNA methylation in the CpG sites of the PE region of Oct-4, and this may contribute directly to abnormal expression of this gene in cloned embryos.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5391	18932209-190	Xenopus follicle-enclosed oocytes are endowed with purinergic receptors located in the follicular cell membrane ; their stimulation by ATP elicits an electrical response that includes generation of a fast inward current (F(Cl)) carried by Cl(-).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5392	18932227-940	Moreover, the dopaminergic and glutamatergic regulation of Homer1 gene activation by cocaine was investigated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5393	18932227-941	The acute cocaine-mediated activation of Homer1 gene was regulated by D1 but not D2 dopamine receptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5394	18932227-942	Activation of Homer1 gene may contribute to the cocaine-mediated synaptic and behavioral plasticity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5395	18935970-1419	Eukaryotes plus their archaebacterial sisters form the clade neomura, which evolved from a radically modified derivative of an actinobacterial posibacterium that had replaced the ancestral eubacterial murein peptidoglycan by N-linked glycoproteins, radically modified its DNA-handling enzymes, and evolved cotranslational protein secretion, but not the isoprenoid-ether lipids of archaebacteria.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5396	18935970-1419	Eukaryotes plus their archaebacterial sisters form the clade neomura, which evolved from a radically modified derivative of an actinobacterial posibacterium that had replaced the ancestral eubacterial murein peptidoglycan by N-linked glycoproteins, radically modified its DNA-handling enzymes, and evolved cotranslational protein secretion, but not the isoprenoid-ether lipids of archaebacteria.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5397	18935973-1420	Necrostatin-1, a new inhibitor of non-apoptotic death, rescued cells from death by RIPs, although the effect was also partial and temporary.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5398	18935985-1424	Here we show the first direct quantitative evidence for PAP binding to the cap analog m(7)GTP.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5399	18935985-1425	van't Hoff analysis of m(7)GTP-PAP equilibrium reveals a binding reaction that is enthalpy driven and entropy favored with TDeltaS degrees contributing 15% to the overall value of DeltaG degrees.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5400	18935985-1426	eIFiso4G was shown to enhance the interaction of PAP with m(7)GTP cap analog by 2.4-fold.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5401	18936084-1443	In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5402	18936084-1443	In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5403	18936084-1443	In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5404	18936084-1443	In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5405	18936084-1443	In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5406	18936084-1444	In both cell types, follistatin attenuated the suppressive effect of activin A and BMP6 on forskolin-induced P4 secretion but had no effect alone.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5407	18936109-1448	1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based inactivator of both human and non-human cytochrome P450 (P450) enzymes.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5408	18936140-1459	7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5409	18936181-1478	ETEC infection also caused a drastic inhibition of host esterase activity, as measured by calcein fluorescence.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5410	18936191-1737	HCV-796 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, and boceprevir is an inhibitor of the NS3 serine protease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5411	18936191-1739	Mutations known to confer resistance to HCV-796 (NS5B C316Y) and boceprevir (NS3 V170A) were present in the combination-resistant replicons.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5412	18936191-1739	Mutations known to confer resistance to HCV-796 (NS5B C316Y) and boceprevir (NS3 V170A) were present in the combination-resistant replicons.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5413	18936772-1665	Increased apoptosis of a human salivary gland (HSG) cell line occurred only in the presence of lipopolysaccharide (LPS-) and interferon (IFN)-gamma-stimulated human monocytic THP-1 cells, which was reversed when caspase-1 in THP-1 cells was targeted by siRNA.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5414	18936912-1717	A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5415	18936912-1718	Genetic type 2 diabetic Goto-Kakizaki rats were fed with a high-fat diet to test hepatic effects of type 2 diabetes with hyperlipidemia and the effect of atorvastatin and insulin, individually and in combination, in systemic and hepatic inflammatory and oxidative stress markers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5416	18936912-1719	Combination of insulin and atorvastatin further improved glycemic and lipid profiles and decreased circulating C-reactive protein levels and liver inflammatory and oxidative stress markers.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5417	18936912-1720	Insulin and atorvastatin combination leads to better glycaemic and lipid profiles and to better protection against liver inflammation and oxidative stress, giving a superior level of liver protection in type 2 diabetic with hyperlipidemia.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5418	18936931-1732	Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5419	18936931-1732	Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5420	18936931-1732	Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5421	18936931-1732	Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5422	18936931-1733	The aim of this study was to assess the influence of the cytochrome (CYP450)3A5 and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5423	18936931-1733	The aim of this study was to assess the influence of the cytochrome (CYP450)3A5 and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5424	18936963-1743	The-417- and-593 bp promoter regions were sufficient for GUS gene activation by ethylene and methyl jasmonate treatments, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5425	18936963-1743	The-417- and-593 bp promoter regions were sufficient for GUS gene activation by ethylene and methyl jasmonate treatments, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5426	18936983-1746	Reversible two-step unfolding of heme-human serum albumin : a (1)H-NMR relaxometric and circular dichroism study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5427	18936983-1747	Human serum albumin (HSA) participates in heme scavenging, the bound heme turning out to be a reactivity center and a powerful spectroscopic probe.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5428	18936983-1747	Human serum albumin (HSA) participates in heme scavenging, the bound heme turning out to be a reactivity center and a powerful spectroscopic probe.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5429	18936983-1748	Here, the reversible unfolding of heme-HSA has been investigated by (1)H-NMR relaxometry, circular dichroism, and absorption spectroscopy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5430	18936994-1754	The purified enzymes were a monomer with an apparent molecular mass of 32 kDa (Chi32) and 46 kDa (Chi46), respectively, and showed chitinase activity bands with 0.01% glycol chitin as a substrate after SDS-PAGE.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5431	18937073-2436	Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5432	18937073-2436	Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5433	18937073-2436	Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5434	18937073-2437	Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5435	18937073-2437	Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5436	18937073-2437	Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5437	18937073-2437	Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5438	18937073-2437	Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5439	18937079-1799	Furthermore, we study the Akt activation after As(2)O(3) treatment and the HCC cells proliferation after combination of As(2)O(3) with PI3K inhibitor Wortmannin.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5440	18937214-1831	Carbofuran is a pesticide whose acute toxicity is due to inhibition of acetylcholinesterase.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5441	18937289-1865	The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5442	18937289-1865	The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5443	18937289-1865	The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5444	18937289-1865	The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5445	18937323-1876	cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5446	18937323-1876	cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5447	18937323-1878	Taken together, our results, obtained with endogenously expressed proteins, are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5448	18937323-1878	Taken together, our results, obtained with endogenously expressed proteins, are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5449	18937360-1888	Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5450	18937368-1889	Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5451	18937368-1889	Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5452	18937368-1889	Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5453	18937368-1889	Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5454	18937368-1891	This study examines the structural basis for HSA binding of Cu-PTSM and Cu-ATSM via competition with drugs having known albumin binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5455	18937368-1891	This study examines the structural basis for HSA binding of Cu-PTSM and Cu-ATSM via competition with drugs having known albumin binding sites.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5456	18937368-1892	Cu-ATSM from HSA.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5457	18937368-1893	At 8:1 warfarin: HSA Cu-ATSM levels increased 300-500%.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5458	18937368-1894	Cu-ATSM was observed except at high ibuprofen: HSA ratios, where secondary ibuprofen binding to the IIA site may cause modest radiopharmaceutical displacement.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5459	18937625-2531	0.05) in the overall glucose-mediated insulin response.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5460	18937625-2532	Glucose-stimulated insulin levels were not significantly different from controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5461	18937643-2052	The inducible form of nitric oxide synthase (NOS2) plays an important role in sepsis incurred as a result of infection with Gram-negative bacteria that elaborate endotoxin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5462	18937643-2052	The inducible form of nitric oxide synthase (NOS2) plays an important role in sepsis incurred as a result of infection with Gram-negative bacteria that elaborate endotoxin.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5463	18937645-884	Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5464	18937645-885	Sialic acid linkages were identified for voltage-gated potassium channels, Kv3.1, 3.3, 3.4, 1.1, 1.2 and 1.4, by evaluating their electrophoretic migration patterns in adult rat brain membranes digested with various glycosidases.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5465	18937879-2138	No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5466	18937879-2139	In this study, regional distribution of dopamine D2 receptor occupancy by risperidone was determined in order to elucidate the limbic and cortical selectivity of second-generation antipsychotics.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5467	18937879-2140	Striatal and extrastriatal dopamine D2 receptor binding FLB 457, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5468	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5469	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5470	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5471	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5472	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5473	18937971-2150	TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5474	18938111-2180	NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP) has been implicated as a key player in intestinal immune health and disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5475	18938142-2192	Exposure of HEK293 cells to BK produced a concentration-dependent rise in intracellular Ca(2+) (EC(50)=36.5+/-8.0 x 10(-9)M), a rapid increase in tyrosine phosphorylation of ERK (EC(50)=9.8+/-0.4 x 10(-9)M), and elevation in ECAR by approximately 20%.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5476	18938163-2196	IGF-I expression coupled with infusion of the IGF binding protein inhibitor NBI-31772 significantly prevented corticospinal motor neuron death 0.05), but did not promote corticospinal axon regeneration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5477	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5478	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5479	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5480	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5481	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5482	18938187-2204	A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5483	18938240-2219	We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clathrin adaptor AP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5484	18938240-2219	We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clathrin adaptor AP-2.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5485	18939895-2826	Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5486	18940183-691	Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5487	18940183-691	Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5488	18940183-692	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5489	18940183-692	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5490	18940188-92	Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5491	18940188-93	We studied the gene-environment interaction in the pathogenesis of KD by assessing the association of low blood selenium and polymorphisms in glutathione peroxidase-1 (GPx-1) gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5492	18940188-93	We studied the gene-environment interaction in the pathogenesis of KD by assessing the association of low blood selenium and polymorphisms in glutathione peroxidase-1 (GPx-1) gene.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5493	18940204-495	However, under the pressure of a death stimulus such as edelfosine treatment, L. infantum EndoG is released from the single mitochondrion and translocates to the nucleus, where it is thought to participate in the process of DNA degradation that is associated with programmed cell death.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5494	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5495	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5496	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5497	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5498	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5499	18940228-124	Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5500	18940247-147	However, these events were blocked by treatment with the antioxidant, N-acetyl-cysteine (NAC), as well as GCK overexpression.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5501	18940267-156	It decreased TG levels in tyloxapol-induced hyperlipidemia and increased high-density lipoprotein cholesterol (HDL-C) and reduced atherogenic index in normotensive rats.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5502	18940894-262	This analysis reveals TRPCs as major and unsuspected gates of Ca(2+) entry that contribute, depending on context, to activation of transcription factors, apoptosis, vascular contractility, platelet activation, and cardiac hypertrophy, as well as to normal and abnormal cell proliferation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5503	18940938-278	A single bout of exercise increases glucose uptake and fatty acid oxidation in skeletal muscle, with a corresponding activation of AMP-activated protein kinase (AMPK).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5504	18940938-278	A single bout of exercise increases glucose uptake and fatty acid oxidation in skeletal muscle, with a corresponding activation of AMP-activated protein kinase (AMPK).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5505	18940938-280	Changes in oxygen consumption and the RQ ratio during sedentary and low-intensity exercise were not different between alpha(1)-AMPK-DN and WT.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5506	18941142-329	ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5507	18941467-423	DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5508	18941467-423	DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5509	18941467-423	DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5510	18941467-423	DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5511	18941467-424	Effects of DHT on COX-2 and iNOS were attenuated by flutamide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5512	18941467-424	Effects of DHT on COX-2 and iNOS were attenuated by flutamide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5513	18941467-424	Effects of DHT on COX-2 and iNOS were attenuated by flutamide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5514	18941467-424	Effects of DHT on COX-2 and iNOS were attenuated by flutamide.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5515	18941467-426	In conclusion, activation of the NFkappaB-mediated COX-2/iNOS pathway by the selective androgen receptor agonist, DHT, results in a state of vascular inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5516	18941467-426	In conclusion, activation of the NFkappaB-mediated COX-2/iNOS pathway by the selective androgen receptor agonist, DHT, results in a state of vascular inflammation.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5517	18941468-399	After MRI, one group of animals had BBB permeability measured in the WM with (14)C-sucrose, and another had Evans blue (EB) injected for fluorescent microscopy for MMP-2, MMP-9, tight junction proteins (TJPs), and in situ zymography.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5518	18941468-399	After MRI, one group of animals had BBB permeability measured in the WM with (14)C-sucrose, and another had Evans blue (EB) injected for fluorescent microscopy for MMP-2, MMP-9, tight junction proteins (TJPs), and in situ zymography.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5519	18941468-399	After MRI, one group of animals had BBB permeability measured in the WM with (14)C-sucrose, and another had Evans blue (EB) injected for fluorescent microscopy for MMP-2, MMP-9, tight junction proteins (TJPs), and in situ zymography.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5520	18941468-399	After MRI, one group of animals had BBB permeability measured in the WM with (14)C-sucrose, and another had Evans blue (EB) injected for fluorescent microscopy for MMP-2, MMP-9, tight junction proteins (TJPs), and in situ zymography.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5521	18941714-1885	The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5522	18941797-421	Effects of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5523	18941818-549	Goldfish scales were incubated either with 20:3n-9 or with oleic acid at 15 degrees C for 6 and 18 h. Both osteoblastic and osteoclastic activities in the scale were assessed by measuring alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5524	18941818-549	Goldfish scales were incubated either with 20:3n-9 or with oleic acid at 15 degrees C for 6 and 18 h. Both osteoblastic and osteoclastic activities in the scale were assessed by measuring alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase, respectively.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5525	18941818-550	MC3T3-E1 cells (an osteoblast cell line derived from the mouse) were incubated with 20:3n-9 or oleic acid at 37 degrees C for 6 and 18 h. ALP activity in cell lysate was measured.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5526	18941890-590	Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5527	18941890-591	Both kinases have been implicated in the phosphorylation of serine 118 and serine 167 on ERalpha, respectively.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5528	18941890-592	Our data show for the first time that ROS can induce post-translational modifications of ERalpha at serine 118 and serine 167, and may lead to ERalpha down-regulation in human breast cancer cells.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5529	18942092-662	Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5530	18942097-665	Expression of the histone H2B-GFP fusion protein was observed exclusively upon doxycycline induction and was uniformly distributed throughout the intestinal epithelium.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5531	18942140-690	On hexanoamide the amidase exhibited a K(m) value of 5.5 mM compared to 0.07 mM for p-nitroacetanilide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5532	18942140-690	On hexanoamide the amidase exhibited a K(m) value of 5.5 mM compared to 0.07 mM for p-nitroacetanilide.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5533	18942727-207	Recoverin is an important neuronal calcium sensor (NCS) protein, which have been implicated in a wide range of Ca(2+) signaling events in neurons and photoreceptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5534	18942727-207	Recoverin is an important neuronal calcium sensor (NCS) protein, which have been implicated in a wide range of Ca(2+) signaling events in neurons and photoreceptors.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5535	18942747-893	A decrease in P2X (7)R expression was observed in cultured OPCs after exposure to oxygen-glucose deprivation (OGD) for 2 h in vitro.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5536	18945212-1760	Reactivity of nitric oxide with the (4Fe-4S) cluster of dihydroxyacid dehydratase from Escherichia coli.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5537	18945212-1763	The rate constant for the initial reaction between NO and the IlvD (4Fe-4S) cluster is estimated to be (7.0+/-2.0)x10(6) M(-2) x s(-1) at 25 degrees C, which is approx.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5538	18945215-1768	Acylcarnitines have been suggested to play a role in insulin resistance, as well as other long-chain fatty acid metabolites.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5539	18945215-1769	In the present study we investigated whether muscle long-chain acylcarnitines increase during fasting and we investigated their relationship with glucose/fat oxidation and insulin sensitivity in lean healthy humans.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5540	18945217-1773	Ethanol attenuates the HFS-induced, ERK-mediated LTP in a dose-dependent manner in rat striatum.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5541	18945429-1846	These results suggest that StAR delivers cholesterol to mitochondria where regulatory oxysterols are generated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5542	18945563-2825	17beta-Hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, which might play an important role in follicular development of the ovary.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5543	18945563-2825	17beta-Hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, which might play an important role in follicular development of the ovary.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5544	18945611-1922	MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5545	18945611-1923	To investigate the correlation between O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and benefit from temozolomide in patients with recurrent high-grade glioma.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5546	18945624-1926	Betulinic acid binding to human serum albumin : a study of protein conformation and binding affinity.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5547	18945756-2007	Adenosine nucleotide translocase (ANT) translocates ADP/ATP across the inner mitochondrial membrane.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5548	18945757-720	This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5549	18945757-720	This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5550	18945783-756	Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5551	18945810-2026	Glucocorticoid-activated GR repressed COX-2 gene induction by lipopolysaccharide (LPS).	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5552	18945821-2039	Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5553	18945824-860	The data provide the first demonstration for the presence of V2R in primary cilia of renal epithelial cells, and a functional cAMP-signaling pathway, which targets ciliary channel function and may help control the sensory function of the primary cilium.	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5554	18945826-2045	The endothelial (Ca(2+))(CYT) response to bradykinin (100 nM) was significantly attenuated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5555	18945826-2045	The endothelial (Ca(2+))(CYT) response to bradykinin (100 nM) was significantly attenuated.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5556	18945930-874	The purpose of this research was to enhance intranasal drug targeting to the CNS by incorporating a vasoconstrictor (phenylephrine (PHE)) into nasal formulations containing therapeutic neuropeptides (hypocretin-1 (HC) or the dipeptide L-Tyr-D-Arg (D-KTP)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5557	18945930-874	The purpose of this research was to enhance intranasal drug targeting to the CNS by incorporating a vasoconstrictor (phenylephrine (PHE)) into nasal formulations containing therapeutic neuropeptides (hypocretin-1 (HC) or the dipeptide L-Tyr-D-Arg (D-KTP)).	No interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5558	18945988-1510	CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5559	18945988-1510	CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5560	18945988-1510	CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5561	18945988-1510	CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked
5562	18945988-1510	CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure.	Interaction	Interaction No interaction Wrong annotation compound Wrong annotation protein Wrong annotation both Unclear		Unchecked